CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (671 views)
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 4.112, 5-year impact factor: 3.526
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84936141104&partnerID=40&md5=9e9726945fb389f0941ef2b268cee1df
Keywords: Cxcl12, Hepatocellular Carcinoma, Prognosis, Chemokine Receptor Cxcr4, Messenger Rna, Plerixafor, Article, Cancer Grading, Cancer Growth, Cancer Prognosis, Cancer Staging, Cancer Survival, Cell Invasion, Cell Migration, Human, Human Cell, Immunocytochemistry, Immunohistochemistry, Liver Cell Carcinoma, Major Clinical Study, Overall Survival, Progression Free Survival, Protein Expression, Protein Function, Protein Localization, Tumor Volume, Upregulation, Adult, 80 And Over, Immunology, Metabolism, Mortality, Disease-Free Survival, Female, Gene Expression Regulation, Neoplastic, Hep G2 Cells, Liver Neoplasms, Middle Aged, Neoplasm Proteins, Biosynthesis, Survival Rate, Cxcr4 Protein, Cxcr7 Protein, Tumor Protein, Disease Free Survival, Hep-G2 Cell Line, Liver Tumor, Very Elderly,
Affiliations:
*** IBB - CNR ***
Oncological Immunology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale"-IRCCS-ITALIA, Naples, Italy.
Pathology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale"-IRCCS-ITALIA, Naples, Italy.
Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
CROM-Centro Ricerche Oncologiche Mercogliano, Mercogliano (AV), Italy.
Institute of Biostructure and Bioimaging (IBB) of the Italian National Research Council, Naples, Italy.
Hepato-Biliary Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale"-IRCCS-ITALIA, Naples, Italy.
References:
Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., Thun, M.J., Cancer statistics (2007 (2007) CA Cancer J Clin, 57, pp. 43-6
Malhi, H., Gores, G.J., Cellular and molecular mechanisms of liver injury (2008) Gastroenterology, 134, pp. 1641-1654
Wald, O., Weiss, I.D., Galun, E., Peled, A., Chemokines in hepatitis C virus infection: Pathogenesis, prognosis and therapeutics (2007) Cytokine, 39, pp. 50-62
Huang, F., Geng, X.P., Chemokines and hepatocellular carcinoma (2010) World J Gastroenterol, 16, pp. 1832-1836
Li, W., Gomez, E., Zhang, Z., Immunohistochemical expression of stromal cell-derived factor-1 (SDF-1) and CXCR4 ligand receptor system in hepatocellular carcinoma (2007) J Exp Clin Cancer Res, 26, pp. 527-533
Liu, H., Pan, Z., Li, A., Roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in metastasis of hepatocellular carcinoma cells (2008) Cell Mol Immunol, 5, pp. 373-378
Schimanski, C.C., Bahre, R., Gockel, I., Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4 (2006) Br J Cancer, 95, pp. 210-217
Xiang, Z.L., Zeng, Z.C., Tang, Z.Y., Fan, J., Zhuang, P.Y., Liang, Y., Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival (2009) BMC Cancer, 9, p. 176
Xiang, Z., Zeng, Z., Tang, Z., Fan, J., Sun, H., Wu, W., Increased expression of vascular endothelial growth factor-C and nuclear CXCR4 in hepatocellular carcinoma is correlated with lymph node metastasis and poor outcome (2009) Cancer J, 15, pp. 519-525
Monnier, J., Boissan, M., Lhelgoualch, A., CXCR7 is up-regulated in human and murine hepatocellular carcinoma and is specifically expressed by endothelial cells (2012) Eur J Cancer, 48, pp. 138-148
Zheng, K., Li, H.Y., Su, X.L., Wang, X.Y., Tian, T., Li, F., Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells (2010) J Exp Clin Cancer Res, 29, p. 31
Balabanian, K., Lagane, B., Infantino, S., The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes (2005) J Biol Chem, 280, pp. 35760-35766
Miao, Z., Luker, K.E., Summers BC CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-Associated vasculature (2007) Proc Natl Acad Sci USA, 104, pp. 15735-15740
Wang, J., Shiozawa, Y., Wang, J., The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer (2008) J Biol Chem, 283, pp. 4283-4294
Tarnowski, M., Grymula, K., Reca, R., Regulation of expression of stromalderived factor-1 receptors: CXCR4 and CXCR7 in human rhabdomyosarcomas (2010) Mol Cancer Res, 8, pp. 1-14
Hattermann, K., Held-Feindt, J., Lucius, R., The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects (2010) Cancer Res, 70, pp. 3299-3308
Müller, A., Homey, B., Soto, H., Involvement of chemokine receptors in breast cancer metastasis (2001) Nature, 410, pp. 50-56
Murphy, P.M., The molecular biology of leukocyte chemoattractant receptors (1994) Annu Rev Immunol, 12, pp. 593-633
Taichman, R.S., Cooper, C., Keller, E.T., Pienta, K.J., Taichman, N.S., McCauley, L.K., Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone (2002) Cancer Res, 62, pp. 1832-1837
Burns, J.M., Summers, B.C., Wang, Y., Melikian, A., Berahovich, R., Miao, Z., A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development (2006) J Exp Med, 203, pp. 2201-2213
Thelen, M., Thelen, S., CXCR7, CXCR4 and CXCL12, an eccentric trio (2008) J Neuroimmunol, 198, pp. 9-13
Sierro, F., Biben, C., Martínez-Muñoz, L., Mellado, M., Ransohoff, R.M., Li, M., Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7 (2007) Proc Natl Acad Sci USA, 104, pp. 14759-14764
Grymula, K., Tarnowski, M., Wysoczynski, M., Drukala, J., Barr, F.G., Ratajczak, J., Overlapping and distinct role of CXCR7-SDF-1/ITAC and CXCR4-SDF-1 axes in regulating metastatic behavior of human rhabdomyosarcomas (2010) Int J Cancer, 127, pp. 2554-2568
Hou, K.L., Hao, M.G., Bo, J.J., Wang, J.H., CXCR7 in tumorigenesis and progression (2010) Chin J Cancer, 29, pp. 456-459
Zabel, B.A., Wang, Y., Lewén, S., Berahovich, R.D., Penfold, M.E., Zhang, P., Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands (2009) J Immunol, 183, pp. 3204-3211
Iwakiri, S., Mino, N., Takahashi, T., Sonobe, M., Nagai, S., Okubo, K., Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage i nonsmall cell lung cancer (2009) Cancer, 115, pp. 2580-2593
Dalterio, C., Consales, C., Polimeno, M., Franco, R., Cindolo, L., Portella, L., Concomitant CXCR4 and CXCR7 expression predicts poor prognosis in renal cancer (2010) Curr Cancer Drug Targets, 10, pp. 772-781
Portella, L., Vitale, R., De Luca, S., Dalterio, C., Ieranò, C., Napolitano, M., Preclinical development of a novel class of CXCR4 antagonist impairing solid tumors growth and metastases (2013) PLoS One, 13, p. 8
Mitra, P., De, A., Ethier, M.F., Mimori, K., Kodys, K., Shibuta, K., Loss of chemokine SDF-1alpha-mediated CXCR4 signalling and receptor internalization in human hepatoma cell line HepG2 (2001) Cell Signal, 13, pp. 311-319
Fedyk, E.R., Ryan, D.H., Ritterman, I., Springer, T.A., Maturation decreases responsiveness of human bone marrow B lineage cells to stromalderived factor 1 (SDF-1 (1999) J Leuk Biol, 66, pp. 667-673
Honczarenko, M., Douglas, R.S., Mathias, C., Lee, B., Ratajczak, M.Z., Silberstein, L.E., SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells (1999) Blood, 94, pp. 2990-2998
Sutton, A., Friand, V., Brulé-Donneger, S., Chaigneau, T., Ziol, M., Sainte-Catherine, O., Stromal cell-derived factor-1/chemokine (C-X-C motif) ligand 12 stimulates human hepatoma cell growth, migration, and invasion (2007) Mol Cancer Res, 5, pp. 21-33
Kim, S.W., Kim, H.Y., Song, I.C., Jin, S.A., Lee, H.J., Yun, H.J., Cytoplasmic trapping of CXCR4 in hepatocellular carcinoma cell lines (2008) Cancer Res Treat, 40, pp. 53-61
Kucia, M., Reca, R., Miekus, K., Wanzeck, J., Wojakowski, W., Janowska-Wieczorek, A., Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis (2005) Stem Cells, 23, pp. 879-894
Xue, T.C., Han, D., Chen, R.X., Zou, J.H., Wang, Y., Tang, Z.Y., High expression of CXCR7 combined with Alpha fetoprotein in hepatocellular carcinoma correlates with extrahepatic metastasis to lung after hepatectomy (2011) Asian Pac J Cancer Prev, 12, pp. 657-663
Levoye, A., Balabanian, K., Baleux, F., Bachelerie, F., Lagane, B., CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling (2009) Blood, 113, pp. 6085-6093
Rajagopal, S., Kim, J., Ahn, S., Craig, S., Lam, C.M., Gerard, N.P., Betaarrestin-but notGprotein-mediatedsignaling by the decoyreceptor CXCR7 (2010) Proc Natl Acad Sci USA, 107, pp. 628-632
Naumann, U., Cameroni, E., Pruenster, M., Mahabaleshwar, H., Raz, E., Zerwes, H.G., CXCR7 functionsas a scavenger for CXCL12 and CXCL11 (2010) PLoS One, 5, p. e9175
Boldajipour, B., Mahabaleshwar, H., Kardash, E., Reichman-Fried, M., Blaser, H., Minina, S., Control of chemokine-guided cell migration by ligand sequestration (2008) Cell, 132, pp. 463-473
Luker, K.E., Lewin, S.A., Mihalko, L.A., Schmidt, B.T., Winkler, J.S., Coggins, N.L., Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells (2012) Oncogene, 31, pp. 4750-4758
De Caillot, F.M., Kazmi, M.A., Lin, Y., Ray-Saha, S., Sakmar, T.P., Sachdev, P., CXCR7/CXCR4 heterodimer constitutive lyrecruits beta-Arrestin to enhance cell migration (2011) J Biol Chem, 286, pp. 32188-32197
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 4.112, 5-year impact factor: 3.526
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84936141104&partnerID=40&md5=9e9726945fb389f0941ef2b268cee1df
Keywords: Cxcl12, Hepatocellular Carcinoma, Prognosis, Chemokine Receptor Cxcr4, Messenger Rna, Plerixafor, Article, Cancer Grading, Cancer Growth, Cancer Prognosis, Cancer Staging, Cancer Survival, Cell Invasion, Cell Migration, Human, Human Cell, Immunocytochemistry, Immunohistochemistry, Liver Cell Carcinoma, Major Clinical Study, Overall Survival, Progression Free Survival, Protein Expression, Protein Function, Protein Localization, Tumor Volume, Upregulation, Adult, 80 And Over, Immunology, Metabolism, Mortality, Disease-Free Survival, Female, Gene Expression Regulation, Neoplastic, Hep G2 Cells, Liver Neoplasms, Middle Aged, Neoplasm Proteins, Biosynthesis, Survival Rate, Cxcr4 Protein, Cxcr7 Protein, Tumor Protein, Disease Free Survival, Hep-G2 Cell Line, Liver Tumor, Very Elderly,
Affiliations:
*** IBB - CNR ***
Oncological Immunology, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale"-IRCCS-ITALIA, Naples, Italy.
Pathology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale"-IRCCS-ITALIA, Naples, Italy.
Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
CROM-Centro Ricerche Oncologiche Mercogliano, Mercogliano (AV), Italy.
Institute of Biostructure and Bioimaging (IBB) of the Italian National Research Council, Naples, Italy.
Hepato-Biliary Surgery Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, "Fondazione Giovanni Pascale"-IRCCS-ITALIA, Naples, Italy.
References:
Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., Thun, M.J., Cancer statistics (2007 (2007) CA Cancer J Clin, 57, pp. 43-6
Malhi, H., Gores, G.J., Cellular and molecular mechanisms of liver injury (2008) Gastroenterology, 134, pp. 1641-1654
Wald, O., Weiss, I.D., Galun, E., Peled, A., Chemokines in hepatitis C virus infection: Pathogenesis, prognosis and therapeutics (2007) Cytokine, 39, pp. 50-62
Huang, F., Geng, X.P., Chemokines and hepatocellular carcinoma (2010) World J Gastroenterol, 16, pp. 1832-1836
Li, W., Gomez, E., Zhang, Z., Immunohistochemical expression of stromal cell-derived factor-1 (SDF-1) and CXCR4 ligand receptor system in hepatocellular carcinoma (2007) J Exp Clin Cancer Res, 26, pp. 527-533
Liu, H., Pan, Z., Li, A., Roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in metastasis of hepatocellular carcinoma cells (2008) Cell Mol Immunol, 5, pp. 373-378
Schimanski, C.C., Bahre, R., Gockel, I., Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4 (2006) Br J Cancer, 95, pp. 210-217
Xiang, Z.L., Zeng, Z.C., Tang, Z.Y., Fan, J., Zhuang, P.Y., Liang, Y., Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival (2009) BMC Cancer, 9, p. 176
Xiang, Z., Zeng, Z., Tang, Z., Fan, J., Sun, H., Wu, W., Increased expression of vascular endothelial growth factor-C and nuclear CXCR4 in hepatocellular carcinoma is correlated with lymph node metastasis and poor outcome (2009) Cancer J, 15, pp. 519-525
Monnier, J., Boissan, M., Lhelgoualch, A., CXCR7 is up-regulated in human and murine hepatocellular carcinoma and is specifically expressed by endothelial cells (2012) Eur J Cancer, 48, pp. 138-148
Zheng, K., Li, H.Y., Su, X.L., Wang, X.Y., Tian, T., Li, F., Chemokine receptor CXCR7 regulates the invasion, angiogenesis and tumor growth of human hepatocellular carcinoma cells (2010) J Exp Clin Cancer Res, 29, p. 31
Balabanian, K., Lagane, B., Infantino, S., The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes (2005) J Biol Chem, 280, pp. 35760-35766
Miao, Z., Luker, K.E., Summers BC CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-Associated vasculature (2007) Proc Natl Acad Sci USA, 104, pp. 15735-15740
Wang, J., Shiozawa, Y., Wang, J., The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer (2008) J Biol Chem, 283, pp. 4283-4294
Tarnowski, M., Grymula, K., Reca, R., Regulation of expression of stromalderived factor-1 receptors: CXCR4 and CXCR7 in human rhabdomyosarcomas (2010) Mol Cancer Res, 8, pp. 1-14
Hattermann, K., Held-Feindt, J., Lucius, R., The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates antiapoptotic effects (2010) Cancer Res, 70, pp. 3299-3308
Müller, A., Homey, B., Soto, H., Involvement of chemokine receptors in breast cancer metastasis (2001) Nature, 410, pp. 50-56
Murphy, P.M., The molecular biology of leukocyte chemoattractant receptors (1994) Annu Rev Immunol, 12, pp. 593-633
Taichman, R.S., Cooper, C., Keller, E.T., Pienta, K.J., Taichman, N.S., McCauley, L.K., Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone (2002) Cancer Res, 62, pp. 1832-1837
Burns, J.M., Summers, B.C., Wang, Y., Melikian, A., Berahovich, R., Miao, Z., A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development (2006) J Exp Med, 203, pp. 2201-2213
Thelen, M., Thelen, S., CXCR7, CXCR4 and CXCL12, an eccentric trio (2008) J Neuroimmunol, 198, pp. 9-13
Sierro, F., Biben, C., Martínez-Muñoz, L., Mellado, M., Ransohoff, R.M., Li, M., Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7 (2007) Proc Natl Acad Sci USA, 104, pp. 14759-14764
Grymula, K., Tarnowski, M., Wysoczynski, M., Drukala, J., Barr, F.G., Ratajczak, J., Overlapping and distinct role of CXCR7-SDF-1/ITAC and CXCR4-SDF-1 axes in regulating metastatic behavior of human rhabdomyosarcomas (2010) Int J Cancer, 127, pp. 2554-2568
Hou, K.L., Hao, M.G., Bo, J.J., Wang, J.H., CXCR7 in tumorigenesis and progression (2010) Chin J Cancer, 29, pp. 456-459
Zabel, B.A., Wang, Y., Lewén, S., Berahovich, R.D., Penfold, M.E., Zhang, P., Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands (2009) J Immunol, 183, pp. 3204-3211
Iwakiri, S., Mino, N., Takahashi, T., Sonobe, M., Nagai, S., Okubo, K., Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage i nonsmall cell lung cancer (2009) Cancer, 115, pp. 2580-2593
Dalterio, C., Consales, C., Polimeno, M., Franco, R., Cindolo, L., Portella, L., Concomitant CXCR4 and CXCR7 expression predicts poor prognosis in renal cancer (2010) Curr Cancer Drug Targets, 10, pp. 772-781
Portella, L., Vitale, R., De Luca, S., Dalterio, C., Ieranò, C., Napolitano, M., Preclinical development of a novel class of CXCR4 antagonist impairing solid tumors growth and metastases (2013) PLoS One, 13, p. 8
Mitra, P., De, A., Ethier, M.F., Mimori, K., Kodys, K., Shibuta, K., Loss of chemokine SDF-1alpha-mediated CXCR4 signalling and receptor internalization in human hepatoma cell line HepG2 (2001) Cell Signal, 13, pp. 311-319
Fedyk, E.R., Ryan, D.H., Ritterman, I., Springer, T.A., Maturation decreases responsiveness of human bone marrow B lineage cells to stromalderived factor 1 (SDF-1 (1999) J Leuk Biol, 66, pp. 667-673
Honczarenko, M., Douglas, R.S., Mathias, C., Lee, B., Ratajczak, M.Z., Silberstein, L.E., SDF-1 responsiveness does not correlate with CXCR4 expression levels of developing human bone marrow B cells (1999) Blood, 94, pp. 2990-2998
Sutton, A., Friand, V., Brulé-Donneger, S., Chaigneau, T., Ziol, M., Sainte-Catherine, O., Stromal cell-derived factor-1/chemokine (C-X-C motif) ligand 12 stimulates human hepatoma cell growth, migration, and invasion (2007) Mol Cancer Res, 5, pp. 21-33
Kim, S.W., Kim, H.Y., Song, I.C., Jin, S.A., Lee, H.J., Yun, H.J., Cytoplasmic trapping of CXCR4 in hepatocellular carcinoma cell lines (2008) Cancer Res Treat, 40, pp. 53-61
Kucia, M., Reca, R., Miekus, K., Wanzeck, J., Wojakowski, W., Janowska-Wieczorek, A., Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: Pivotal role of the SDF-1-CXCR4 axis (2005) Stem Cells, 23, pp. 879-894
Xue, T.C., Han, D., Chen, R.X., Zou, J.H., Wang, Y., Tang, Z.Y., High expression of CXCR7 combined with Alpha fetoprotein in hepatocellular carcinoma correlates with extrahepatic metastasis to lung after hepatectomy (2011) Asian Pac J Cancer Prev, 12, pp. 657-663
Levoye, A., Balabanian, K., Baleux, F., Bachelerie, F., Lagane, B., CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling (2009) Blood, 113, pp. 6085-6093
Rajagopal, S., Kim, J., Ahn, S., Craig, S., Lam, C.M., Gerard, N.P., Betaarrestin-but notGprotein-mediatedsignaling by the decoyreceptor CXCR7 (2010) Proc Natl Acad Sci USA, 107, pp. 628-632
Naumann, U., Cameroni, E., Pruenster, M., Mahabaleshwar, H., Raz, E., Zerwes, H.G., CXCR7 functionsas a scavenger for CXCL12 and CXCL11 (2010) PLoS One, 5, p. e9175
Boldajipour, B., Mahabaleshwar, H., Kardash, E., Reichman-Fried, M., Blaser, H., Minina, S., Control of chemokine-guided cell migration by ligand sequestration (2008) Cell, 132, pp. 463-473
Luker, K.E., Lewin, S.A., Mihalko, L.A., Schmidt, B.T., Winkler, J.S., Coggins, N.L., Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells (2012) Oncogene, 31, pp. 4750-4758
De Caillot, F.M., Kazmi, M.A., Lin, Y., Ray-Saha, S., Sakmar, T.P., Sachdev, P., CXCR7/CXCR4 heterodimer constitutive lyrecruits beta-Arrestin to enhance cell migration (2011) J Biol Chem, 286, pp. 32188-32197
CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not
Hepatocellular carcinoma (HCC) is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expression was analyzed by immunohistochemistry in 86 HCC patients (training cohort) and validated in 42 unrelated HCC patients (validation cohort). CXCR4 levels were low in 22.1% of patients, intermediate in 30.2%, and high in 47.7%, whereas CXCR7 levels were low in 9.3% of patients, intermediate in 44.2% and high in 46.5% of the patients in the training cohort. When correlated to patient outcome, only CXCR4 affected overall survival (P=0.03). CXCR4-CXCL12-CXCR7 mRNA levels were examined in 33/86 patients. Interestingly, the common CXCR4-CXCR7 ligand CXCL12 was expressed at significantly lower levels in tumor tissues compared to adjacent normal liver (P=0.032). The expression and function of CXCR4 and CXCR7 was also analyzed in several human HCC cell lines. CXCR4 was expressed in Huh7, Hep3B, SNU398, SNU449 and SNU475 cells, whereas CXCR7 was expressed in HepG2, Huh7, SNU449 and SNU475 cells. Huh7, SNU449 and SNU475 cells migrated toward CXCL12, and this migration was inhibited by AMD3100/anti-CXCR4 and by CCX771/anti-CXCR7. Moreover, SNU449 and Huh7 cells exhibited matrix invasion in the presence of CXCL12 and CXCL11, a ligand exclusive to CXCR7. In conclusion, CXCR4 affects the prognosis of HCC patients but CXCR7 does not. Therefore, the CXCR4-CXCL12-CXCR7 axis plays a role in the interaction of HCC with the surrounding normal tissue and represents a suitable therapeutic target.Cellular & Molecular Immunology advance online publication, 3 November 2014; doi:10.1038/cmi.2014.102.
Hepatocellular carcinoma (HCC) is a heterogeneous disease with a poor prognosis and limited markers for predicting patient survival. Because chemokines and chemokine receptors play numerous and integral roles in HCC disease progression, the CXCR4-CXCL12-CXCR7 axis was studied in HCC patients. CXCR4 and CXCR7 expression was analyzed by immunohistochemistry in 86 HCC patients (training cohort) and validated in 42 unrelated HCC patients (validation cohort). CXCR4 levels were low in 22.1% of patients, intermediate in 30.2%, and high in 47.7%, whereas CXCR7 levels were low in 9.3% of patients, intermediate in 44.2% and high in 46.5% of the patients in the training cohort. When correlated to patient outcome, only CXCR4 affected overall survival (P=0.03). CXCR4-CXCL12-CXCR7 mRNA levels were examined in 33/86 patients. Interestingly, the common CXCR4-CXCR7 ligand CXCL12 was expressed at significantly lower levels in tumor tissues compared to adjacent normal liver (P=0.032). The expression and function of CXCR4 and CXCR7 was also analyzed in several human HCC cell lines. CXCR4 was expressed in Huh7, Hep3B, SNU398, SNU449 and SNU475 cells, whereas CXCR7 was expressed in HepG2, Huh7, SNU449 and SNU475 cells. Huh7, SNU449 and SNU475 cells migrated toward CXCL12, and this migration was inhibited by AMD3100/anti-CXCR4 and by CCX771/anti-CXCR7. Moreover, SNU449 and Huh7 cells exhibited matrix invasion in the presence of CXCL12 and CXCL11, a ligand exclusive to CXCR7. In conclusion, CXCR4 affects the prognosis of HCC patients but CXCR7 does not. Therefore, the CXCR4-CXCL12-CXCR7 axis plays a role in the interaction of HCC with the surrounding normal tissue and represents a suitable therapeutic target.Cellular & Molecular Immunology advance online publication, 3 November 2014; doi:10.1038/cmi.2014.102.
CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not
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CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not
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* Role and function of exosomal miR-9-3p in hepatocellular carcinoma (243 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 2018 Feb; 109(1): 4-6.
Impact Factor: 0.913
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Pelagalli A, Nardelli A, Lucarelli E, Zannetti A, Brunetti A
* Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression (723 views)
J Cell Physiol (ISSN: 1097-4652electronic, 0021-9541linking), 2018 Jan 18; 233(8): 6241-6249.
Impact Factor: 5.546
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Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
* Ligand-Based NMR Study of C-X-C Chemokine Receptor Type 4 (CXCR4)-Ligand Interactions on Living Cancer Cells (1108 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2018; 61(7): 2910-2923.
Impact Factor: 5.207
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Ricco G, Cavallone D, Cosma C, Caviglia GP, Oliveri F, Biasiolo A, Abate ML, Plebani M, Smedile A, Bonino F, Pontisso P, Brunetto MR
* Impact of etiology of chronic liver disease on hepatocellular carcinoma biomarkers (608 views)
Cancer Biomark (ISSN: 1574-0153, 1574-0153linking), 2017 Dec 15; 21(3): 603-612.
Impact Factor: 2.392
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Gallicchio R, Nardelli A, Venetucci A, Capacchione D, Pelagalli A, Sirignano C, Mainenti P, Pedicini P, Guglielmi G, Storto G
* F-18 FDG PET/CT metabolic tumor volume predicts overall survival in patients with disseminated epithelial ovarian cancer (412 views) (PDF 13 views)
Eur J Radiol (ISSN: 0720-048x), 2017 Aug; 93: 107-113.
Impact Factor: 2.843
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Imbriaco M, De LucaS, Coppola M, Fusari M, Klain M, Puglia M, Mainenti P, Liuzzi R, Maurea S
* Diagnostic Accuracy of Gd-EOB-DTPA for Detection Hepatocellular Carcinoma (HCC): A Comparative Study with Dynamic Contrast Enhanced Magnetic Resonance Imaging (MRI) and Dynamic Contrast Enhanced Computed Tomography (CT) (253 views)
Pol J Radiol (ISSN: 1733-134xprint, 1733-134xlinking, 1899-0967electronic), 2017 Feb 01; 82: 50-57.
Impact Factor: 0.567
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Pelagalli A, Nardelli A, Fontanella R, Zannetti A
* Inhibition of AQP1 Hampers Osteosarcoma and Hepatocellular Carcinoma Progression Mediated by Bone Marrow-Derived Mesenchymal Stem Cells (427 views) (PDF 311 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2016 Jul 11; 17(7): N/D-N/D.
Impact Factor: 4.556
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Mainenti PP, Pizzuti LM, Segreto S, Comerci M, Fronzo SD, Romano F, Crisci V, Smaldone M, Laccetti E, Storto G, Alfano B, Maurea S, Salvatore M, Pace L
* Diffusion volume (DV) measurement in endometrial and cervical cancer: A new MRI parameter in the evaluation of the tumor grading and the risk classification (950 views) (PDF 238 views)
Eur J Radiol (ISSN: 0720-048x, 0720-048xlinking), 2016 Jan; 85(1): 113-124.
Impact Factor: 2.462
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Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (931 views) (PDF 283 views)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 7.36
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Erra P, Puglia M, Ragozzino A, Maurea S, Liuzzi R, Sabino G, Barbuto L, Cuocolo A, Imbriaco M
* Appearance of hepatocellular carcinoma on gadoxetic acid-enhanced hepato-biliary phase MR imaging: a systematic review (263 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 0033-8362linking), 2015 Apr 22; 120(11): 1002-1011.
Impact Factor: 1.523
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Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (424 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
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Calce E, Vitale RM, Scaloni A, Amodeo P, De Luca S
* Air oxidation method employed for the disulfide bond formation of natural and synthetic peptides (604 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015; 47(8): 1507-1515.
Impact Factor: 3.196
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Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (604 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Impact Factor: 3.257
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Bisconte MG, Caldora M, Musollino G, Cardiero G, Flagiello A, La Porta G, Lagona L, Prezioso R, Qualtieri G, Gaudiano C, Medulla E, Merlino A, Pucci P, Lacerra G
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Impact Factor: 3.057
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D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
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Impact Factor: 3.534
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (554 views)
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Esposito G, De Falco F, Tinto N, Testa F, Vitagliano L, Tandurella IC, Iannone L, Rossi S, Rinaldi E, Simonelli F, Zagari A, Salvatore F
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Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
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Impact Factor: 5.712
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (377 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
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Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (464 views)
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Impact Factor: 4.106
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Di Lorenzo G, Imbimbo M, Leopardo D, Marciano R, Federico P, Buonerba C, Salvatore B, Marinelli A, Palmieri G. A
* A long-lasting response to sorafenib treatment in an advanced hepatocellular carcinoma patient (296 views)
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Impact Factor: 2.685
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
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Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
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Impact Factor: 1.724
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Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
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Impact Factor: 4.106
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
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Impact Factor: 4.293
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Galasso G, De Rosa R, Piscione F, Iaccarino G, Vosa C, Sorriento D, Piccolo R, Rapacciuolo A, Walsh K, Chiariello M
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Impact Factor: 4.512
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Criscuolo C, Filla A, Coppola G, Rinaldi C, Carbone R, Pinto S, Wang Q, De Leva MF, Salvatore E, Banfi S, Brunetti A, Quarantelli M, Geschwind DH, Pappata S, De Michele G
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Impact Factor: 2.903
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
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Impact Factor: 4.087
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
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Impact Factor: 2.26
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Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (349 views)
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Impact Factor: 0.1
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (401 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Saporito A, Marasco D, Chambery A, Botti P, Monti SM, Pedone C, Ruvo M
* The chemical synthesis of the GstI protein by NCL on a X-Met site (645 views)
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Impact Factor: 2.48
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Morante A, Romano M, Cuomo A, De Sio I, Cozzolino A, Mucherino C, Salerno R, Blanco C, Romano M
* Massive gastric ulceration after transarterial chemoembolization for hepatocellular carcinoma (179 views)
Gastrointestinal Endoscopy (ISSN: 0016-5107), 2006 Apr; 63(4): 718-720.
Impact Factor: 4.825
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
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Impact Factor: 4.782
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Sirignano C, Soscia E, Mainenti PP, Camera L, Salvatore M
* Tumor Thrombus In The Right Atrium And In The Inferior Vena Cava As Primary Clinical Manifestations Of Hepatocellular Carcinoma. A Case Report (316 views)
42 Congresso Nazionale Sirm Milano, 2006; N/D: 1-3.
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Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (378 views)
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Impact Factor: 3.415
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Agmon I, Amit M, Auerbach T, Bashan A, Baram D, Bartels H, Berisio R, Greenberg I, Harms J, Hansen HAS, Kessler M, Pyetan E, Schluenzen F, Sittner A, Yonath A, Zarivach R
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Impact Factor: 3.843
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Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
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Impact Factor: 0.46
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Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
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Peptide Revolution, 2003 Apr; 10(2): 133-138.
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Romano M, Giojelli A, Tamburrini O, Salvatore M
* Chemoembolization for hepatocellular carcinoma: Effect of intraarterial lidocaine in peri- and post-procedural pain and hospitalization (488 views)
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Impact Factor: 1.368
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Pasquali D, Bellastella A, Valente A, Botti G, Capasso I, del Vecchio S, Salvatore M, Colantuoni V, Sinisi AA
Retinoic acid receptors α, β and γ, and cellular retinol binding protein-I expression in breast fibrocystic disease and cancer (589 views)
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (446 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (442 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
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* Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery (18 views)
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Gaia S, Ciruolo M, Ribaldone DG, Rolle E, Migliore E, Mosso E, Vola S, Risso A, Fagoonee S, Saracco GM, Carucci P
* Higher Efficiency of Percutaneous Microwave (MWA) Than Radiofrequency Ablation (RFA) in Achieving Complete Response in Cirrhotic Patients with Early Hepatocellular Carcinoma (18 views)
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Scarpellini E, Fagoonee S, Rinninella E, Rasetti C, Aquila I, Larussa T, Ricci P, Luzza F, Abenavoli L
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Impact Factor: 6.78
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Ricco G, Cosma C, Bedogni G, Biasiolo A, Guarino M, Pontisso P, Morisco F, Oliveri F, Cavallone D, Bonino F, Plebani M, Brunetto MR
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Testino G, Leone S, Fagoonee S
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Impact Factor: 1.957
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (379 views)
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Impact Factor: 3.173
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Caviglia GP, Fagoonee S
* Role and function of exosomal miR-9-3p in hepatocellular carcinoma (243 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 2018 Feb; 109(1): 4-6.
Impact Factor: 0.913
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Pelagalli A, Nardelli A, Lucarelli E, Zannetti A, Brunetti A
* Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression (723 views)
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Impact Factor: 5.546
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Brancaccio D, Diana D, Di Maro S, Di Leva FS, Tomassi S, Fattorusso R, Russo L, Scala S, Trotta AM, Portella L, Novellino E, Marinelli L, Carotenuto A
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Impact Factor: 5.207
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Ricco G, Cavallone D, Cosma C, Caviglia GP, Oliveri F, Biasiolo A, Abate ML, Plebani M, Smedile A, Bonino F, Pontisso P, Brunetto MR
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Impact Factor: 2.392
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Gallicchio R, Nardelli A, Venetucci A, Capacchione D, Pelagalli A, Sirignano C, Mainenti P, Pedicini P, Guglielmi G, Storto G
* F-18 FDG PET/CT metabolic tumor volume predicts overall survival in patients with disseminated epithelial ovarian cancer (412 views) (PDF 13 views)
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Impact Factor: 2.843
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Imbriaco M, De LucaS, Coppola M, Fusari M, Klain M, Puglia M, Mainenti P, Liuzzi R, Maurea S
* Diagnostic Accuracy of Gd-EOB-DTPA for Detection Hepatocellular Carcinoma (HCC): A Comparative Study with Dynamic Contrast Enhanced Magnetic Resonance Imaging (MRI) and Dynamic Contrast Enhanced Computed Tomography (CT) (253 views)
Pol J Radiol (ISSN: 1733-134xprint, 1733-134xlinking, 1899-0967electronic), 2017 Feb 01; 82: 50-57.
Impact Factor: 0.567
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Pelagalli A, Nardelli A, Fontanella R, Zannetti A
* Inhibition of AQP1 Hampers Osteosarcoma and Hepatocellular Carcinoma Progression Mediated by Bone Marrow-Derived Mesenchymal Stem Cells (427 views) (PDF 311 views)
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Impact Factor: 4.556
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Mainenti PP, Pizzuti LM, Segreto S, Comerci M, Fronzo SD, Romano F, Crisci V, Smaldone M, Laccetti E, Storto G, Alfano B, Maurea S, Salvatore M, Pace L
* Diffusion volume (DV) measurement in endometrial and cervical cancer: A new MRI parameter in the evaluation of the tumor grading and the risk classification (950 views) (PDF 238 views)
Eur J Radiol (ISSN: 0720-048x, 0720-048xlinking), 2016 Jan; 85(1): 113-124.
Impact Factor: 2.462
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Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (931 views) (PDF 283 views)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 7.36
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Erra P, Puglia M, Ragozzino A, Maurea S, Liuzzi R, Sabino G, Barbuto L, Cuocolo A, Imbriaco M
* Appearance of hepatocellular carcinoma on gadoxetic acid-enhanced hepato-biliary phase MR imaging: a systematic review (263 views)
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Impact Factor: 1.523
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Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (424 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
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Calce E, Vitale RM, Scaloni A, Amodeo P, De Luca S
* Air oxidation method employed for the disulfide bond formation of natural and synthetic peptides (604 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015; 47(8): 1507-1515.
Impact Factor: 3.196
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Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, Colonna G, Guillon J, Portella L, Trotta AM, Ronga L, Rossi F
* Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4 (604 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2015; 16(6): 12159-12173.
Impact Factor: 3.257
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Bisconte MG, Caldora M, Musollino G, Cardiero G, Flagiello A, La Porta G, Lagona L, Prezioso R, Qualtieri G, Gaudiano C, Medulla E, Merlino A, Pucci P, Lacerra G
* α-thalassemia associated with Hb instability: A tale of two features. The case of Hb Rogliano or α1 Cod 108(G15)Thr→Asn and Hb Policoro or α2 Cod 124(H7)Ser→Pro (421 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015; 10(3): N/D-N/D.
Impact Factor: 3.057
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D'Alterio C, Avallone A, Tatangelo F, Delrio P, Pecori B, Cella L, Pelella A, D'Armiento FP, Carlomagno C, Bianco F, Silvestro L, Pacelli R, Napolitano M, Iaffaioli RV, Scala S
* A prognostic model comprising pT stage, N status, and the chemokine receptors CXCR4 and CXCR7 powerfully predicts outcome in neoadjuvant resistant rectal cancer patients (441 views)
Int J Cancer (ISSN: 0020-7136), 2014 Jul 15; 135(2): 379-390.
Impact Factor: 5.085
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
* Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases (505 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Sep 13; 8(9): N/D-N/D.
Impact Factor: 3.534
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (554 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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Esposito G, De Falco F, Tinto N, Testa F, Vitagliano L, Tandurella IC, Iannone L, Rossi S, Rinaldi E, Simonelli F, Zagari A, Salvatore F
* Comprehensive mutation analysis (20 families) of the choroideremia gene reveals a missense variant that prevents the binding of REP1 with Rab geranylgeranyl transferase (835 views)
Hum Mutat (ISSN: 1059-7794, 1098-1004, 1098-1004electronic), 2011 Dec; 32(12): 1460-1469.
Impact Factor: 5.686
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Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
* Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity (596 views)
Faseb J (ISSN: 0892-6638, 0892-6638linking), 2011 Apr; 25(4): 1230-1243.
Impact Factor: 5.712
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Pensato S, Saviano M, Bianchi N, Borgatti M, Fabbri E, Gambari R, Romanelli A
* Gamma-Hydroxymethyl Pnas: Synthesis, Interaction With Dna And Inhibition Of Protein/Dna Interactions (377 views)
Bioorg Chem, 2010 Sep; 38(5): 196-201.
Impact Factor: 2.141
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Roviello GN, Crescenzo C, Capasso D, Di Gaetano S, Franco S, Bucci EM, Pedone C
* Synthesis of a novel Fmoc-protected nucleoaminoacid for the solid phase assembly of 4-piperidyl glycine/L-arginine-containing nucleopeptides and preliminary RNA interaction studies (464 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 Sep; 39(3): 795-800.
Impact Factor: 4.106
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Di Lorenzo G, Imbimbo M, Leopardo D, Marciano R, Federico P, Buonerba C, Salvatore B, Marinelli A, Palmieri G. A
* A long-lasting response to sorafenib treatment in an advanced hepatocellular carcinoma patient (296 views)
Int J Immunopathol Pharmacol (ISSN: 0394-6320), 2010 Jul; 23(3): 951-954.
Impact Factor: 2.685
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Roviello GN, Di Gaetano S, Capasso D, Cesarani A, Bucci EM, Pedone C
* Synthesis, spectroscopic studies and biological activity of a novel nucleopeptide with Moloney murine leukemia virus reverse transcriptase inhibitory activity (443 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2010 May; 38(5): 1489-1496.
Impact Factor: 4.106
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (403 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Galasso G, De Rosa R, Piscione F, Iaccarino G, Vosa C, Sorriento D, Piccolo R, Rapacciuolo A, Walsh K, Chiariello M
* Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure (304 views)
Eur J Heart Fail European Journal Of Heart Failure (ISSN: 1388-9842), 2010; 12(12): 1290-1296.
Impact Factor: 4.512
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Criscuolo C, Filla A, Coppola G, Rinaldi C, Carbone R, Pinto S, Wang Q, De Leva MF, Salvatore E, Banfi S, Brunetti A, Quarantelli M, Geschwind DH, Pappata S, De Michele G
* Two novel CYP7B1 mutations in Italian families with SPG5: A clinical and genetic study (359 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2009 Sep; 256(8): 1252-1257.
Impact Factor: 2.903
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Ierano C, Giuliano P, D'Alterio C, Cioffi M, Mettivier V, Portella L, Napolitano M, Barbieri A, Arra C, Liguori G, Franco R, Palmieri G, Rozzo C, Pacelli R, Castello G, Scala S
* A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration (394 views)
Cell Cycle (ISSN: 1538-4101), 2009 Apr 15; 8(8): 1228-1237.
Impact Factor: 4.087
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1402 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Breveglieri G, Pensato S, Salvatori F, Saviano M, Pedone C, Romanelli A, Gambari R
* PNA-mediated alteration of mRNA splicing (349 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 175-181.
Impact Factor: 0.1
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Marchelli R, Saviano M, Licandro E, Spoto G, Borgatti M, Gambari R
* PNAs targeting the "RNA world": Micro RNA next? (401 views)
Minerva Biotecnol (ISSN: 1120-4826), 2008; 20(4): 183-188.
Impact Factor: 0.1
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Saporito A, Marasco D, Chambery A, Botti P, Monti SM, Pedone C, Ruvo M
* The chemical synthesis of the GstI protein by NCL on a X-Met site (645 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2006 Dec 5; 83(5): 508-518.
Impact Factor: 2.48
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Morante A, Romano M, Cuomo A, De Sio I, Cozzolino A, Mucherino C, Salerno R, Blanco C, Romano M
* Massive gastric ulceration after transarterial chemoembolization for hepatocellular carcinoma (179 views)
Gastrointestinal Endoscopy (ISSN: 0016-5107), 2006 Apr; 63(4): 718-720.
Impact Factor: 4.825
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Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
* Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling (582 views)
Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
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Sirignano C, Soscia E, Mainenti PP, Camera L, Salvatore M
* Tumor Thrombus In The Right Atrium And In The Inferior Vena Cava As Primary Clinical Manifestations Of Hepatocellular Carcinoma. A Case Report (316 views)
42 Congresso Nazionale Sirm Milano, 2006; N/D: 1-3.
Impact Factor: 0
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Palladino P, Tizzano B, Pedone C, Ragone R, Rossi F, Saviano G, Tancredi T, Benedetti E
* Structural determinants of unexpected agonist activity in a retro-peptide analogue of the SDF-1α N-terminus (378 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 Oct 10; 579(24): 5293-5298.
Impact Factor: 3.415
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Agmon I, Amit M, Auerbach T, Bashan A, Baram D, Bartels H, Berisio R, Greenberg I, Harms J, Hansen HAS, Kessler M, Pyetan E, Schluenzen F, Sittner A, Yonath A, Zarivach R
* Ribosomal crystallography: A flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism (312 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2004 Jun 1; 567(1): 20-26.
Impact Factor: 3.843
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Palladino P, Pedone C, Ragone R, Rossi F, Saviano M, Benedetti E
* A simplified model of the binding interaction between stromal cell-derived factor-1 chemokine and CXC chemokine receptor (351 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2003 Apr; 10(2): 133-138.
Impact Factor: 0.46
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Palladino P, De Capua A, Pedone C, Ragone R, Rossi F, Limatola C, Ragozzino D, Benedetti E
* A simplified model of the interaction between SDF-1 chemokine and the CXCR4 receptor (384 views)
Peptide Revolution, 2003 Apr; 10(2): 133-138.
Impact Factor: 4.659
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Romano M, Giojelli A, Tamburrini O, Salvatore M
* Chemoembolization for hepatocellular carcinoma: Effect of intraarterial lidocaine in peri- and post-procedural pain and hospitalization (488 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2003 Apr; 105(4): 350-355.
Impact Factor: 1.368
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Pasquali D, Bellastella A, Valente A, Botti G, Capasso I, del Vecchio S, Salvatore M, Colantuoni V, Sinisi AA
Retinoic acid receptors α, β and γ, and cellular retinol binding protein-I expression in breast fibrocystic disease and cancer (589 views)
Eur J Endocrinol (ISSN: 0804-4643), 1997 Oct; 137(4): 410-414.
Impact Factor: 1.968
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (446 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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Papa V, Reese CC, Brunetti A, Vigneri R, Siiteri PK, Goldfine ID
Progestins increase insulin receptor content and insulin stimulation of growth in human breast carcinoma cells (442 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1990 Dec 15; 50(24): 7858-7862.
Impact Factor: 8.426
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50 Records (48 excluding Abstracts).
Total impact factor: 159.689 (156.155 excluding Abstracts).
Total 5 year impact factor: 142.839 (138.824 excluding Abstracts).
Total impact factor: 159.689 (156.155 excluding Abstracts).
Total 5 year impact factor: 142.839 (138.824 excluding Abstracts).
671 views. Last view on Saturday 03 June 2023, 11:31:33
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