The effect of track structure on the induction of chromosomal aberrations in murine cells(737 views) Durante M, Cella L, Furusawa Y, George K, Gialanella G, Grossi G, Pugliese M, Saito M, Yang TC
Int J Radiat Biol International Journal Of Radiation Biology (ISSN: 0955-3002), 1998 Mar; 73(3): 253-262.
Keywords: Article, Chromatid Exchange, Chromosome 2, Chromosome Aberration, Dna Probe, Fluorescence In Situ Hybridization, Mitosis Rate, Mouse, Nonhuman, Priority Journal, Radiation Exposure, Radiation Injury, Nasa Center Jsc, Nasa Discipline Radiation Health, Animals, Cell Line, Dna Damage, Dose-Response Relationship, Inbred C3h, Particle Accelerators, Protons, Translocation, Genetic,
Affiliations: Dipartimento di Scienze Fisiche, Univ. Federico II, Monte S. Angelo, Via Cintia, 80126 Napoli, Italy
Space and Particle Radiation Group, Natl. Inst. for Radiological Sci., 9-1 Anagawa-4-chome, Inage-ku, Chiba 263, Japan
Krug Life Sciences, 1290 Hercules Drive, Houston, TX 77058, United States
NASA Johnson Space Center, Mail Code SD2, Houston, TX 77058, United States
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Boei, J. J. W. A., Natarajan, A. T., Classification of X-ray-induced Robertsonian fusion-like configurations in mouse splenocytes (1996) International Journal of Radiation Biology, 69, pp. 421-427
Breneman, J. W., Ramsey, M. J., Lee, D. A., Eveleth, G. G., Minkler, J. L., Tucker, J. D., The development of chromosome-specific composite DNA probes for the mouse and their application to chromosome painting (1993) Chromosoma, 102, pp. 591-598
Butts, J. J., Katz, R., Theory of RBE for heavy ion bombardment of dry enzymes and viruses (1967) Radiation Research, 30, pp. 855-871
Chadwick, K. H., Leenhouts, H. P., (1981) The Molecular Theory of Radiation Biology, , Springer-Verlag, Berlin
Cornforth, M. N., Bedford, J. S., Ionizing radiation damage and its early development in chromosomes (1993) Advances in Radiation Biology, 17, pp. 423-497
Edwards, A. A., Lloyd, D. C., Prosser, J. S., The induction of chromosome aberrations in human lymphocytes by accelerated charged particles (1985) Radiation Protection Dosimetry, 13, pp. 205-209
Goodhead, D. T., Belli, M., Mill, A. J., Bance, D. A., Allen, L. A., Hall, S. C., Ianzini, F., Wilkinson, R. A., Direct comparison between protons and alpha-particles at the same LET. I. Irradiation methods and inactivation of synchronous V79, HeLa and C3H10T1/2 cells (1992) International Journal of Radiation Biology, 61, pp. 611-624
Goodwin, E. H., Bailey, S. M., Chen, D. J., Cornforth, M. N., The effect of track structure on cell inactivation and chromosome damage at a constant LET of 120 keV/ m (1996) Advances in Space Research, 18 (1-2), pp. 93-98
Hande, M. P., Boei, J. J. W. A., Granath, F., Natarajan, A. T., Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body irradiation analysed by fluorescence in situ hybridization. I. Dicentrics and translocations (1996) International Journal of Radiation Biology, 69, pp. 437-446
Hei, T. K., Komatsu, K., Hall, E. J., Zaider, M., Oncogenic transformation by charged particles of defined LET (1988) Carcinogenesis, 9, pp. 747-750
Natarajan, A. T., Balajee, A. S., Boei, J. J. W. A., Chatterjee, S., Darroudi, F., Grigorova, M., Noditi, M., Vermeulen, S., Recent developments in the assessment of chromosomal damage (1994) International Journal of Radiation Biology, 66, pp. 615-623
Neary, G. J., Chromosome aberrations and the theory of RBE. 1. General considerations (1965) International Journal of Radiation Biology, 9, pp. 477-502
Reznikoff, C. A., Brankow, D. W., Heidelberger, C., Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of growth (1973) Cancer Research, 33, pp. 3231-3238
Savage, J. R. K., Interchanges and intra-nuclear architecture (1993) Environmental and Molecular Mutagenesis, 22, pp. 234-244
Sachs, R. K., Chen, A. M., Brenner, D. J., Proximity effects in the production of chromosome aberrations by ionizing radiation (1997) International Journal of Radiation Biology, 71, pp. 1-19
Tucker, J. D., Morgan, W. F., Awa, A. A., Bauchinger, M., Blakey, D., Cornforth, M. N., Littlefield, L. G., Shasserre, C., A proposed system for scoring structural aberrations detected by chromosome painting (1995) Cytogenetics and Cell Genetics, 68, pp. 211-221
Yang, T. C., Craise, L. M., Mei, M., Tobias, C. A., Neoplastic cell transformation by heavy charged particles (1985) Radiation Research, 104, pp. S177-S187
Ziegler, J. F., (1996) SRIM, the Stopping and Range of Ions in Matter, , IBM Research, Yorktown, NY 10598
The effect of track structure on the induction of chromosomal aberrations in murine cells
Purpose: To measure chromosome aberrations in C3H 10T1/2 mouse fibroblasts using FISH painting at the first mitosis following exposure to 30 keV/μm hydrogen or neon ions. Materials and methods: Cells in plateau-phase were irradiated with 0.86 MeV protons at the TTT-3 Tandem accelerator in Naples (Italy), or with 400 MeV/n Ne ions at the HIMAC accelerator in Chiba (Japan). Colcemid-blocked cells were harvested at the first mitosis following exposure, and chromosome spreads were hybridized in situ with a fluorescein- labelled composite mouse DNA probe specific for chromosomes 2 and 8. Results: Protons were more efficient than neon ions at the same LET in the induction of chromosome interchanges and breaks. Yields of complex exchanges were similar for both particles at the same dose, but protons produced mostly insertions, while with Ne exposure non-reciprocal exchanges were the most frequent complex-type exchange. Conclusions: Charged particles with the same LET produce different yields of chromosome aberrations, and some observed differences can be explained based on the available track-structure models.
The effect of track structure on the induction of chromosomal aberrations in murine cells
No results.
The effect of track structure on the induction of chromosomal aberrations in murine cells