Clinical radiobiology of glioblastoma multiforme: estimation of tumor control probability from various radiotherapy fractionation schemes (769 views)
Strahlenther Onkol (ISSN: 0179-7158, 0179-7158linking), 2014 Oct; 190(10): 925-932.
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Paper type: Journal Article, Evaluation Studies, Validation Studies,
Impact factor: 2.914, 5-year impact factor: 2.402
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84919873901&partnerID=40&md5=8a68c7c1f7d3f80637d3bcd33c9d7fe9
Keywords: Accelerated Proliferation, Glioblastoma Multiforme, Hypofractionation, Intrinsic Radiosensitivity, Repopulation Kinetics, Carmustine, Temozolomide, Article, Cancer Adjuvant Therapy, Cancer Control, Cancer Radiotherapy, Cancer Surgery, Clinical Study, Controlled Study, Human, Hypothesis, Major Clinical Study, Outcome Assessment, Radiation Dose, Radiobiology, Biological Model, Brain Neoplasms, Computer Assisted Radiotherapy, Computer Simulation, Evaluation Study, Pathophysiology, Procedures, Prognosis, Radiation Dose Fractionation, Reproducibility, Risk Assessment, Sensitivity And Specificity, Statistical Analysis, Statistical Model, Statistics And Numerical Data, Treatment Outcome, Validation Study, Data Interpretation, Outcome Assessment (health Care), Radiation Tolerance, Conformal, Reproducibility Of Results, Brain Neoplasms Physiopathology Radiotherapy, Glioblastoma Physiopathology Radiotherapy, Outcome Assessment (health Care) Methods, Conformal Statistics, Risk Assessment Methods,
Affiliations:
*** IBB - CNR ***
Unit of Nuclear Medicine, Department of Radiation and Metabolic Therapies, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, 1-Padre-Pio-Street, Rionero-in-Vulture, Italy, ppiern@libero.it.
Radiation Oncology Department, Sacro Cuore – Don Calabria HospitalNegrar, Verona, Italy
Laboratory of Preclinical and Translational Research, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.BRionero-in-Vulture, Italy
Unit of Radiation Oncology, Department of Medicine Surgery and Neurological Sciences, University of Siena and Tuscany Tumor InstituteSiena, Italy
Unit of Radiotherapy, Department of Radiation and Metabolic Therapies, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.BRionero-in-Vulture, Italy
References:
Not available.
Strahlenther Onkol (ISSN: 0179-7158, 0179-7158linking), 2014 Oct; 190(10): 925-932.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Evaluation Studies, Validation Studies,
Impact factor: 2.914, 5-year impact factor: 2.402
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84919873901&partnerID=40&md5=8a68c7c1f7d3f80637d3bcd33c9d7fe9
Keywords: Accelerated Proliferation, Glioblastoma Multiforme, Hypofractionation, Intrinsic Radiosensitivity, Repopulation Kinetics, Carmustine, Temozolomide, Article, Cancer Adjuvant Therapy, Cancer Control, Cancer Radiotherapy, Cancer Surgery, Clinical Study, Controlled Study, Human, Hypothesis, Major Clinical Study, Outcome Assessment, Radiation Dose, Radiobiology, Biological Model, Brain Neoplasms, Computer Assisted Radiotherapy, Computer Simulation, Evaluation Study, Pathophysiology, Procedures, Prognosis, Radiation Dose Fractionation, Reproducibility, Risk Assessment, Sensitivity And Specificity, Statistical Analysis, Statistical Model, Statistics And Numerical Data, Treatment Outcome, Validation Study, Data Interpretation, Outcome Assessment (health Care), Radiation Tolerance, Conformal, Reproducibility Of Results, Brain Neoplasms Physiopathology Radiotherapy, Glioblastoma Physiopathology Radiotherapy, Outcome Assessment (health Care) Methods, Conformal Statistics, Risk Assessment Methods,
Affiliations:
*** IBB - CNR ***
Unit of Nuclear Medicine, Department of Radiation and Metabolic Therapies, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.B, 1-Padre-Pio-Street, Rionero-in-Vulture, Italy, ppiern@libero.it.
Radiation Oncology Department, Sacro Cuore – Don Calabria HospitalNegrar, Verona, Italy
Laboratory of Preclinical and Translational Research, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.BRionero-in-Vulture, Italy
Unit of Radiation Oncology, Department of Medicine Surgery and Neurological Sciences, University of Siena and Tuscany Tumor InstituteSiena, Italy
Unit of Radiotherapy, Department of Radiation and Metabolic Therapies, I.R.C.C.S.-Regional-Cancer-Hospital-C.R.O.BRionero-in-Vulture, Italy
References:
Not available.
Clinical radiobiology of glioblastoma multiforme: estimation of tumor control probability from various radiotherapy fractionation schemes
BACKGROUND AND PURPOSE: The aim of this study was to estimate a radiobiological set of parameters from the available clinical data on glioblastoma (GB).; PATIENTS AND METHODS: A number of clinical trial outcomes from patients affected by GB and treated with surgery and adjuvant radiochemotherapy were analyzed to estimate a set of radiobiological parameters for a tumor control probability (TCP) model. The analytical/graphical method employed to fit the clinical data allowed us to estimate the intrinsic tumor radiosensitivity (alpha), repair capability (b), and repopulation doubling time (T d ) in a first phase, and subsequently the number of clonogens (N) and kick-off time for accelerated proliferation (T(k)). The results were used to formulate a hypothesis for a schedule expected to significantly improve local control. The 95 % confidence intervals (CI(95 %)) of all parameters are also discussed.; RESULTS: The pooled analysis employed to estimate the parameters summarizes the data of 559 patients, while the studies selected to verify the results summarize data of 104 patients. The best estimates and the CI(95 %) are alpha = 0.12 Gy⁻ (0.10-0.14), b = 0.015 Gy⁻ (0.013-0.020), alpha/b = 8 Gy (5.0-10.8), T(d) = 15.4 days (13.2-19.5), N = 1.10⁴(1.2.10 - 1.10⁵), and T(k) = 37 days (29-46). The dose required to offset the repopulation occurring after 1 day (D(prolif)) and starting after T k was estimated as 0.30 Gy/day (0.22-0.39).; CONCLUSION: The analysis confirms a high value for the alpha/b ratio. Moreover, a high intrinsic radiosensitivity together with a long kick-off time for accelerated repopulation and moderate repopulation kinetics were found. The results indicate a substantial independence of the duration of the overall treatment and an improvement in the treatment effectiveness by increasing the total dose without increasing the dose fraction.
BACKGROUND AND PURPOSE: The aim of this study was to estimate a radiobiological set of parameters from the available clinical data on glioblastoma (GB).; PATIENTS AND METHODS: A number of clinical trial outcomes from patients affected by GB and treated with surgery and adjuvant radiochemotherapy were analyzed to estimate a set of radiobiological parameters for a tumor control probability (TCP) model. The analytical/graphical method employed to fit the clinical data allowed us to estimate the intrinsic tumor radiosensitivity (alpha), repair capability (b), and repopulation doubling time (T d ) in a first phase, and subsequently the number of clonogens (N) and kick-off time for accelerated proliferation (T(k)). The results were used to formulate a hypothesis for a schedule expected to significantly improve local control. The 95 % confidence intervals (CI(95 %)) of all parameters are also discussed.; RESULTS: The pooled analysis employed to estimate the parameters summarizes the data of 559 patients, while the studies selected to verify the results summarize data of 104 patients. The best estimates and the CI(95 %) are alpha = 0.12 Gy⁻ (0.10-0.14), b = 0.015 Gy⁻ (0.013-0.020), alpha/b = 8 Gy (5.0-10.8), T(d) = 15.4 days (13.2-19.5), N = 1.10⁴(1.2.10 - 1.10⁵), and T(k) = 37 days (29-46). The dose required to offset the repopulation occurring after 1 day (D(prolif)) and starting after T k was estimated as 0.30 Gy/day (0.22-0.39).; CONCLUSION: The analysis confirms a high value for the alpha/b ratio. Moreover, a high intrinsic radiosensitivity together with a long kick-off time for accelerated repopulation and moderate repopulation kinetics were found. The results indicate a substantial independence of the duration of the overall treatment and an improvement in the treatment effectiveness by increasing the total dose without increasing the dose fraction.
Clinical radiobiology of glioblastoma multiforme: estimation of tumor control probability from various radiotherapy fractionation schemes
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Clinical radiobiology of glioblastoma multiforme: estimation of tumor control probability from various radiotherapy fractionation schemes
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Pedicini P, Fiorentino A, Improta G, Nappi A, Salvatore M, Storto G
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Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
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Impact Factor: 2.107
View Export to BibTeX Export to EndNote
* Normal tissue complication probability (NTCP) models for modern radiation therapy (337 views)
Semin Oncol (ISSN: 0093-7754linking), 2019 Jun; 46(3): 210-218.
Impact Factor: 3.606
View Export to BibTeX Export to EndNote
Pedicini P, Fiorentino A, Improta G, Nappi A, Salvatore M, Storto G
* Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma (553 views)
Clin Transl Oncol (ISSN: 1699-048x), 2013 Nov; 15(11): 919-924.
Impact Factor: 1.6
View Export to BibTeX Export to EndNote
Costa B, Bendinelli S, Gabelloni P, Da Pozzo E, Daniele S, Scatena F, Vanacore R, Campiglia P, Bertamino A, Gomez-Monterrey I, Sorriento D, Del Giudice C, Iaccarino G, Novellino E, Martini C
* Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor (588 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013; 8(8): e72281-e72281.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (698 views)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
View Export to BibTeX Export to EndNote
4 Records (3 excluding Abstracts).
Total impact factor: 10.847 (8.74 excluding Abstracts).
Total 5 year impact factor: 7.88 (5.394 excluding Abstracts).
Total impact factor: 10.847 (8.74 excluding Abstracts).
Total 5 year impact factor: 7.88 (5.394 excluding Abstracts).
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