Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study (1899 views)
Curr Oncol (ISSN: 1198-0052, 1718-7729electronic, 1198-0052linking), 2014 Jun; 21(3): 125-133.
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Paper type: Journal Article,
Impact factor: 1.785, 5-year impact factor: 1.802
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84902682619&partnerID=40&md5=48ce915a30712be1de353144188d8160
Keywords: Folfox4, Gastroesophageal Junction Cancer, Preoperative Chemoradiotherapy, Fluorouracil, Folinic Acid, Oxaliplatin, Adenocarcinoma, Adult, Anemia, Article, Asthenia, Cancer Surgery, Clinical Article, Clinical Effectiveness, Computer Assisted Tomography, Dermatitis, Diarrhea, Disease Course, Drug Dose Reduction, Drug Withdrawal, Echography, Esophagitis, Esophagogastroduodenoscopy, Female, Human, Lower Esophagus Sphincter, Lymph Node, Multiple Cycle Treatment, Neutropenia, Outcome Assessment, Overall Survival, Paresthesia, Pathology, Patient Selection, Pilot Study, Radiation Dose Reduction, Radiation Safety, Stomatitis, Thrombocytopenia, Thrombophlebitis, Toxicity Testing, Treatment Response, Tumor Recurrence,
Affiliations:
*** IBB - CNR ***
Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
Divisions of Surgical Oncology, Department of An-esthesiologic, Surgical, and Emergency Sciences, Second University of Naples School of Medicine, Naples, Italy
Division of General Surgery 1, University of Padua, School of Medicine, Padua, Italy
Division of Radiotherapy, Federico n University of Naples School of Medicine, Naples, Italy
References:
Not available.
Curr Oncol (ISSN: 1198-0052, 1718-7729electronic, 1198-0052linking), 2014 Jun; 21(3): 125-133.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.785, 5-year impact factor: 1.802
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84902682619&partnerID=40&md5=48ce915a30712be1de353144188d8160
Keywords: Folfox4, Gastroesophageal Junction Cancer, Preoperative Chemoradiotherapy, Fluorouracil, Folinic Acid, Oxaliplatin, Adenocarcinoma, Adult, Anemia, Article, Asthenia, Cancer Surgery, Clinical Article, Clinical Effectiveness, Computer Assisted Tomography, Dermatitis, Diarrhea, Disease Course, Drug Dose Reduction, Drug Withdrawal, Echography, Esophagitis, Esophagogastroduodenoscopy, Female, Human, Lower Esophagus Sphincter, Lymph Node, Multiple Cycle Treatment, Neutropenia, Outcome Assessment, Overall Survival, Paresthesia, Pathology, Patient Selection, Pilot Study, Radiation Dose Reduction, Radiation Safety, Stomatitis, Thrombocytopenia, Thrombophlebitis, Toxicity Testing, Treatment Response, Tumor Recurrence,
Affiliations:
*** IBB - CNR ***
Division of Medical Oncology, Department of Clinical and Experimental Medicine and Surgery, Second University of Naples School of Medicine, Naples, Italy
Divisions of Surgical Oncology, Department of An-esthesiologic, Surgical, and Emergency Sciences, Second University of Naples School of Medicine, Naples, Italy
Division of General Surgery 1, University of Padua, School of Medicine, Padua, Italy
Division of Radiotherapy, Federico n University of Naples School of Medicine, Naples, Italy
References:
Not available.
Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study
Background To date, few studies of preoperative chemotherapy or chemoradiotherapy (crt) in gastroesophageal junction (gej) cancer have been statistically powered; indeed, gej tumours have thus far been grouped with esophageal or gastric cancer in phase iii trials, there by generating conflicting results. Methods We studied 41 patients affected by locally advanced Siewert type i and ii gej adenocarcinoma who were treated with a neoadjuvant crt regimen [folfox4 (leucovorin-5-fuorouracil-oxaliplatin) for 4 cycles, and concurrent computed tomography-based three-dimensional conformal radiotherapy delivered using 5 daily fractions of 1.8 Gy per week for a total dose of 45 Gy], followed by surgery. Completeness of tumour resection (performed approximately 6 weeks after completion of crt), clinical and pathologic response rates, and safety and outcome of the treatment were the main endpoints of the study. Results All 41 patients completed preoperative treatment. Combined therapy was well tolerated, with no treatment-related deaths. Dose reduction was necessary in 8 patients (19.5%). After crt, 78% of the patients showed a partial clinical response, 17% were stable, and 5% experienced disease progression. Pathology examination of surgical specimens demonstrated a 10% complete response rate. The median and mean survival times were 26 and 36 months respectively (95% confdence interval: 14 to 37 months and 30 to 41 months respectively). On multivariate analysis, TNM staging and clinical response were demonstrated to be the only independent variables related to long-term survival. Conclusions In our experience, preoperative chemoradiotherapy with folfox4 is feasible in locally advanced gej ad-enocarcinoma, but shows mild efficacy, as suggested by the low rate of pathologic complete response. © 2014 Multimed Inc.
Background To date, few studies of preoperative chemotherapy or chemoradiotherapy (crt) in gastroesophageal junction (gej) cancer have been statistically powered; indeed, gej tumours have thus far been grouped with esophageal or gastric cancer in phase iii trials, there by generating conflicting results. Methods We studied 41 patients affected by locally advanced Siewert type i and ii gej adenocarcinoma who were treated with a neoadjuvant crt regimen [folfox4 (leucovorin-5-fuorouracil-oxaliplatin) for 4 cycles, and concurrent computed tomography-based three-dimensional conformal radiotherapy delivered using 5 daily fractions of 1.8 Gy per week for a total dose of 45 Gy], followed by surgery. Completeness of tumour resection (performed approximately 6 weeks after completion of crt), clinical and pathologic response rates, and safety and outcome of the treatment were the main endpoints of the study. Results All 41 patients completed preoperative treatment. Combined therapy was well tolerated, with no treatment-related deaths. Dose reduction was necessary in 8 patients (19.5%). After crt, 78% of the patients showed a partial clinical response, 17% were stable, and 5% experienced disease progression. Pathology examination of surgical specimens demonstrated a 10% complete response rate. The median and mean survival times were 26 and 36 months respectively (95% confdence interval: 14 to 37 months and 30 to 41 months respectively). On multivariate analysis, TNM staging and clinical response were demonstrated to be the only independent variables related to long-term survival. Conclusions In our experience, preoperative chemoradiotherapy with folfox4 is feasible in locally advanced gej ad-enocarcinoma, but shows mild efficacy, as suggested by the low rate of pathologic complete response. © 2014 Multimed Inc.
Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study
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Effect of preoperative chemoradiotherapy on outcome of patients with locally advanced esophagogastric junction adenocarcinoma-a pilot study
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View Export to BibTeX Export to EndNote
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Impact Factor: 4.041
View Export to BibTeX Export to EndNote
Gustavsson T, Banyasz A, Lazzarotto E, Markovitsi D, Scalmani G, Frisch MJ, Barone V, Improta R
* Singlet excited-state behavior of uracil and thymine in aqueous solution: A combined experimental and computational study of 11 uracil derivatives (562 views)
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Impact Factor: 7.696
View Export to BibTeX Export to EndNote
d'Alesio V, Pacelli R, Durante M, Canale Cama G, Cella L, Gialanella G, Grossi G, Pugliese M, Punzo G, Sardi I, Scampoli P, Solla R, Salvatore M
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Impact Factor: 4.285
View Export to BibTeX Export to EndNote
Mainenti PP, Romano L, Contegiacomo A, Romano M, Casella V, Cuccuru A, Insabato L, Salvatore M
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Impact Factor: 0.996
View Export to BibTeX Export to EndNote
19 Records (19 excluding Abstracts).
Total impact factor: 78.979 (78.979 excluding Abstracts).
Total 5 year impact factor: 82.374 (82.374 excluding Abstracts).
Total impact factor: 78.979 (78.979 excluding Abstracts).
Total 5 year impact factor: 82.374 (82.374 excluding Abstracts).
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