Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study (1872 views)
Curr Oncol (ISSN: 1198-0052, 1718-7729electronic, 1198-0052linking), 2014 Jun; 21(3): 125-133.
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Paper type: Journal Article,
Impact factor: 1.785, 5-year impact factor: 1.802
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84902682619&partnerID=40&md5=48ce915a30712be1de353144188d8160
Keywords: Folfox4, Gastroesophageal Junction Cancer, Preoperative Chemoradiotherapy, Fluorouracil, Folinic Acid, Oxaliplatin, Adenocarcinoma, Adult, Anemia, Article, Asthenia, Cancer Surgery, Clinical Article, Clinical Effectiveness, Computer Assisted Tomography, Dermatitis, Diarrhea, Disease Course, Drug Dose Reduction, Drug Withdrawal, Echography, Esophagitis, Esophagogastroduodenoscopy, Female, Human, Lower Esophagus Sphincter, Lymph Node, Multiple Cycle Treatment, Neutropenia, Outcome Assessment, Overall Survival, Paresthesia, Pathology, Patient Selection, Pilot Study, Radiation Dose Reduction, Radiation Safety, Stomatitis, Thrombocytopenia, Thrombophlebitis, Toxicity Testing, Treatment Response, Tumor Recurrence,
Affiliations:
*** IBB - CNR ***
Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
Divisions of Surgical Oncology, Department of An-esthesiologic, Surgical, and Emergency Sciences, Second University of Naples School of Medicine, Naples, Italy
Division of General Surgery 1, University of Padua, School of Medicine, Padua, Italy
Division of Radiotherapy, Federico n University of Naples School of Medicine, Naples, Italy
References:
Parkin, D.M., Bray, F., Ferlay, J., Pisani, P., Global cancer statistics, 2002 (2005) CA Cancer J Clin, 55, pp. 74-10
Catalano, V., Labianca, R., Beretta, G.D., Gatta, G., de Braud, F., van Cutsem, E., Gastric cancer (2009) Crit Rev Oncol Hematol, 71, pp. 127-164
Botterweck, A.A., Schouten, L.J., Volovics, A., Dorant, E., van Den Brandt, P.A., Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries (2000) Int J Epidemiol, 29, pp. 645-654
Ferlay, J., Autier, P., Boniol, M., Heanue, M., Colombet, M., Boyle, P., Estimates of the cancer incidence and mortality in Europe in 2006 (2007) Ann Oncol, 18, pp. 581-592
Siewert, J.R., Stein, H.J., Classifcation of adenocarcinoma of the oesophagogastric junction (1998) Br J Surg, 85, pp. 1457-1459
Wilkinson, N.W., Howe, J., Gay, G., Patel Parekh, L., Scott Conner, C., Donohue, J., Differences in the pattern of presentation and treatment of proximal and distal gastric cancer: Results of the 2001 gastric patient care evaluation (2008) Ann Surg Oncol, 15, pp. 1644-1650
Griffths, E.A., Pritchard, S.A., Mapstone, N.P., Welch, I.M., Emerging aspects of oesophageal and gastro-oesophageal junction cancer histopathology-an update for the surgical oncologist (2006) World J Surg Oncol, 4, p. 82
Dresner, S.M., Lamb, P.J., Bennet, M.K., Hayes, N., Griffn, S.M., The pattern of metastatic lymph node dissemination from adenocarcinoma of the esophagogastric junction (2001) Surgery, 129, pp. 103-109
Wajman, J., Bennett, M.K., Raimes, S.A., Griffn, S.M., The pattern of recurrence of adenocarcinoma of the oesophago-gastric junction (2002) Br J Cancer, 86, pp. 1223-1229
Hingorani, M., Crosby, T., Maraveyas, A., Dixit, S., Bateman, A., Roy, R., Neoadjuvant chemoradiotherapy for resectable oesophageal and gastro-oesophageal junction cancer. Do we need another randomized trial? (2011) Clin Oncol (R Coll Radiol, 23, pp. 696-705
Stahl, M., Walz, M.K., Stuschke, M., Phase iii comparison of preoperative chemotherapy compared with chemoradio-therapy in patients with locally advanced adenocarcinoma of the esophagogastric junction (2009) J Clin Oncol, 27, pp. 851-856
Orditura, M., de Vita, F., Muto, P., Adjuvant chemoradio-therapy in patients with stage iii or iv radically resected gastric cancer: A pilot study (2010) Arch Surg, 145, pp. 233-238
Edge, S.B., Byrd, D.R., Compton, C.C., Fritz, A.G., Greene, F.L., Trotti, A., (2009) AJCC Cancer Staging Manual. 7 Th Ed, , New York, NY: Springer-Verlag
(1999) Common Toxicity Criteria (CTC). Ver. 2.0, , http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcv20_4-30-992.pdf, United States, Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Cancer Therapy Evaluation Program (ctep, Bethesda, MD: ctep, cited May 12, 2011
Cox, J.D., Stetz, J., Pajak, T.F., Toxicity criteria of the Radiation Therapy Oncology Group (rtog) and the European Organiza-tion for Research and Treatment of Cancer (eortc) (1995) Int J Radiat Oncol Biol Phys, 31, pp. 1341-1346
Japanese gastric cancer t reatment guidelines 2010 (ver. 3) (2011) Gastric Cancer, 14, pp. 113-123. , Japanese Gastric Cancer Association
Yang, K., Chen, H.N., Chen, X.Z., Transthoracic resection versus non-transthoracic resection for gastroesophageal junction cancer: A meta-analysis (2012) PLoS One, 7, pp. e37698
Mandard, A.M., Dalibard, F., Mandard, J.C., Pathologic assessment of tumor regression after preoperative chemora-diotherapy of esophageal carcinoma (1994) Cancer, 73, pp. 2680-2686
Kaplan, E.L., Meier, P., Nonparametric estimation from incomplete observations (1958) J Am Stat Assoc, 53, pp. 457-481
Chan, Y.H., Biostatistics 203. Survival analysis (2004) Singapore Med J, 45, pp. 249-256
Walsh, T.N., Noonan, N., Hollywood, D., Kelly, A., Keeling, N., Hennessy, T.P., A comparison of multimodal therapy and surgery for adenocarcinoma (1996) N Engl J Med, 335, pp. 462-467
Tepper, J., Krasna, M.J., Niedzwiecki, D., Phase iii trial of trimodality therapy with cisplatin, fuorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer. calgb 9781 (2008) J Clin Oncol, 26, pp. 1086-1092
Urba, S.G., Orringer, M.B., Turrisi, A., Iannettoni, M., Forastiere, A., Strawderman, M., Randomized trial of preoperative chemo-radiation versus surgery alone in patients with locoregional esophageal carcinoma (2001) J Clin Oncol, 19, pp. 305-313
Burmeister, B.H., Smithers, B.M., Gebski, V., Su rger y alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: A randomised controlled phase iii trial (2005) Lancet Oncol, 6, pp. 659-668
Fiorica, F., Di Bona, D., Schepis, F., Preoperative chemora-diotherapy for oesophageal cancer: A systematic review and meta-analysis (2004) Gut, 53, pp. 925-930
Reynolds, J.V., Ravi, N., Hollywood, D., Neoadjuvant chemoradiation may increase the risk of respiratory complications and sepsis after transthoracic esophagectomy (2006) J Thorac Cardiovasc Surg, 132, pp. 549-555
van Hagen, P., Hulshof, M.C., van Lanschot, J.J., Preopera-tive chemoradiotherapy for esophageal or junctional cancer (2012) N Engl J Med, 366, pp. 2074-2084
Pera, M., Gallego, R., Montagut, C., Phase ii trial of pre-operative chemoradiotherapy with oxaliplatin, cisplatin, and 5-fu in locally advanced esophageal and gastric cancer (2012) Ann Oncol, 23, pp. 664-670
Wahba, H.A., El-Hadaad, H.A., Abd-Ellatif, E.A., Neoadjuvant concurrent chemoradiotherapy with capecitabine and oxali-platin in patients with locally advanced esophageal cancer (2012) Med Oncol, 29, pp. 1693-1698
Chiarion-Sileni, V., Innocente, R., Cavina, R., Multi-center phase ii trial of chemo-radiotherapy with 5-fuorouracil, leu-covorin and oxaliplatin in locally advanced esophageal cancer (2009) Cancer Chemother Pharmacol, 63, pp. 1111-1119
de Vita, F., Orditura, M., Martinelli, E., A multicenter phase ii study of induction chemotherapy with folfox-4 and cetuximab followed by radiation and cetuximab in locally advanced oesophageal cancer (2011) Br J Cancer, 10 (4), pp. 427-432
Rivera, F., Galan, M., Tabernero, J., Phase ii trial of preop-erative irinotecan-cisplatin followed by concurrent irinote-can-cisplatin and radiotherapy for resectable locally advanced gastric and esophagogastric junction adenocarcinoma (2009) Int J Radiat Oncol Biol Phys, 75, pp. 1430-1436
Ajani, J.A., Winter, K., Okawara, G.S., Phase ii trial of preoperative chemoradiation in patients with localized gastric adenocarcinoma (rtog 9904): Quality of combined modality therapy and pathological response (2006) J Clin Oncol, 24, pp. 3953-3958
Orditura, M., Galizia, G., Napolitano, V., Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esopha-geal cancer: A phase ii study (2010) Cancer Invest, 28, pp. 820-827
Ychou, M., Boige, V., Pignon, J.P., Perioperative chemotherapy compared with surgery alone for resectable gastro-esophageal adenocarcinoma: An fnclcc and ffcd multicenter phase iii trial (2011) J Clin Oncol, 29, pp. 1715-1721
Parkin, D. M., Bray, F., Ferlay, J., Pisani, P., Global cancer statistics, 2002 (2005) CA Cancer J Clin, 55, pp. 74-10
Botterweck, A. A., Schouten, L. J., Volovics, A., Dorant, E., van Den Brandt, P. A., Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries (2000) Int J Epidemiol, 29, pp. 645-654
Siewert, J. R., Stein, H. J., Classifcation of adenocarcinoma of the oesophagogastric junction (1998) Br J Surg, 85, pp. 1457-1459
Wilkinson, N. W., Howe, J., Gay, G., Patel Parekh, L., Scott Conner, C., Donohue, J., Differences in the pattern of presentation and treatment of proximal and distal gastric cancer: Results of the 2001 gastric patient care evaluation (2008) Ann Surg Oncol, 15, pp. 1644-1650
Griffths, E. A., Pritchard, S. A., Mapstone, N. P., Welch, I. M., Emerging aspects of oesophageal and gastro-oesophageal junction cancer histopathology-an update for the surgical oncologist (2006) World J Surg Oncol, 4, p. 82
Dresner, S. M., Lamb, P. J., Bennet, M. K., Hayes, N., Griffn, S. M., The pattern of metastatic lymph node dissemination from adenocarcinoma of the esophagogastric junction (2001) Surgery, 129, pp. 103-109
Edge, S. B., Byrd, D. R., Compton, C. C., Fritz, A. G., Greene, F. L., Trotti, A., (2009) AJCC Cancer Staging Manual. 7 Th Ed, , New York, NY: Springer-Verlag
(1999) Common Toxicity Criteria (CTC). Ver. 2. 0, , http: //ctep. cancer. gov/protocolDevelopment/electronic_applications/docs/ctcv20_4-30-992. pdf, United States, Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Cancer Therapy Evaluation Program (ctep, Bethesda, MD: ctep, cited May 12, 2011
Cox, J. D., Stetz, J., Pajak, T. F., Toxicity criteria of the Radiation Therapy Oncology Group (rtog) and the European Organiza-tion for Research and Treatment of Cancer (eortc) (1995) Int J Radiat Oncol Biol Phys, 31, pp. 1341-1346
Yang, K., Chen, H. N., Chen, X. Z., Transthoracic resection versus non-transthoracic resection for gastroesophageal junction cancer: A meta-analysis (2012) PLoS One, 7, pp. e37698
Mandard, A. M., Dalibard, F., Mandard, J. C., Pathologic assessment of tumor regression after preoperative chemora-diotherapy of esophageal carcinoma (1994) Cancer, 73, pp. 2680-2686
Kaplan, E. L., Meier, P., Nonparametric estimation from incomplete observations (1958) J Am Stat Assoc, 53, pp. 457-481
Chan, Y. H., Biostatistics 203. Survival analysis (2004) Singapore Med J, 45, pp. 249-256
Walsh, T. N., Noonan, N., Hollywood, D., Kelly, A., Keeling, N., Hennessy, T. P., A comparison of multimodal therapy and surgery for adenocarcinoma (1996) N Engl J Med, 335, pp. 462-467
Urba, S. G., Orringer, M. B., Turrisi, A., Iannettoni, M., Forastiere, A., Strawderman, M., Randomized trial of preoperative chemo-radiation versus surgery alone in patients with locoregional esophageal carcinoma (2001) J Clin Oncol, 19, pp. 305-313
Burmeister, B. H., Smithers, B. M., Gebski, V., Su rger y alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: A randomised controlled phase iii trial (2005) Lancet Oncol, 6, pp. 659-668
Reynolds, J. V., Ravi, N., Hollywood, D., Neoadjuvant chemoradiation may increase the risk of respiratory complications and sepsis after transthoracic esophagectomy (2006) J Thorac Cardiovasc Surg, 132, pp. 549-555
Wahba, H. A., El-Hadaad, H. A., Abd-Ellatif, E. A., Neoadjuvant concurrent chemoradiotherapy with capecitabine and oxali-platin in patients with locally advanced esophageal cancer (2012) Med Oncol, 29, pp. 1693-1698
Ajani, J. A., Winter, K., Okawara, G. S., Phase ii trial of preoperative chemoradiation in patients with localized gastric adenocarcinoma (rtog 9904): Quality of combined modality therapy and pathological response (2006) J Clin Oncol, 24, pp. 3953-3958
Curr Oncol (ISSN: 1198-0052, 1718-7729electronic, 1198-0052linking), 2014 Jun; 21(3): 125-133.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.785, 5-year impact factor: 1.802
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84902682619&partnerID=40&md5=48ce915a30712be1de353144188d8160
Keywords: Folfox4, Gastroesophageal Junction Cancer, Preoperative Chemoradiotherapy, Fluorouracil, Folinic Acid, Oxaliplatin, Adenocarcinoma, Adult, Anemia, Article, Asthenia, Cancer Surgery, Clinical Article, Clinical Effectiveness, Computer Assisted Tomography, Dermatitis, Diarrhea, Disease Course, Drug Dose Reduction, Drug Withdrawal, Echography, Esophagitis, Esophagogastroduodenoscopy, Female, Human, Lower Esophagus Sphincter, Lymph Node, Multiple Cycle Treatment, Neutropenia, Outcome Assessment, Overall Survival, Paresthesia, Pathology, Patient Selection, Pilot Study, Radiation Dose Reduction, Radiation Safety, Stomatitis, Thrombocytopenia, Thrombophlebitis, Toxicity Testing, Treatment Response, Tumor Recurrence,
Affiliations:
*** IBB - CNR ***
Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
Divisions of Surgical Oncology, Department of An-esthesiologic, Surgical, and Emergency Sciences, Second University of Naples School of Medicine, Naples, Italy
Division of General Surgery 1, University of Padua, School of Medicine, Padua, Italy
Division of Radiotherapy, Federico n University of Naples School of Medicine, Naples, Italy
References:
Parkin, D.M., Bray, F., Ferlay, J., Pisani, P., Global cancer statistics, 2002 (2005) CA Cancer J Clin, 55, pp. 74-10
Catalano, V., Labianca, R., Beretta, G.D., Gatta, G., de Braud, F., van Cutsem, E., Gastric cancer (2009) Crit Rev Oncol Hematol, 71, pp. 127-164
Botterweck, A.A., Schouten, L.J., Volovics, A., Dorant, E., van Den Brandt, P.A., Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries (2000) Int J Epidemiol, 29, pp. 645-654
Ferlay, J., Autier, P., Boniol, M., Heanue, M., Colombet, M., Boyle, P., Estimates of the cancer incidence and mortality in Europe in 2006 (2007) Ann Oncol, 18, pp. 581-592
Siewert, J.R., Stein, H.J., Classifcation of adenocarcinoma of the oesophagogastric junction (1998) Br J Surg, 85, pp. 1457-1459
Wilkinson, N.W., Howe, J., Gay, G., Patel Parekh, L., Scott Conner, C., Donohue, J., Differences in the pattern of presentation and treatment of proximal and distal gastric cancer: Results of the 2001 gastric patient care evaluation (2008) Ann Surg Oncol, 15, pp. 1644-1650
Griffths, E.A., Pritchard, S.A., Mapstone, N.P., Welch, I.M., Emerging aspects of oesophageal and gastro-oesophageal junction cancer histopathology-an update for the surgical oncologist (2006) World J Surg Oncol, 4, p. 82
Dresner, S.M., Lamb, P.J., Bennet, M.K., Hayes, N., Griffn, S.M., The pattern of metastatic lymph node dissemination from adenocarcinoma of the esophagogastric junction (2001) Surgery, 129, pp. 103-109
Wajman, J., Bennett, M.K., Raimes, S.A., Griffn, S.M., The pattern of recurrence of adenocarcinoma of the oesophago-gastric junction (2002) Br J Cancer, 86, pp. 1223-1229
Hingorani, M., Crosby, T., Maraveyas, A., Dixit, S., Bateman, A., Roy, R., Neoadjuvant chemoradiotherapy for resectable oesophageal and gastro-oesophageal junction cancer. Do we need another randomized trial? (2011) Clin Oncol (R Coll Radiol, 23, pp. 696-705
Stahl, M., Walz, M.K., Stuschke, M., Phase iii comparison of preoperative chemotherapy compared with chemoradio-therapy in patients with locally advanced adenocarcinoma of the esophagogastric junction (2009) J Clin Oncol, 27, pp. 851-856
Orditura, M., de Vita, F., Muto, P., Adjuvant chemoradio-therapy in patients with stage iii or iv radically resected gastric cancer: A pilot study (2010) Arch Surg, 145, pp. 233-238
Edge, S.B., Byrd, D.R., Compton, C.C., Fritz, A.G., Greene, F.L., Trotti, A., (2009) AJCC Cancer Staging Manual. 7 Th Ed, , New York, NY: Springer-Verlag
(1999) Common Toxicity Criteria (CTC). Ver. 2.0, , http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcv20_4-30-992.pdf, United States, Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Cancer Therapy Evaluation Program (ctep, Bethesda, MD: ctep, cited May 12, 2011
Cox, J.D., Stetz, J., Pajak, T.F., Toxicity criteria of the Radiation Therapy Oncology Group (rtog) and the European Organiza-tion for Research and Treatment of Cancer (eortc) (1995) Int J Radiat Oncol Biol Phys, 31, pp. 1341-1346
Japanese gastric cancer t reatment guidelines 2010 (ver. 3) (2011) Gastric Cancer, 14, pp. 113-123. , Japanese Gastric Cancer Association
Yang, K., Chen, H.N., Chen, X.Z., Transthoracic resection versus non-transthoracic resection for gastroesophageal junction cancer: A meta-analysis (2012) PLoS One, 7, pp. e37698
Mandard, A.M., Dalibard, F., Mandard, J.C., Pathologic assessment of tumor regression after preoperative chemora-diotherapy of esophageal carcinoma (1994) Cancer, 73, pp. 2680-2686
Kaplan, E.L., Meier, P., Nonparametric estimation from incomplete observations (1958) J Am Stat Assoc, 53, pp. 457-481
Chan, Y.H., Biostatistics 203. Survival analysis (2004) Singapore Med J, 45, pp. 249-256
Walsh, T.N., Noonan, N., Hollywood, D., Kelly, A., Keeling, N., Hennessy, T.P., A comparison of multimodal therapy and surgery for adenocarcinoma (1996) N Engl J Med, 335, pp. 462-467
Tepper, J., Krasna, M.J., Niedzwiecki, D., Phase iii trial of trimodality therapy with cisplatin, fuorouracil, radiotherapy, and surgery compared with surgery alone for esophageal cancer. calgb 9781 (2008) J Clin Oncol, 26, pp. 1086-1092
Urba, S.G., Orringer, M.B., Turrisi, A., Iannettoni, M., Forastiere, A., Strawderman, M., Randomized trial of preoperative chemo-radiation versus surgery alone in patients with locoregional esophageal carcinoma (2001) J Clin Oncol, 19, pp. 305-313
Burmeister, B.H., Smithers, B.M., Gebski, V., Su rger y alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: A randomised controlled phase iii trial (2005) Lancet Oncol, 6, pp. 659-668
Fiorica, F., Di Bona, D., Schepis, F., Preoperative chemora-diotherapy for oesophageal cancer: A systematic review and meta-analysis (2004) Gut, 53, pp. 925-930
Reynolds, J.V., Ravi, N., Hollywood, D., Neoadjuvant chemoradiation may increase the risk of respiratory complications and sepsis after transthoracic esophagectomy (2006) J Thorac Cardiovasc Surg, 132, pp. 549-555
van Hagen, P., Hulshof, M.C., van Lanschot, J.J., Preopera-tive chemoradiotherapy for esophageal or junctional cancer (2012) N Engl J Med, 366, pp. 2074-2084
Pera, M., Gallego, R., Montagut, C., Phase ii trial of pre-operative chemoradiotherapy with oxaliplatin, cisplatin, and 5-fu in locally advanced esophageal and gastric cancer (2012) Ann Oncol, 23, pp. 664-670
Wahba, H.A., El-Hadaad, H.A., Abd-Ellatif, E.A., Neoadjuvant concurrent chemoradiotherapy with capecitabine and oxali-platin in patients with locally advanced esophageal cancer (2012) Med Oncol, 29, pp. 1693-1698
Chiarion-Sileni, V., Innocente, R., Cavina, R., Multi-center phase ii trial of chemo-radiotherapy with 5-fuorouracil, leu-covorin and oxaliplatin in locally advanced esophageal cancer (2009) Cancer Chemother Pharmacol, 63, pp. 1111-1119
de Vita, F., Orditura, M., Martinelli, E., A multicenter phase ii study of induction chemotherapy with folfox-4 and cetuximab followed by radiation and cetuximab in locally advanced oesophageal cancer (2011) Br J Cancer, 10 (4), pp. 427-432
Rivera, F., Galan, M., Tabernero, J., Phase ii trial of preop-erative irinotecan-cisplatin followed by concurrent irinote-can-cisplatin and radiotherapy for resectable locally advanced gastric and esophagogastric junction adenocarcinoma (2009) Int J Radiat Oncol Biol Phys, 75, pp. 1430-1436
Ajani, J.A., Winter, K., Okawara, G.S., Phase ii trial of preoperative chemoradiation in patients with localized gastric adenocarcinoma (rtog 9904): Quality of combined modality therapy and pathological response (2006) J Clin Oncol, 24, pp. 3953-3958
Orditura, M., Galizia, G., Napolitano, V., Weekly chemotherapy with cisplatin and paclitaxel and concurrent radiation therapy as preoperative treatment in locally advanced esopha-geal cancer: A phase ii study (2010) Cancer Invest, 28, pp. 820-827
Ychou, M., Boige, V., Pignon, J.P., Perioperative chemotherapy compared with surgery alone for resectable gastro-esophageal adenocarcinoma: An fnclcc and ffcd multicenter phase iii trial (2011) J Clin Oncol, 29, pp. 1715-1721
Parkin, D. M., Bray, F., Ferlay, J., Pisani, P., Global cancer statistics, 2002 (2005) CA Cancer J Clin, 55, pp. 74-10
Botterweck, A. A., Schouten, L. J., Volovics, A., Dorant, E., van Den Brandt, P. A., Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries (2000) Int J Epidemiol, 29, pp. 645-654
Siewert, J. R., Stein, H. J., Classifcation of adenocarcinoma of the oesophagogastric junction (1998) Br J Surg, 85, pp. 1457-1459
Wilkinson, N. W., Howe, J., Gay, G., Patel Parekh, L., Scott Conner, C., Donohue, J., Differences in the pattern of presentation and treatment of proximal and distal gastric cancer: Results of the 2001 gastric patient care evaluation (2008) Ann Surg Oncol, 15, pp. 1644-1650
Griffths, E. A., Pritchard, S. A., Mapstone, N. P., Welch, I. M., Emerging aspects of oesophageal and gastro-oesophageal junction cancer histopathology-an update for the surgical oncologist (2006) World J Surg Oncol, 4, p. 82
Dresner, S. M., Lamb, P. J., Bennet, M. K., Hayes, N., Griffn, S. M., The pattern of metastatic lymph node dissemination from adenocarcinoma of the esophagogastric junction (2001) Surgery, 129, pp. 103-109
Edge, S. B., Byrd, D. R., Compton, C. C., Fritz, A. G., Greene, F. L., Trotti, A., (2009) AJCC Cancer Staging Manual. 7 Th Ed, , New York, NY: Springer-Verlag
(1999) Common Toxicity Criteria (CTC). Ver. 2. 0, , http: //ctep. cancer. gov/protocolDevelopment/electronic_applications/docs/ctcv20_4-30-992. pdf, United States, Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Cancer Therapy Evaluation Program (ctep, Bethesda, MD: ctep, cited May 12, 2011
Cox, J. D., Stetz, J., Pajak, T. F., Toxicity criteria of the Radiation Therapy Oncology Group (rtog) and the European Organiza-tion for Research and Treatment of Cancer (eortc) (1995) Int J Radiat Oncol Biol Phys, 31, pp. 1341-1346
Yang, K., Chen, H. N., Chen, X. Z., Transthoracic resection versus non-transthoracic resection for gastroesophageal junction cancer: A meta-analysis (2012) PLoS One, 7, pp. e37698
Mandard, A. M., Dalibard, F., Mandard, J. C., Pathologic assessment of tumor regression after preoperative chemora-diotherapy of esophageal carcinoma (1994) Cancer, 73, pp. 2680-2686
Kaplan, E. L., Meier, P., Nonparametric estimation from incomplete observations (1958) J Am Stat Assoc, 53, pp. 457-481
Chan, Y. H., Biostatistics 203. Survival analysis (2004) Singapore Med J, 45, pp. 249-256
Walsh, T. N., Noonan, N., Hollywood, D., Kelly, A., Keeling, N., Hennessy, T. P., A comparison of multimodal therapy and surgery for adenocarcinoma (1996) N Engl J Med, 335, pp. 462-467
Urba, S. G., Orringer, M. B., Turrisi, A., Iannettoni, M., Forastiere, A., Strawderman, M., Randomized trial of preoperative chemo-radiation versus surgery alone in patients with locoregional esophageal carcinoma (2001) J Clin Oncol, 19, pp. 305-313
Burmeister, B. H., Smithers, B. M., Gebski, V., Su rger y alone versus chemoradiotherapy followed by surgery for resectable cancer of the oesophagus: A randomised controlled phase iii trial (2005) Lancet Oncol, 6, pp. 659-668
Reynolds, J. V., Ravi, N., Hollywood, D., Neoadjuvant chemoradiation may increase the risk of respiratory complications and sepsis after transthoracic esophagectomy (2006) J Thorac Cardiovasc Surg, 132, pp. 549-555
Wahba, H. A., El-Hadaad, H. A., Abd-Ellatif, E. A., Neoadjuvant concurrent chemoradiotherapy with capecitabine and oxali-platin in patients with locally advanced esophageal cancer (2012) Med Oncol, 29, pp. 1693-1698
Ajani, J. A., Winter, K., Okawara, G. S., Phase ii trial of preoperative chemoradiation in patients with localized gastric adenocarcinoma (rtog 9904): Quality of combined modality therapy and pathological response (2006) J Clin Oncol, 24, pp. 3953-3958
Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study
Background To date, few studies of preoperative chemotherapy or chemoradiotherapy (crt) in gastroesophageal junction (gej) cancer have been statistically powered; indeed, gej tumours have thus far been grouped with esophageal or gastric cancer in phase iii trials, there by generating conflicting results. Methods We studied 41 patients affected by locally advanced Siewert type i and ii gej adenocarcinoma who were treated with a neoadjuvant crt regimen [folfox4 (leucovorin-5-fuorouracil-oxaliplatin) for 4 cycles, and concurrent computed tomography-based three-dimensional conformal radiotherapy delivered using 5 daily fractions of 1.8 Gy per week for a total dose of 45 Gy], followed by surgery. Completeness of tumour resection (performed approximately 6 weeks after completion of crt), clinical and pathologic response rates, and safety and outcome of the treatment were the main endpoints of the study. Results All 41 patients completed preoperative treatment. Combined therapy was well tolerated, with no treatment-related deaths. Dose reduction was necessary in 8 patients (19.5%). After crt, 78% of the patients showed a partial clinical response, 17% were stable, and 5% experienced disease progression. Pathology examination of surgical specimens demonstrated a 10% complete response rate. The median and mean survival times were 26 and 36 months respectively (95% confdence interval: 14 to 37 months and 30 to 41 months respectively). On multivariate analysis, TNM staging and clinical response were demonstrated to be the only independent variables related to long-term survival. Conclusions In our experience, preoperative chemoradiotherapy with folfox4 is feasible in locally advanced gej ad-enocarcinoma, but shows mild efficacy, as suggested by the low rate of pathologic complete response. © 2014 Multimed Inc.
Background To date, few studies of preoperative chemotherapy or chemoradiotherapy (crt) in gastroesophageal junction (gej) cancer have been statistically powered; indeed, gej tumours have thus far been grouped with esophageal or gastric cancer in phase iii trials, there by generating conflicting results. Methods We studied 41 patients affected by locally advanced Siewert type i and ii gej adenocarcinoma who were treated with a neoadjuvant crt regimen [folfox4 (leucovorin-5-fuorouracil-oxaliplatin) for 4 cycles, and concurrent computed tomography-based three-dimensional conformal radiotherapy delivered using 5 daily fractions of 1.8 Gy per week for a total dose of 45 Gy], followed by surgery. Completeness of tumour resection (performed approximately 6 weeks after completion of crt), clinical and pathologic response rates, and safety and outcome of the treatment were the main endpoints of the study. Results All 41 patients completed preoperative treatment. Combined therapy was well tolerated, with no treatment-related deaths. Dose reduction was necessary in 8 patients (19.5%). After crt, 78% of the patients showed a partial clinical response, 17% were stable, and 5% experienced disease progression. Pathology examination of surgical specimens demonstrated a 10% complete response rate. The median and mean survival times were 26 and 36 months respectively (95% confdence interval: 14 to 37 months and 30 to 41 months respectively). On multivariate analysis, TNM staging and clinical response were demonstrated to be the only independent variables related to long-term survival. Conclusions In our experience, preoperative chemoradiotherapy with folfox4 is feasible in locally advanced gej ad-enocarcinoma, but shows mild efficacy, as suggested by the low rate of pathologic complete response. © 2014 Multimed Inc.
Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study
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Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study
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View Export to BibTeX Export to EndNote
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Impact Factor: 4.115
View Export to BibTeX Export to EndNote
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Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Gustavsson T, Banyasz A, Lazzarotto E, Markovitsi D, Scalmani G, Frisch MJ, Barone V, Improta R
* Singlet excited-state behavior of uracil and thymine in aqueous solution: A combined experimental and computational study of 11 uracil derivatives (467 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2006 Jan 18; 128(2): 607-619.
Impact Factor: 7.696
View Export to BibTeX Export to EndNote
d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
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Impact Factor: 4.285
View Export to BibTeX Export to EndNote
Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
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Impact Factor: 0.996
View Export to BibTeX Export to EndNote
19 Records (19 excluding Abstracts).
Total impact factor: 78.979 (78.979 excluding Abstracts).
Total 5 year impact factor: 82.374 (82.374 excluding Abstracts).
Total impact factor: 78.979 (78.979 excluding Abstracts).
Total 5 year impact factor: 82.374 (82.374 excluding Abstracts).
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