Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress(562 views) Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Keywords: Aif Cypa Complex, Mitochondria, Neuronal Death, Oxidative Stress, Peptide Inhibitor, Apoptosis Inducing Factor, Calcium Ion, Cyclophilin A, Glutamic Acid, Small Interfering Rna, Article, Cell Survival, Complex Formation, Controlled Study, In Vitro Study, Intracellular Signaling, Mitochondrial Membrane Potential, Nerve Cell Necrosis, Neuroprotection, Priority Journal, Protein Binding, Protein Expression, Protein Protein Interaction, Protein Secretion, Protein Transport, Amino Acid Motifs, Down-Regulation, Humans, Apoptosis Inducing Factor Chemistry Genetics Metabolism, Cyclophilin A Genetics Metabolism, Mitochondria Enzymology Metabolism, Neurons Cytology Enzymology Metabolism,
Affiliations: *** IBB - CNR ***
Institute of Biostructures and Bioimaging (IBB), CNR, CIRPEB, Via Mezzocannone, 16, Naples 80134, Italy
Institute of Pharmacology and Clinical Pharmacy, Philipps University of Marburg, Karl-von-Frisch-Straße 1, Marburg 35032, Germany
Department of Neurodegeneration, Royal College of Surgeons in Ireland, Dublin 2, Ireland
Institute for Stroke and Dementia Research (ISD), University of Munich Medical School-Campus Großhadern, Max-Lebsche Platz 30, Munich 81377, Germany
1] Institute of Biostructures and Bioimaging (IBB)-CNR, CIRPEB, Via Mezzocannone, 16, Naples 80134, Italy [2] Institute of Pharmacology and Clinical Pharmacy, Philipps University of Marburg, Marburg 35032, Germany [3] Department of Neurodegeneration, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
1] Department of Neurodegeneration, Royal College of Surgeons in Ireland, Dublin 2, Ireland [2] Institute for Stroke and Dementia Research (ISD), University of Munich Medical School-Campus Grosshadern, Max-Lebsche Platz 30, Munich D-81377, Germany.
References: Hangen, E., Blomgren, K., Bénit, P., Kroemer, G., Modjtahedi, N., Life with or without AIF (2010) Trends Biochem Sci, 35, pp. 278-28
Sevrioukova, I.F., Apoptosis-inducing factor: Structure, function, and redox regulation (2011) Antioxid Redox Signal, 14, pp. 2545-2579
Polster, B.M., AIF, reactive oxygen species, and neurodegeneration: A "complex" problem (2013) Neurochem Int, 62, pp. 695-702
Cheung, E.C., Joza, N., Steenaart, N.A., McClellan, K.A., Neuspiel, M., McNamara, S., Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis (2006) EMBO J, 25, pp. 4061-4073
Cao, G., Clark, R.S., Pei, W., Yin, W., Zhang, F., Sun, F.Y., Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation (2003) J Cereb Blood Flow Metab, 23, pp. 1137-1150
Pallast, S., Arai, K., Pekcec, A., Yigitkanli, K., Yu, Z., Wang, X., Increased nuclear apoptosisinducing factor after transient focal ischemia: A 12/15-lipoxygenase-dependent organelle damage pathway (2010) J Cereb Blood Flow Metab, 30, pp. 1157-1167
Plesnila, N., Zhu, C., Culmsee, C., Gröger, M., Moskowitz, M.A., Blomgren, K., Nuclear translocation of apoptosis-inducing factor after focal cerebral ischemia (2004) J Cereb Blood Flow Metab, 24, pp. 458-466
Thal, S.E., Zhu, C., Thal, S.C., Blomgren, K., Plesnila, N., Role of apoptosis inducing factor (AIF) for hippocampal neuronal cell death following global cerebral ischemia in mice (2011) Neurosci Lett, 499, pp. 1-3
Culmsee, C., Zhu, C., Landshamer, S., Becattini, B., Wagner, E., Pellecchia, M., Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia (2005) J Neuroscience, 25, pp. 10262-10272
Slemmer, J.E., Zhu, C., Landshamer, S., Trabold, R., Grohm, J., Ardeshiri, A., Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury (2008) Am J Pathol, 173, pp. 1795-1805
Piao, C.S., Loane, D.J., Stoica, B.A., Li, S., Hanscom, M., Cabatbat, R., Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury (2012) Neurobiol Dis, 46, pp. 745-758
Candé, C., Vahsen, N., Kouranti, I., Schmitt, E., Daugas, E., Spahr, C., AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis (2004) Oncogene, 23, pp. 1514-1521
Zhu, C., Wang, X., Deinum, J., Huang, Z., Gao, J., Modjtahedi, N., Cyclophilin A participates in the nuclear translocation of apoptosis-inducing factor in neurons after cerebral hypoxiaischemia (2007) J Exp Med, 204, pp. 1741-1748
Handschumacher, R.E., Harding, M.W., Rice, J., Drugge, R.J., Speicher, D.W., Cyclophilin: A specific cytosolic binding protein for cyclosporin A (1984) Science, 226, pp. 544-547
Goldner, F.M., Patrick, J.W., Neuronal localization of the cyclophilin A protein in the adult rat brain (1996) J Comp Neurol, 372, pp. 283-293
Montague, J.W., Hughes Jr., F.M., Cidlowski, J.A., Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis (1997) J Biol Chem, 272, pp. 6677-6684
Zhang, X.C., Wang, W.D., Wang, J.S., Pan, J.C., PPIase independent chaperone-like function of recombinant human Cyclophilin A during arginine kinase refolding (2013) FEBS Lett, 587, pp. 666-672
Gurbuxani, S., Schmitt, E., Cande, C., Parcellier, A., Hammann, A., Daugas, E., Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor (2003) Oncogene, 22, pp. 6669-6678
Fukui, M., Song, J.H., Choi, J., Choi, H.J., Zhu, B.T., Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells (2009) Eur J Pharmacol, 617, pp. 1-11
Artus, C., Boujrad, H., Bouharrour, A., Brunelle, M.N., Hoos, S., Yuste, V.J., AIF promotes chromatinolysis and caspase-independent programmed necrosis by interacting with histone H2AX (2010) EMBO J, 29, pp. 1585-1599
Guo, X., Surface plasmon resonance based biosensor technique: A review (2012) J Biophotonics, 5, pp. 483-501
Susin, S.A., Lorenzo, H.K., Zamzami, N., Marzo, I., Snow, B.E., Brothers, G.M., Molecular characterization of mitochondrial apoptosis-inducing factor (1999) Nature, 397, pp. 441-446
Ke, H., Similarities and differences between human cyclophilin A and other beta-barrel structures. Structural refinement at 1.63A resolution (1992) J Mol Biol, 228, pp. 539-550
Grohm, J., Plesnila, N., Culmsee, C., Bid mediates fission, membrane permeabilization and perinuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death (2010) Brain Behav Immun, 24, pp. 831-838
Grohm, J., Kim, S.W., Mamrak, U., Tobaben, S., Cassidy-Stone, A., Nunnari, J., Inhibition of Drp1 provides neuroprotection in vitro and in vivo (2012) Cell Death Differ, 19, pp. 1446-1458
Petit, P.X., Susin, S.A., Zamzami, N., Mignotte, B., Kroemer, G., Mitochondria and programmed cell death: Back to the future (1996) FEBS Lett, 396, pp. 7-13
Tobaben, S., Grohm, J., Seiler, A., Conrad, M., Plesnila, N., Culmsee, C., Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons (2011) Cell Death Differ, 18, pp. 282-292
Smiley, S.T., Reers, M., Mottola-Hartshorn, C., Lin, M., Chen, A., Smith, T.W., Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1 (1991) Proc Natl Acad Sci USA, 88, pp. 3671-3675
Xu, J., Hao, Z., Gou, X., Tian, W., Jin, Y., Cui, S., Imaging of reactive oxygen species burst from mitochondria using laser scanning confocal microscopy (2013) Microsc Res Tech, 76, pp. 612-617
Pinton, P., Giorgi, C., Siviero, R., Zecchini, E., Rizzuto, R., Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis (2008) Oncogene, 27, pp. 6407-6418
Utkina-Sosunova, I.V., Niatsetskaya, Z.V., Sosunov, S.A., Ratner, V.I., Matsiukevich, D., Ten, V.S., Nelfinavir inhibits intra-mitochondrial calcium influx and protects brain against hypoxicischemic injury in neonatal mice (2013) PLoS One, 8, pp. e62448
Cao, G., Xing, J., Xiao, X., Liou, A.F.K., Yin, X.M., Clark, R.S.B., Critical role of calpain i in mitochondrial release of apoptosis-inducing factor in ischemic neuronal injury (2007) J Neurosci, 27, pp. 9278-9293
Wang, P., Heitman, J., The cyclophilins (2005) Genome Biol, 6, p. 226
Yu, S.W., Wang, Y., Frydenlund, D.S., Ottersen, O.P., Dawson, V.L., Dawson, T.M., Outer mitochondrial membrane localization of apoptosis-inducing factor: Mechanistic implications for release (2009) ASN Neuro, 1, pp. e00021
Tremper-Wells, B., Vallano, M.L., Nuclear calpain regulates Ca2+-dependent signaling via proteolysis of nuclear Ca2+/calmodulin-dependent protein kinase type IV in cultured neurons (2005) J Biol Chem, 280, pp. 2165-2175
Fields, G.B., Noble, R.L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int J Pept Protein Res, 35, pp. 161-214
Johnsson, B., Lofas, S., Lindquist, G., Immobilization of proteins to a carboxymethyldextran modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors (1991) Anal Biochem, 198, pp. 268-277
Dolga, A.M., Letsche, T., Gold, M., Doti, N., Bacher, M., Chiamvimonvat, N., Activation of KCNN3/SK3/K(Ca) 2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (2012) Glia, 60, pp. 2050-2064
Myszka, D.G., Analysis of small-molecule interactions using Biacore S51 technology (2004) Anal Biochem, 329, pp. 316-323
Diemert, S., Dolga, A.M., Tobaben, S., Grohm, J., Pfeifer, S., Oexler, E., Impedance measurement for real time detection of neuronal cell death (2012) J Neurosci Methods, 203, pp. 69-77
Öxler, E.M., Dolga, A., Culmsee, C., AIF depletion provides neuroprotection through a preconditioning effect (2012) Apoptosis, 17, pp. 1027-1038
Sevrioukova, I. F., Apoptosis-inducing factor: Structure, function, and redox regulation (2011) Antioxid Redox Signal, 14, pp. 2545-2579
Polster, B. M., AIF, reactive oxygen species, and neurodegeneration: A "complex" problem (2013) Neurochem Int, 62, pp. 695-702
Vahsen, N., Cand c, Bri re, J. J., B nit, P., Joza, N., Larochette, N., AIF deficiency compromises oxidative phosphorylation (2004) EMBO J, 23, pp. 4679-4689
Cheung, E. C., Joza, N., Steenaart, N. A., McClellan, K. A., Neuspiel, M., McNamara, S., Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis (2006) EMBO J, 25, pp. 4061-4073
Cao, G., Clark, R. S., Pei, W., Yin, W., Zhang, F., Sun, F. Y., Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation (2003) J Cereb Blood Flow Metab, 23, pp. 1137-1150
Thal, S. E., Zhu, C., Thal, S. C., Blomgren, K., Plesnila, N., Role of apoptosis inducing factor (AIF) for hippocampal neuronal cell death following global cerebral ischemia in mice (2011) Neurosci Lett, 499, pp. 1-3
Slemmer, J. E., Zhu, C., Landshamer, S., Trabold, R., Grohm, J., Ardeshiri, A., Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury (2008) Am J Pathol, 173, pp. 1795-1805
Piao, C. S., Loane, D. J., Stoica, B. A., Li, S., Hanscom, M., Cabatbat, R., Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury (2012) Neurobiol Dis, 46, pp. 745-758
Cand, C., Vahsen, N., Kouranti, I., Schmitt, E., Daugas, E., Spahr, C., AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis (2004) Oncogene, 23, pp. 1514-1521
Handschumacher, R. E., Harding, M. W., Rice, J., Drugge, R. J., Speicher, D. W., Cyclophilin: A specific cytosolic binding protein for cyclosporin A (1984) Science, 226, pp. 544-547
Goldner, F. M., Patrick, J. W., Neuronal localization of the cyclophilin A protein in the adult rat brain (1996) J Comp Neurol, 372, pp. 283-293
Montague, J. W., Hughes Jr., F. M., Cidlowski, J. A., Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis (1997) J Biol Chem, 272, pp. 6677-6684
Zhang, X. C., Wang, W. D., Wang, J. S., Pan, J. C., PPIase independent chaperone-like function of recombinant human Cyclophilin A during arginine kinase refolding (2013) FEBS Lett, 587, pp. 666-672
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Molecular characterization of mitochondrial apoptosis-inducing factor (1999) Nature, 397, pp. 441-446
Grohm, J., Kim, S. W., Mamrak, U., Tobaben, S., Cassidy-Stone, A., Nunnari, J., Inhibition of Drp1 provides neuroprotection in vitro and in vivo (2012) Cell Death Differ, 19, pp. 1446-1458
Petit, P. X., Susin, S. A., Zamzami, N., Mignotte, B., Kroemer, G., Mitochondria and programmed cell death: Back to the future (1996) FEBS Lett, 396, pp. 7-13
Smiley, S. T., Reers, M., Mottola-Hartshorn, C., Lin, M., Chen, A., Smith, T. W., Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1 (1991) Proc Natl Acad Sci USA, 88, pp. 3671-3675
Yu, S. W., Wang, Y., Frydenlund, D. S., Ottersen, O. P., Dawson, V. L., Dawson, T. M., Outer mitochondrial membrane localization of apoptosis-inducing factor: Mechanistic implications for release (2009) ASN Neuro, 1, pp. e00021
Fields, G. B., Noble, R. L., Solid phase peptide synthesis utilizing 9-fluorenylmethoxycarbonyl amino acids (1990) Int J Pept Protein Res, 35, pp. 161-214
Dolga, A. M., Letsche, T., Gold, M., Doti, N., Bacher, M., Chiamvimonvat, N., Activation of KCNN3/SK3/K (Ca) 2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (2012) Glia, 60, pp. 2050-2064
Myszka, D. G., Analysis of small-molecule interactions using Biacore S51 technology (2004) Anal Biochem, 329, pp. 316-323
xler, E. M., Dolga, A., Culmsee, C., AIF depletion provides neuroprotection through a preconditioning effect (2012) Apoptosis, 17, pp. 1027-1038
Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress
Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G * Adrenergic Receptors(262 views) Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315. Impact Factor:0 ViewExport to BibTeXExport to EndNote