The effect of track structure on the induction of chromosomal aberrations in murine cells (737 views)
Int J Radiat Biol International Journal Of Radiation Biology (ISSN: 0955-3002), 1998 Mar; 73(3): 253-262.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.579, 5-year impact factor: 1.933
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031946676&partnerID=40&md5=fba5d682817409f433ddfedf86b008b1
Keywords: Article, Chromatid Exchange, Chromosome 2, Chromosome Aberration, Dna Probe, Fluorescence In Situ Hybridization, Mitosis Rate, Mouse, Nonhuman, Priority Journal, Radiation Exposure, Radiation Injury, Nasa Center Jsc, Nasa Discipline Radiation Health, Animals, Cell Line, Dna Damage, Dose-Response Relationship, Inbred C3h, Particle Accelerators, Protons, Translocation, Genetic,
Affiliations:
Dipartimento di Scienze Fisiche, Univ. Federico II, Monte S. Angelo, Via Cintia, 80126 Napoli, Italy
Space and Particle Radiation Group, Natl. Inst. for Radiological Sci., 9-1 Anagawa-4-chome, Inage-ku, Chiba 263, Japan
Krug Life Sciences, 1290 Hercules Drive, Houston, TX 77058, United States
NASA Johnson Space Center, Mail Code SD2, Houston, TX 77058, United States
References:
Barendsen, G.W., Mechanisms of cell reproductive death and shapes of radiation dose-survival curves of mammalian cells (1990) International Journal of Radiation Biology, 57, pp. 885-89
Boei, J.J.W.A., Natarajan, A.T., Classification of X-ray-induced Robertsonian fusion-like configurations in mouse splenocytes (1996) International Journal of Radiation Biology, 69, pp. 421-427
Boei, J.J.W.A., Balajee, A.S., De Boer, P., Rens, W., Aten, J.A., Mullenders, L.H.F., Natarajan, A.T., Construction of mouse chromosome-specific DNA libraries and their use for the detection of X-ray-induced aberrations (1994) International Journal of Radiation Biology, 65, pp. 583-590
Breneman, J.W., Ramsey, M.J., Lee, D.A., Eveleth, G.G., Minkler, J.L., Tucker, J.D., The development of chromosome-specific composite DNA probes for the mouse and their application to chromosome painting (1993) Chromosoma, 102, pp. 591-598
Butts, J.J., Katz, R., Theory of RBE for heavy ion bombardment of dry enzymes and viruses (1967) Radiation Research, 30, pp. 855-871
Chadwick, K.H., Leenhouts, H.P., (1981) The Molecular Theory of Radiation Biology, , Springer-Verlag, Berlin
Cornforth, M.N., Bedford, J.S., Ionizing radiation damage and its early development in chromosomes (1993) Advances in Radiation Biology, 17, pp. 423-497
Durante, M., Grossi, G., Napolitano, M., Pugliese, M., Gialanella, G., Chromosome damage induced by high-LET α-particles in plateau-phase C3H 10T1/2 cells (1992) International Journal of Radiation Biology, 62, pp. 571-580
Durante, M., Gialanella, G., Grossi, G., Pugliese, M., Thickness measurements on living cell monolayers by nuclear methods (1993) Nuclear Instruments and Methods, B73, pp. 543-549
Edwards, A.A., Lloyd, D.C., Prosser, J.S., The induction of chromosome aberrations in human lymphocytes by accelerated charged particles (1985) Radiation Protection Dosimetry, 13, pp. 205-209
Goodhead, D.T., Belli, M., Mill, A.J., Bance, D.A., Allen, L.A., Hall, S.C., Ianzini, F., Wilkinson, R.A., Direct comparison between protons and alpha-particles at the same LET. I. Irradiation methods and inactivation of synchronous V79, HeLa and C3H10T1/2 cells (1992) International Journal of Radiation Biology, 61, pp. 611-624
Goodwin, E.H., Bailey, S.M., Chen, D.J., Cornforth, M.N., The effect of track structure on cell inactivation and chromosome damage at a constant LET of 120 keV/μm (1996) Advances in Space Research, 18 (1-2), pp. 93-98
Hande, M.P., Boei, J.J.W.A., Granath, F., Natarajan, A.T., Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body irradiation analysed by fluorescence in situ hybridization. I. Dicentrics and translocations (1996) International Journal of Radiation Biology, 69, pp. 437-446
Hei, T.K., Komatsu, K., Hall, E.J., Zaider, M., Oncogenic transformation by charged particles of defined LET (1988) Carcinogenesis, 9, pp. 747-750
Quantities and units in radiation protection dosimetry (1993) ICRU Report No. 51, , Bethesda, ICRU Publications
James, F., Roos, M., (1983) Function Minimization and Error Analysis, , CERN Computer Center Program Library D506, Geneva
Katz, R., Radiobiological modeling based on track structure (1988) Quantitative Mathematical Models in Radiation Biology, pp. 57-84. , Edited by J. Kiefer, (Springer Verlag, Berlin)
Kiefer, J., Straaten, H., A model of ion track structure based on classical collision dynamics (1986) Physics in Medicine and Biology, 31, pp. 1201-1209
Kodama, Y., Nakano, M., Ohtaki, K., Delongchamp, R., Awa, A.A., Nakamura, N., Estimation of the minimal size of translocated chromosome segments detectable by fluorescence in situ hybridization (1997) International Journal of Radiation Biology, 71, pp. 35-39
Kraft, G., Radiobiological effects of very heavy ions: Inactivation, induction of chromosome aberrations and strand breaks (1987) Nuclear Science Applications, 3, pp. 1-28
Nagasawa, H., Robertson, J., Little, J.B., Induction of chromosomal aberrations and sister chromatid exchanges by alpha-particles in density-inhibited cultures of mouse 10T1/2 and 3T3 cells (1990) International Journal of Radiation Biology, 57, pp. 35-44
Napolitano, M., Durante, M., Grossi, G., Pugliese, M., Gialanella, G., Inactivation of C3H 10T1/2 cells by monoenergetic high-LET α-particles (1992) International of Radiation Biology, 61, pp. 813-820
Natarajan, A.T., Balajee, A.S., Boei, J.J.W.A., Chatterjee, S., Darroudi, F., Grigorova, M., Noditi, M., Vermeulen, S., Recent developments in the assessment of chromosomal damage (1994) International Journal of Radiation Biology, 66, pp. 615-623
Neary, G.J., Chromosome aberrations and the theory of RBE. 1. General considerations (1965) International Journal of Radiation Biology, 9, pp. 477-502
Ottolenghi, A., Merzagora, M., Tallone, L., Durante, M., Paretzke, H.G., Wilson, W.E., The quality of DNA double-strand breaks: A Monte Carlo simulation of end-structure of strand breaks produced by protons and alpha-particles (1995) Radiation and Environmental Biophysics, 34, pp. 239-244
Pinkel, D., Straume, T., Gray, J.W., Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization (1986) Proceedings of the National Academy of Sciences USA, 83, pp. 2934-2938
Reznikoff, C.A., Brankow, D.W., Heidelberger, C., Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of growth (1973) Cancer Research, 33, pp. 3231-3238
Savage, J.R.K., Interchanges and intra-nuclear architecture (1993) Environmental and Molecular Mutagenesis, 22, pp. 234-244
Sachs, R.K., Chen, A.M., Brenner, D.J., Proximity effects in the production of chromosome aberrations by ionizing radiation (1997) International Journal of Radiation Biology, 71, pp. 1-19
Tucker, J.D., Morgan, W.F., Awa, A.A., Bauchinger, M., Blakey, D., Cornforth, M.N., Littlefield, L.G., Shasserre, C., A proposed system for scoring structural aberrations detected by chromosome painting (1995) Cytogenetics and Cell Genetics, 68, pp. 211-221
Yang, T.C., Craise, L.M., Mei, M., Tobias, C.A., Neoplastic cell transformation by heavy charged particles (1985) Radiation Research, 104, pp. S177-S187
Zaider, M., Brenner, D.J., The application of track calculations to radiobiology. III. Analysis of the molecular beam experiment (1984) Radiation Research, 100, pp. 213-221
Ziegler, J.F., (1996) SRIM, the Stopping and Range of Ions in Matter, , IBM Research, Yorktown, NY 10598
Barendsen, G. W., Mechanisms of cell reproductive death and shapes of radiation dose-survival curves of mammalian cells (1990) International Journal of Radiation Biology, 57, pp. 885-89
Boei, J. J. W. A., Natarajan, A. T., Classification of X-ray-induced Robertsonian fusion-like configurations in mouse splenocytes (1996) International Journal of Radiation Biology, 69, pp. 421-427
Breneman, J. W., Ramsey, M. J., Lee, D. A., Eveleth, G. G., Minkler, J. L., Tucker, J. D., The development of chromosome-specific composite DNA probes for the mouse and their application to chromosome painting (1993) Chromosoma, 102, pp. 591-598
Butts, J. J., Katz, R., Theory of RBE for heavy ion bombardment of dry enzymes and viruses (1967) Radiation Research, 30, pp. 855-871
Chadwick, K. H., Leenhouts, H. P., (1981) The Molecular Theory of Radiation Biology, , Springer-Verlag, Berlin
Cornforth, M. N., Bedford, J. S., Ionizing radiation damage and its early development in chromosomes (1993) Advances in Radiation Biology, 17, pp. 423-497
Edwards, A. A., Lloyd, D. C., Prosser, J. S., The induction of chromosome aberrations in human lymphocytes by accelerated charged particles (1985) Radiation Protection Dosimetry, 13, pp. 205-209
Goodhead, D. T., Belli, M., Mill, A. J., Bance, D. A., Allen, L. A., Hall, S. C., Ianzini, F., Wilkinson, R. A., Direct comparison between protons and alpha-particles at the same LET. I. Irradiation methods and inactivation of synchronous V79, HeLa and C3H10T1/2 cells (1992) International Journal of Radiation Biology, 61, pp. 611-624
Goodwin, E. H., Bailey, S. M., Chen, D. J., Cornforth, M. N., The effect of track structure on cell inactivation and chromosome damage at a constant LET of 120 keV/ m (1996) Advances in Space Research, 18 (1-2), pp. 93-98
Hande, M. P., Boei, J. J. W. A., Granath, F., Natarajan, A. T., Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body irradiation analysed by fluorescence in situ hybridization. I. Dicentrics and translocations (1996) International Journal of Radiation Biology, 69, pp. 437-446
Hei, T. K., Komatsu, K., Hall, E. J., Zaider, M., Oncogenic transformation by charged particles of defined LET (1988) Carcinogenesis, 9, pp. 747-750
Natarajan, A. T., Balajee, A. S., Boei, J. J. W. A., Chatterjee, S., Darroudi, F., Grigorova, M., Noditi, M., Vermeulen, S., Recent developments in the assessment of chromosomal damage (1994) International Journal of Radiation Biology, 66, pp. 615-623
Neary, G. J., Chromosome aberrations and the theory of RBE. 1. General considerations (1965) International Journal of Radiation Biology, 9, pp. 477-502
Reznikoff, C. A., Brankow, D. W., Heidelberger, C., Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of growth (1973) Cancer Research, 33, pp. 3231-3238
Savage, J. R. K., Interchanges and intra-nuclear architecture (1993) Environmental and Molecular Mutagenesis, 22, pp. 234-244
Sachs, R. K., Chen, A. M., Brenner, D. J., Proximity effects in the production of chromosome aberrations by ionizing radiation (1997) International Journal of Radiation Biology, 71, pp. 1-19
Tucker, J. D., Morgan, W. F., Awa, A. A., Bauchinger, M., Blakey, D., Cornforth, M. N., Littlefield, L. G., Shasserre, C., A proposed system for scoring structural aberrations detected by chromosome painting (1995) Cytogenetics and Cell Genetics, 68, pp. 211-221
Yang, T. C., Craise, L. M., Mei, M., Tobias, C. A., Neoplastic cell transformation by heavy charged particles (1985) Radiation Research, 104, pp. S177-S187
Ziegler, J. F., (1996) SRIM, the Stopping and Range of Ions in Matter, , IBM Research, Yorktown, NY 10598
Int J Radiat Biol International Journal Of Radiation Biology (ISSN: 0955-3002), 1998 Mar; 73(3): 253-262.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.579, 5-year impact factor: 1.933
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0031946676&partnerID=40&md5=fba5d682817409f433ddfedf86b008b1
Keywords: Article, Chromatid Exchange, Chromosome 2, Chromosome Aberration, Dna Probe, Fluorescence In Situ Hybridization, Mitosis Rate, Mouse, Nonhuman, Priority Journal, Radiation Exposure, Radiation Injury, Nasa Center Jsc, Nasa Discipline Radiation Health, Animals, Cell Line, Dna Damage, Dose-Response Relationship, Inbred C3h, Particle Accelerators, Protons, Translocation, Genetic,
Affiliations:
Dipartimento di Scienze Fisiche, Univ. Federico II, Monte S. Angelo, Via Cintia, 80126 Napoli, Italy
Space and Particle Radiation Group, Natl. Inst. for Radiological Sci., 9-1 Anagawa-4-chome, Inage-ku, Chiba 263, Japan
Krug Life Sciences, 1290 Hercules Drive, Houston, TX 77058, United States
NASA Johnson Space Center, Mail Code SD2, Houston, TX 77058, United States
References:
Barendsen, G.W., Mechanisms of cell reproductive death and shapes of radiation dose-survival curves of mammalian cells (1990) International Journal of Radiation Biology, 57, pp. 885-89
Boei, J.J.W.A., Natarajan, A.T., Classification of X-ray-induced Robertsonian fusion-like configurations in mouse splenocytes (1996) International Journal of Radiation Biology, 69, pp. 421-427
Boei, J.J.W.A., Balajee, A.S., De Boer, P., Rens, W., Aten, J.A., Mullenders, L.H.F., Natarajan, A.T., Construction of mouse chromosome-specific DNA libraries and their use for the detection of X-ray-induced aberrations (1994) International Journal of Radiation Biology, 65, pp. 583-590
Breneman, J.W., Ramsey, M.J., Lee, D.A., Eveleth, G.G., Minkler, J.L., Tucker, J.D., The development of chromosome-specific composite DNA probes for the mouse and their application to chromosome painting (1993) Chromosoma, 102, pp. 591-598
Butts, J.J., Katz, R., Theory of RBE for heavy ion bombardment of dry enzymes and viruses (1967) Radiation Research, 30, pp. 855-871
Chadwick, K.H., Leenhouts, H.P., (1981) The Molecular Theory of Radiation Biology, , Springer-Verlag, Berlin
Cornforth, M.N., Bedford, J.S., Ionizing radiation damage and its early development in chromosomes (1993) Advances in Radiation Biology, 17, pp. 423-497
Durante, M., Grossi, G., Napolitano, M., Pugliese, M., Gialanella, G., Chromosome damage induced by high-LET α-particles in plateau-phase C3H 10T1/2 cells (1992) International Journal of Radiation Biology, 62, pp. 571-580
Durante, M., Gialanella, G., Grossi, G., Pugliese, M., Thickness measurements on living cell monolayers by nuclear methods (1993) Nuclear Instruments and Methods, B73, pp. 543-549
Edwards, A.A., Lloyd, D.C., Prosser, J.S., The induction of chromosome aberrations in human lymphocytes by accelerated charged particles (1985) Radiation Protection Dosimetry, 13, pp. 205-209
Goodhead, D.T., Belli, M., Mill, A.J., Bance, D.A., Allen, L.A., Hall, S.C., Ianzini, F., Wilkinson, R.A., Direct comparison between protons and alpha-particles at the same LET. I. Irradiation methods and inactivation of synchronous V79, HeLa and C3H10T1/2 cells (1992) International Journal of Radiation Biology, 61, pp. 611-624
Goodwin, E.H., Bailey, S.M., Chen, D.J., Cornforth, M.N., The effect of track structure on cell inactivation and chromosome damage at a constant LET of 120 keV/μm (1996) Advances in Space Research, 18 (1-2), pp. 93-98
Hande, M.P., Boei, J.J.W.A., Granath, F., Natarajan, A.T., Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body irradiation analysed by fluorescence in situ hybridization. I. Dicentrics and translocations (1996) International Journal of Radiation Biology, 69, pp. 437-446
Hei, T.K., Komatsu, K., Hall, E.J., Zaider, M., Oncogenic transformation by charged particles of defined LET (1988) Carcinogenesis, 9, pp. 747-750
Quantities and units in radiation protection dosimetry (1993) ICRU Report No. 51, , Bethesda, ICRU Publications
James, F., Roos, M., (1983) Function Minimization and Error Analysis, , CERN Computer Center Program Library D506, Geneva
Katz, R., Radiobiological modeling based on track structure (1988) Quantitative Mathematical Models in Radiation Biology, pp. 57-84. , Edited by J. Kiefer, (Springer Verlag, Berlin)
Kiefer, J., Straaten, H., A model of ion track structure based on classical collision dynamics (1986) Physics in Medicine and Biology, 31, pp. 1201-1209
Kodama, Y., Nakano, M., Ohtaki, K., Delongchamp, R., Awa, A.A., Nakamura, N., Estimation of the minimal size of translocated chromosome segments detectable by fluorescence in situ hybridization (1997) International Journal of Radiation Biology, 71, pp. 35-39
Kraft, G., Radiobiological effects of very heavy ions: Inactivation, induction of chromosome aberrations and strand breaks (1987) Nuclear Science Applications, 3, pp. 1-28
Nagasawa, H., Robertson, J., Little, J.B., Induction of chromosomal aberrations and sister chromatid exchanges by alpha-particles in density-inhibited cultures of mouse 10T1/2 and 3T3 cells (1990) International Journal of Radiation Biology, 57, pp. 35-44
Napolitano, M., Durante, M., Grossi, G., Pugliese, M., Gialanella, G., Inactivation of C3H 10T1/2 cells by monoenergetic high-LET α-particles (1992) International of Radiation Biology, 61, pp. 813-820
Natarajan, A.T., Balajee, A.S., Boei, J.J.W.A., Chatterjee, S., Darroudi, F., Grigorova, M., Noditi, M., Vermeulen, S., Recent developments in the assessment of chromosomal damage (1994) International Journal of Radiation Biology, 66, pp. 615-623
Neary, G.J., Chromosome aberrations and the theory of RBE. 1. General considerations (1965) International Journal of Radiation Biology, 9, pp. 477-502
Ottolenghi, A., Merzagora, M., Tallone, L., Durante, M., Paretzke, H.G., Wilson, W.E., The quality of DNA double-strand breaks: A Monte Carlo simulation of end-structure of strand breaks produced by protons and alpha-particles (1995) Radiation and Environmental Biophysics, 34, pp. 239-244
Pinkel, D., Straume, T., Gray, J.W., Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization (1986) Proceedings of the National Academy of Sciences USA, 83, pp. 2934-2938
Reznikoff, C.A., Brankow, D.W., Heidelberger, C., Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of growth (1973) Cancer Research, 33, pp. 3231-3238
Savage, J.R.K., Interchanges and intra-nuclear architecture (1993) Environmental and Molecular Mutagenesis, 22, pp. 234-244
Sachs, R.K., Chen, A.M., Brenner, D.J., Proximity effects in the production of chromosome aberrations by ionizing radiation (1997) International Journal of Radiation Biology, 71, pp. 1-19
Tucker, J.D., Morgan, W.F., Awa, A.A., Bauchinger, M., Blakey, D., Cornforth, M.N., Littlefield, L.G., Shasserre, C., A proposed system for scoring structural aberrations detected by chromosome painting (1995) Cytogenetics and Cell Genetics, 68, pp. 211-221
Yang, T.C., Craise, L.M., Mei, M., Tobias, C.A., Neoplastic cell transformation by heavy charged particles (1985) Radiation Research, 104, pp. S177-S187
Zaider, M., Brenner, D.J., The application of track calculations to radiobiology. III. Analysis of the molecular beam experiment (1984) Radiation Research, 100, pp. 213-221
Ziegler, J.F., (1996) SRIM, the Stopping and Range of Ions in Matter, , IBM Research, Yorktown, NY 10598
Barendsen, G. W., Mechanisms of cell reproductive death and shapes of radiation dose-survival curves of mammalian cells (1990) International Journal of Radiation Biology, 57, pp. 885-89
Boei, J. J. W. A., Natarajan, A. T., Classification of X-ray-induced Robertsonian fusion-like configurations in mouse splenocytes (1996) International Journal of Radiation Biology, 69, pp. 421-427
Breneman, J. W., Ramsey, M. J., Lee, D. A., Eveleth, G. G., Minkler, J. L., Tucker, J. D., The development of chromosome-specific composite DNA probes for the mouse and their application to chromosome painting (1993) Chromosoma, 102, pp. 591-598
Butts, J. J., Katz, R., Theory of RBE for heavy ion bombardment of dry enzymes and viruses (1967) Radiation Research, 30, pp. 855-871
Chadwick, K. H., Leenhouts, H. P., (1981) The Molecular Theory of Radiation Biology, , Springer-Verlag, Berlin
Cornforth, M. N., Bedford, J. S., Ionizing radiation damage and its early development in chromosomes (1993) Advances in Radiation Biology, 17, pp. 423-497
Edwards, A. A., Lloyd, D. C., Prosser, J. S., The induction of chromosome aberrations in human lymphocytes by accelerated charged particles (1985) Radiation Protection Dosimetry, 13, pp. 205-209
Goodhead, D. T., Belli, M., Mill, A. J., Bance, D. A., Allen, L. A., Hall, S. C., Ianzini, F., Wilkinson, R. A., Direct comparison between protons and alpha-particles at the same LET. I. Irradiation methods and inactivation of synchronous V79, HeLa and C3H10T1/2 cells (1992) International Journal of Radiation Biology, 61, pp. 611-624
Goodwin, E. H., Bailey, S. M., Chen, D. J., Cornforth, M. N., The effect of track structure on cell inactivation and chromosome damage at a constant LET of 120 keV/ m (1996) Advances in Space Research, 18 (1-2), pp. 93-98
Hande, M. P., Boei, J. J. W. A., Granath, F., Natarajan, A. T., Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body irradiation analysed by fluorescence in situ hybridization. I. Dicentrics and translocations (1996) International Journal of Radiation Biology, 69, pp. 437-446
Hei, T. K., Komatsu, K., Hall, E. J., Zaider, M., Oncogenic transformation by charged particles of defined LET (1988) Carcinogenesis, 9, pp. 747-750
Natarajan, A. T., Balajee, A. S., Boei, J. J. W. A., Chatterjee, S., Darroudi, F., Grigorova, M., Noditi, M., Vermeulen, S., Recent developments in the assessment of chromosomal damage (1994) International Journal of Radiation Biology, 66, pp. 615-623
Neary, G. J., Chromosome aberrations and the theory of RBE. 1. General considerations (1965) International Journal of Radiation Biology, 9, pp. 477-502
Reznikoff, C. A., Brankow, D. W., Heidelberger, C., Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of growth (1973) Cancer Research, 33, pp. 3231-3238
Savage, J. R. K., Interchanges and intra-nuclear architecture (1993) Environmental and Molecular Mutagenesis, 22, pp. 234-244
Sachs, R. K., Chen, A. M., Brenner, D. J., Proximity effects in the production of chromosome aberrations by ionizing radiation (1997) International Journal of Radiation Biology, 71, pp. 1-19
Tucker, J. D., Morgan, W. F., Awa, A. A., Bauchinger, M., Blakey, D., Cornforth, M. N., Littlefield, L. G., Shasserre, C., A proposed system for scoring structural aberrations detected by chromosome painting (1995) Cytogenetics and Cell Genetics, 68, pp. 211-221
Yang, T. C., Craise, L. M., Mei, M., Tobias, C. A., Neoplastic cell transformation by heavy charged particles (1985) Radiation Research, 104, pp. S177-S187
Ziegler, J. F., (1996) SRIM, the Stopping and Range of Ions in Matter, , IBM Research, Yorktown, NY 10598
The effect of track structure on the induction of chromosomal aberrations in murine cells
Purpose: To measure chromosome aberrations in C3H 10T1/2 mouse fibroblasts using FISH painting at the first mitosis following exposure to 30 keV/μm hydrogen or neon ions. Materials and methods: Cells in plateau-phase were irradiated with 0.86 MeV protons at the TTT-3 Tandem accelerator in Naples (Italy), or with 400 MeV/n Ne ions at the HIMAC accelerator in Chiba (Japan). Colcemid-blocked cells were harvested at the first mitosis following exposure, and chromosome spreads were hybridized in situ with a fluorescein- labelled composite mouse DNA probe specific for chromosomes 2 and 8. Results: Protons were more efficient than neon ions at the same LET in the induction of chromosome interchanges and breaks. Yields of complex exchanges were similar for both particles at the same dose, but protons produced mostly insertions, while with Ne exposure non-reciprocal exchanges were the most frequent complex-type exchange. Conclusions: Charged particles with the same LET produce different yields of chromosome aberrations, and some observed differences can be explained based on the available track-structure models.
Purpose: To measure chromosome aberrations in C3H 10T1/2 mouse fibroblasts using FISH painting at the first mitosis following exposure to 30 keV/μm hydrogen or neon ions. Materials and methods: Cells in plateau-phase were irradiated with 0.86 MeV protons at the TTT-3 Tandem accelerator in Naples (Italy), or with 400 MeV/n Ne ions at the HIMAC accelerator in Chiba (Japan). Colcemid-blocked cells were harvested at the first mitosis following exposure, and chromosome spreads were hybridized in situ with a fluorescein- labelled composite mouse DNA probe specific for chromosomes 2 and 8. Results: Protons were more efficient than neon ions at the same LET in the induction of chromosome interchanges and breaks. Yields of complex exchanges were similar for both particles at the same dose, but protons produced mostly insertions, while with Ne exposure non-reciprocal exchanges were the most frequent complex-type exchange. Conclusions: Charged particles with the same LET produce different yields of chromosome aberrations, and some observed differences can be explained based on the available track-structure models.
The effect of track structure on the induction of chromosomal aberrations in murine cells
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The effect of track structure on the induction of chromosomal aberrations in murine cells
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Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Olgiati S, De Rosa A, Quadri M, Criscuolo C, Breedveld GJ, Picillo M, Pappata S, Quarantelli M, Barone P, De Michele G, Bonifati V
* Park20 Caused By Synj1 Homozygous Arg258gln Mutation In A New Italian Family (476 views)
Neurogenetics (ISSN: 1364-6745, 1364-6753), 2014 Aug; 15(3): 183-188.
Impact Factor: 2.884
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Ceccarelli M, Speranza A, Grimaldi D, Lamonaca F
* A Computer Vision Approach to Micro-Nucleus automatic detection and surface measurements (406 views)
Vols 1 3i2mtc (ISSN: 0018-9456), 2010 Sep 10; 59(9): 2383-2390.
Impact Factor: 1.79
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Volpe P, Paladini D, Resta M, Stanziano A, Salvatore M, Quarantelli M, De Robertis V, Buonadonna AL, Caruso G, Gentile M
* Characteristics, associations and outcome of partial agenesis of the corpus callosum in the fetus (362 views)
Ultrasound Obst Gyn (ISSN: 0960-7692, 1469-0705), 2006 May; 27(5): 509-516.
Impact Factor: 2.288
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d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
* Lymph nodes in the irradiated field influence the yield of radiation-induced chromosomal aberrations in lymphocytes from breast cancer patients (342 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2003 Nov 1; 57(3): 732-738.
Impact Factor: 4.285
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Della Ragione F, Oliva A, Palumbo R, Russo GL, Zappia V
Enzyme deficiency and tumor suppressor genes: absence of 5'-deoxy-5'-methylthioadenosine phosphorylase in human tumors (247 views)
Adv Exp Med Biol (ISSN: 0065-2598print, 0065-2598linking), 1993; 348: 31-43.
Impact Factor: 0.36
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6 Records (6 excluding Abstracts).
Total impact factor: 15.062 (15.062 excluding Abstracts).
Total 5 year impact factor: 16.514 (16.514 excluding Abstracts).
Total impact factor: 15.062 (15.062 excluding Abstracts).
Total 5 year impact factor: 16.514 (16.514 excluding Abstracts).
737 views. Last view on Wednesday 15 March 2023, 18:16:21
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