Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes (559 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.65, 5-year impact factor: 4.011
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84904339330&partnerID=40&md5=e3bcdfd63b03d8e2d41a4c0d5c3aaf29
Keywords: Bombesin Peptide, Drug Delivery, Gold Complexes, Sterically Stabilized Micelles, 2 Distearoyl Sn Glycero 3 Phosphoethanolamine, 2 Distearoyl Sn Glycero 3 Phosphoethanolamine N [amino(polyethylene Glycol) 2000], Antineoplastic Agent, Bombesin Derivative, Bombesin Receptor, Dioleoylphosphatidylcholine, Dithiocarbamato Gold Complex, Drug Carrier, Gastrin Releasing Peptide Receptor, Levo Alpha Phosphatidylcholine, Mony Bn Aa1, Peptide Derivative, Phospholipid, Unclassified Drug, Article, Cell Survival, Cell Viability, Controlled Study, Cytotoxicity, Drug Delivery System, Drug Formulation, Drug Release, Drug Stability, Drug Structure, Human, Human Cell, Hydrophobicity, In Vitro Study, Mtt Assay, Nanoencapsulation, Priority Journal, Prostate Cancer Cell Line, Protein Expression, Sterically Stabilized Mixed Micelle, Ultraviolet Spectroscopy, 2 Distearoyl Sn Glycero 3 Phosphoethanolamine N [amino (polyethylene Glycol) 2000],
Affiliations:
*** IBB - CNR ***
University of Naples Federico II, Department of Pharmacy, IBB CNR, Via Mezzocannone 16, 80134 Napoli, Italy
University of Padua, Department of Chemical Sciences, Via Marzolo 1, 35131 Padova, Italy
References:
Abiraj, K., Mansi, R., Tamma, M.L., Fani, M., Forrer, F., Nicolas, G., Cescato, R., Maecke, H.R., Bombesin antagonist-based radioligands for translational nuclear imaging of gastrin-releasing peptide receptor-positive tumors (2011) J. Nucl. Med., 52, pp. 1970-197
Accardo, A., Tesauro, D., Mangiapia, G., Pedone, C., Morelli, G., Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (2007) Biopolymers - Peptide Science Section, 88 (2), pp. 115-121. , DOI 10.1002/bip.20648
Accardo, A., Mansi, R., Morisco, A., Mangiapia, G., Paduano, L., Tesauro, D., Radulescu, A., Morelli, G., Peptide modified nanocarriers for selective targeting of bombesin receptors (2010) Mol. Biosyst., 6, pp. 878-887
Accardo, A., Salsano, G., Morisco, A., Aurilio, M., Parisi, A., Maione, F., Cicala, C., Morelli, G., Peptide modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (2012) Int. J. Nanomed., 7, pp. 2007-2017
Ashok, B., Arleth, L., Hjelm, R.P., Rubinstein, I., Onyuksel, H., In vitro characterization of PEGylated phospholipid micelles for improved drug solubilization: Effects of PEG chain length and PC incorporation (2004) Journal of Pharmaceutical Sciences, 93 (10), pp. 2476-2487. , DOI 10.1002/jps.20150
Casini, A., Kelter, G., Gabbiani, C., Cinellu, M.A., Minghetti, G., Fregona, D., Fiebig, H., Messori, L., Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: A systematic study (2009) J. Biol. Inorg. Chem., 14, pp. 1139-1149
Chen, L., Sha, X., Jiang, X., Chen, Y., Ren, Q., Fang, X., Pluronic P105/F127 mixed micelles for the delivery of docetaxel against taxol-resistant non-small cell lung cancer: Optimization and in vitro, in vivo evaluation (2013) Int. J. Nanomed., 8, pp. 73-84
Dagar, A., Kuzmis, A., Rubinstein, I., Sekosan, M., Önyüksel, H., VIP-targeted cytotoxic nanomedicine for breast cancer (2012) Drug Deliv. Transl. Res., 2, pp. 454-462
Dalla Via, L., Nardon, C., Fregona, D., Targeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer. A challenge for the future (2012) Future Med. Chem., 4, pp. 525-543
Deshpande, P.P., Biswas, S., Torchilin, V.P., Current trends in the use of liposomes for tumor targeting (2013) Nanomedicine (Lond.), 8, pp. 1509-1528
Drbohlavova, J., Chomoucka, J., Adam, V., Ryvolova, M., Eckschlager, T., Hubalek, J., Kizek, R., Nanocarriers for anticancer drugs-new trends in nanomedicine (2013) Curr. Drug Metab., 14, pp. 547-564
Falciani, C., Accardo, A., Brunetti, J., Tesauro, D., Lelli, B., Pini, A., Bracci, L., Morelli, G., Target selective drug delivery through liposome labeled with oligobranched neurotensin peptides (2011) ChemMedChem, 6, pp. 678-685
Guarnieri, D., Falanga, A., Muscetti, O., Tarallo, R., Fusco, S., Galdiero, M., Galdiero, S., Netti, P.A., Shuttle-mediated nanoparticle delivery to the blood-brain barrier (2013) Small, 9, pp. 853-862
Höhne, A., Mu, L., Honer, M., Schubiger, P.A., Ametamey, S.M., Graham, K., Stellfeld, T., Srinivasan, A., Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks (2008) Bioconjug. Chem., 19, pp. 1871-1879
He, X., Na, M.H., Kim, J.S., Lee, G.Y., Park, J.Y., Hoffman, A.S., Nam, J.O., Lee, B.H., A novel peptide probe for imaging and targeted delivery of liposomal doxorubicin to lung tumor (2011) Mol. Pharm., 8, pp. 430-438
Kaur, A., Kaur, M., Sharma, R., Kumar, S., Doxorubicin: A critical review on toxicity (2012) J. Pharm. Res., 5, pp. 2890-2894
Kelland, L., The resurgence of platinum-based cancer chemotherapy (2007) Nature Reviews Cancer, 7 (8), pp. 573-584. , DOI 10.1038/nrc2167, PII NRC2167
Koo, O.M., Rubinstein, I., Onyuksel, H., Camptothecin in sterically stabilized phospholipid micelles: A novel nanomedicine (2005) Nanomedicine: Nanotechnology, Biology, and Medicine, 1 (1), pp. 77-84. , DOI 10.1016/j.nano.2004.11.002, PII S1549963404000036
Krishnadas, A., Rubinstein, I., Onyuksel, H., Sterically stabilized phospholipid mixed micelles: In vitro evaluation as a novel carrier for water-insoluble drugs (2003) Pharmaceutical Research, 20 (2), pp. 297-302. , DOI 10.1023/A:1022243709003
Lim, S.B., Banerjee, A., Önyüksel, H., Improvement of drug safety by the use of lipid-based nanocarriers (2012) J. Control. Release, 163, pp. 34-45
Lippert, B., (1999) Cisplatin: Chemistry and Biochemistry of A Leading Anticancer Drug, , Wiley-VCH Weinheim
Llinares, M., Devin, C., Chaloin, O., Azay, J., Noel-Artis, A.-M., Bernad, N., Fehrentz, J.-A., Martinez, J., Syntheses and biological activities of potent bombesin receptor antagonists (1999) Journal of Peptide Research, 53 (3), pp. 275-283. , DOI 10.1034/j.1399-3011.1999.00028.x
Mansi, R., Wang, X., Forrer, F., Kneifel, S., Tamma, M.L., Waser, B., Cescato, R., Maecke, H.R., Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radio antagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides (2009) Clin. Cancer Res., 15, pp. 5240-5249
Marzano, C., Ronconi, L., Chiara, F., Giron, M.C., Faustinelli, I., Cristofori, P., Trevisan, A., Fregona, D., Gold(III)-dithiocarbamato anticancer agents: Activity, toxicology and histopathological studies in rodents (2011) Int. J. Cancer, 129, pp. 487-496
Messori, L., Abbate, F., Marcon, G., Orioli, P., Fontani, M., Mini, E., Mazzei, T., Zanello, P., Gold(III) complexes as potential antitumor agents: Solution chemistry and cytotoxic properties of some selected gold(III) compounds (2000) J. Med. Chem., 43, pp. 3541-3548
Morisco, A., Accardo, A., Gianolio, E., Tesauro, D., Benedetti, E., Morelli, G., Micelles derivatized with octreotide as potential target selective contrast agents in MRI (2009) J. Pept. Sci., 15, pp. 242-250
Nagy, E.M., Nardon, C., Giovagnini, L., Marchiò, L., Trevisan, A., Fregona, D., Promising anticancer mono- and dinuclear ruthenium(III) dithiocarbamato complexes: Systematic solution studies (2011) Dalton Trans., 40, pp. 11885-11895
Nagy, E.M., Ronconi, L., Nardon, C., Fregona, D., Noble metal-dithiocarbamates precious allies in the fight against cancer (2012) Mini Rev. Med. Chem., 12, pp. 1216-1229
Nardon, C., Boscutti, G., Fregona, D., Beyond platinums: Gold complexes as anticancer agents (2014) Anticancer Res., 34, pp. 487-492
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Ronconi, L., Fregona, D., The Midas touch in cancer chemotherapy: From platinum- to gold-dithiocarbamato complexes (2009) Dalton Trans., pp. 10670-10680
Ronconi, L., Giovagnini, L., Marzano, C., Bettio, F., Graziani, R., Pilloni, G., Fregona, D., Gold dithiocarbamate derivatives as potential antineoplastic agents: Design, spectroscopic properties, and in vitro antitumor activity (2005) Inorganic Chemistry, 44 (6), pp. 1867-1881. , DOI 10.1021/ic048260v
Schmitt, L., Dietrich, C., Tampe, R., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Tarallo, R., Accardo, A., Falanga, A., Guarnieri, D., Vitiello, G., Netti, P., D'Errico, G., Galdiero, S., Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (2011) Chem. Eur. J., 17, pp. 12659-12668
Yu, M.K., Park, J., Jon, S., Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy (2012) Theranostic, 2, pp. 3-44
Deshpande, P. P., Biswas, S., Torchilin, V. P., Current trends in the use of liposomes for tumor targeting (2013) Nanomedicine (Lond.), 8, pp. 1509-1528
H hne, A., Mu, L., Honer, M., Schubiger, P. A., Ametamey, S. M., Graham, K., Stellfeld, T., Srinivasan, A., Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks (2008) Bioconjug. Chem., 19, pp. 1871-1879
He, X., Na, M. H., Kim, J. S., Lee, G. Y., Park, J. Y., Hoffman, A. S., Nam, J. O., Lee, B. H., A novel peptide probe for imaging and targeted delivery of liposomal doxorubicin to lung tumor (2011) Mol. Pharm., 8, pp. 430-438
Koo, O. M., Rubinstein, I., Onyuksel, H., Camptothecin in sterically stabilized phospholipid micelles: A novel nanomedicine (2005) Nanomedicine: Nanotechnology, Biology, and Medicine, 1 (1), pp. 77-84. , DOI 10. 1016/j. nano. 2004. 11. 002, PII S1549963404000036
Lim, S. B., Banerjee, A., ny ksel, H., Improvement of drug safety by the use of lipid-based nanocarriers (2012) J. Control. Release, 163, pp. 34-45
Nagy, E. M., Nardon, C., Giovagnini, L., Marchi, L., Trevisan, A., Fregona, D., Promising anticancer mono- and dinuclear ruthenium (III) dithiocarbamato complexes: Systematic solution studies (2011) Dalton Trans., 40, pp. 11885-11895
Nagy, E. M., Ronconi, L., Nardon, C., Fregona, D., Noble metal-dithiocarbamates precious allies in the fight against cancer (2012) Mini Rev. Med. Chem., 12, pp. 1216-1229
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Yu, M. K., Park, J., Jon, S., Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy (2012) Theranostic, 2, pp. 3-44
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2014 Oct 1; 473(1-2): 194-202.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 3.65, 5-year impact factor: 4.011
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84904339330&partnerID=40&md5=e3bcdfd63b03d8e2d41a4c0d5c3aaf29
Keywords: Bombesin Peptide, Drug Delivery, Gold Complexes, Sterically Stabilized Micelles, 2 Distearoyl Sn Glycero 3 Phosphoethanolamine, 2 Distearoyl Sn Glycero 3 Phosphoethanolamine N [amino(polyethylene Glycol) 2000], Antineoplastic Agent, Bombesin Derivative, Bombesin Receptor, Dioleoylphosphatidylcholine, Dithiocarbamato Gold Complex, Drug Carrier, Gastrin Releasing Peptide Receptor, Levo Alpha Phosphatidylcholine, Mony Bn Aa1, Peptide Derivative, Phospholipid, Unclassified Drug, Article, Cell Survival, Cell Viability, Controlled Study, Cytotoxicity, Drug Delivery System, Drug Formulation, Drug Release, Drug Stability, Drug Structure, Human, Human Cell, Hydrophobicity, In Vitro Study, Mtt Assay, Nanoencapsulation, Priority Journal, Prostate Cancer Cell Line, Protein Expression, Sterically Stabilized Mixed Micelle, Ultraviolet Spectroscopy, 2 Distearoyl Sn Glycero 3 Phosphoethanolamine N [amino (polyethylene Glycol) 2000],
Affiliations:
*** IBB - CNR ***
University of Naples Federico II, Department of Pharmacy, IBB CNR, Via Mezzocannone 16, 80134 Napoli, Italy
University of Padua, Department of Chemical Sciences, Via Marzolo 1, 35131 Padova, Italy
References:
Abiraj, K., Mansi, R., Tamma, M.L., Fani, M., Forrer, F., Nicolas, G., Cescato, R., Maecke, H.R., Bombesin antagonist-based radioligands for translational nuclear imaging of gastrin-releasing peptide receptor-positive tumors (2011) J. Nucl. Med., 52, pp. 1970-197
Accardo, A., Tesauro, D., Mangiapia, G., Pedone, C., Morelli, G., Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (2007) Biopolymers - Peptide Science Section, 88 (2), pp. 115-121. , DOI 10.1002/bip.20648
Accardo, A., Mansi, R., Morisco, A., Mangiapia, G., Paduano, L., Tesauro, D., Radulescu, A., Morelli, G., Peptide modified nanocarriers for selective targeting of bombesin receptors (2010) Mol. Biosyst., 6, pp. 878-887
Accardo, A., Salsano, G., Morisco, A., Aurilio, M., Parisi, A., Maione, F., Cicala, C., Morelli, G., Peptide modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (2012) Int. J. Nanomed., 7, pp. 2007-2017
Ashok, B., Arleth, L., Hjelm, R.P., Rubinstein, I., Onyuksel, H., In vitro characterization of PEGylated phospholipid micelles for improved drug solubilization: Effects of PEG chain length and PC incorporation (2004) Journal of Pharmaceutical Sciences, 93 (10), pp. 2476-2487. , DOI 10.1002/jps.20150
Casini, A., Kelter, G., Gabbiani, C., Cinellu, M.A., Minghetti, G., Fregona, D., Fiebig, H., Messori, L., Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: A systematic study (2009) J. Biol. Inorg. Chem., 14, pp. 1139-1149
Chen, L., Sha, X., Jiang, X., Chen, Y., Ren, Q., Fang, X., Pluronic P105/F127 mixed micelles for the delivery of docetaxel against taxol-resistant non-small cell lung cancer: Optimization and in vitro, in vivo evaluation (2013) Int. J. Nanomed., 8, pp. 73-84
Dagar, A., Kuzmis, A., Rubinstein, I., Sekosan, M., Önyüksel, H., VIP-targeted cytotoxic nanomedicine for breast cancer (2012) Drug Deliv. Transl. Res., 2, pp. 454-462
Dalla Via, L., Nardon, C., Fregona, D., Targeting the ubiquitin-proteasome pathway with inorganic compounds to fight cancer. A challenge for the future (2012) Future Med. Chem., 4, pp. 525-543
Deshpande, P.P., Biswas, S., Torchilin, V.P., Current trends in the use of liposomes for tumor targeting (2013) Nanomedicine (Lond.), 8, pp. 1509-1528
Drbohlavova, J., Chomoucka, J., Adam, V., Ryvolova, M., Eckschlager, T., Hubalek, J., Kizek, R., Nanocarriers for anticancer drugs-new trends in nanomedicine (2013) Curr. Drug Metab., 14, pp. 547-564
Falciani, C., Accardo, A., Brunetti, J., Tesauro, D., Lelli, B., Pini, A., Bracci, L., Morelli, G., Target selective drug delivery through liposome labeled with oligobranched neurotensin peptides (2011) ChemMedChem, 6, pp. 678-685
Guarnieri, D., Falanga, A., Muscetti, O., Tarallo, R., Fusco, S., Galdiero, M., Galdiero, S., Netti, P.A., Shuttle-mediated nanoparticle delivery to the blood-brain barrier (2013) Small, 9, pp. 853-862
Höhne, A., Mu, L., Honer, M., Schubiger, P.A., Ametamey, S.M., Graham, K., Stellfeld, T., Srinivasan, A., Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks (2008) Bioconjug. Chem., 19, pp. 1871-1879
He, X., Na, M.H., Kim, J.S., Lee, G.Y., Park, J.Y., Hoffman, A.S., Nam, J.O., Lee, B.H., A novel peptide probe for imaging and targeted delivery of liposomal doxorubicin to lung tumor (2011) Mol. Pharm., 8, pp. 430-438
Kaur, A., Kaur, M., Sharma, R., Kumar, S., Doxorubicin: A critical review on toxicity (2012) J. Pharm. Res., 5, pp. 2890-2894
Kelland, L., The resurgence of platinum-based cancer chemotherapy (2007) Nature Reviews Cancer, 7 (8), pp. 573-584. , DOI 10.1038/nrc2167, PII NRC2167
Koo, O.M., Rubinstein, I., Onyuksel, H., Camptothecin in sterically stabilized phospholipid micelles: A novel nanomedicine (2005) Nanomedicine: Nanotechnology, Biology, and Medicine, 1 (1), pp. 77-84. , DOI 10.1016/j.nano.2004.11.002, PII S1549963404000036
Krishnadas, A., Rubinstein, I., Onyuksel, H., Sterically stabilized phospholipid mixed micelles: In vitro evaluation as a novel carrier for water-insoluble drugs (2003) Pharmaceutical Research, 20 (2), pp. 297-302. , DOI 10.1023/A:1022243709003
Lim, S.B., Banerjee, A., Önyüksel, H., Improvement of drug safety by the use of lipid-based nanocarriers (2012) J. Control. Release, 163, pp. 34-45
Lippert, B., (1999) Cisplatin: Chemistry and Biochemistry of A Leading Anticancer Drug, , Wiley-VCH Weinheim
Llinares, M., Devin, C., Chaloin, O., Azay, J., Noel-Artis, A.-M., Bernad, N., Fehrentz, J.-A., Martinez, J., Syntheses and biological activities of potent bombesin receptor antagonists (1999) Journal of Peptide Research, 53 (3), pp. 275-283. , DOI 10.1034/j.1399-3011.1999.00028.x
Mansi, R., Wang, X., Forrer, F., Kneifel, S., Tamma, M.L., Waser, B., Cescato, R., Maecke, H.R., Evaluation of a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-conjugated bombesin-based radio antagonist for the labeling with single-photon emission computed tomography, positron emission tomography, and therapeutic radionuclides (2009) Clin. Cancer Res., 15, pp. 5240-5249
Marzano, C., Ronconi, L., Chiara, F., Giron, M.C., Faustinelli, I., Cristofori, P., Trevisan, A., Fregona, D., Gold(III)-dithiocarbamato anticancer agents: Activity, toxicology and histopathological studies in rodents (2011) Int. J. Cancer, 129, pp. 487-496
Messori, L., Abbate, F., Marcon, G., Orioli, P., Fontani, M., Mini, E., Mazzei, T., Zanello, P., Gold(III) complexes as potential antitumor agents: Solution chemistry and cytotoxic properties of some selected gold(III) compounds (2000) J. Med. Chem., 43, pp. 3541-3548
Morisco, A., Accardo, A., Gianolio, E., Tesauro, D., Benedetti, E., Morelli, G., Micelles derivatized with octreotide as potential target selective contrast agents in MRI (2009) J. Pept. Sci., 15, pp. 242-250
Nagy, E.M., Nardon, C., Giovagnini, L., Marchiò, L., Trevisan, A., Fregona, D., Promising anticancer mono- and dinuclear ruthenium(III) dithiocarbamato complexes: Systematic solution studies (2011) Dalton Trans., 40, pp. 11885-11895
Nagy, E.M., Ronconi, L., Nardon, C., Fregona, D., Noble metal-dithiocarbamates precious allies in the fight against cancer (2012) Mini Rev. Med. Chem., 12, pp. 1216-1229
Nardon, C., Boscutti, G., Fregona, D., Beyond platinums: Gold complexes as anticancer agents (2014) Anticancer Res., 34, pp. 487-492
Pace, C.N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Ronconi, L., Fregona, D., The Midas touch in cancer chemotherapy: From platinum- to gold-dithiocarbamato complexes (2009) Dalton Trans., pp. 10670-10680
Ronconi, L., Giovagnini, L., Marzano, C., Bettio, F., Graziani, R., Pilloni, G., Fregona, D., Gold dithiocarbamate derivatives as potential antineoplastic agents: Design, spectroscopic properties, and in vitro antitumor activity (2005) Inorganic Chemistry, 44 (6), pp. 1867-1881. , DOI 10.1021/ic048260v
Schmitt, L., Dietrich, C., Tampe, R., Synthesis and characterization of chelator-lipids for reversible immobilization of engineered proteins at self-assembled lipid interfaces (1994) J. Am. Chem. Soc., 116, pp. 8485-8491
Tarallo, R., Accardo, A., Falanga, A., Guarnieri, D., Vitiello, G., Netti, P., D'Errico, G., Galdiero, S., Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (2011) Chem. Eur. J., 17, pp. 12659-12668
Yu, M.K., Park, J., Jon, S., Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy (2012) Theranostic, 2, pp. 3-44
Deshpande, P. P., Biswas, S., Torchilin, V. P., Current trends in the use of liposomes for tumor targeting (2013) Nanomedicine (Lond.), 8, pp. 1509-1528
H hne, A., Mu, L., Honer, M., Schubiger, P. A., Ametamey, S. M., Graham, K., Stellfeld, T., Srinivasan, A., Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks (2008) Bioconjug. Chem., 19, pp. 1871-1879
He, X., Na, M. H., Kim, J. S., Lee, G. Y., Park, J. Y., Hoffman, A. S., Nam, J. O., Lee, B. H., A novel peptide probe for imaging and targeted delivery of liposomal doxorubicin to lung tumor (2011) Mol. Pharm., 8, pp. 430-438
Koo, O. M., Rubinstein, I., Onyuksel, H., Camptothecin in sterically stabilized phospholipid micelles: A novel nanomedicine (2005) Nanomedicine: Nanotechnology, Biology, and Medicine, 1 (1), pp. 77-84. , DOI 10. 1016/j. nano. 2004. 11. 002, PII S1549963404000036
Lim, S. B., Banerjee, A., ny ksel, H., Improvement of drug safety by the use of lipid-based nanocarriers (2012) J. Control. Release, 163, pp. 34-45
Nagy, E. M., Nardon, C., Giovagnini, L., Marchi, L., Trevisan, A., Fregona, D., Promising anticancer mono- and dinuclear ruthenium (III) dithiocarbamato complexes: Systematic solution studies (2011) Dalton Trans., 40, pp. 11885-11895
Nagy, E. M., Ronconi, L., Nardon, C., Fregona, D., Noble metal-dithiocarbamates precious allies in the fight against cancer (2012) Mini Rev. Med. Chem., 12, pp. 1216-1229
Pace, C. N., Vajdos, F., Fee, L., Grimsley, G., Gray, T., How to measure and predict the molar absorption coefficient of a protein (1995) Protein Sci., 4, pp. 2411-2423
Yu, M. K., Park, J., Jon, S., Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy (2012) Theranostic, 2, pp. 3-44
Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes
Pure sterically stabilized micelles (SSM) of DSPE-PEG2000, and sterically stabilized mixed micelles (SSMM) containing PC or DOPC phospholipids (5, 10 or 20% mol/mol with respect to DSPE-PEG2000) are developed as delivery systems for the gold based cytotoxic drug Au(III)-dithiocarbamato complex AuL12. In particular, SSMM containing 5% of PC at 5 mM of lipid concentration encapsulates 61.0 μg of AuL12 with a DL% of 1.13. The gold complex remains stable up to 72 h when incorporated in the aggregate, as indicated by UV-vis measurements. Incorporation in micelle composition of a low amount of the peptide derivative MonY-BN-AA1, containing a bombesin peptide analogue does not influence structural parameters of the micelles (diameter around 20 nm) neither the AuL12 loading parameters. Target selective properties of the peptide containing full aggregate on PC-3 cells overexpressing the GRP/bombesin receptors are observed by in vitro cytotoxic studies: a decrease of cell viability, ∼50%, is obtained in cells treated with AuL12-targeted micelles at 10 μM drug concentration for 48 h with respect to untargeted micelles. © 2014 Elsevier B.V.
Pure sterically stabilized micelles (SSM) of DSPE-PEG2000, and sterically stabilized mixed micelles (SSMM) containing PC or DOPC phospholipids (5, 10 or 20% mol/mol with respect to DSPE-PEG2000) are developed as delivery systems for the gold based cytotoxic drug Au(III)-dithiocarbamato complex AuL12. In particular, SSMM containing 5% of PC at 5 mM of lipid concentration encapsulates 61.0 μg of AuL12 with a DL% of 1.13. The gold complex remains stable up to 72 h when incorporated in the aggregate, as indicated by UV-vis measurements. Incorporation in micelle composition of a low amount of the peptide derivative MonY-BN-AA1, containing a bombesin peptide analogue does not influence structural parameters of the micelles (diameter around 20 nm) neither the AuL12 loading parameters. Target selective properties of the peptide containing full aggregate on PC-3 cells overexpressing the GRP/bombesin receptors are observed by in vitro cytotoxic studies: a decrease of cell viability, ∼50%, is obtained in cells treated with AuL12-targeted micelles at 10 μM drug concentration for 48 h with respect to untargeted micelles. © 2014 Elsevier B.V.
Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes
Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes
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Caputo T, Cusano AM, Ruvo M, Aliberti A, Cusano A
* Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery (18 views)
Curr Pharm Biotechnol (ISSN: 1389-2010linking), 2021 Aug 26; N/D: N/D-N/D.
Impact Factor: 2.097
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Doti N, Mardirossian M, Sandomenico A, Ruvo M, Caporale A
* Recent Applications of Retro-Inverso Peptides (24 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2021 Aug 12; 22(16): N/D-N/D.
Impact Factor: 4.556
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Agnello L, Tortorella S, D’argenio A, Carbone C, Camorani S, Locatelli E, Auletta L, Sorrentino D, Fedele M, Zannetti A, Franchini MC, Cerchia L
* Optimizing cisplatin delivery to triple-negative breast cancer through novel EGFR aptamer-conjugated polymeric nanovectors (25 views)
J Exp Clin Canc Res (ISSN: 1756-9966electronic, 0392-9078linking), 2021 Jul 22; 40(1): 239-239.
Impact Factor: 11.161
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (379 views)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2018 May 15; DOI10.1007/s00726-01: 933-941.
Impact Factor: 3.173
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Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
* Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe (298 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2018 Feb 14; 8(1): 2998-2998.
Impact Factor: 4.259
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (202 views)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
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Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (618 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (291 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
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Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (268 views) (PDF 207 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (447 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Ringhieri P, Pannunzio A, Boccarelli A, Morelli G, Coluccia M, Tesauro D
* Effect of cisplatin containing liposomes formulated by unsaturated chain-containing lipids on gynecological tumor cells (284 views)
J Liposome Res (ISSN: 0898-2104), 2016; N/D: 1-6.
Impact Factor: 1.971
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Ringhieri P, Avitabile C, Saviano M, Morelli G, Romanelli A, Accardo A
* The influence of liposomal formulation on the incorporation and retention of PNA oligomers (233 views)
Colloid Surface B (ISSN: 0927-7765), 2016; 145: 462-469.
Impact Factor: 3.887
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Vincenzi M, Accardo A, Costantini S, Scala S, Portella L, Trotta A, Ronga L, Guillon J, Leone M, Colonna G, Rossi F, Tesauro D
* Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles (392 views)
Mol Biosyst (ISSN: 1742-206x), 2015 Oct 13; 11(11): 2925-2932.
Impact Factor: 2.829
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (572 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (530 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
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Roviello GN, Musumeci D, Roviello V
* Cationic peptides as RNA compaction agents: A study on the polyA compaction activity of a linear alpha, epsilon-oligo-l-lysine (480 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2015; 485(1-2): 244-248.
Impact Factor: 3.994
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (470 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (481 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2015; 26(8): 1533-1541.
Impact Factor: 4.5
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (453 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
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Ferraro G, Massai L, Messori L, Cinellu MA, Merlino A
* Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme (360 views)
Biometals (ISSN: 0966-0844), 2015; 28(4): 745-754.
Impact Factor: 2.134
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (454 views)
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Impact Factor: 3.234
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (709 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (509 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (471 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (706 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
* Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (404 views)
Rsc Adv (ISSN: 2046-2069), 2014; 4(54): 28691-28698.
Impact Factor: 3.84
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (431 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
Impact Factor: 2.385
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Clemente F, Arpaia P, Manna C
* Characterization of human skin impedance after electrical treatment for transdermal drug delivery (411 views)
Measurement (ISSN: 0263-2241), 2013 Nov; 46(9): 3494-3501.
Impact Factor: 1.526
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (1094 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (467 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204.
Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (410 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (483 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
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Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (339 views)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (446 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (554 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (410 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (439 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (924 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (383 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (1132 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (458 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (609 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (409 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (913 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1131 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (561 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (392 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (321 views)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Maggi A, Salvatore M
Molecular imaging (327 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (617 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (438 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (302 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (393 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (431 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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* Self‑assembly of thyminyl l‑tryptophanamide (TrpT) building blocks for the potential development of drug delivery nanosystems (13 views)
Journal Of Nanostructure In Chemistry, 2023 Feb; N/D: N/D-N/D.
Impact Factor: 8
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Caputo T, Cusano AM, Ruvo M, Aliberti A, Cusano A
* Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery (18 views)
Curr Pharm Biotechnol (ISSN: 1389-2010linking), 2021 Aug 26; N/D: N/D-N/D.
Impact Factor: 2.097
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Doti N, Mardirossian M, Sandomenico A, Ruvo M, Caporale A
* Recent Applications of Retro-Inverso Peptides (24 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2021 Aug 12; 22(16): N/D-N/D.
Impact Factor: 4.556
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Agnello L, Tortorella S, D’argenio A, Carbone C, Camorani S, Locatelli E, Auletta L, Sorrentino D, Fedele M, Zannetti A, Franchini MC, Cerchia L
* Optimizing cisplatin delivery to triple-negative breast cancer through novel EGFR aptamer-conjugated polymeric nanovectors (25 views)
J Exp Clin Canc Res (ISSN: 1756-9966electronic, 0392-9078linking), 2021 Jul 22; 40(1): 239-239.
Impact Factor: 11.161
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Roviello GN
* Novel insights into nucleoamino acids: biomolecular recognition and aggregation studies of a thymine-conjugated L-phenyl alanine (379 views)
Amino Acids (ISSN: 1438-2199electronic, 0939-4451linking), 2018 May 15; DOI10.1007/s00726-01: 933-941.
Impact Factor: 3.173
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Honarvar H, Calce E, Doti N, Langella E, Orlova A, Buijs J, D’amato V, Bianco R, Saviano M, Tolmachev V, De Luca S
* Evaluation of HER2-specific peptide ligand for its employment as radiolabeled imaging probe (298 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2018 Feb 14; 8(1): 2998-2998.
Impact Factor: 4.259
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (202 views)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
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Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (618 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (291 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
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Greco A, Albanese S, Auletta L, De Carlo F, Salvatore M, Howard CM, Claudio PP
* Advances in molecular preclinical therapy mediated by imaging (268 views) (PDF 207 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1827-1936), 2017 Mar; 61(1): 76-94.
Impact Factor: 2.368
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (447 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
View Export to BibTeX Export to EndNote
Ringhieri P, Pannunzio A, Boccarelli A, Morelli G, Coluccia M, Tesauro D
* Effect of cisplatin containing liposomes formulated by unsaturated chain-containing lipids on gynecological tumor cells (284 views)
J Liposome Res (ISSN: 0898-2104), 2016; N/D: 1-6.
Impact Factor: 1.971
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Ringhieri P, Avitabile C, Saviano M, Morelli G, Romanelli A, Accardo A
* The influence of liposomal formulation on the incorporation and retention of PNA oligomers (233 views)
Colloid Surface B (ISSN: 0927-7765), 2016; 145: 462-469.
Impact Factor: 3.887
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Vincenzi M, Accardo A, Costantini S, Scala S, Portella L, Trotta A, Ronga L, Guillon J, Leone M, Colonna G, Rossi F, Tesauro D
* Intrinsically disordered amphiphilic peptides as potential targets in drug delivery vehicles (392 views)
Mol Biosyst (ISSN: 1742-206x), 2015 Oct 13; 11(11): 2925-2932.
Impact Factor: 2.829
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (572 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (530 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
Impact Factor: 5.158
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Roviello GN, Musumeci D, Roviello V
* Cationic peptides as RNA compaction agents: A study on the polyA compaction activity of a linear alpha, epsilon-oligo-l-lysine (480 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2015; 485(1-2): 244-248.
Impact Factor: 3.994
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Nardon C, Boscutti G, Dalla Via L, Ringhieri P, Di Noto V, Morelli G, Accardo A, Fregona D
* CCK8 peptide-labeled Pluronic® F127 micelles as a targeted vehicle of gold-based anticancer chemotherapeutics (470 views)
Medchemcomm (ISSN: 2040-2503), 2015; 6(1): 155-163.
Impact Factor: 2.319
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Avitabile C, Accardo A, Ringhieri P, Morelli G, Saviano M, Montagner G, Fabbri E, Gallerani E, Gambari R, Romanelli A
* Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (481 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812), 2015; 26(8): 1533-1541.
Impact Factor: 4.5
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Ringhieri P, Diaferia C, Galdiero S, Palumbo R, Morelli G, Accardo A
* Liposomal doxorubicin doubly functionalized with CCK8 and R8 peptide sequences for selective intracellular drug delivery (453 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2015; 21(5): 415-425.
Impact Factor: 1.951
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Ferraro G, Massai L, Messori L, Cinellu MA, Merlino A
* Structural evidences for a secondary gold binding site in the hydrophobic box of lysozyme (360 views)
Biometals (ISSN: 0966-0844), 2015; 28(4): 745-754.
Impact Factor: 2.134
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (454 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (709 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
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Galdiero S, Falanga A, Vitiello M, Grieco P, Caraglia M, Morelli G, Galdiero M
* Exploitation of viral properties for intracellular delivery (509 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617linking), 2014 Jul; 20(7): 468-478.
Impact Factor: 1.546
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (471 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Accardo A, Aloj L, Aurilio M, Morelli G, Tesauro D
* Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugs (706 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 Mar 27; 9(1): 1537-1557.
Impact Factor: 4.383
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Roviello GN, Roviello GN, Musumeci D, Capasso D, Di Gaetano S, Costanzo M, Pedone C
* Synthesis and supramolecular assembly of 1, 3-bis(1 '-uracilyl)-2-propanone (404 views)
Rsc Adv (ISSN: 2046-2069), 2014; 4(54): 28691-28698.
Impact Factor: 3.84
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Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G
* The Structural Comparison Between Membrane-Associated Human Carbonic Anhydrases Provides Insights Into Drug Design Of Selective Inhibitors (431 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2014; 101(7): 769-778.
Impact Factor: 2.385
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Clemente F, Arpaia P, Manna C
* Characterization of human skin impedance after electrical treatment for transdermal drug delivery (411 views)
Measurement (ISSN: 0263-2241), 2013 Nov; 46(9): 3494-3501.
Impact Factor: 1.526
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Galdiero S, Falanga A, Cantisani M, Vitiello M, Morelli G, Galdiero M
* Peptide-Lipid Interactions: Experiments and Applications (1094 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2013 Sep; 14(9): 18758-18789.
Impact Factor: 2.339
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Falciani C, Brunetti J, Lelli B, Accardo A, Tesauro D, Morelli G, Bracci L
* Nanoparticles exposing neurotensin tumor-specific drivers (467 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 198-204.
Impact Factor: 1.862
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (410 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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Calce E, Monfregola L, Sandomenico A, Saviano M, De Luca S
* Fluorescence study for selecting specific ligands toward HER2 receptor: An example of receptor fragment approach (483 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2013 Mar; 61: 116-121.
Impact Factor: 3.432
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Travaglia A, Satriano C, Giuffrida ML, La Mendola D, Rampazzo E, Prodi L, Rizzarelli E
* Electrostatically driven interaction of silica-supported lipid bilayer nanoplatforms and a nerve growth factor-mimicking peptide (339 views)
Soft Matter (ISSN: 1744-683x), 2013; 9(18): 4648-4654.
Impact Factor: 4.151
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (446 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (554 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
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Accardo A, Mansi R, Salzano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Ziaco B, Tesauro D, Aloj L, De Rosa G, Morelli G
* Bombesin peptide antagonist for target-selective delivery of liposomal doxorubicin on cancer cells (410 views)
Journal Of Drug Targeting (ISSN: 1061-186x), 2012 Nov 21; 21(3): 240-249.
Impact Factor: 2.768
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Roviello GN, Roviello G, Musumeci D, Bucci EM, Pedone C
* Dakin-West reaction on 1-thyminyl acetic acid for the synthesis of 1, 3-bis(1-thyminyl)-2-propanone, a heteroaromatic compound with nucleopeptide-binding properties (439 views)
Amino Acids (ISSN: 1438-2199, 0939-4451, 1438-2199electronic), 2012 Oct; 43(4): 1615-1623.
Impact Factor: 3.914
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (924 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (383 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Falanga A, Vitiello MT, Cantisani M, Tarallo R, Guarnieri D, Mignogna E, Netti P, Pedone C, Galdiero M, Galdiero S
* A peptide derived from herpes simplex virus type 1 glycoprotein H: membrane translocation and applications to the delivery of quantum dots (1132 views)
Nanomedicine (ISSN: 1549-9642, 1549-9634, 1549-9642electronic), 2011 Dec; 7(6): 925-934.
Impact Factor: 6.692
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (458 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Falciani C, Accardo A, Brunetti J, Tesauro D, Lelli B, Pini A, Bracci L, Morelli G
* Target-Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides (609 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2011 Apr 4; 6(4): 678-685.
Impact Factor: 3.151
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (409 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G
* Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells (360 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2011; 96(1): 88-96.
Impact Factor: 2.87
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Moccia M, Musumeci D, Roviello GN, Fusco S, Valente M, Bucci EM, Sapio R, Pedonea C, Netti PA
* Preliminary studies on noncovalent hyperbranched polymers based on PNA and DNA building blocks (913 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Oct; 15(10): 647-653.
Impact Factor: 1.807
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1131 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Accardo A, Tesauro D, Morelli G, Del Pozzo L, Pedone C, Tornesello AL, Benedetti E
* Supramolecular aggregates derivatized by CCK8 peptide as selective nanocarriers for drug delivery (362 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 603-604.
Impact Factor: 2.02
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Marasco D, Perretta G, Sabatella M, Ruvo M
* Past and Future Perspectives of Synthetic Peptide Libraries (561 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2008 Oct; 9(5): 447-467.
Impact Factor: 3.011
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Accardo A, Tesauro D, Aloj L, Tarallo L, Arra C, Mangiapia G, Vaccaro M, Pedone C, Paduano L, Morelli G
* Peptide-containing aggregates as selective nanocarriers for therapeutics (392 views)
Chemmedchem (ISSN: 1860-7179, 1860-7187, 1860-7187electronic), 2008 Apr; 3(4): 594-602.
Impact Factor: 3.15
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (321 views)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Maggi A, Salvatore M
Molecular imaging (327 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 95-95.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (617 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Accardo A, Tesauro D, Mangiapia G, Pedone C, Morelli G
* Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers (438 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2007; 88(2): 115-121.
Impact Factor: 2.389
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Pappalardo M, Milardi D, Grasso D, La Rosa C
* Phase behaviour of polymer-grafted DPPC membranes for drug delivery systems design (302 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2005 May; 80(2): 413-418.
Impact Factor: 1.425
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Cortesi R, Mischiati C, Borgatti M, Breda L, Romanelli A, Saviano M, Pedone C, Gambari R, Nastruzzi C
* Formulations for natural and peptide nucleic acids based on cationic polymeric submicron particles (393 views)
The Aaps Journal (ISSN: 1522-1059, 1550-7416), 2004 Jan 20; 6(1): N/D-N/D.
Impact Factor: 1.938
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Borgatti M, Breda L, Cortesi R, Nastruzzi C, Romanelli A, Saviano M, Bianchi N, Mischiati C, Pedone C, Gambari R
* Cationic Liposomes As Delivery Systems For Double-Stranded Pna-Dna Chimeras Exhibiting Decoy Activity Against Nf-Kappab Transcription Factors (431 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 1873-2968, 0006-2952), 2002 Sep 15; 64(4): 609-616.
Impact Factor: 3.542
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59 Records (55 excluding Abstracts).
Total impact factor: 195.964 (184.809 excluding Abstracts).
Total 5 year impact factor: 188.985 (173.514 excluding Abstracts).
Total impact factor: 195.964 (184.809 excluding Abstracts).
Total 5 year impact factor: 188.985 (173.514 excluding Abstracts).
559 views. Last view on Sunday 14 May 2023, 21:10:55
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