Screening for dopa-responsive dystonia in patients with scans without evidence of dopaminergic deficiency (SWEDD) (447 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 0340-5354print), 2014 Nov; 261(11): 2204-2208.
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Paper type: Journal Article,
Impact factor: 3.377, 5-year impact factor: 3.495
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84920942539&partnerID=40&md5=d23377bd1dd3db05d1d69f0188aaaef7
Keywords: Dopa-Responsive Dystonia, Gtp-Cyclohydrolase1, Swedd, [123i]fp-Cit Spect, Biopterin, Guanosine Triphosphate Cyclohydrolase I, Iodine 123, Neopterin, Phenylalanine, Adult, Aged, Article, Biochemical Composition, Bradykinesia, Clinical Article, Controlled Study, Dopa Responsive Dystonia, Dyskinesia, Female, Gene Mutation, Human, Hypothesis, Middle Aged, Neurologic Disease, Neurologic Examination, Parkinsonism, Priority Journal, Scans Without Evidence Of Dopaminergic Deficiency, Segmental Dystonia, Single Photon Emission Computer Tomography, Tremor, [123i] Fp-Cit Spect, Dystonic Disorders, Genetic Screening, Procedures, Genetic Testing, Gtp Cyclohydrolase,
Affiliations:
*** IBB - CNR ***
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Federico II University, Via Pansini 5, 80131, Naples, Italy, anna_derosa@libero.it.
Department of Experimental Medicine, Sapienza University of RomeRome, Italy
Biostructure and Bioimaging Institute CNRNaples, Italy
References:
Parkinson Study Group, Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression (2002) JAMA, 287, pp. 1653-166
Whone, A.L., Watts, R.L., Stoessl, A.J., Davis, M., Reske, S., Nahmias, C., Lang, A.E., REAL-PET Study Group, Slower progression of Parkinson’s disease with ropinirole versus levodopa: the REAL-PET study (2003) Ann Neurol, 54, pp. 93-101. , COI: 1:CAS:528:DC%2BD3sXlvVWisrw%3D, PID: 12838524
Fahn, S., Oakes, D., Shoulson, I., Kieburtz, K., Rudolph, A., Lang, A., Olanow, C.W., Parkinson Study Group, Levodopa and the progression of Parkinson’s disease (2004) N Engl J Med, 351, pp. 2498-2508. , COI: 1:CAS:528:DC%2BD2cXhtVGksbnE, PID: 15590952
Marshall, V.L., Patterson, J., Hadley, D.M., Grosset, K.A., Grosset, D.G., Two-year follow-up in 150 consecutive cases with normal dopamine transporter imaging (2006) Nucl Med Commun, 27, pp. 933-937. , PID: 17088677
Hughes, A.J., Daniel, S.E., Ben-Shlomo, Y., Lees, A.J., The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service (2002) Brain, 125, pp. 861-870. , PID: 11912118
Silveira-Moriyama, L., Schwingenschuh, P., O’Donnell, A., Schneider, S.A., Mir, P., Carrillo, F., Terranova, C., Lees, A.J., Olfaction in patients with suspected Parkinsonism and scans without evidence of dopaminergic deficit (SWEDDs) (2009) J Neurol Neurosurg Psychiatry, 80, pp. 744-748. , COI: 1:STN:280:DC%2BD1MvitlSrtw%3D%3D, PID: 19276101
Schneider, S.A., Edwards, M.J., Mir, P., Cordivari, C., Hooker, J., Dickson, J., Quinn, N., Bhatia, K.P., Patients with adult-onset dystonic tremor resembling parkinsonian tremor have scans without evidence of dopaminergic deficit (SWEDDs) (2007) Mov Disord, 22, pp. 2210-2215. , PID: 17712858
Segawa, M., Autosomal dominant GTP cyclohydrolase I (AD GCH 1) deficiency (Segawa disease, dystonia 5
DYT 5) (2003) Chang Gung Med J, 32, pp. 1-11
Ichinose, H., Ohye, T., Takahashi, E., Seki, N., Hori, T., Segawa, M., Nomura, Y., Nagatsu, T., Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene (1994) Nat Genet, 8, pp. 236-242. , COI: 1:CAS:528:DyaK2MXitVOgtLk%3D, PID: 7874165
Nygaard, T.G., Trugman, J.M., de Yebenes, J.G., Fahn, S., Dopa-responsive dystonia: the spectrum of clinical manifestations in a large North American family (1990) Neurology, 40, pp. 66-69. , COI: 1:STN:280:DyaK3c7hsVKrtg%3D%3D, PID: 2296384
Trender-Gerhard, I., Sweeney, M.G., Schwingenschuh, P., Mir, P., Edwards, M.J., Gerhard, A., Polke, J.M., Bhatia, K.P., Autosomal-dominant GTPCH1-deficient DRD: clinical characteristics and long-term outcome of 34 patients (2009) J Neurol Neurosurg Psychiatry, 80, pp. 839-845. , COI: 1:STN:280:DC%2BD1MvovVKjsw%3D%3D, PID: 19332422
Jeon, B.S., Jeong, J.M., Park, S.S., Kim, J.M., Chang, Y.S., Song, H.C., Kim, K.M., Lee, S.B., Dopamine transporter density measured by [123I]beta-CIT single-photon emission computed tomography is normal in dopa-responsive dystonia (1998) Ann Neurol, 43, pp. 792-800. , COI: 1:CAS:528:DyaK1cXktVSjs7c%3D, PID: 9629849
Furukawa, Y., Nishi, K., Kondo, T., Mizuno, Y., Narabayashi, H., CSF biopterin levels and clinical features of patients with juvenile parkinsonism (1993) Adv Neurol, 60, pp. 562-567. , COI: 1:STN:280:DyaK3s7ivVSqsA%3D%3D, PID: 8420192
Bandmann, O., Goertz, M., Zschocke, J., Deuschl, G., Jost, W., Hefter, H., Müller, U., Oertel, W., The phenylalanine loading test in the differential diagnosis of dystonia (2003) Neurology, 60, pp. 700-702. , COI: 1:CAS:528:DC%2BD3sXptFKkuw%3D%3D, PID: 12601115
Erro, R., Picillo, M., Vitale, C., Amboni, M., Moccia, M., Longo, K., Cozzolino, A., Barone, P., Non-motor symptoms in early Parkinson’s disease: a 2-year follow-up study on previously untreated patients (2013) J Neurol Neurosurg Psychiatry, 84, pp. 14-17. , PID: 22993448
Antonozzi, I., Carducci, C., Vestri, L., Pontecorvi, A., Moretti, F., Rapid and sensitive method for high-performance liquid chromatographic analysis of pterins in biological fluids (1988) J Chromatogr, 459, pp. 319-324. , COI: 1:CAS:528:DyaL1MXhtFWjt7s%3D, PID: 3243907
Hyland, K., Fryburg, J.S., Wilson, W.G., Bebin, E.M., Arnold, L.A., Gunasekera, R.S., Jacobson, R.D., Trugman, J.M., Oral phenylalanine loading in dopa-responsive dystonia: a possible diagnostic test (1997) Neurology, 48, pp. 1290-1297. , COI: 1:CAS:528:DyaK2sXjsF2lu7k%3D, PID: 9153460
Chace, D.H., Millington, D.S., Terada, N., Kahler, S.G., Roe, C.R., Hofman, L.F., Rapid diagnosis of phenylketonuria by quantitative analysis for phenylalanine and tyrosine in neonatal blood spots by tandem mass spectrometry (1993) Clin Chem, 39, pp. 66-71. , COI: 1:CAS:528:DyaK3sXpslertg%3D%3D, PID: 8419060
Saunders-Pullmana, R., Blau, N., Hyland, K., Zschocke, J., Nygaard, T., Raymond, D., Shanker, V., Bressman, S.B., Phenylalanine loading as a diagnostic test for DRD: interpreting the utility of the test (2004) Mol Genet Metabol, 83, pp. 207-212
Benamer, T.S., Patterson, J., Grosset, D.G., Booij, J., de Bruin, K., van Royen, E., Speelman, J.D., Ries, V., Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group (2000) Mov Disord, 15, pp. 503-510. , COI: 1:STN:280:DC%2BD3cvnsVSntw%3D%3D, PID: 10830416
Jennings, D.L., Seibyl, J.P., Oakes, D., Eberly, S., Murphy, J., Marek, K., (23I) beta-CIT and single-photon emission computed tomographic imaging vs clinical evaluation in Parkinsonian syndrome: unmasking an early diagnosis (2004) Arch Neurol, 61, pp. 1224-1229. , PID: 15313838
Utiumi, M.A., Felício, A.C., Borges, C.R., Braatz, V.L., Rezende, S.A., Munhoz, R.P., Bressan, R.A., Teive, H.A., Dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of scans without evidence of dopaminergic deficit (SWEDDs) (2012) Arq Neuropsiquiatr, 70, pp. 667-673. , PID: 22990721
Sixel-Doring, F., Liepe, K., Mollenhauer, B., Trautmann, E., Trenkwalder, C., The role of 123I-FP-CIT-SPECT in the differential diagnosis of Parkinson and tremor syndromes: a critical assessment of 125 cases (2011) J Neurol, 258, pp. 2147-2154. , PID: 21547379
Marek, K., Seibyl, J., Eberly, S., Oakes, D., Shoulson, I., Lang, A.E., Hyson, C., Parkinson Study Group PRECEPT Investigators, Longitudinal follow-up of SWEDD subjects in the PRECEPT study (2014) Neurology, 82, pp. 1791-1797. , PID: 24759846
Leuzzi, V., Carducci, C., Chiarotti, F., D’Agnano, D., Giannini, M.T., Antonozzi, I., Carducci, C., Urinary neopterin and phenylalanine loading test as tools for the biochemical diagnosis of Segawa disease (2013) JIMD Rep, 7, pp. 67-75. , PID: 23430498
J Neurol (ISSN: 0340-5354, 1432-1459, 0340-5354print), 2014 Nov; 261(11): 2204-2208.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.377, 5-year impact factor: 3.495
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84920942539&partnerID=40&md5=d23377bd1dd3db05d1d69f0188aaaef7
Keywords: Dopa-Responsive Dystonia, Gtp-Cyclohydrolase1, Swedd, [123i]fp-Cit Spect, Biopterin, Guanosine Triphosphate Cyclohydrolase I, Iodine 123, Neopterin, Phenylalanine, Adult, Aged, Article, Biochemical Composition, Bradykinesia, Clinical Article, Controlled Study, Dopa Responsive Dystonia, Dyskinesia, Female, Gene Mutation, Human, Hypothesis, Middle Aged, Neurologic Disease, Neurologic Examination, Parkinsonism, Priority Journal, Scans Without Evidence Of Dopaminergic Deficiency, Segmental Dystonia, Single Photon Emission Computer Tomography, Tremor, [123i] Fp-Cit Spect, Dystonic Disorders, Genetic Screening, Procedures, Genetic Testing, Gtp Cyclohydrolase,
Affiliations:
*** IBB - CNR ***
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Federico II University, Via Pansini 5, 80131, Naples, Italy, anna_derosa@libero.it.
Department of Experimental Medicine, Sapienza University of RomeRome, Italy
Biostructure and Bioimaging Institute CNRNaples, Italy
References:
Parkinson Study Group, Dopamine transporter brain imaging to assess the effects of pramipexole vs levodopa on Parkinson disease progression (2002) JAMA, 287, pp. 1653-166
Whone, A.L., Watts, R.L., Stoessl, A.J., Davis, M., Reske, S., Nahmias, C., Lang, A.E., REAL-PET Study Group, Slower progression of Parkinson’s disease with ropinirole versus levodopa: the REAL-PET study (2003) Ann Neurol, 54, pp. 93-101. , COI: 1:CAS:528:DC%2BD3sXlvVWisrw%3D, PID: 12838524
Fahn, S., Oakes, D., Shoulson, I., Kieburtz, K., Rudolph, A., Lang, A., Olanow, C.W., Parkinson Study Group, Levodopa and the progression of Parkinson’s disease (2004) N Engl J Med, 351, pp. 2498-2508. , COI: 1:CAS:528:DC%2BD2cXhtVGksbnE, PID: 15590952
Marshall, V.L., Patterson, J., Hadley, D.M., Grosset, K.A., Grosset, D.G., Two-year follow-up in 150 consecutive cases with normal dopamine transporter imaging (2006) Nucl Med Commun, 27, pp. 933-937. , PID: 17088677
Hughes, A.J., Daniel, S.E., Ben-Shlomo, Y., Lees, A.J., The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service (2002) Brain, 125, pp. 861-870. , PID: 11912118
Silveira-Moriyama, L., Schwingenschuh, P., O’Donnell, A., Schneider, S.A., Mir, P., Carrillo, F., Terranova, C., Lees, A.J., Olfaction in patients with suspected Parkinsonism and scans without evidence of dopaminergic deficit (SWEDDs) (2009) J Neurol Neurosurg Psychiatry, 80, pp. 744-748. , COI: 1:STN:280:DC%2BD1MvitlSrtw%3D%3D, PID: 19276101
Schneider, S.A., Edwards, M.J., Mir, P., Cordivari, C., Hooker, J., Dickson, J., Quinn, N., Bhatia, K.P., Patients with adult-onset dystonic tremor resembling parkinsonian tremor have scans without evidence of dopaminergic deficit (SWEDDs) (2007) Mov Disord, 22, pp. 2210-2215. , PID: 17712858
Segawa, M., Autosomal dominant GTP cyclohydrolase I (AD GCH 1) deficiency (Segawa disease, dystonia 5
DYT 5) (2003) Chang Gung Med J, 32, pp. 1-11
Ichinose, H., Ohye, T., Takahashi, E., Seki, N., Hori, T., Segawa, M., Nomura, Y., Nagatsu, T., Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene (1994) Nat Genet, 8, pp. 236-242. , COI: 1:CAS:528:DyaK2MXitVOgtLk%3D, PID: 7874165
Nygaard, T.G., Trugman, J.M., de Yebenes, J.G., Fahn, S., Dopa-responsive dystonia: the spectrum of clinical manifestations in a large North American family (1990) Neurology, 40, pp. 66-69. , COI: 1:STN:280:DyaK3c7hsVKrtg%3D%3D, PID: 2296384
Trender-Gerhard, I., Sweeney, M.G., Schwingenschuh, P., Mir, P., Edwards, M.J., Gerhard, A., Polke, J.M., Bhatia, K.P., Autosomal-dominant GTPCH1-deficient DRD: clinical characteristics and long-term outcome of 34 patients (2009) J Neurol Neurosurg Psychiatry, 80, pp. 839-845. , COI: 1:STN:280:DC%2BD1MvovVKjsw%3D%3D, PID: 19332422
Jeon, B.S., Jeong, J.M., Park, S.S., Kim, J.M., Chang, Y.S., Song, H.C., Kim, K.M., Lee, S.B., Dopamine transporter density measured by [123I]beta-CIT single-photon emission computed tomography is normal in dopa-responsive dystonia (1998) Ann Neurol, 43, pp. 792-800. , COI: 1:CAS:528:DyaK1cXktVSjs7c%3D, PID: 9629849
Furukawa, Y., Nishi, K., Kondo, T., Mizuno, Y., Narabayashi, H., CSF biopterin levels and clinical features of patients with juvenile parkinsonism (1993) Adv Neurol, 60, pp. 562-567. , COI: 1:STN:280:DyaK3s7ivVSqsA%3D%3D, PID: 8420192
Bandmann, O., Goertz, M., Zschocke, J., Deuschl, G., Jost, W., Hefter, H., Müller, U., Oertel, W., The phenylalanine loading test in the differential diagnosis of dystonia (2003) Neurology, 60, pp. 700-702. , COI: 1:CAS:528:DC%2BD3sXptFKkuw%3D%3D, PID: 12601115
Erro, R., Picillo, M., Vitale, C., Amboni, M., Moccia, M., Longo, K., Cozzolino, A., Barone, P., Non-motor symptoms in early Parkinson’s disease: a 2-year follow-up study on previously untreated patients (2013) J Neurol Neurosurg Psychiatry, 84, pp. 14-17. , PID: 22993448
Antonozzi, I., Carducci, C., Vestri, L., Pontecorvi, A., Moretti, F., Rapid and sensitive method for high-performance liquid chromatographic analysis of pterins in biological fluids (1988) J Chromatogr, 459, pp. 319-324. , COI: 1:CAS:528:DyaL1MXhtFWjt7s%3D, PID: 3243907
Hyland, K., Fryburg, J.S., Wilson, W.G., Bebin, E.M., Arnold, L.A., Gunasekera, R.S., Jacobson, R.D., Trugman, J.M., Oral phenylalanine loading in dopa-responsive dystonia: a possible diagnostic test (1997) Neurology, 48, pp. 1290-1297. , COI: 1:CAS:528:DyaK2sXjsF2lu7k%3D, PID: 9153460
Chace, D.H., Millington, D.S., Terada, N., Kahler, S.G., Roe, C.R., Hofman, L.F., Rapid diagnosis of phenylketonuria by quantitative analysis for phenylalanine and tyrosine in neonatal blood spots by tandem mass spectrometry (1993) Clin Chem, 39, pp. 66-71. , COI: 1:CAS:528:DyaK3sXpslertg%3D%3D, PID: 8419060
Saunders-Pullmana, R., Blau, N., Hyland, K., Zschocke, J., Nygaard, T., Raymond, D., Shanker, V., Bressman, S.B., Phenylalanine loading as a diagnostic test for DRD: interpreting the utility of the test (2004) Mol Genet Metabol, 83, pp. 207-212
Benamer, T.S., Patterson, J., Grosset, D.G., Booij, J., de Bruin, K., van Royen, E., Speelman, J.D., Ries, V., Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group (2000) Mov Disord, 15, pp. 503-510. , COI: 1:STN:280:DC%2BD3cvnsVSntw%3D%3D, PID: 10830416
Jennings, D.L., Seibyl, J.P., Oakes, D., Eberly, S., Murphy, J., Marek, K., (23I) beta-CIT and single-photon emission computed tomographic imaging vs clinical evaluation in Parkinsonian syndrome: unmasking an early diagnosis (2004) Arch Neurol, 61, pp. 1224-1229. , PID: 15313838
Utiumi, M.A., Felício, A.C., Borges, C.R., Braatz, V.L., Rezende, S.A., Munhoz, R.P., Bressan, R.A., Teive, H.A., Dopamine transporter imaging in clinically unclear cases of parkinsonism and the importance of scans without evidence of dopaminergic deficit (SWEDDs) (2012) Arq Neuropsiquiatr, 70, pp. 667-673. , PID: 22990721
Sixel-Doring, F., Liepe, K., Mollenhauer, B., Trautmann, E., Trenkwalder, C., The role of 123I-FP-CIT-SPECT in the differential diagnosis of Parkinson and tremor syndromes: a critical assessment of 125 cases (2011) J Neurol, 258, pp. 2147-2154. , PID: 21547379
Marek, K., Seibyl, J., Eberly, S., Oakes, D., Shoulson, I., Lang, A.E., Hyson, C., Parkinson Study Group PRECEPT Investigators, Longitudinal follow-up of SWEDD subjects in the PRECEPT study (2014) Neurology, 82, pp. 1791-1797. , PID: 24759846
Leuzzi, V., Carducci, C., Chiarotti, F., D’Agnano, D., Giannini, M.T., Antonozzi, I., Carducci, C., Urinary neopterin and phenylalanine loading test as tools for the biochemical diagnosis of Segawa disease (2013) JIMD Rep, 7, pp. 67-75. , PID: 23430498
Screening for dopa-responsive dystonia in patients with scans without evidence of dopaminergic deficiency (SWEDD)
The clinical diagnosis of Parkinson’s Disease (PD) is not supported by Single Photon Emission Computed Tomography (SPECT) using dopamine transporter radioligand in 4–15 % of patients. It has been hypothesized that this phenomenon, named “Scans Without Evidence of Dopaminergic Deficiency” (SWEDD), may be an adult-onset dystonia. We investigated the hypothesis that these patients might be affected by Dopa-Responsive Dystonia (DRD). We enrolled eleven unrelated patients (8 F and 3 M) with clinical parkinsonism and normal [123I]FP-CIT SPECT. The GTP-cyclohydrolase1 (GCH1) gene was sequenced in all patients; urine biopterin and neopterin analysis was carried out in nine and oral phenylalanine (Phe) loading in seven. Neurological examination showed bradykinesia and resting/postural tremor in all patients, and rigidity in ten, suggesting a clinical diagnosis of PD. We detected mild dystonic signs in eight cases. In particular, five of them presented cranial dyskinesias. No mutation of the GCH1 gene was found. The results of the urine biopterin and neopterin analysis and the oral Phe loading did not reveal biochemical abnormalities suggestive of reduced GCH1 activity. We confirm that some clinical features, namely the presence of focal or segmental dystonia, suggest an adult-onset dystonia in SWEDD cases. However, we exclude DRD caused by GCH1 gene mutations in the present series. © 2014, Springer-Verlag Berlin Heidelberg.
The clinical diagnosis of Parkinson’s Disease (PD) is not supported by Single Photon Emission Computed Tomography (SPECT) using dopamine transporter radioligand in 4–15 % of patients. It has been hypothesized that this phenomenon, named “Scans Without Evidence of Dopaminergic Deficiency” (SWEDD), may be an adult-onset dystonia. We investigated the hypothesis that these patients might be affected by Dopa-Responsive Dystonia (DRD). We enrolled eleven unrelated patients (8 F and 3 M) with clinical parkinsonism and normal [123I]FP-CIT SPECT. The GTP-cyclohydrolase1 (GCH1) gene was sequenced in all patients; urine biopterin and neopterin analysis was carried out in nine and oral phenylalanine (Phe) loading in seven. Neurological examination showed bradykinesia and resting/postural tremor in all patients, and rigidity in ten, suggesting a clinical diagnosis of PD. We detected mild dystonic signs in eight cases. In particular, five of them presented cranial dyskinesias. No mutation of the GCH1 gene was found. The results of the urine biopterin and neopterin analysis and the oral Phe loading did not reveal biochemical abnormalities suggestive of reduced GCH1 activity. We confirm that some clinical features, namely the presence of focal or segmental dystonia, suggest an adult-onset dystonia in SWEDD cases. However, we exclude DRD caused by GCH1 gene mutations in the present series. © 2014, Springer-Verlag Berlin Heidelberg.
Screening for dopa-responsive dystonia in patients with scans without evidence of dopaminergic deficiency (SWEDD)
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Screening for dopa-responsive dystonia in patients with scans without evidence of dopaminergic deficiency (SWEDD)
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Kim KM, Varrone A, Watabe H, Shidahara M, Fujita M, Innis RB, Iida H
* Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities (278 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2003 Apr; 44(4): 512-519.
Impact Factor: 4.899
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Acampa W, Di Benedetto C, Cuocolo A
An overview of radiotracers in nuclear cardiology (376 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Nov; 7(6): 701-707.
Impact Factor: 1.854
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Varrone A, Soricelli A, Postiglione A, Salvatore M
Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT (312 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1999 Sep; 24(9): 660-665.
Impact Factor: 0.253
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Postiglione A, Soricelli, Salvatore M, Lassen NA
123I-iomazenil as a clinical tool for studying neuronal loss [4] (340 views)
J Am Geriatr Soc (ISSN: 0002-8614), 1997 Apr; 45(4): 534-536.
Impact Factor: 2.806
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Soricelli A, Postiglione A, GrivetFojaja M, Mainenti PP, Discepolo A, Varrone A, Salvatore M, Lassen N
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (417 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
Impact Factor: 2.692
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* Efficacy of dopamine agonist treatment in delayed-onset parkinsonism due to midbrain hemorrhage (255 views)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1353-8020print), 2015 Feb; 21(2): 156-158.
Impact Factor: 3.794
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Erro R, Barone P, Vicidomini C, Picillo M, Pappata S
* Patients with Parkinson's disease and scans with (predominant) ipsilateral dopaminergic deficit (354 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2013 Sep; 260(9): 2405-2406.
Impact Factor: 3.841
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Erro R, Amboni M, Vitale C, Longo K, Rocco M, Russo C, Pappata S, Brunetti A, Barone P
* The "eye of the tiger" sign in pure akinesia with gait freezing (313 views) (PDF 222 views)
Neurol Sci (ISSN: 1590-1874, 1590-3478, 1590-1874linking), 2011 Sep; 32(4): 703-705.
Impact Factor: 1.315
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Varrone A, Halldin C
Molecular imaging of the dopamine transporter (542 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
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Darcourt J, Booij J, Tatsch K, Varrone A, Borght TV, Kapucu OL, Nagren K, Nobili F, Walker Z, Van Laere K
* EANM procedure guidelines for brain neurotransmission SPECT using 123I-labelled dopamine transporter ligands, version (723 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Feb; 37(2): 443-450.
Impact Factor: 5.036
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Dickson JC, Tossici-bolt L, Sera T, Erlandsson K, Varrone A, Tatsch K, Hutton BF
* The impact of reconstruction method on the quantification of DaTSCAN images (428 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jan; 37(1): 23-35.
Impact Factor: 5.036
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Varrone A, Sansone V, Pellecchia MT, Amboni M, Salvatore E, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Comparison between a dual-head and a brain-dedicated SPECT system in the measurement of the loss of dopamine transporters with [123I]FP-CIT (341 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2008 Jul; 35(7): 1343-1349.
Impact Factor: 4.532
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De Rosa A, Carducci C, Antonozzi I, Giovanniello T, Xhoxhi E, Criscuolo C, Menchise V, Striano S, Filla A, De Michele G
* A novel mutation in GCH-1 gene in a case of dopa-responsive dystonia [9] (314 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 1432-1459electronic), 2007 Sep; 254(8): 1133-1134.
Impact Factor: 2.477
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Vander Borght T, Asenbaum S, Bartenstein P, Halldin C, Kapucu O, Van Laere K, Varrone A, Tatsch K
* EANM procedure guidelines for brain tumour imaging using labelled amino acid analogues (523 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Nov; 33(11): 1374-1380.
Impact Factor: 4.041
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Varrone A, Pellecchia MT, Amboni M, Sansone V, Salvatore E, Ghezzi D, Garavaglia B, Brice A, Brunetti A, Bonavita V, De Michele G, Salvatore M, Pappata S, Barone P
* Imaging of dopaminergic dysfunction with [123I]FP-CIT SPECT in early-onset parkin disease (4017 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2004 Dec 14; 63(11): 2097-2103.
Impact Factor: 5.973
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Covelli EM, Brunetti A, Di Lauro A, Sullo P, Mazzarella G, Tedeschi E, Belfiore G
* Clinical impact of correlative [123I]-FP-CIT brain imaging and neurological findings in suspect Parkinson's disease (360 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2004 Oct; 108(4): 417-425.
Impact Factor: 1.368
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Kim KM, Varrone A, Watabe H, Shidahara M, Fujita M, Innis RB, Iida H
* Contribution of scatter and attenuation compensation to SPECT images of nonuniformly distributed brain activities (278 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2003 Apr; 44(4): 512-519.
Impact Factor: 4.899
View Export to BibTeX Export to EndNote
Acampa W, Di Benedetto C, Cuocolo A
An overview of radiotracers in nuclear cardiology (376 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2000 Nov; 7(6): 701-707.
Impact Factor: 1.854
View Export to BibTeX Export to EndNote
Varrone A, Soricelli A, Postiglione A, Salvatore M
Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT (312 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1999 Sep; 24(9): 660-665.
Impact Factor: 0.253
View Export to BibTeX Export to EndNote
Postiglione A, Soricelli, Salvatore M, Lassen NA
123I-iomazenil as a clinical tool for studying neuronal loss [4] (340 views)
J Am Geriatr Soc (ISSN: 0002-8614), 1997 Apr; 45(4): 534-536.
Impact Factor: 2.806
View Export to BibTeX Export to EndNote
Soricelli A, Postiglione A, GrivetFojaja M, Mainenti PP, Discepolo A, Varrone A, Salvatore M, Lassen N
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (417 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
Impact Factor: 2.692
View Export to BibTeX Export to EndNote
16 Records (16 excluding Abstracts).
Total impact factor: 56.939 (56.939 excluding Abstracts).
Total 5 year impact factor: 66.481 (66.481 excluding Abstracts).
Total impact factor: 56.939 (56.939 excluding Abstracts).
Total 5 year impact factor: 66.481 (66.481 excluding Abstracts).
447 views. Last view on Tuesday 07 March 2023, 5:31:36
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