Service de Neurologie, Hôpital Lariboisière, 3 rue Ambroise Paré, 75010 Paris, France
Department of Neurology, CHU Lariboisière, Paris, France
INSERM U562, SHFJ-CEA, Orsay, France
UNAF-IFR 49, SHFJ-CEA, Orsay, France
The Department of Neurology, CHU Lariboisiere, Paris, France.
References: Kataoka, K., Hoyakawa, T., Yamada, K., Neuronal network disturbance after focal ischemia in rats (1989) Stroke, 20, pp. 1220-123
De Reuck, J., Decoo, D., Lemahieu, I., Ipsilateral thalamic diaschisis after middle cerebral artery infarction (1995) J Neurol Sci, 134, pp. 130-135
Seitz, R.J., Azari, N.P., Knorr, U., The role of diaschisis in stroke recovery (1999) Stroke, 30, pp. 1844-1850
Binkofski, F., Seitz, R.J., Arnold, S., Thalamic metabolism and corticospinal tract integrity determine motor recovery in stroke (1996) Ann Neurol, 39, pp. 460-470
Lizuka, H., Sakatani, K., Young, W., Neural damage in the rat thalamus after cortical infarcts (1990) Stroke, 21, pp. 790-794
Ogawa, T., Yoshida, Y., Okudera, T., Secondary thalamic degeneration after cerebral infarction in the middle cerebral artery distribution: Evaluation with MR imaging (1997) Radiology, 204, pp. 255-262
Tamura, A., Tahira, Y., Nagashima, H., Thalamic atrophy following cerebral infarction in the territory of the middle cerebral artery (1991) Stroke, 22, pp. 615-618
Le Bihan, D., Mangin, J.F., Poupon, C., Diffusion tensor imaging: Concepts and applications (2001) J Magn Reson Imaging, 13, pp. 534-546
Werring, D.J., Toosy, A.T., Clark, C.A., Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke (2000) J Neurol Neurosurg Psychiatry, 69, pp. 269-272
Poupon, C., Clark, C.A., Frouin, V., Regularization of diffusion-based direction maps for the tracking of brain white matter fascicles (2000) Neuroimage, 12, pp. 184-195
Pierpooli, C., Jezzard, P., Basser, P.J., Diffusion tensor MR imaging of the human brain (1996) Radiology, 201, pp. 637-648
Molko, N., Pappata, S., Mangin, J.F., Monitoring disease progression in CADASIL with diffusion magnetic resonance imaging: A study with whole brain histogram analysis (2002) Stroke, 33 (12), pp. 2902-2908. , Dec
Chabriat, H., Pappata, S., Poupon, C., Clinical severity in cadasil related to ultrastructural damage in white matter: In vivo study with diffusion tensor MRI (1999) Stroke, 30, pp. 2637-2643
Pierpaoli, C., Barnett, A., Pajevic, S., Water diffusion changes in wallerian degeneration and their dependence on white-matter architecture (2001) Neuro Image, 13, pp. 1174-1185
Carpenter, M.B., (1991) Core Text of Neuroanatomy, , Timothy S, ed. Lippencott, Williams & Wilkins
Dihne, M., Grommes, C., Lutzenburg, M., Different mechanisms of secondary neuronal damage in thalamic nuclei after focal cerebral ischemia in rats (2002) Stroke, 33, pp. 3006-3011
Dauguet, J., Cointepas, D., Hervé, D., (2003) Eleventh Meeting of the International Society of Magnetic Resonance in Medicine
Virley, J.S., Beech, S.C.S.S.C., Williams, A.J., Secondary degeneration following transient mcao in the rat: Quantitative changes using MRI (1999) The International Society for Cerebral Blood Flow and Metabolism, 19 (SUPPL. 1), pp. S493
Nakane, M., Tamura, A., Miyasaka, N., Astrocytic swelling in the ipsilateral substantia nigra after occlusion of the middle cerebral artery in rats (2001) AJNR, 22, pp. 660-663
Acarin, L., Gonzalez, B., Hidalgo, J., Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: Astroglial response and metallothionein expression (1999) Neuroscience, 92, pp. 827-839
Pappata, S., Levasseur, M., Gunn, R.N., Thalamic microglial activation in ischemic stroke detected in vivo by pet and [11c]pk1195 (2000) Neurology, 55, pp. 1052-1054
Guerrini, U., Sironi, L., Tremoli, E., New insights into brain damage in stroke-prone rats: A nuclear magnetic imaging study (2002) Stroke, 33, pp. 825-830
Seitz, R. J., Azari, N. P., Knorr, U., The role of diaschisis in stroke recovery (1999) Stroke, 30, pp. 1844-1850
Werring, D. J., Toosy, A. T., Clark, C. A., Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke (2000) J Neurol Neurosurg Psychiatry, 69, pp. 269-272
Carpenter, M. B., (1991) Core Text of Neuroanatomy, , Timothy S, ed. Lippencott, Williams & Wilkins
Virley, J. S., Beech, S. C. S. S. C., Williams, A. J., Secondary degeneration following transient mcao in the rat: Quantitative changes using MRI (1999) The International Society for Cerebral Blood Flow and Metabolism, 19 (SUPPL. 1), pp. S493
Longitudinal thalamic diffusion changes after middle cerebral artery infarcts
Background: Cerebral infarcts are responsible for functional alterations and microscopic tissue damage at distance from the ischaemic area. Such remote effects have been involved in stroke recovery. Thalamic hypometabolism is related to motor recovery in middle cerebral artery (MCA) infarcts but little is known concerning the tissue changes underlying these metabolic changes. Diffusion tensor imaging (DTI) is highly sensitive to microstructural tissue alterations and can be used to quantify in vivo the longitudinal microscopic tissue changes occurring in the thalamus after MCA infarcts in humans. Methods: Nine patients underwent DTI after an isolated MCA infarct. Mean diffusivity (MD), fractional anisotropy (FA), and thalamic region volume were measured from the first week to the sixth month after stroke onset in these patients and in 10 age matched controls. Results: MD significantly increased in the ipsilateral thalamus between the first and the sixth month (0.766×10-3 mm2/s first month; 0.792×10-3 mm2/s third month; 0.806×10-3 mm2/s sixth month). No significant modification of FA was detected. In six patients, the ipsilateral/contralateral index of MD was higher than the upper limit of the 95% CI calculated in 10 age matched controls. An early decrease of MD preceded the increase of ipsilateral thalamic diffusion in one patient at the first week and in two other patients at the first month. Conclusion: After MCA infarcts, an increase in diffusion is observed with DTI in the ipsilateral thalamus later than 1 month after the stroke onset. This is presumably because of the progressive loss of neurons and/or glial cells. In some patients, this increase is preceded by a transient decrease in diffusion possibly related to an early swelling of these cells or to microglial activation. Further studies in larger series are needed to assess the clinical correlates of these findings.
Longitudinal thalamic diffusion changes after middle cerebral artery infarcts
No results.
Longitudinal thalamic diffusion changes after middle cerebral artery infarcts
Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G * Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation(894 views) Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806. Impact Factor:8.017 ViewExport to BibTeXExport to EndNote