Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (284 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.623, 5-year impact factor: 2.442
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0032891335&partnerID=40&md5=4f03b29e8e055cd92d87b0175450d18b
Keywords: Mrk16, Multidrug Resistance, P-Glycoprotein, Quantitative Autoradiography, Self-Competitive Binding Assay, Iodine 125, Monoclonal Antibody Mrk 16, Animal Experiment, Article, Cancer Cell Culture, Cancer Transplantation, Human, Human Cell, Isotope Labeling, Mouse, Neuroblastoma, Nonhuman, Nude Mouse, Protein Determination, Protein Expression, Quantitative Assay, Radioassay, Tissue Distribution, Antibodies, Multiple, Iodine Radioisotopes, Inbred Balb C, Neoplasm Transplantation, Heterologous, Tumor Cells,
Affiliations:
Department of Nuclear Medicine, Mem. Sloan-Kettering Cancer C., New York, NY, United States
Inst. of Molec. and Cell. Biosci., University of Tokyo, Tokyo, Japan
References:
Aldrich, C.D., Pleiotropic phenothype of cultured murine cells resistant to maytansine, vincristine, colchicine and adriamycin (1979) J. Natl. Cancer Inst., 63, pp. 751-75
Beck, W.T., Grogan, T.M., Willman, C.L., Cordon-Cardo, C., Parham, D.M., Kuttesch, J.F., Andreeff, M., Weinstein, R., Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: Consensus recommendations (1996) Cancer Res, 56, pp. 3010-3020
Biedler, J.L., Cassals, D., Chang, T.D., Meyers, M.B., Ross, R.A., Multidrug resistant human neuroblastoma cells are more differentiated than controls and retinoic acid further induces lineage-specific differentiation (1991) Adv. Neuroblastoma Res., 3, pp. 181-191
Biedler, J.L., Peterson, R.H.F., Molecular actions and targets for cancer chemotherapeutic agents (1981) Bristol-Myers Cancer Symposia, pp. 453-482. , A.C. Sartorelli, J.S. Lazo, & J.R. Bertino. New York: Academic Press
Biedler, J.L., Spengler, B.A., Cytogenetic manifestations of multidrug resistance (1996) Multidrug Resistance in Cancer Cells, pp. 61-78. , S. Gupta, & T. Tsruo. New York: Wiley
Bradley, G., Juranka, P.F., Ling, V., Mechanism of multidrug resistance (1988) Biochim. Biophys. Acta, 948, pp. 87-128
Chan, H.S.L., Haddad, G., Thorner, P.S., Deboer, D., Lin, Y.P., Ondrusek, N., Yeger, H., Ling, V., P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma (1991) N. Engl. J. Med., 325, pp. 1608-1614
Dano, K., Cross-resistance between vinca-alkaloids and anthra cyclines in Ehrlich ascites tumor in vivo (1972) Cancer Chemother. Rep., 56, pp. 701-708
Dano, K., Active outward transport of daunomicin in resistant Ehrlich ascites tumor cells (1973) Biochim. Biophys. Acta, 323, pp. 466-483
Del Vecchio, S., Ciarmiello, A., Pace, L., Potena, M.I., Carriero, M.V., Mainolfi, C., Thomas, R., Salvatore, M., Fractional retention of technetium-99m-sestamibi as an index of P-glycoprotein expression in untreated breast cancer patients (1997) J. Nucl. Med., 38, pp. 1348-1351
Del Vecchio, S., Reynolds, J.C., Blasberg, R.G., Neumann, R.D., Carrasquillo, J.A., Hellstrom, I., Larson, S.M., Measurement of local Mr 97,000 and 250,000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (1988) Cancer Res, 48, pp. 5475-5481
Del Vecchio, S., Stoppelli, M.P., Carriero, M.V., Fonti, R., Massa, O., Li, P.J., Botti, G., Salvatore, M., Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (1993) Cancer Res, 53, pp. 3198-3206
Fojo, A.T., Ueda, K., Slamon, D.J., Poplack, D.G., Gottesman, M.M., Pastan, I., Expression of a multidrug-resistance gene in human tumors and tissues (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 265-269
Fraker, P.J., Speck, J.C., Protein and cell membrane iodinations with a sparingly soluble chloramide 1,3,4,6-tetrachloro-3 a,6a-diphenylglycouril (1978) Biochem. Biophys. Res. Commun., 80, pp. 849-857
Georges, E., Tsuruo, T., Ling, V., Topology of P-glycoprtein as determined by epitope mapping of MRK16 monoclonal antibody (1993) J. Biol. Chem., 268, pp. 1792-1798
Gudkov, A.V., Multiple drug resistance in tumor cells: Manifestations, clinical basis, clinical aspects (1987) Mol. Gen. Microbiol. Virusol., 3, pp. 3-9
Hulme, E.C., (1992) Receptor-Ligand Interactions. a Practical Approach, , New York: Oxford University Press
Inaba, M., Fujikura, R., Sakurai, Y., Active efflux common to vincristine and daunorubicin in vincristine resistant P388 leukemia (1981) Biochem. Pharmacol., 30, pp. 1863-1865
Juliano, R.L., Ling, V., A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants (1976) Biochim. Biophys. Acta, 455, pp. 152-162
Kartner, N., Everdnen-Porelle, D., Bradley, G., Ling, V., Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies (1985) Nature, 316, pp. 820-823
Kartner, N., Shales, M., Riordan, J.R., Ling, V., Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug-resistance and a cell surface P-glycoprotein (1983) Cancer Res, 43, pp. 4413-4419
Kobayashi, Y., Yamashiro, T., Nagatake, H., Yamamoto, Y., Watanabe, N., Tanaka, H., Shigenobu, K., Tsuruo, T., Expression and function of multidrug resistance P-glycoprotein in a cultured natural killer cell-rich population revealed by MRK16 monoclonal antibody and AHC-52 (1994) Biochem. Pharmacol., 48, pp. 1641-1646
Kohno, K., Molecular mechanism of the stress induction of MDR1 gene (1997) Nippon Rinsho, 55, pp. 1054-1058
Levchenko, A., Mehta, B.M., Spengler, B.A., Narkar, A.A., Fonti, R., Biedler, J.L., Tsuruo, T., Larson, S.M., Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (1996) Anal. Biochem., 236, pp. 338-343
Lindmo, T., Boven, E., Cutitta, F., Fedorko, J., Bunn, P.A., Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess (1984) J. Immunol. Methods, 72, pp. 77-89
Ling, V., Thompson, L.H., Reduced permeability in CHO cells as a mechanism of resistance to colchicine (1974) J. Cell Physiol., 83, pp. 103-116
Mehta, B.M., Levchenko, A., Rosa, E., Kim, S.W., Winnick, S., Zhang, J.J., Kalaigian, H., Larson, S.M., Evaluation of carbon-14-colchicine biodistribution with whole body quantitative autoradiography in colchicine sensitive and resistant xenografts (1996) J. Nucl. Med., 37, pp. 312-314
Mehta, B., Rosa, E., Fissekis, J.D., Bading, J.R., Biedler, J.R., Larson, S.M., In vivo identification of tumor multidrug resistance with H3-colchicine (1992) J. Nucl. Med., 33, pp. 1373-1377
Merkel, D.E., Fuqua, S.A.W., Tandon, A.K., Hill, S.M., Buzdar, A.U., McGuire, W.L., Electrophoretic analysis of 248 clinical breast cancer specimens for P-glycoprotein overexpression or gene amplification (1989) J. Clin. Oncol., 7, pp. 1129-1136
Motulsky, H.J., Ransnas, L.A., Fitting curves to data using nonlinear regression: A practical and nonmathematical review (1987) FASEB J, 1, pp. 365-374
Ramu, A., Glaubiger, D., Magrath, I.T., Joshi, A., Plasma membrane lipid structural order in doxorubicin-sensitive resistant P388 cells (1983) Cancer Res, 43, pp. 5533-5537
Scott, A.M., Rosa, E., Mehta, B.M., Divgi, C.R., Finn, R.D., Biedler, J.L., Tsuruo, T., Larson, S.M., In vivo imaging and specific targeting of P-glycoprotein expression in multidrug resistant nude mice xenografts with 125I-MRK16 monoclonal antibody (1995) Nucl. Med. Biol., 22, pp. 497-504
Shen, D.W., Pastan, I., Gottesman, M.M., In situ hybridization analysis of acquisition and loss of human multidrug resistance gene (1988) Cancer Res, 48, pp. 4334-4339
Sirotnak, F.M., Yang, C.H., Mines, L.S., Oribe, E., Biedler, J.L., Markedly altered membrane transport and intracellular binding of vincristine in multidrug-resistant Chinese hamster cells selected for resistance to vinca alkaloids (1986) J. Cell Physiol., 126, pp. 266-274
Skovsgaard, T., Mechanism of cross-resistance between vincristine and daunorubicin in Erlich ascites tumor cells (1978) Cancer Res, 38, pp. 4722-4727
Sugawara, I., Kataoka, I., Morishita, Y., Hamada, H., Tsuruo, T., Itoyama, S., Mori, S., Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by the monoclonal antibody MRK16 (1988) Cancer Res, 48, pp. 1926-1929
Tanaka, Y., Abe, Y., Tsugu, A., Takamiya, Y., Akatsuka, A., Tsuruo, T., Yamazaki, H., Nakamura, M., Ultrastructural localization of P-glycoprotein on capillary endothelial cells in human gliomas (1994) Virchows Arch, 425, pp. 133-138
Thiebaut, T., Tsuruo, T., Hamada, H., Gottesman, M.M., Pastan, I., Willingam, M.C., Cellular localization of the multidrug-resistant gene product P-glycoprotein in normal human tissues (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 7735-7738
Tsuji, A., Terasaki, T., Takabatake, Y., Tenda, Y., Tamai, I., Yamashima, T., Moritani, S., Yamashita, J., P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells (1992) Life Sci, 51, pp. 1427-1437
Van Der Bliek, A.M., Borst, P., Multidrug resistance (1989) Adv. Cancer Res., 52, pp. 165-202
Verelle, P., Meissonmier, F., Fonck, Y., Clinical relevance of immunohistochemical detection of multidrug-resistance in breast carcinoma (1991) J. Natl. Cancer Inst., 83, pp. 111-116
Vollrath, V., Chianale, J., Gonzales, S., Duarte, I., Andrade, L., Ibanez, L., Multidrug resistance gene and P-glycoprotein expression in gastric adenocarcinoma and precursor lesions (1991) Virchows Archiv. B, Cell Pathol. Mol. Pathol., 60, pp. 133-138
Young, A.B., Frey, K.A., Agranoff, B.W., Receptor assay: In vitro and in vivo (1986) Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart, pp. 73-111. , M. Phelps, J. Mazziotta, & H. Schelbert. New York: Raven Press
Aldrich, C. D., Pleiotropic phenothype of cultured murine cells resistant to maytansine, vincristine, colchicine and adriamycin (1979) J. Natl. Cancer Inst., 63, pp. 751-75
Beck, W. T., Grogan, T. M., Willman, C. L., Cordon-Cardo, C., Parham, D. M., Kuttesch, J. F., Andreeff, M., Weinstein, R., Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: Consensus recommendations (1996) Cancer Res, 56, pp. 3010-3020
Biedler, J. L., Cassals, D., Chang, T. D., Meyers, M. B., Ross, R. A., Multidrug resistant human neuroblastoma cells are more differentiated than controls and retinoic acid further induces lineage-specific differentiation (1991) Adv. Neuroblastoma Res., 3, pp. 181-191
Biedler, J. L., Peterson, R. H. F., Molecular actions and targets for cancer chemotherapeutic agents (1981) Bristol-Myers Cancer Symposia, pp. 453-482. , A. C. Sartorelli, J. S. Lazo, & J. R. Bertino. New York: Academic Press
Biedler, J. L., Spengler, B. A., Cytogenetic manifestations of multidrug resistance (1996) Multidrug Resistance in Cancer Cells, pp. 61-78. , S. Gupta, & T. Tsruo. New York: Wiley
Chan, H. S. L., Haddad, G., Thorner, P. S., Deboer, D., Lin, Y. P., Ondrusek, N., Yeger, H., Ling, V., P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma (1991) N. Engl. J. Med., 325, pp. 1608-1614
Fojo, A. T., Ueda, K., Slamon, D. J., Poplack, D. G., Gottesman, M. M., Pastan, I., Expression of a multidrug-resistance gene in human tumors and tissues (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 265-269
Fraker, P. J., Speck, J. C., Protein and cell membrane iodinations with a sparingly soluble chloramide 1, 3, 4, 6-tetrachloro-3 a, 6a-diphenylglycouril (1978) Biochem. Biophys. Res. Commun., 80, pp. 849-857
Gudkov, A. V., Multiple drug resistance in tumor cells: Manifestations, clinical basis, clinical aspects (1987) Mol. Gen. Microbiol. Virusol., 3, pp. 3-9
Hulme, E. C., (1992) Receptor-Ligand Interactions. a Practical Approach, , New York: Oxford University Press
Juliano, R. L., Ling, V., A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants (1976) Biochim. Biophys. Acta, 455, pp. 152-162
Mehta, B. M., Levchenko, A., Rosa, E., Kim, S. W., Winnick, S., Zhang, J. J., Kalaigian, H., Larson, S. M., Evaluation of carbon-14-colchicine biodistribution with whole body quantitative autoradiography in colchicine sensitive and resistant xenografts (1996) J. Nucl. Med., 37, pp. 312-314
Merkel, D. E., Fuqua, S. A. W., Tandon, A. K., Hill, S. M., Buzdar, A. U., McGuire, W. L., Electrophoretic analysis of 248 clinical breast cancer specimens for P-glycoprotein overexpression or gene amplification (1989) J. Clin. Oncol., 7, pp. 1129-1136
Motulsky, H. J., Ransnas, L. A., Fitting curves to data using nonlinear regression: A practical and nonmathematical review (1987) FASEB J, 1, pp. 365-374
Scott, A. M., Rosa, E., Mehta, B. M., Divgi, C. R., Finn, R. D., Biedler, J. L., Tsuruo, T., Larson, S. M., In vivo imaging and specific targeting of P-glycoprotein expression in multidrug resistant nude mice xenografts with 125I-MRK16 monoclonal antibody (1995) Nucl. Med. Biol., 22, pp. 497-504
Shen, D. W., Pastan, I., Gottesman, M. M., In situ hybridization analysis of acquisition and loss of human multidrug resistance gene (1988) Cancer Res, 48, pp. 4334-4339
Sirotnak, F. M., Yang, C. H., Mines, L. S., Oribe, E., Biedler, J. L., Markedly altered membrane transport and intracellular binding of vincristine in multidrug-resistant Chinese hamster cells selected for resistance to vinca alkaloids (1986) J. Cell Physiol., 126, pp. 266-274
Van Der Bliek, A. M., Borst, P., Multidrug resistance (1989) Adv. Cancer Res., 52, pp. 165-202
Young, A. B., Frey, K. A., Agranoff, B. W., Receptor assay: In vitro and in vivo (1986) Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart, pp. 73-111. , M. Phelps, J. Mazziotta, & H. Schelbert. New York: Raven Press
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.623, 5-year impact factor: 2.442
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0032891335&partnerID=40&md5=4f03b29e8e055cd92d87b0175450d18b
Keywords: Mrk16, Multidrug Resistance, P-Glycoprotein, Quantitative Autoradiography, Self-Competitive Binding Assay, Iodine 125, Monoclonal Antibody Mrk 16, Animal Experiment, Article, Cancer Cell Culture, Cancer Transplantation, Human, Human Cell, Isotope Labeling, Mouse, Neuroblastoma, Nonhuman, Nude Mouse, Protein Determination, Protein Expression, Quantitative Assay, Radioassay, Tissue Distribution, Antibodies, Multiple, Iodine Radioisotopes, Inbred Balb C, Neoplasm Transplantation, Heterologous, Tumor Cells,
Affiliations:
Department of Nuclear Medicine, Mem. Sloan-Kettering Cancer C., New York, NY, United States
Inst. of Molec. and Cell. Biosci., University of Tokyo, Tokyo, Japan
References:
Aldrich, C.D., Pleiotropic phenothype of cultured murine cells resistant to maytansine, vincristine, colchicine and adriamycin (1979) J. Natl. Cancer Inst., 63, pp. 751-75
Beck, W.T., Grogan, T.M., Willman, C.L., Cordon-Cardo, C., Parham, D.M., Kuttesch, J.F., Andreeff, M., Weinstein, R., Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: Consensus recommendations (1996) Cancer Res, 56, pp. 3010-3020
Biedler, J.L., Cassals, D., Chang, T.D., Meyers, M.B., Ross, R.A., Multidrug resistant human neuroblastoma cells are more differentiated than controls and retinoic acid further induces lineage-specific differentiation (1991) Adv. Neuroblastoma Res., 3, pp. 181-191
Biedler, J.L., Peterson, R.H.F., Molecular actions and targets for cancer chemotherapeutic agents (1981) Bristol-Myers Cancer Symposia, pp. 453-482. , A.C. Sartorelli, J.S. Lazo, & J.R. Bertino. New York: Academic Press
Biedler, J.L., Spengler, B.A., Cytogenetic manifestations of multidrug resistance (1996) Multidrug Resistance in Cancer Cells, pp. 61-78. , S. Gupta, & T. Tsruo. New York: Wiley
Bradley, G., Juranka, P.F., Ling, V., Mechanism of multidrug resistance (1988) Biochim. Biophys. Acta, 948, pp. 87-128
Chan, H.S.L., Haddad, G., Thorner, P.S., Deboer, D., Lin, Y.P., Ondrusek, N., Yeger, H., Ling, V., P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma (1991) N. Engl. J. Med., 325, pp. 1608-1614
Dano, K., Cross-resistance between vinca-alkaloids and anthra cyclines in Ehrlich ascites tumor in vivo (1972) Cancer Chemother. Rep., 56, pp. 701-708
Dano, K., Active outward transport of daunomicin in resistant Ehrlich ascites tumor cells (1973) Biochim. Biophys. Acta, 323, pp. 466-483
Del Vecchio, S., Ciarmiello, A., Pace, L., Potena, M.I., Carriero, M.V., Mainolfi, C., Thomas, R., Salvatore, M., Fractional retention of technetium-99m-sestamibi as an index of P-glycoprotein expression in untreated breast cancer patients (1997) J. Nucl. Med., 38, pp. 1348-1351
Del Vecchio, S., Reynolds, J.C., Blasberg, R.G., Neumann, R.D., Carrasquillo, J.A., Hellstrom, I., Larson, S.M., Measurement of local Mr 97,000 and 250,000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (1988) Cancer Res, 48, pp. 5475-5481
Del Vecchio, S., Stoppelli, M.P., Carriero, M.V., Fonti, R., Massa, O., Li, P.J., Botti, G., Salvatore, M., Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (1993) Cancer Res, 53, pp. 3198-3206
Fojo, A.T., Ueda, K., Slamon, D.J., Poplack, D.G., Gottesman, M.M., Pastan, I., Expression of a multidrug-resistance gene in human tumors and tissues (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 265-269
Fraker, P.J., Speck, J.C., Protein and cell membrane iodinations with a sparingly soluble chloramide 1,3,4,6-tetrachloro-3 a,6a-diphenylglycouril (1978) Biochem. Biophys. Res. Commun., 80, pp. 849-857
Georges, E., Tsuruo, T., Ling, V., Topology of P-glycoprtein as determined by epitope mapping of MRK16 monoclonal antibody (1993) J. Biol. Chem., 268, pp. 1792-1798
Gudkov, A.V., Multiple drug resistance in tumor cells: Manifestations, clinical basis, clinical aspects (1987) Mol. Gen. Microbiol. Virusol., 3, pp. 3-9
Hulme, E.C., (1992) Receptor-Ligand Interactions. a Practical Approach, , New York: Oxford University Press
Inaba, M., Fujikura, R., Sakurai, Y., Active efflux common to vincristine and daunorubicin in vincristine resistant P388 leukemia (1981) Biochem. Pharmacol., 30, pp. 1863-1865
Juliano, R.L., Ling, V., A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants (1976) Biochim. Biophys. Acta, 455, pp. 152-162
Kartner, N., Everdnen-Porelle, D., Bradley, G., Ling, V., Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies (1985) Nature, 316, pp. 820-823
Kartner, N., Shales, M., Riordan, J.R., Ling, V., Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug-resistance and a cell surface P-glycoprotein (1983) Cancer Res, 43, pp. 4413-4419
Kobayashi, Y., Yamashiro, T., Nagatake, H., Yamamoto, Y., Watanabe, N., Tanaka, H., Shigenobu, K., Tsuruo, T., Expression and function of multidrug resistance P-glycoprotein in a cultured natural killer cell-rich population revealed by MRK16 monoclonal antibody and AHC-52 (1994) Biochem. Pharmacol., 48, pp. 1641-1646
Kohno, K., Molecular mechanism of the stress induction of MDR1 gene (1997) Nippon Rinsho, 55, pp. 1054-1058
Levchenko, A., Mehta, B.M., Spengler, B.A., Narkar, A.A., Fonti, R., Biedler, J.L., Tsuruo, T., Larson, S.M., Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (1996) Anal. Biochem., 236, pp. 338-343
Lindmo, T., Boven, E., Cutitta, F., Fedorko, J., Bunn, P.A., Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess (1984) J. Immunol. Methods, 72, pp. 77-89
Ling, V., Thompson, L.H., Reduced permeability in CHO cells as a mechanism of resistance to colchicine (1974) J. Cell Physiol., 83, pp. 103-116
Mehta, B.M., Levchenko, A., Rosa, E., Kim, S.W., Winnick, S., Zhang, J.J., Kalaigian, H., Larson, S.M., Evaluation of carbon-14-colchicine biodistribution with whole body quantitative autoradiography in colchicine sensitive and resistant xenografts (1996) J. Nucl. Med., 37, pp. 312-314
Mehta, B., Rosa, E., Fissekis, J.D., Bading, J.R., Biedler, J.R., Larson, S.M., In vivo identification of tumor multidrug resistance with H3-colchicine (1992) J. Nucl. Med., 33, pp. 1373-1377
Merkel, D.E., Fuqua, S.A.W., Tandon, A.K., Hill, S.M., Buzdar, A.U., McGuire, W.L., Electrophoretic analysis of 248 clinical breast cancer specimens for P-glycoprotein overexpression or gene amplification (1989) J. Clin. Oncol., 7, pp. 1129-1136
Motulsky, H.J., Ransnas, L.A., Fitting curves to data using nonlinear regression: A practical and nonmathematical review (1987) FASEB J, 1, pp. 365-374
Ramu, A., Glaubiger, D., Magrath, I.T., Joshi, A., Plasma membrane lipid structural order in doxorubicin-sensitive resistant P388 cells (1983) Cancer Res, 43, pp. 5533-5537
Scott, A.M., Rosa, E., Mehta, B.M., Divgi, C.R., Finn, R.D., Biedler, J.L., Tsuruo, T., Larson, S.M., In vivo imaging and specific targeting of P-glycoprotein expression in multidrug resistant nude mice xenografts with 125I-MRK16 monoclonal antibody (1995) Nucl. Med. Biol., 22, pp. 497-504
Shen, D.W., Pastan, I., Gottesman, M.M., In situ hybridization analysis of acquisition and loss of human multidrug resistance gene (1988) Cancer Res, 48, pp. 4334-4339
Sirotnak, F.M., Yang, C.H., Mines, L.S., Oribe, E., Biedler, J.L., Markedly altered membrane transport and intracellular binding of vincristine in multidrug-resistant Chinese hamster cells selected for resistance to vinca alkaloids (1986) J. Cell Physiol., 126, pp. 266-274
Skovsgaard, T., Mechanism of cross-resistance between vincristine and daunorubicin in Erlich ascites tumor cells (1978) Cancer Res, 38, pp. 4722-4727
Sugawara, I., Kataoka, I., Morishita, Y., Hamada, H., Tsuruo, T., Itoyama, S., Mori, S., Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by the monoclonal antibody MRK16 (1988) Cancer Res, 48, pp. 1926-1929
Tanaka, Y., Abe, Y., Tsugu, A., Takamiya, Y., Akatsuka, A., Tsuruo, T., Yamazaki, H., Nakamura, M., Ultrastructural localization of P-glycoprotein on capillary endothelial cells in human gliomas (1994) Virchows Arch, 425, pp. 133-138
Thiebaut, T., Tsuruo, T., Hamada, H., Gottesman, M.M., Pastan, I., Willingam, M.C., Cellular localization of the multidrug-resistant gene product P-glycoprotein in normal human tissues (1987) Proc. Natl. Acad. Sci. USA, 84, pp. 7735-7738
Tsuji, A., Terasaki, T., Takabatake, Y., Tenda, Y., Tamai, I., Yamashima, T., Moritani, S., Yamashita, J., P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells (1992) Life Sci, 51, pp. 1427-1437
Van Der Bliek, A.M., Borst, P., Multidrug resistance (1989) Adv. Cancer Res., 52, pp. 165-202
Verelle, P., Meissonmier, F., Fonck, Y., Clinical relevance of immunohistochemical detection of multidrug-resistance in breast carcinoma (1991) J. Natl. Cancer Inst., 83, pp. 111-116
Vollrath, V., Chianale, J., Gonzales, S., Duarte, I., Andrade, L., Ibanez, L., Multidrug resistance gene and P-glycoprotein expression in gastric adenocarcinoma and precursor lesions (1991) Virchows Archiv. B, Cell Pathol. Mol. Pathol., 60, pp. 133-138
Young, A.B., Frey, K.A., Agranoff, B.W., Receptor assay: In vitro and in vivo (1986) Positron Emission Tomography and Autoradiography: Principles and Applications for the Brain and Heart, pp. 73-111. , M. Phelps, J. Mazziotta, & H. Schelbert. New York: Raven Press
Aldrich, C. D., Pleiotropic phenothype of cultured murine cells resistant to maytansine, vincristine, colchicine and adriamycin (1979) J. Natl. Cancer Inst., 63, pp. 751-75
Beck, W. T., Grogan, T. M., Willman, C. L., Cordon-Cardo, C., Parham, D. M., Kuttesch, J. F., Andreeff, M., Weinstein, R., Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: Consensus recommendations (1996) Cancer Res, 56, pp. 3010-3020
Biedler, J. L., Cassals, D., Chang, T. D., Meyers, M. B., Ross, R. A., Multidrug resistant human neuroblastoma cells are more differentiated than controls and retinoic acid further induces lineage-specific differentiation (1991) Adv. Neuroblastoma Res., 3, pp. 181-191
Biedler, J. L., Peterson, R. H. F., Molecular actions and targets for cancer chemotherapeutic agents (1981) Bristol-Myers Cancer Symposia, pp. 453-482. , A. C. Sartorelli, J. S. Lazo, & J. R. Bertino. New York: Academic Press
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Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography
P-glycoprotein (P-gp) has a role in multidrug resistance (MDR) encountered in human cancers. In this study, we used the colchicine-resistant cell line BE(2)-C/CHCb(0.2), a strain of neuroblastoma cell line BE(2)-C, as a model to measure variations of P-gp expression in cells grown in vitro and in vivo. Cells were cultured in the medium supplemented with colchicine. At the beginning of the study the drug was withdrawn and, after 22 days, added back to the culture medium. Cells were harvested at various time points and xenografted in nude mice. P-gp COntent in cells was measured by self- competitive binding assay and in tumors, by quantitative autoradiography (QAR). Both assays were carried out using 125I-labeled monoclonal antibody MRK16, reactive with P-gp. Concentration of P-gp in cells varied from a maximum of 1,361 pmol/g in the presence of colchicine to a minimum of 374 pmol/g in the absence of colchicine in the culture medium. P-gp concentration in the tumors ranged from 929 to 188 pmol/g, which correlated with P-gp content in the cells at the time of their injection in the mice. QAR is an accurate and reliable method to quantify P-gp expression in tumors. Changes in colchicine concentration in the ambient medium of BE(2)-C/CHCb(0.2) cells growing in vitro resulted in a change in phenotype of P-gp expression, which was stable under conditions of in vivo growth over approximately 9 cell divisions in nude mice xenografts. Therefore, P-gp content in xenografts depends only on the level of resistance of the cells at the time of their injection in the mice.
P-glycoprotein (P-gp) has a role in multidrug resistance (MDR) encountered in human cancers. In this study, we used the colchicine-resistant cell line BE(2)-C/CHCb(0.2), a strain of neuroblastoma cell line BE(2)-C, as a model to measure variations of P-gp expression in cells grown in vitro and in vivo. Cells were cultured in the medium supplemented with colchicine. At the beginning of the study the drug was withdrawn and, after 22 days, added back to the culture medium. Cells were harvested at various time points and xenografted in nude mice. P-gp COntent in cells was measured by self- competitive binding assay and in tumors, by quantitative autoradiography (QAR). Both assays were carried out using 125I-labeled monoclonal antibody MRK16, reactive with P-gp. Concentration of P-gp in cells varied from a maximum of 1,361 pmol/g in the presence of colchicine to a minimum of 374 pmol/g in the absence of colchicine in the culture medium. P-gp concentration in the tumors ranged from 929 to 188 pmol/g, which correlated with P-gp content in the cells at the time of their injection in the mice. QAR is an accurate and reliable method to quantify P-gp expression in tumors. Changes in colchicine concentration in the ambient medium of BE(2)-C/CHCb(0.2) cells growing in vitro resulted in a change in phenotype of P-gp expression, which was stable under conditions of in vivo growth over approximately 9 cell divisions in nude mice xenografts. Therefore, P-gp content in xenografts depends only on the level of resistance of the cells at the time of their injection in the mice.
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography
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Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography
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View Export to BibTeX Export to EndNote
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Impact Factor: 5.377
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Impact Factor: 5.377
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Del Vecchio S, Salvatore M
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Impact Factor: 3.935
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Impact Factor: 2.222
View Export to BibTeX Export to EndNote
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Impact Factor: 3.568
View Export to BibTeX Export to EndNote
Del Vecchio S, Ciarmiello A, Salvatore M
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Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2000 Sep; 15(4): 327-337.
Impact Factor: 0.989
View Export to BibTeX Export to EndNote
Del Vecchio S, Ciarmiello A, Salvatore M
Clinical imaging of multidrug resistance in cancer (360 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1999 Jun; 43(2): 125-131.
Impact Factor: 2.125
View Export to BibTeX Export to EndNote
Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
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View Export to BibTeX Export to EndNote
Salvatore M, Del Vecchio S
Dynamic imaging: Scintimammography (383 views)
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Impact Factor: 0.537
View Export to BibTeX Export to EndNote
Mansi L, Rambaldi PF, Cuccurullo V, Pecori B, Quarantelli M, Fallanca F, Del Vecchio E
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Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 1997 Sep; 41(3): 239-250.
Impact Factor: 2.125
View Export to BibTeX Export to EndNote
Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
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Impact Factor: 3.491
View Export to BibTeX Export to EndNote
Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
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Impact Factor: 3.419
View Export to BibTeX Export to EndNote
Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (283 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (450 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Del Vecchio S, Ciarmiello A, Potena MI, Carriero MV, Mainolfi C, Botti G, Tsuruo T, Salvatore M
Quantitation of P-glycoprotein in sections of human breast carcinoma (298 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995; 36(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Ciarmiello A, Del Vecchio S, Potena MI, Mainolfi C, Carriero MV, Tsuruo T, Marone A, Salvatore M
Tc-99m-SESTAMIBI efflux and P-glycoprotein expression in human breast carcinoma (261 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995; 36(5SUPPL.): N/D-N/D.
Impact Factor: 3.491
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Del Vecchio S, Stoppelli MP, Carriero MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
IN-VITRO RECEPTOR IMAGING FOR CHARACTERIZATION OF HUMAN SOLID TUMORS (266 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1994 Jul; 21(5): 771-774.
Impact Factor: 1.042
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Correale P, Caraglia M, Pepe S, Ricciardi B, Barile C, Montagnani S, Pacelli R, Bianco A, Tagliaferri P
PHORBOL 12-MYRISTATE 13-ACETATE (PMA) INDUCES NEUROENDOCRINE-LIKE DIFFERENTIATION AND REVERSES DOXORUBICIN-RESISTANCE OF HUMAN COLON-CARCINOMA CELLS IN-VITRO (299 views)
Int J Oncol (ISSN: 1019-6439, 1791-2423electronic, 1019-6439linking), 1994 Feb; 4(2): 423-427.
Impact Factor: 1.181
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Del Vecchio S, Stoppelli MP, Carriere MV, Fonti R, Massa O, Li PY, Botti G, Cerra M, D'Aiuto G, Esposito G, Salvatore M
Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: Comparison with urokinase levels (289 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1993 Jul 1; 53(13): 3198-3206.
Impact Factor: 8.426
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Del Vecchio S, Reynolds JC, Blasberg RG, Neumann RD, Carrasquillo JA, Hellström I, Larson SM
Measurement of local Mr 97, 000 and 250, 000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (528 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1988; 48(19): 5475-5481.
Impact Factor: 8.426
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Trischitta V, Benzi L, Brunetti A, Cecchetti P, Marchetti P, Vigneri R, Navalesi R
Intracellular insulin processing is altered in monocytes from patients with type II diabetes mellitus (971 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1987 May; 64(5): 914-920.
Impact Factor: 4.575
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31 Records (26 excluding Abstracts).
Total impact factor: 99.917 (83.477 excluding Abstracts).
Total 5 year impact factor: 122.281 (98.653 excluding Abstracts).
Total impact factor: 99.917 (83.477 excluding Abstracts).
Total 5 year impact factor: 122.281 (98.653 excluding Abstracts).
284 views. Last view on Saturday 14 January 2023, 17:20:32
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