Optimizing radiotherapy of orbital and paraorbital tumors: intensity-modulated X-ray beams vs. intensity-modulated proton beams (433 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2000; 47(4): 1111-1119.
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Paper type: Journal Article,
Impact factor: 3.058, 5-year impact factor: 4.441
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034237463&partnerID=40&md5=ae3bb3e9a20f80f2c8c14819a9186f7b
Keywords: Intensity Modulation, Meningioma, Orbital Tumors, Protontherapy, Rhabdomyosarcoma, Article, Beam Therapy, Case Report, Human, Lymphoma, Optic Nerve Tumor, Orbit Tumor, Priority Journal, Radiation Dose Distribution, Radiation Injury, Treatment Planning, X Ray, Optic Nerve Neoplasms, Orbital Neoplasms, Radiotherapy, Conformal, Skull Neoplasms, Sphenoid Bone, Tomography, X-Ray Computed,
Affiliations:
Division de Radio-Oncologie, Hôpitaux Universitaires, Genève, Switzerland
Strahlenmedizin Abteilung, Paul Scherrer Institut, Villigen, Switzerland
References:
Not available.
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2000; 47(4): 1111-1119.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.058, 5-year impact factor: 4.441
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034237463&partnerID=40&md5=ae3bb3e9a20f80f2c8c14819a9186f7b
Keywords: Intensity Modulation, Meningioma, Orbital Tumors, Protontherapy, Rhabdomyosarcoma, Article, Beam Therapy, Case Report, Human, Lymphoma, Optic Nerve Tumor, Orbit Tumor, Priority Journal, Radiation Dose Distribution, Radiation Injury, Treatment Planning, X Ray, Optic Nerve Neoplasms, Orbital Neoplasms, Radiotherapy, Conformal, Skull Neoplasms, Sphenoid Bone, Tomography, X-Ray Computed,
Affiliations:
Division de Radio-Oncologie, Hôpitaux Universitaires, Genève, Switzerland
Strahlenmedizin Abteilung, Paul Scherrer Institut, Villigen, Switzerland
References:
Not available.
Optimizing radiotherapy of orbital and paraorbital tumors: intensity-modulated X-ray beams vs. intensity-modulated proton beams
Purpose: This study presents a dosimetric optimization effort aiming to compare intensity-modulated (IM) X-rays and IM protons in 4 different orbital and paraorbital tumors. These are most challenging targets for standard radiotherapy due to their close relationship with the eyes and related structures.Methods and Materials: A primary orbital lymphoma, an optic nerve meningioma, a sphenoidal ridge meningioma protruding into the orbit, and a pediatric parameningeal paraorbital rhabdomyosarcoma were selected for the purpose of this study. Planning target volumes (PTVs) and organs at risk (OAR) were defined in each patient CT data set for each tumor site. IM X-ray and IM proton three-dimensional treatment plans were implemented. The following total tumor doses were prescribed: 30 Gy for the orbital lymphoma, 54 Gy for both meningiomas, and 50.4 Gy for the rhabdomyosarcoma case. Dose-volume histograms (DVHs) were obtained for all targets and OAR with both treatment techniques. DVHs were used to predict normal tissue complication probabilities (NTCPs) for the OAR in the vicinity of the tumor.Results: The PTV coverage was optimal and equally homogeneous with both IM X-rays and IM proton plans in the 4 tumor sites. DVHs for most OAR were better with IM proton beams especially in the low- to mid-dose range region. The integral nontarget dose was lower with IM protons in every case (factor ranging from 1.5 to 1.9). However, predicted NTCPs (for severe late effects) were equally low for both treatment techniques in every tumor site.Conclusion: Although IM proton plans optimally decreased the dose to the OAR in all tumor sites, both optimized X-ray and proton beams equally succeeded to reduce severe-toxicity prediction risks to less than 5% while optimally treating the PTV. Copyright (C) 2000 Elsevier Science Inc.
Purpose: This study presents a dosimetric optimization effort aiming to compare intensity-modulated (IM) X-rays and IM protons in 4 different orbital and paraorbital tumors. These are most challenging targets for standard radiotherapy due to their close relationship with the eyes and related structures.Methods and Materials: A primary orbital lymphoma, an optic nerve meningioma, a sphenoidal ridge meningioma protruding into the orbit, and a pediatric parameningeal paraorbital rhabdomyosarcoma were selected for the purpose of this study. Planning target volumes (PTVs) and organs at risk (OAR) were defined in each patient CT data set for each tumor site. IM X-ray and IM proton three-dimensional treatment plans were implemented. The following total tumor doses were prescribed: 30 Gy for the orbital lymphoma, 54 Gy for both meningiomas, and 50.4 Gy for the rhabdomyosarcoma case. Dose-volume histograms (DVHs) were obtained for all targets and OAR with both treatment techniques. DVHs were used to predict normal tissue complication probabilities (NTCPs) for the OAR in the vicinity of the tumor.Results: The PTV coverage was optimal and equally homogeneous with both IM X-rays and IM proton plans in the 4 tumor sites. DVHs for most OAR were better with IM proton beams especially in the low- to mid-dose range region. The integral nontarget dose was lower with IM protons in every case (factor ranging from 1.5 to 1.9). However, predicted NTCPs (for severe late effects) were equally low for both treatment techniques in every tumor site.Conclusion: Although IM proton plans optimally decreased the dose to the OAR in all tumor sites, both optimized X-ray and proton beams equally succeeded to reduce severe-toxicity prediction risks to less than 5% while optimally treating the PTV. Copyright (C) 2000 Elsevier Science Inc.
Optimizing radiotherapy of orbital and paraorbital tumors: intensity-modulated X-ray beams vs. intensity-modulated proton beams
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Optimizing radiotherapy of orbital and paraorbital tumors: intensity-modulated X-ray beams vs. intensity-modulated proton beams
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Tedeschi E, Soricelli A, Brunetti A, Romano M, Bucciero A, Iaconetta G, Alfieri A, Postiglione A, Salvatore M
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* A novel framework for spatial normalization of dose distributions in voxel-based analyses of brain irradiation outcomes (170 views)
Phys Med (ISSN: 1120-1797linking), 2020 Jan; 69: 164-169.
Impact Factor: 2.485
View Export to BibTeX Export to EndNote
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
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Impact Factor: 19.358
View Export to BibTeX Export to EndNote
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Impact Factor: 8.303
View Export to BibTeX Export to EndNote
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Impact Factor: 3.151
View Export to BibTeX Export to EndNote
Pacelli R, Cella L, Conson M, Tranfa F, Strianese D, Liuzzi R, Solla R, Farella A, Salvatore M, Bonavolonta G
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Impact Factor: 1.683
View Export to BibTeX Export to EndNote
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Impact Factor: 5.036
View Export to BibTeX Export to EndNote
Pacelli R, Tranfa F, Strianese D, Nieddu V, Baronissi I, Solla R, Farella A, Cella L, Liuzzi R, Punzo G, Salvatore M, Bonovolontà G
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Impact Factor: 4.337
View Export to BibTeX Export to EndNote
Miralbell R, Lomax A, Cella L, Schneider U
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Impact Factor: 3.756
View Export to BibTeX Export to EndNote
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Phys Med (ISSN: 1120-1797, 1120-1797linking), 2001; 17(SUPPL.1): 100-102.
Impact Factor: 0.556
View Export to BibTeX Export to EndNote
Soricelli A, Cuocolo A, Varrone A, Discepolo A, Tedeschi E, Mainenti PP, Grivet-Fojaja MR, Covelli EM, Postiglione A, Salvatore M
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Impact Factor: 3.064
View Export to BibTeX Export to EndNote
Tedeschi E, Soricelli A, Brunetti A, Romano M, Bucciero A, Iaconetta G, Alfieri A, Postiglione A, Salvatore M
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Impact Factor: 2.692
View Export to BibTeX Export to EndNote
11 Records (9 excluding Abstracts).
Total impact factor: 54.421 (41.781 excluding Abstracts).
Total 5 year impact factor: 63.911 (51.207 excluding Abstracts).
Total impact factor: 54.421 (41.781 excluding Abstracts).
Total 5 year impact factor: 63.911 (51.207 excluding Abstracts).
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