Mixed conformation in C(α, α)-disubstituted tripeptides: X-ray crystal structures of Z-Aib-Dph-Gly-OMe and Bz-Dph-Dph-Gly-OMe(593 views) Pavone V, Lombardi A, Saviano M, Di Blasio B, Nastri F, Fattorusso R, Zaccaro L, Maglio O, Yamada T, Omote Y
Keywords: Amino Acids, Atoms, Carbon, Crystal Structure, Molecular Structure, Synthesis (chemical), Diphenylglycine, Tripeptides, Ugi Reaction, X Ray Crystal Structure, Proteins, Article, Conformational Transition, Molecular Dynamics, Peptide Analysis, Peptide Synthesis, Protein Conformation, X Ray Crystallography, Amino Acid Sequence, X-Ray, Molecular Sequence Data, Oligopeptides, Support, Non-U S Gov,
Affiliations: CIRPB, CEINGE-Biotecnologie Avanzate, University of Naples Federico II, Via Mezzocannone 4, 80134 Napoli, Italy
References: Not available.
Mixed conformation in C(α, α)-disubstituted tripeptides: X-ray crystal structures of Z-Aib-Dph-Gly-OMe and Bz-Dph-Dph-Gly-OMe
We report here the synthesis and molecular structure in the solid state of fully protected tripeptides containing C(α,α)-diphenylglycine (Dph), namely Z-Aib-Dph-Gly-OMe (Aib: C(α,α)-dimethylglycine) and Bz-Dph-Dph-Gly-OMe. The molecular conformation around the Dph residue, containing two bulky substituents, is fully extended, while the Aib residue, containing two smaller groups on the C(α) atom, adopts the typical 310/α-helical conformation. Gly residues, without substituents on the C(α) atom, show different conformational preferences. Each residue seems to behave, from a conformational point of view, independently from the presence of the other residues, and thus mixed local conformations (folded and extended) are present in the crystals. The nonconventional peptide synthesis, using the Ugi reaction, is also reported.
Mixed conformation in C(α, α)-disubstituted tripeptides: X-ray crystal structures of Z-Aib-Dph-Gly-OMe and Bz-Dph-Dph-Gly-OMe
Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I * Copper(II) complexes of rat amylin fragments(659 views) Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721. Impact Factor:3.838 ViewExport to BibTeXExport to EndNote