Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity (510 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.463, 5-year impact factor: 4.027
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84870331075&partnerID=40&md5=9fa398d8e04f2028cd2717dd16c2c95d
Keywords: Complementary-Peptide, Porin, Rational Design, Activating Protein I, Cell Protein, Complementary Dna, Immunoglobulin Enhancer Binding Protein, Interleukin 6, Mitogen Activated Protein Kinase, Polypeptide Antibiotic Agent, Tumor Necrosis Factor Alpha, Unclassified Drug, Antibacterial Activity, Article, Bacterium Identification, Binding Affinity, Binding Site, Controlled Study, Cytokine Production, Disease Association, Drug Determination, Drug Protein Binding, Drug Synthesis, Enzyme Linked Immunosorbent Assay, Feedback System, Gel Filtration, Haemophilus Infection, Haemophilus Influenzae Type B, Molecular Dynamics, Molecular Pathology, Nonhuman, Protein Function, Protein Secretion, Signal Transduction, Algorithms, Bacterial Proteins, Catalytic Domain, Chromatography, Map Kinase Signaling System, Models, Biological, Nf-Kappa B, Salmonella Typhimurium, Transcription Factor Ap-1, Tumor Necrosis Factor-Alpha, U937 Cells, Bacteria (microorganisms), Haemophilus Influenzae Serotype B,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB and IBB CNR, University of Naples 'Federico II', Napoli, Italy
Department of Experimental Medicine, II University of Naples, Napoli, Italy
References:
Stein, R.A., Staros, J.V., Evolutionary analysis of the ErbB receptor and ligand families (2000) J Mol Evol., 50 (5), pp. 397-41
Ren, Y., Blaker, M., Seshadri, L., McBride, E.W., Beinborn, M., Kopin, A.S., Conserved cholecystokinin receptor transmembrane domain IV amino acids confer peptide affinity (2003) J Mol Neurosci., 20 (2), pp. 115-124
Selz, K.A., Samoylova, T.I., Samoylov, A.M., Vodyanoy, V.J., Mandell, A.J., Designing allosteric peptide ligands targeting a globular protein (2007) Biopolymers., 85 (1), pp. 38-59
Baranyi, L., Campbell, W., Ohshima, K., Fujimoto, S., Boros, M., Okada, H., The antisense homology box: A new motif within proteins that encodes biologically active peptides (1995) Nat Med., 1 (9), pp. 894-901
Blalock, J.E., Genetic origins of protein shape and interaction rules (1995) Nat Med., 1 (9), pp. 876-878
Bost, K.L., Blalock, J.E., Production of anti-idiotypic antibodies by immunization with a pair of complementary peptides (1989) J Mol Recognit., 1 (4), pp. 179-183
Rovati, G.E., Merli, S., Schwarz, S., Identification of hydropathically complementary putative contact sequences within epidermal growth factor (EGF) and the EGF receptor (1992) Life Sci., 51 (1), pp. 37-47
Araga, S., LeBoeuf, R.D., Blalock, J.E., Prevention of experimental autoimmune myasthenia gravis by manipulation of the immune network with a complementary peptide for the acetylcholine receptor (1993) Proc Natl Acad Sci U S A., 90 (18), pp. 8747-8751
Ruiz-Opazo, N., Akimoto, K., Herrera, V.L., Identification of a novel dual angiotensin II/vasopressin receptor on the basis of molecular recognition theory (1995) Nat Med., 1 (10), pp. 1074-1081
Davids, J.W., El-Bakri, A., Heal, J., Design of Antisense (Complementary) Peptides as Selective Inhibitors of Cytokine Interleukin-1 (1997) Angew Chem Int Ed Engl., 36, p. 6
Doherty, P., Williams, G., Williams, E.J., CAMs and axonal growth: A critical evaluation of the role of calcium and the MAPK cascade (2000) Mol Cell Neurosci., 16 (4), pp. 283-295
Heal, J.R., Roberts, G.W., Raynes, J.G., Bhakoo, A., Miller, A.D., Specific interactions between sense and complementary peptides: The basis for the proteomic code (2002) Chem Bio Chem., 3 (2-3), pp. 136-151
Imai, M., Baranyi, L., Okada, N., Okada, H., Inhibition of HIV-1 infection by synthetic peptides derived CCR5 fragments (2007) Biochem Biophys Res Commun., 353 (4), pp. 851-856
Luo, J., Zhang, Q., Huang, Y., Liu, G., Zhao, R., Quartz crystal microbalance biosensor for recombinant human interferon-beta detection based on antisense peptide approach (2007) Anal Chim Acta., 590 (1), pp. 91-97
Blalock, J.E., Smith, E.M., Hydropathic anti-complementarity of amino acids based on the genetic code (1984) Biochem Biophys Res Commun., 121 (1), pp. 203-207
Zhao, R., Yu, X., Liu, H., Study on the degeneracy of antisense peptides using affinity chromatography (2001) J Chromatogr A., 913 (1-2), pp. 421-428
Achouak, W., Heulin, T., Pages, J.M., Multiple facets of bacterial porins (2001) FEMS Microbiol Lett., 199 (1), pp. 1-7
Galdiero, M., Vitiello, M., Galdiero, S., Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (2003) FEMS Microbiol Lett., 226 (1), pp. 57-64
Naumann, M., Rudel, T., Meyer, T.F., Host cell interactions and signaling with Neisseria gonorrhoeae (1999) Curr Opin Microbiol., 2 (1), pp. 62-70
Galdiero, S., Galdiero, M., Pedone, C., beta-Barrel membrane bacterial proteins: Structure, function, assembly and interaction with lipids (2007) Curr Protein Pept Sci., 8 (1), pp. 63-82
Galdiero, S., Capasso, D., Vitiello, M., D'Isanto, M., Pedone, C., Galdiero, M., Role of surface-exposed loops of Haemophilus influenzae protein P2 in the mitogen-activated protein kinase cascade (2003) Infect Immun., 71 (5), pp. 2798-2809
Srikumar, R., Dahan, D., Gras, M.F., Ratcliffe, M.J., van Alphen, L., Coulton, J.W., Antigenic sites on porin of Haemophilus influenzae type b: Mapping with synthetic peptides and evaluation of structure predictions (1992) J Bacteriol., 174 (12), pp. 4007-4016
Galdiero, S., Vitiello, M., Amodeo, P., Structural requirements for proinflammatory activity of porin P2 Loop 7 from Haemophilus influenzae (2006) Biochemistry., 45 (14), pp. 4491-4501
Severino, V., Chambery, A., Vitiello, M., Proteomic analysis of human U937 cell line activation mediated by Haemophilus influenzae type b P2 porin and its surface-exposed loop 7 (2010) J Proteome Res., 9 (2), pp. 1050-1062
Galdiero, M., Tortora, A., Damiano, N., Vitiello, M., Longanella, A., Galdiero, E., Induction of cytokine mRNA expression in U937 cells by Salmonella typhimurium porins is regulated by different phosphorylation pathways (2005) Med Microbiol Immunol., 194 (1-2), pp. 13-23
Galdiero, M., D'Amico, M., Gorga, F., Haemophilus influenzae porin contributes to signaling of the inflammatory cascade in rat brain (2001) Infect Immun., 69 (1), pp. 221-227
Galdiero, M., D'Isanto, M., Vitiello, M., Finamore, E., Peluso, L., Porins from Salmonella enterica serovar Typhimurium induce TNF-alpha, IL-6 and IL-8 release by CD14-independent and CD11a/CD18-dependent mechanisms (2001) Microbiology., 147 (PART 10), pp. 2697-2704
Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) J Biol Chem., 193 (1), pp. 265-275
Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature., 227 (5259), pp. 680-685
Tsai, C.M., Frasch, C.E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal Biochem., 119 (1), pp. 115-119
Yin, E.T., Galanos, C., Kinsky, S., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria (1972) Biochim Biophys Acta., 261 (1), pp. 284-289
Nikaido, H., Rosenberg, E.Y., Porin channels in Escherichia coli: Studies with liposomes reconstituted from purified proteins (1983) J Bacteriol., 153 (1), pp. 241-252
Rapaport, D., Shai, Y., Interaction of fluorescently labeled analogues of the amino-terminal fusion peptide of Sendai virus with phospholipid membranes (1994) J Biol Chem., 269 (21), pp. 15124-15131
Issekutz, A.C., Removal of gram-negative endotoxin from solutions by affinity chromatography (1983) J Immunol Methods., 61 (3), pp. 275-281
Renard, P., Ernest, I., Houbion, A., Development of a sensitive multi-well colorimetric assay for active NFkappaB (2001) Nucleic Acids Res., 29 (4), pp. E21
Root-Bernstein, R.S., Amino acid pairing (1982) J Theor Biol., 94 (4), pp. 885-894
Kyte, J., Doolittle, R.F., A simple method for displaying the hydropathic character of a protein (1982) J Mol Biol., 157 (1), pp. 105-132
Yao, J., McKman, N., Edgington, T.S., Fan, S.T., Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors (1997) J Biol Chem., 272 (28), pp. 17795-17801
Marcatili, A., D'Isanto, M., Galdiero, M., Role of Pasteurella multocida, Pasteurella haemolytica and Salmonella typhimurium porins on inducible nitric oxide release by murine macrophages (2000) Res Microbiol., 151 (3), pp. 217-228
Galdiero, M., de Martino, L., Marcatili, A., Nuzzo, I., Vitiello, M., Cipollaro de l'Ero, G., Th1 and Th2 cell involvement in immune response to Salmonella typhimurium porins (1998) Immunology., 94 (1), pp. 5-13
Finamore, E., Vitiello, M., D'Isanto, M., Evidence for IL-6 promoter nuclear activation in U937 cells stimulated with Salmonella enterica serovar Typhimurium porins (2009) Eur Cytokine Netw., 20 (3), pp. 140-147
Iovane, G., Pagnini, P., Galdiero, M., Role of Pasteurella multocida porin on cytokine expression and release by murine splenocytes (1998) Vet Immunol Immunopathol., 66 (3-4), pp. 391-404
Fassina, G., Cassani, G., Gnocchi, P., Fornasiero, M.C., Isetta, A.M., Inhibition of interleukin-2/p55 receptor subunit interaction by complementary peptides (1995) Arch Biochem Biophys., 318 (1), pp. 37-45
Galdiero, M., Cantisani, M., Tarallo, R., Falanga, A., Galdiero, S., (2012) Septic Shock by Gram-Negative Infections: Role of Outer Membrane Proteins, in Severe Sepsis and Septic Shock-Understanding a Serious Killer, pp. 27-46. , Dr Ricardo Fernandez (Ed.), ISBN: 978-953-307-950-9, InTech
Stein, R. A., Staros, J. V., Evolutionary analysis of the ErbB receptor and ligand families (2000) J Mol Evol., 50 (5), pp. 397-41
Selz, K. A., Samoylova, T. I., Samoylov, A. M., Vodyanoy, V. J., Mandell, A. J., Designing allosteric peptide ligands targeting a globular protein (2007) Biopolymers., 85 (1), pp. 38-59
Blalock, J. E., Genetic origins of protein shape and interaction rules (1995) Nat Med., 1 (9), pp. 876-878
Bost, K. L., Blalock, J. E., Production of anti-idiotypic antibodies by immunization with a pair of complementary peptides (1989) J Mol Recognit., 1 (4), pp. 179-183
Rovati, G. E., Merli, S., Schwarz, S., Identification of hydropathically complementary putative contact sequences within epidermal growth factor (EGF) and the EGF receptor (1992) Life Sci., 51 (1), pp. 37-47
Davids, J. W., El-Bakri, A., Heal, J., Design of Antisense (Complementary) Peptides as Selective Inhibitors of Cytokine Interleukin-1 (1997) Angew Chem Int Ed Engl., 36, p. 6
Heal, J. R., Roberts, G. W., Raynes, J. G., Bhakoo, A., Miller, A. D., Specific interactions between sense and complementary peptides: The basis for the proteomic code (2002) Chem Bio Chem., 3 (2-3), pp. 136-151
Blalock, J. E., Smith, E. M., Hydropathic anti-complementarity of amino acids based on the genetic code (1984) Biochem Biophys Res Commun., 121 (1), pp. 203-207
Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J., Protein measurement with the Folin phenol reagent (1951) J Biol Chem., 193 (1), pp. 265-275
Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature., 227 (5259), pp. 680-685
Tsai, C. M., Frasch, C. E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal Biochem., 119 (1), pp. 115-119
Yin, E. T., Galanos, C., Kinsky, S., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria (1972) Biochim Biophys Acta., 261 (1), pp. 284-289
Issekutz, A. C., Removal of gram-negative endotoxin from solutions by affinity chromatography (1983) J Immunol Methods., 61 (3), pp. 275-281
Root-Bernstein, R. S., Amino acid pairing (1982) J Theor Biol., 94 (4), pp. 885-894
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2012; 7: 2361-2371.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.463, 5-year impact factor: 4.027
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84870331075&partnerID=40&md5=9fa398d8e04f2028cd2717dd16c2c95d
Keywords: Complementary-Peptide, Porin, Rational Design, Activating Protein I, Cell Protein, Complementary Dna, Immunoglobulin Enhancer Binding Protein, Interleukin 6, Mitogen Activated Protein Kinase, Polypeptide Antibiotic Agent, Tumor Necrosis Factor Alpha, Unclassified Drug, Antibacterial Activity, Article, Bacterium Identification, Binding Affinity, Binding Site, Controlled Study, Cytokine Production, Disease Association, Drug Determination, Drug Protein Binding, Drug Synthesis, Enzyme Linked Immunosorbent Assay, Feedback System, Gel Filtration, Haemophilus Infection, Haemophilus Influenzae Type B, Molecular Dynamics, Molecular Pathology, Nonhuman, Protein Function, Protein Secretion, Signal Transduction, Algorithms, Bacterial Proteins, Catalytic Domain, Chromatography, Map Kinase Signaling System, Models, Biological, Nf-Kappa B, Salmonella Typhimurium, Transcription Factor Ap-1, Tumor Necrosis Factor-Alpha, U937 Cells, Bacteria (microorganisms), Haemophilus Influenzae Serotype B,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, CIRPeB and IBB CNR, University of Naples 'Federico II', Napoli, Italy
Department of Experimental Medicine, II University of Naples, Napoli, Italy
References:
Stein, R.A., Staros, J.V., Evolutionary analysis of the ErbB receptor and ligand families (2000) J Mol Evol., 50 (5), pp. 397-41
Ren, Y., Blaker, M., Seshadri, L., McBride, E.W., Beinborn, M., Kopin, A.S., Conserved cholecystokinin receptor transmembrane domain IV amino acids confer peptide affinity (2003) J Mol Neurosci., 20 (2), pp. 115-124
Selz, K.A., Samoylova, T.I., Samoylov, A.M., Vodyanoy, V.J., Mandell, A.J., Designing allosteric peptide ligands targeting a globular protein (2007) Biopolymers., 85 (1), pp. 38-59
Baranyi, L., Campbell, W., Ohshima, K., Fujimoto, S., Boros, M., Okada, H., The antisense homology box: A new motif within proteins that encodes biologically active peptides (1995) Nat Med., 1 (9), pp. 894-901
Blalock, J.E., Genetic origins of protein shape and interaction rules (1995) Nat Med., 1 (9), pp. 876-878
Bost, K.L., Blalock, J.E., Production of anti-idiotypic antibodies by immunization with a pair of complementary peptides (1989) J Mol Recognit., 1 (4), pp. 179-183
Rovati, G.E., Merli, S., Schwarz, S., Identification of hydropathically complementary putative contact sequences within epidermal growth factor (EGF) and the EGF receptor (1992) Life Sci., 51 (1), pp. 37-47
Araga, S., LeBoeuf, R.D., Blalock, J.E., Prevention of experimental autoimmune myasthenia gravis by manipulation of the immune network with a complementary peptide for the acetylcholine receptor (1993) Proc Natl Acad Sci U S A., 90 (18), pp. 8747-8751
Ruiz-Opazo, N., Akimoto, K., Herrera, V.L., Identification of a novel dual angiotensin II/vasopressin receptor on the basis of molecular recognition theory (1995) Nat Med., 1 (10), pp. 1074-1081
Davids, J.W., El-Bakri, A., Heal, J., Design of Antisense (Complementary) Peptides as Selective Inhibitors of Cytokine Interleukin-1 (1997) Angew Chem Int Ed Engl., 36, p. 6
Doherty, P., Williams, G., Williams, E.J., CAMs and axonal growth: A critical evaluation of the role of calcium and the MAPK cascade (2000) Mol Cell Neurosci., 16 (4), pp. 283-295
Heal, J.R., Roberts, G.W., Raynes, J.G., Bhakoo, A., Miller, A.D., Specific interactions between sense and complementary peptides: The basis for the proteomic code (2002) Chem Bio Chem., 3 (2-3), pp. 136-151
Imai, M., Baranyi, L., Okada, N., Okada, H., Inhibition of HIV-1 infection by synthetic peptides derived CCR5 fragments (2007) Biochem Biophys Res Commun., 353 (4), pp. 851-856
Luo, J., Zhang, Q., Huang, Y., Liu, G., Zhao, R., Quartz crystal microbalance biosensor for recombinant human interferon-beta detection based on antisense peptide approach (2007) Anal Chim Acta., 590 (1), pp. 91-97
Blalock, J.E., Smith, E.M., Hydropathic anti-complementarity of amino acids based on the genetic code (1984) Biochem Biophys Res Commun., 121 (1), pp. 203-207
Zhao, R., Yu, X., Liu, H., Study on the degeneracy of antisense peptides using affinity chromatography (2001) J Chromatogr A., 913 (1-2), pp. 421-428
Achouak, W., Heulin, T., Pages, J.M., Multiple facets of bacterial porins (2001) FEMS Microbiol Lett., 199 (1), pp. 1-7
Galdiero, M., Vitiello, M., Galdiero, S., Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (2003) FEMS Microbiol Lett., 226 (1), pp. 57-64
Naumann, M., Rudel, T., Meyer, T.F., Host cell interactions and signaling with Neisseria gonorrhoeae (1999) Curr Opin Microbiol., 2 (1), pp. 62-70
Galdiero, S., Galdiero, M., Pedone, C., beta-Barrel membrane bacterial proteins: Structure, function, assembly and interaction with lipids (2007) Curr Protein Pept Sci., 8 (1), pp. 63-82
Galdiero, S., Capasso, D., Vitiello, M., D'Isanto, M., Pedone, C., Galdiero, M., Role of surface-exposed loops of Haemophilus influenzae protein P2 in the mitogen-activated protein kinase cascade (2003) Infect Immun., 71 (5), pp. 2798-2809
Srikumar, R., Dahan, D., Gras, M.F., Ratcliffe, M.J., van Alphen, L., Coulton, J.W., Antigenic sites on porin of Haemophilus influenzae type b: Mapping with synthetic peptides and evaluation of structure predictions (1992) J Bacteriol., 174 (12), pp. 4007-4016
Galdiero, S., Vitiello, M., Amodeo, P., Structural requirements for proinflammatory activity of porin P2 Loop 7 from Haemophilus influenzae (2006) Biochemistry., 45 (14), pp. 4491-4501
Severino, V., Chambery, A., Vitiello, M., Proteomic analysis of human U937 cell line activation mediated by Haemophilus influenzae type b P2 porin and its surface-exposed loop 7 (2010) J Proteome Res., 9 (2), pp. 1050-1062
Galdiero, M., Tortora, A., Damiano, N., Vitiello, M., Longanella, A., Galdiero, E., Induction of cytokine mRNA expression in U937 cells by Salmonella typhimurium porins is regulated by different phosphorylation pathways (2005) Med Microbiol Immunol., 194 (1-2), pp. 13-23
Galdiero, M., D'Amico, M., Gorga, F., Haemophilus influenzae porin contributes to signaling of the inflammatory cascade in rat brain (2001) Infect Immun., 69 (1), pp. 221-227
Galdiero, M., D'Isanto, M., Vitiello, M., Finamore, E., Peluso, L., Porins from Salmonella enterica serovar Typhimurium induce TNF-alpha, IL-6 and IL-8 release by CD14-independent and CD11a/CD18-dependent mechanisms (2001) Microbiology., 147 (PART 10), pp. 2697-2704
Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) J Biol Chem., 193 (1), pp. 265-275
Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature., 227 (5259), pp. 680-685
Tsai, C.M., Frasch, C.E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal Biochem., 119 (1), pp. 115-119
Yin, E.T., Galanos, C., Kinsky, S., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria (1972) Biochim Biophys Acta., 261 (1), pp. 284-289
Nikaido, H., Rosenberg, E.Y., Porin channels in Escherichia coli: Studies with liposomes reconstituted from purified proteins (1983) J Bacteriol., 153 (1), pp. 241-252
Rapaport, D., Shai, Y., Interaction of fluorescently labeled analogues of the amino-terminal fusion peptide of Sendai virus with phospholipid membranes (1994) J Biol Chem., 269 (21), pp. 15124-15131
Issekutz, A.C., Removal of gram-negative endotoxin from solutions by affinity chromatography (1983) J Immunol Methods., 61 (3), pp. 275-281
Renard, P., Ernest, I., Houbion, A., Development of a sensitive multi-well colorimetric assay for active NFkappaB (2001) Nucleic Acids Res., 29 (4), pp. E21
Root-Bernstein, R.S., Amino acid pairing (1982) J Theor Biol., 94 (4), pp. 885-894
Kyte, J., Doolittle, R.F., A simple method for displaying the hydropathic character of a protein (1982) J Mol Biol., 157 (1), pp. 105-132
Yao, J., McKman, N., Edgington, T.S., Fan, S.T., Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells. Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors (1997) J Biol Chem., 272 (28), pp. 17795-17801
Marcatili, A., D'Isanto, M., Galdiero, M., Role of Pasteurella multocida, Pasteurella haemolytica and Salmonella typhimurium porins on inducible nitric oxide release by murine macrophages (2000) Res Microbiol., 151 (3), pp. 217-228
Galdiero, M., de Martino, L., Marcatili, A., Nuzzo, I., Vitiello, M., Cipollaro de l'Ero, G., Th1 and Th2 cell involvement in immune response to Salmonella typhimurium porins (1998) Immunology., 94 (1), pp. 5-13
Finamore, E., Vitiello, M., D'Isanto, M., Evidence for IL-6 promoter nuclear activation in U937 cells stimulated with Salmonella enterica serovar Typhimurium porins (2009) Eur Cytokine Netw., 20 (3), pp. 140-147
Iovane, G., Pagnini, P., Galdiero, M., Role of Pasteurella multocida porin on cytokine expression and release by murine splenocytes (1998) Vet Immunol Immunopathol., 66 (3-4), pp. 391-404
Fassina, G., Cassani, G., Gnocchi, P., Fornasiero, M.C., Isetta, A.M., Inhibition of interleukin-2/p55 receptor subunit interaction by complementary peptides (1995) Arch Biochem Biophys., 318 (1), pp. 37-45
Galdiero, M., Cantisani, M., Tarallo, R., Falanga, A., Galdiero, S., (2012) Septic Shock by Gram-Negative Infections: Role of Outer Membrane Proteins, in Severe Sepsis and Septic Shock-Understanding a Serious Killer, pp. 27-46. , Dr Ricardo Fernandez (Ed.), ISBN: 978-953-307-950-9, InTech
Stein, R. A., Staros, J. V., Evolutionary analysis of the ErbB receptor and ligand families (2000) J Mol Evol., 50 (5), pp. 397-41
Selz, K. A., Samoylova, T. I., Samoylov, A. M., Vodyanoy, V. J., Mandell, A. J., Designing allosteric peptide ligands targeting a globular protein (2007) Biopolymers., 85 (1), pp. 38-59
Blalock, J. E., Genetic origins of protein shape and interaction rules (1995) Nat Med., 1 (9), pp. 876-878
Bost, K. L., Blalock, J. E., Production of anti-idiotypic antibodies by immunization with a pair of complementary peptides (1989) J Mol Recognit., 1 (4), pp. 179-183
Rovati, G. E., Merli, S., Schwarz, S., Identification of hydropathically complementary putative contact sequences within epidermal growth factor (EGF) and the EGF receptor (1992) Life Sci., 51 (1), pp. 37-47
Davids, J. W., El-Bakri, A., Heal, J., Design of Antisense (Complementary) Peptides as Selective Inhibitors of Cytokine Interleukin-1 (1997) Angew Chem Int Ed Engl., 36, p. 6
Heal, J. R., Roberts, G. W., Raynes, J. G., Bhakoo, A., Miller, A. D., Specific interactions between sense and complementary peptides: The basis for the proteomic code (2002) Chem Bio Chem., 3 (2-3), pp. 136-151
Blalock, J. E., Smith, E. M., Hydropathic anti-complementarity of amino acids based on the genetic code (1984) Biochem Biophys Res Commun., 121 (1), pp. 203-207
Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J., Protein measurement with the Folin phenol reagent (1951) J Biol Chem., 193 (1), pp. 265-275
Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4 (1970) Nature., 227 (5259), pp. 680-685
Tsai, C. M., Frasch, C. E., A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels (1982) Anal Biochem., 119 (1), pp. 115-119
Yin, E. T., Galanos, C., Kinsky, S., Picogram-sensitive assay for endotoxin: Gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria (1972) Biochim Biophys Acta., 261 (1), pp. 284-289
Issekutz, A. C., Removal of gram-negative endotoxin from solutions by affinity chromatography (1983) J Immunol Methods., 61 (3), pp. 275-281
Root-Bernstein, R. S., Amino acid pairing (1982) J Theor Biol., 94 (4), pp. 885-894
Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity
Haemophilus influenzae type b (Hib) is one of the leading causes of invasive bacterial infection in young children. It is characterized by inflammation that is mainly mediated by cytokines and chemokines. One of the most abundant components of the Hib outer membrane is the P2 porin, which has been shown to induce the release of several inflammatory cytokines. A synthetic peptide corresponding to loop L7 of the porin activates JNK and p38 mitogen-activated protein kinase (MAPK) pathways. We report a novel use of the complementary peptide approach to design a peptide that is able to bind selectively to the protein P2, thereby reducing its activity. This work provides insights into essential molecular details of P2 that may affect the pathogenesis of Hib infections where interruption of the signaling cascade could represent an attractive therapeutic strategy.
Haemophilus influenzae type b (Hib) is one of the leading causes of invasive bacterial infection in young children. It is characterized by inflammation that is mainly mediated by cytokines and chemokines. One of the most abundant components of the Hib outer membrane is the P2 porin, which has been shown to induce the release of several inflammatory cytokines. A synthetic peptide corresponding to loop L7 of the porin activates JNK and p38 mitogen-activated protein kinase (MAPK) pathways. We report a novel use of the complementary peptide approach to design a peptide that is able to bind selectively to the protein P2, thereby reducing its activity. This work provides insights into essential molecular details of P2 that may affect the pathogenesis of Hib infections where interruption of the signaling cascade could represent an attractive therapeutic strategy.
Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity
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Peptides complementary to the active loop of porin P2 from Haemophilus influenzae modulate its activity
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Ronda L, Tonelli A, Sogne E, Autiero I, Spyrakis F, Pellegrino S, Abbiati G, Maffioli E, Schulte C, Piano R, Cozzini P, Mozzarelli A, Bettati S, Clerici F, Milani P, Lenardi C, Tedeschi G, Gelmi ML
* Rational Design of a User-Friendly Aptamer/Peptide-Based Device for the Detection of Staphylococcus aureus (84 views)
Sensors (ISSN: 1424-8220linking, 1424-3210), 2020 Sep 2; 20(17): N/D-N/D.
Impact Factor: 3.275
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Caserta G, Chino M, Firpo V, Zambrano G, Leone L, D'Alonzo D, Nastri F, Maglio O, Pavone V, Lombardi A
* Enhancement of Peroxidase Activity in Artificial Mimochrome VI Catalysts through Rational Design (266 views)
Chembiochem, 2018; 19: 1823-1826.
Impact Factor: 2.774
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Cucciolito ME, Trinchillo M, Iannitti R, Palumbo R, Tesauro D, Tuzi A, Ruffo F, D'Amora A
* Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (328 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Impact Factor: 2.507
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D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
* Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis (453 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Feb; 97(1): 114-120.
Impact Factor: 2.963
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Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
* Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity (568 views)
Faseb J (ISSN: 0892-6638, 0892-6638linking), 2011 Apr; 25(4): 1230-1243.
Impact Factor: 5.712
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA (414 views)
Lect Notes Electr Eng, 2010 May 15; 91LNEE: 485-488.
Impact Factor: 0
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (422 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
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Palladino P, Ronga L, Benedetti E, Rossi F, Ragone R
* Peptide Fragment Approach to Prion Misfolding: The Alpha-2 Domain (401 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2009 Sep; 15(3): 165-176.
Impact Factor: 0.869
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Francalanci F, Avolio M, De Luca E, Longo DL, Menchise V, Guazzi P, Sgro F, Marino M, Goitre L, Balzac F, Trabalzini L, Retta SF
* Structural and functional differences between KRIT1A and KRIT1B isoforms: A framework for understanding CCM pathogenesis (493 views)
Exp Cell Res (ISSN: 0014-4827), 2009 Jan 15; 315(2): 285-303.
Impact Factor: 3.589
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Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (302 views)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
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Staiano M, Saviano M, Herman P, Grycznyski Z, Fini C, Varriale A, Parracino A, Kold AB, Rossi M, D'Auria S
* Time-resolved fluorescence spectroscopy and molecular dynamics simulations point out the effects of pressure on the stability and dynamics of the porcine odorant-binding protein (608 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 89(4): 284-291.
Impact Factor: 2.823
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Chambery A, Pisante M, Di Maro A, Di Zazzo E, Ruvo M, Costantini S, Colonna G, Parente A
* Invariant Ser211 is involved in the catalysis of PD-L4, type I RIP from Phytolacca dioica leaves (364 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Apr 1; 67(1): 209-218.
Impact Factor: 3.354
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Pedone E, Limauro D, D'Alterio R, Rossi M, Bartolucci S
* Characterization of a multifunctional protein disulfide oxidoreductase from Sulfolobus solfataricus (328 views)
Febs Journal (ISSN: 1742-464x), 2006 Dec; 273(23): 5407-5420.
Impact Factor: 3.033
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Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (478 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
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Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (511 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
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Esposito G, Vitagliano L, Costanzo P, Borrelli L, Barone R, Pavone L, Izzo P, Zagari A, Salvatore F
* Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function (378 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2004 May 15; 380: 51-56.
Impact Factor: 4.278
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (581 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
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Yonath A, Bashan A, Zarivach R, Franceschi F, Schluenzen F, Harms J, Albrecht R, Berisio R
* Methods Of Growing Crystals Of Free, Antibiotic-Complexed, And Substrate-Complexed Large Ribosomal Subunits, And Methods Of Rational Designing Or Identifying Antibiotics Using Structure Coordinate Data Derived From Such Crystals (292 views)
International Publication Number, 2003; N/D: N/D-N/D.
Impact Factor: 4.622
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Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (401 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
View Export to BibTeX Export to EndNote
De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (622 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
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De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
A facile solid-phase strategy for the synthesis of oligonucleotide- tetraphenylporphyrin conjugates (399 views)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2000; (6): 1013-1018.
Impact Factor: 2.15
View Export to BibTeX Export to EndNote
* Rational Design of a User-Friendly Aptamer/Peptide-Based Device for the Detection of Staphylococcus aureus (84 views)
Sensors (ISSN: 1424-8220linking, 1424-3210), 2020 Sep 2; 20(17): N/D-N/D.
Impact Factor: 3.275
View Export to BibTeX Export to EndNote
Caserta G, Chino M, Firpo V, Zambrano G, Leone L, D'Alonzo D, Nastri F, Maglio O, Pavone V, Lombardi A
* Enhancement of Peroxidase Activity in Artificial Mimochrome VI Catalysts through Rational Design (266 views)
Chembiochem, 2018; 19: 1823-1826.
Impact Factor: 2.774
View Export to BibTeX Export to EndNote
Cucciolito ME, Trinchillo M, Iannitti R, Palumbo R, Tesauro D, Tuzi A, Ruffo F, D'Amora A
* Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (328 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Impact Factor: 2.507
View Export to BibTeX Export to EndNote
D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
* Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis (453 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Feb; 97(1): 114-120.
Impact Factor: 2.963
View Export to BibTeX Export to EndNote
Lusso P, Vangelista L, Cimbro R, Secchi M, Sironi F, Longhi R, Faiella M, Maglio O, Pavone V
* Molecular engineering of RANTES peptide mimetics with potent anti-HIV-1 activity (568 views)
Faseb J (ISSN: 0892-6638, 0892-6638linking), 2011 Apr; 25(4): 1230-1243.
Impact Factor: 5.712
View Export to BibTeX Export to EndNote
D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA (414 views)
Lect Notes Electr Eng, 2010 May 15; 91LNEE: 485-488.
Impact Factor: 0
View Export to BibTeX Export to EndNote
D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (422 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
View Export to BibTeX Export to EndNote
Palladino P, Ronga L, Benedetti E, Rossi F, Ragone R
* Peptide Fragment Approach to Prion Misfolding: The Alpha-2 Domain (401 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2009 Sep; 15(3): 165-176.
Impact Factor: 0.869
View Export to BibTeX Export to EndNote
Francalanci F, Avolio M, De Luca E, Longo DL, Menchise V, Guazzi P, Sgro F, Marino M, Goitre L, Balzac F, Trabalzini L, Retta SF
* Structural and functional differences between KRIT1A and KRIT1B isoforms: A framework for understanding CCM pathogenesis (493 views)
Exp Cell Res (ISSN: 0014-4827), 2009 Jan 15; 315(2): 285-303.
Impact Factor: 3.589
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, Bucci EM, Castiglione M, Cesarani A, Pedone C, Piccialli G
* Evidences for complex formation between l-dabPNA and aegPNA (302 views)
Bioorg Med Chem Lett (ISSN: 0960-894x, 1464-3405, 1464-3405electronic), 2008 Sep 1; 18(17): 4757-4760.
Impact Factor: 2.531
View Export to BibTeX Export to EndNote
Staiano M, Saviano M, Herman P, Grycznyski Z, Fini C, Varriale A, Parracino A, Kold AB, Rossi M, D'Auria S
* Time-resolved fluorescence spectroscopy and molecular dynamics simulations point out the effects of pressure on the stability and dynamics of the porcine odorant-binding protein (608 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 89(4): 284-291.
Impact Factor: 2.823
View Export to BibTeX Export to EndNote
Chambery A, Pisante M, Di Maro A, Di Zazzo E, Ruvo M, Costantini S, Colonna G, Parente A
* Invariant Ser211 is involved in the catalysis of PD-L4, type I RIP from Phytolacca dioica leaves (364 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Apr 1; 67(1): 209-218.
Impact Factor: 3.354
View Export to BibTeX Export to EndNote
Pedone E, Limauro D, D'Alterio R, Rossi M, Bartolucci S
* Characterization of a multifunctional protein disulfide oxidoreductase from Sulfolobus solfataricus (328 views)
Febs Journal (ISSN: 1742-464x), 2006 Dec; 273(23): 5407-5420.
Impact Factor: 3.033
View Export to BibTeX Export to EndNote
Roviello GN, Moccia M, Sapio R, Valente M, Bucci EM, Castiglione M, Pedone C, Perretta G, Benedetti E, Musumeci D
* Synthesis, Characterization And Hybridization Studies Of New Nucleo-Gamma-Peptides Based On Diaminobutyric Acid (478 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 829-835.
Impact Factor: 1.801
View Export to BibTeX Export to EndNote
Zannetti A, Del Vecchio S, Romanelli A, Scala S, Saviano M, Cali' G, Stoppelli MP, Pedone C, Salvatore M
* Inhibition of Sp1 activity by a decoy PNA-DNA chimera prevents urokinase receptor expression and migration of breast cancer cells (511 views)
Biochem Pharmacol Biochemical Pharmacology (ISSN: 0006-2952, 1873-2968), 2005 Nov 1; 70(9): 1277-1287.
Impact Factor: 3.617
View Export to BibTeX Export to EndNote
Esposito G, Vitagliano L, Costanzo P, Borrelli L, Barone R, Pavone L, Izzo P, Zagari A, Salvatore F
* Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function (378 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2004 May 15; 380: 51-56.
Impact Factor: 4.278
View Export to BibTeX Export to EndNote
Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (581 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
View Export to BibTeX Export to EndNote
Yonath A, Bashan A, Zarivach R, Franceschi F, Schluenzen F, Harms J, Albrecht R, Berisio R
* Methods Of Growing Crystals Of Free, Antibiotic-Complexed, And Substrate-Complexed Large Ribosomal Subunits, And Methods Of Rational Designing Or Identifying Antibiotics Using Structure Coordinate Data Derived From Such Crystals (292 views)
International Publication Number, 2003; N/D: N/D-N/D.
Impact Factor: 4.622
View Export to BibTeX Export to EndNote
Zell R, Sidigi K, Bucci E, Stelzner A, Goerlach M
* Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C (401 views)
Rna (ISSN: 1355-8382), 2002; 8(2): 188-201.
Impact Factor: 5.099
View Export to BibTeX Export to EndNote
De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (622 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
View Export to BibTeX Export to EndNote
De Napoli L, De Luca S, Di Fabio G, Messere A, Montesarchio D, Morelli G, Piccialli G, Tesauro D
A facile solid-phase strategy for the synthesis of oligonucleotide- tetraphenylporphyrin conjugates (399 views)
European Journal Of Organic Chemistry (ISSN: 1434-193x), 2000; (6): 1013-1018.
Impact Factor: 2.15
View Export to BibTeX Export to EndNote
21 Records (21 excluding Abstracts).
Total impact factor: 69.629 (69.629 excluding Abstracts).
Total 5 year impact factor: 69.193 (69.193 excluding Abstracts).
Total impact factor: 69.629 (69.629 excluding Abstracts).
Total 5 year impact factor: 69.193 (69.193 excluding Abstracts).
510 views. Last view on Friday 17 March 2023, 12:27:53
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