Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c)(324 views) Messori L, Cinellu MA, Merlino A
Acs Med Chem Lett (ISSN: 1948-5875, 1948-5875linking), 2014 Jul 31; 5(10): 1110-1113.
Keywords: Gold-Based Drugs, Metallodrugs, Protein-Ligand Interactions, Antineoplastic Agent, Egg White, Glutamine, Lysozyme, Organogold Compound, Prodrug, Article, Complex Formation, Crystal Structure, Drug Protein Binding, Molecular Recognition, Reduction, X Ray Crystallography, X Ray Diffraction,
Affiliations: *** IBB - CNR ***
Department of Chemistry, University of Florence, Via della Lastruccia, 3-13Florence, Italy
CNR Institute of Biostructure and Bioimages, via Mezzocannone 16Napoli, Italy
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Tanley, S. W. M., Schreurs, A. M. M., Helliwell, J. R., Kroon-Batenburg, L. M. J., Experience with exchange and archiving of raw data: Comparison of data from two diffractometers and four software packages on a series of lysozyme crystals (2013) J. Appl. Crystallogr., 46, pp. 108-119
Tanley, S. W. M., Diederichs, K., Kroon-Batenburg, L. M. J., Schreurs, A. M. M., Helliwell, J. R., Experiences with archived raw diffraction images data: Capturing cisplatin after chemical conversion of carboplatin in high salt conditions for a protein crystal (2013) J. Synchrotron Radiat., 20, pp. 880-883
Murshudov, G. N., Skuba, K. P., Lebedev, A. A., Pannu, N. S., Steiner, R. A., Nicholls, R. A., Winn, M. D., Vagin, A. A., REFMAC5 for the refinement of macromolecular crystal structures (2011) Acta Crystallogr., Sect. D: Biol. Crystallogr., 67, pp. 355-367
Cinellu, M. A., Minghetti, G., Pinna, M. V., Stoccoro, S., Zucca, A., Synthesis and characterization of mononuclear amidogold (III) complexes. Crystal structure of [Au (N2C10H7 (CMe2C6H4) -6] (NHC6H3Me2-2, 6)] [PF6]. Oxidation of 4-methyl-aniline to azotoluene (2003) Eur. J. Inorg. Chem., p. 2304. , Results to be published. For N-H bond activation of aryl- and alkylamines by Aubipyc see - 2310
Soldatov, M. A., Ascone, I., Congiu-Castellano, A., Messori, L., Cinellu, M. A., Balerna, A., Soldatov, A. V., Yalovega, G. E., Potential antitumor gold drugs: DFT and XANES studies of local atomic and electronic structure (2009) J. Phys.: Conf. Ser., 190, pp. 1-4
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Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c)
The structure of the adduct formed in the reaction between Aubipy(c), a cytotoxic organogold(III) compound, and the model protein hen egg white lysozyme (HEWL) has been solved by X-ray crystallography. It emerges that Aubipyc, after interaction with HEWL, undergoes reduction of the gold(III) center followed by detaching of the cyclometalated ligand; the resulting naked gold(I) ion is found bound to the protein at G1n121. A direct comparison between the present structure and those previously solved for the lysozyme adducts with other gold(III) compounds demonstrates that coordinated ligands play a key role in the protein metallodrug recognition process. Structural data support the view that gold(III)-based antitumor prodrugs are activated through metal reduction.
Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c)
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Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c)
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