Absolute quantification by positron emission tomography of the endogenous ligand (342 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2001 May; 21(5): 613-630.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.477, 5-year impact factor: 5.373
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0035024445&partnerID=40&md5=b8bad5c1e3db5b32f8dc119ef5815c51
Keywords: Apparent Affinity, Endogenous Ligand, Ligand-Receptor Model, Quantification By Positron Emission Tomography, Dopamine, Dopamine 2 Receptor, Isoremoxipride, Neurotransmitter, Reserpine, Animal Experiment, Article, Baboon, Binding Site, Corpus Striatum, Dopamine Brain Level, Drug Receptor Binding, Ligand Binding, Nonhuman, Priority Journal, Adrenergic Uptake Inhibitors, Dopamine Antagonists, Flumazenil, Gaba Modulators, Kinetics, Mathematics, Biological, Neurotransmitter Agents, Papio, Pyrrolidines, Salicylamides, Emission-Computed,
Affiliations:
*** IBB - CNR ***
Laboratoire de Radiotoxicologie, Commissariat a l'Energie Atomique, Ctr. d'Etudes de Bruyeres-le-Chatel, BP 12, F-91680 Bruyeres-le-Chatel, France
Service Hospitalier Frederic Joliot, Commissariat a l'Energie Atomique, Orsay, France.
References:
Andreasen, N., Carson, C., Diksic, M., Evans, A., Farde, L., Gjedde, A., Hakim, A., Wong, D., Workshop on schizophrenia PET, and dopamine D2 receptors in human neostriatum (1988) Schizophr Bull, 14, pp. 471-48
Bendriem, B., Dewey, S.L., Schlyer, D.J., Wolf, A.P., Volkow, N.D., Quantitation of the human basal ganglia with positron emission tomography
a phantom study of the effect of contrast and axial positioning (1991) IEEE Trans Med Imag, 10, pp. 216-222
Breier, A., Su, T.P., Saunders, R., Carson, R.E., Kolachana, B.S., De Bartolomeis, A., Weinberger, D.R., Pickar, D., Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentration (1997) Proc Nat Acad Sci USA, 94, pp. 2569-2574
Carson, R.E., Breier, A., De Bartolomeis, A., Saunders, R.C., Su, T.P., Schmall, B., Der, M.G., Eckelman, W.C., Quantification of amphetamine-induced changes in [11C]raclopride binding with continuous infusion (1997) J Cereb Blood Flow Metab, 17, pp. 437-447
Delforge, J., Syrota, A., Mazoyer, B., Identifiability analysis and parameter identification of an in vivo ligand-receptor model from PET data (1990) IEEE Trans Biomed Eng, 37, pp. 653-661
Delforge, J., Pappata, S., Millet, P., Samson, Y., Bendriem, B., Jobert, A., Crouzel, C., Syrota, A., Quantification of benzodiazepine receptor in human brain using PET, [11C]flumazenil and a single-experiment protocol (1995) J Cereb Blood Flow Metab, 19, pp. 533-546
Delforge, J., Spelle, L., Bendriem, B., Samson, Y., Syrota, A., Parametric images of benzodiazepine receptor concentration using a partial-saturation injection (1997) J Cereb Blood Flow Metab, 17, pp. 343-355
Delforge, J., Bottlaender, M., Loc'h, C., Guenther, I., Fuseau, C., Bendriem, B., Syrota, A., Mazière, B., Quantification of extrastriatal D2 receptors using a very high affinity ligand (FLB 457) and the multi-injection approach (1999) J Cereb Blood Flow Metab, 15, pp. 284-300
Dewey, S.L., Smith, G.S., Logan, J., Brodie, J., Yu, D.W., Ferrieri, R., King, P., Meller, E., Gabaergic inhibition of endogeneous dopamine release measured in vivo with 11C-raclopride and positron emission tomography (1992) Neuroscience, 12, pp. 3773-3780
Endres, C.J., Kolachana, B.S., Saunders, R.C., Su, T., Weinberger, D., Breier, A., Eckelman, W.C., Carson, R.E., Kinetic modeling of [11C]raclopride: Combined PET-microdialysis studies (1997) J Cereb Blood Flow Metab, 17, pp. 932-942
Farde, L., Hall, H., Pauli, S., Halldin, C., Variability in D2-dopamine receptor density and affinity: A PET study with [11C]raclopride in man (1995) Synapse, 20, pp. 200-208
Fisher, R.E., Morris, E.D., Alpert, N., Fischman, A.J., In vivo imaging of neuromodulatory synaptic transmission using PET: A review of relevant neurophysiology (1995) Human Brain Mapping, 3, pp. 24-34
Garris, P.A., Wightman, R.M., Different kinetics govern dopaminergic transmission in amygdala, prefrontal cortex and striatum: An in vivo voltammetric study (1994) J Neurosci, 14, pp. 442-450
Ginovart, N., Farde, L., Halldin, C., Swahn, C.G., Effect of reserpine-induced depletion of synaptic dopamine on C11-raclopride binding to D2-dopamine receptors in the monkey brain (1997) Synapse, 24, pp. 321-325
Guidotti, A., Forchetti, C.M., Corda, M.G., Konkel, D., Benett, K.D., Costa, E., Isolation, characterization, and purification of an endogenous polypeptide with agonistic action on benzodiazepine receptors (1983) Proc Nat Acad Sci USA, 80, pp. 3531-3535
Huang, S.C., Barrio, J.R., Phelps, M.E., Neuroreceptor assay with positron emission tomography: Equilibrium versus dynamic approach (1986) J Cereb Blood Flow Metab, 6, pp. 515-521
Kawagoe, K.T., Garris, P.A., Wiedemann, D.J., Wightman, R.M., Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum (1992) Neuroscience, 51, pp. 55-64
Klotz, U., Occurrence of "natural" benzodiazepine (1991) Life Sci, 48, pp. 209-215
Koepp, M.J., Gunn, R.N., Lawrence, A.D., Cunningham, V.J., Dagher, A., Jones, T., Brooks, D.J., Grasby, P.M., Evidence for striatal dopamine release during a video game (1998) Nature, 393, pp. 266-268
Kuczenski, R., Segal, D.S., Effects of methylphenidate on extracellular dopamine serotonin, and norepinephrine: Comparison with amphetamine (1977) J Neurochem, 68, pp. 2032-2037
Laruelle, M., D'Souza, C.D., Baldwin, R.M., Abi-Dargham, A., Kanes, S.J., Fingado, C.L., Seibyl, J.P., Innis, R.B., Imaging D2 receptor occupancy by endogenous dopamine in humans (1997) Neuropshychopharmacology, 13, pp. 162-174
Laruelle, M., Iyer, R.N., Al-Tikriti, M.S., Zea-Ponce, Y., Malison, R.T., Zoghbi, S.S., Baldwin, R.M., Bradberry, C.W., Microdialysis and SPECT measurements of amphetamine-induced dopamine release in non-human primates (1997) Synapse, 25, pp. 1-14
Laruelle, M., Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review (2000) J Cereb Blood Flow Metab, 20, pp. 423-451
Logan, J., Dewey, S.L., Wolf, A.P., Fowler, J.S., Brodie, J.D., Angrist, B., Volkow, N.D., Gatley, S.J., Effects of endogenous dopamine on measures of [18F]N-methylspiroperidol binding in the basal ganglia: Comparison of simulations and experimental results from PET studies in baboons (1991) Synapse, 9, pp. 195-207
Millet, P.H., Delforge, J., Mauguière, F., Pappata, S., Cinotti, L., Frouin, V., Samson, Y., Syrota, A., Parametric images of benzodiazepine receptor concentration in human brain: Comparison with the distribution volume approach (1995) J Nucl Med, 36, pp. 1462-1471
Mintun, M.A., Raichle, M.E., Kilbourn, M.R., Wooten, G.F., Welch, M.J., A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography (1984) Ann Neurol, 15, pp. 217-227
Morris, E.D., Fisher, R.E., Alpert, N.M., Rauch, S.L., Fischman, A.J., In vivo imaging of neuromodulation using positron emission tomography: Optimal ligand characteristics and task length for detection of activation (1995) Hum Brain Mapp, 3, pp. 35-55
Naudon, L., Leroux-Nicollet, I., Raisman-Vozari, R., Botton, D., Costentin, J., Time-course of modifications elicited by reserpine on the density of mRNA synthesis of the vesicular monoamine transporter and on the density of the membrane dopamine uptake complex (1995) Synapse, 21, pp. 29-36
Price, J.C., Mason, N.S., Lopresti, B., Holt, D., Simpson, N.R., Drevets, W., Smith, G.S., Mathis, C.A., PET measurement of endogenous neurotransmitter activity using high and low affinity radiotracers (1998) Quantitative functional brain imaging with positron emission tomography, pp. 441-448. , (Carson RE, Daube-Witherspoon M, Herscovitch P, eds), San Diego: Academic Press
Ross, S.B., Jackson, D.M., Kinetic properties of the in vivo accumulation of 3H-(-)-N-n-propylnorapomorphine in mouse brain (1989) Naunyn Schmiedebergs Arch Pharmacol, 340, pp. 6-12
Ross, S.B., Synaptic concentration of dopamine in the mouse striatum in relationship to the kinetic properties of the dopamine receptors and uptake mechanism (1991) J Neurochem, 56, pp. 22-29
Seeman, P., Guan, H.-C., Niznik, H.B., Endogenous dopamine lowers the dopamine D2 receptor density as measured by [3H]raclopride: Implications for positron emission tomography of the human brain (1989) Synapse, 3, pp. 96-97
Seeman, P., Sunahara, R.K., Niznik, H.B., Receptor-receptor link in membranes revealed by ligand competition: Example for dopamine D1 and D2 receptors (1994) Synapse, 17, pp. 62-64
Swahn, C.-G., Halldin, C., Farde, L., Sedvall, G., Metabolism of the PET ligand [11C]SCH 23390. Identification of two radiolabeled metabolites with HPLC (1994) Human Psychopharmacology, 9, pp. 25-31
Syrota, A., Paillotin, G., Davy, J.M., Aumont, M.C., Kinetics of in vivo binding of antagonist to muscarinic cholinergic receptor in the human heart studied by positron emission tomography (1984) Life Sci, 35, pp. 937-945
Volkow, N.D., Wang, G.-J., Fowler, J., Logan, J., Schlyer, D., Hitzemann, R., Lieberman, J., Wolf, A., Imaging endogenous dopamine competition with 11C raclopride in the human brain (1994) Synapse, 16, pp. 255-262
Volkow, N.D., Fowler, J.S., Gatley, S.J., Logan, J., Wang, G.W., Ding, Y.S., Dewey, S., PET evaluation of the dopamine system of the human brain (1996) J Nucl Med, 37, pp. 1242-1256
Breier, A., Su, T. P., Saunders, R., Carson, R. E., Kolachana, B. S., De Bartolomeis, A., Weinberger, D. R., Pickar, D., Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentration (1997) Proc Nat Acad Sci USA, 94, pp. 2569-2574
Carson, R. E., Breier, A., De Bartolomeis, A., Saunders, R. C., Su, T. P., Schmall, B., Der, M. G., Eckelman, W. C., Quantification of amphetamine-induced changes in [11C] raclopride binding with continuous infusion (1997) J Cereb Blood Flow Metab, 17, pp. 437-447
Dewey, S. L., Smith, G. S., Logan, J., Brodie, J., Yu, D. W., Ferrieri, R., King, P., Meller, E., Gabaergic inhibition of endogeneous dopamine release measured in vivo with 11C-raclopride and positron emission tomography (1992) Neuroscience, 12, pp. 3773-3780
Endres, C. J., Kolachana, B. S., Saunders, R. C., Su, T., Weinberger, D., Breier, A., Eckelman, W. C., Carson, R. E., Kinetic modeling of [11C] raclopride: Combined PET-microdialysis studies (1997) J Cereb Blood Flow Metab, 17, pp. 932-942
Fisher, R. E., Morris, E. D., Alpert, N., Fischman, A. J., In vivo imaging of neuromodulatory synaptic transmission using PET: A review of relevant neurophysiology (1995) Human Brain Mapping, 3, pp. 24-34
Garris, P. A., Wightman, R. M., Different kinetics govern dopaminergic transmission in amygdala, prefrontal cortex and striatum: An in vivo voltammetric study (1994) J Neurosci, 14, pp. 442-450
Huang, S. C., Barrio, J. R., Phelps, M. E., Neuroreceptor assay with positron emission tomography: Equilibrium versus dynamic approach (1986) J Cereb Blood Flow Metab, 6, pp. 515-521
Kawagoe, K. T., Garris, P. A., Wiedemann, D. J., Wightman, R. M., Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum (1992) Neuroscience, 51, pp. 55-64
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Grasby, P. M., Evidence for striatal dopamine release during a video game (1998) Nature, 393, pp. 266-268
Millet, P. H., Delforge, J., Maugui re, F., Pappata, S., Cinotti, L., Frouin, V., Samson, Y., Syrota, A., Parametric images of benzodiazepine receptor concentration in human brain: Comparison with the distribution volume approach (1995) J Nucl Med, 36, pp. 1462-1471
Mintun, M. A., Raichle, M. E., Kilbourn, M. R., Wooten, G. F., Welch, M. J., A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography (1984) Ann Neurol, 15, pp. 217-227
Morris, E. D., Fisher, R. E., Alpert, N. M., Rauch, S. L., Fischman, A. J., In vivo imaging of neuromodulation using positron emission tomography: Optimal ligand characteristics and task length for detection of activation (1995) Hum Brain Mapp, 3, pp. 35-55
Price, J. C., Mason, N. S., Lopresti, B., Holt, D., Simpson, N. R., Drevets, W., Smith, G. S., Mathis, C. A., PET measurement of endogenous neurotransmitter activity using high and low affinity radiotracers (1998) Quantitative functional brain imaging with positron emission tomography, pp. 441-448. , (Carson RE, Daube-Witherspoon M, Herscovitch P, eds), San Diego: Academic Press
Ross, S. B., Jackson, D. M., Kinetic properties of the in vivo accumulation of 3H- (-) -N-n-propylnorapomorphine in mouse brain (1989) Naunyn Schmiedebergs Arch Pharmacol, 340, pp. 6-12
Ross, S. B., Synaptic concentration of dopamine in the mouse striatum in relationship to the kinetic properties of the dopamine receptors and uptake mechanism (1991) J Neurochem, 56, pp. 22-29
Swahn, C. -G., Halldin, C., Farde, L., Sedvall, G., Metabolism of the PET ligand [11C] SCH 23390. Identification of two radiolabeled metabolites with HPLC (1994) Human Psychopharmacology, 9, pp. 25-31
Volkow, N. D., Wang, G. -J., Fowler, J., Logan, J., Schlyer, D., Hitzemann, R., Lieberman, J., Wolf, A., Imaging endogenous dopamine competition with 11C raclopride in the human brain (1994) Synapse, 16, pp. 255-262
Volkow, N. D., Fowler, J. S., Gatley, S. J., Logan, J., Wang, G. W., Ding, Y. S., Dewey, S., PET evaluation of the dopamine system of the human brain (1996) J Nucl Med, 37, pp. 1242-1256
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2001 May; 21(5): 613-630.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.477, 5-year impact factor: 5.373
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0035024445&partnerID=40&md5=b8bad5c1e3db5b32f8dc119ef5815c51
Keywords: Apparent Affinity, Endogenous Ligand, Ligand-Receptor Model, Quantification By Positron Emission Tomography, Dopamine, Dopamine 2 Receptor, Isoremoxipride, Neurotransmitter, Reserpine, Animal Experiment, Article, Baboon, Binding Site, Corpus Striatum, Dopamine Brain Level, Drug Receptor Binding, Ligand Binding, Nonhuman, Priority Journal, Adrenergic Uptake Inhibitors, Dopamine Antagonists, Flumazenil, Gaba Modulators, Kinetics, Mathematics, Biological, Neurotransmitter Agents, Papio, Pyrrolidines, Salicylamides, Emission-Computed,
Affiliations:
*** IBB - CNR ***
Laboratoire de Radiotoxicologie, Commissariat a l'Energie Atomique, Ctr. d'Etudes de Bruyeres-le-Chatel, BP 12, F-91680 Bruyeres-le-Chatel, France
Service Hospitalier Frederic Joliot, Commissariat a l'Energie Atomique, Orsay, France.
References:
Andreasen, N., Carson, C., Diksic, M., Evans, A., Farde, L., Gjedde, A., Hakim, A., Wong, D., Workshop on schizophrenia PET, and dopamine D2 receptors in human neostriatum (1988) Schizophr Bull, 14, pp. 471-48
Bendriem, B., Dewey, S.L., Schlyer, D.J., Wolf, A.P., Volkow, N.D., Quantitation of the human basal ganglia with positron emission tomography
a phantom study of the effect of contrast and axial positioning (1991) IEEE Trans Med Imag, 10, pp. 216-222
Breier, A., Su, T.P., Saunders, R., Carson, R.E., Kolachana, B.S., De Bartolomeis, A., Weinberger, D.R., Pickar, D., Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentration (1997) Proc Nat Acad Sci USA, 94, pp. 2569-2574
Carson, R.E., Breier, A., De Bartolomeis, A., Saunders, R.C., Su, T.P., Schmall, B., Der, M.G., Eckelman, W.C., Quantification of amphetamine-induced changes in [11C]raclopride binding with continuous infusion (1997) J Cereb Blood Flow Metab, 17, pp. 437-447
Delforge, J., Syrota, A., Mazoyer, B., Identifiability analysis and parameter identification of an in vivo ligand-receptor model from PET data (1990) IEEE Trans Biomed Eng, 37, pp. 653-661
Delforge, J., Pappata, S., Millet, P., Samson, Y., Bendriem, B., Jobert, A., Crouzel, C., Syrota, A., Quantification of benzodiazepine receptor in human brain using PET, [11C]flumazenil and a single-experiment protocol (1995) J Cereb Blood Flow Metab, 19, pp. 533-546
Delforge, J., Spelle, L., Bendriem, B., Samson, Y., Syrota, A., Parametric images of benzodiazepine receptor concentration using a partial-saturation injection (1997) J Cereb Blood Flow Metab, 17, pp. 343-355
Delforge, J., Bottlaender, M., Loc'h, C., Guenther, I., Fuseau, C., Bendriem, B., Syrota, A., Mazière, B., Quantification of extrastriatal D2 receptors using a very high affinity ligand (FLB 457) and the multi-injection approach (1999) J Cereb Blood Flow Metab, 15, pp. 284-300
Dewey, S.L., Smith, G.S., Logan, J., Brodie, J., Yu, D.W., Ferrieri, R., King, P., Meller, E., Gabaergic inhibition of endogeneous dopamine release measured in vivo with 11C-raclopride and positron emission tomography (1992) Neuroscience, 12, pp. 3773-3780
Endres, C.J., Kolachana, B.S., Saunders, R.C., Su, T., Weinberger, D., Breier, A., Eckelman, W.C., Carson, R.E., Kinetic modeling of [11C]raclopride: Combined PET-microdialysis studies (1997) J Cereb Blood Flow Metab, 17, pp. 932-942
Farde, L., Hall, H., Pauli, S., Halldin, C., Variability in D2-dopamine receptor density and affinity: A PET study with [11C]raclopride in man (1995) Synapse, 20, pp. 200-208
Fisher, R.E., Morris, E.D., Alpert, N., Fischman, A.J., In vivo imaging of neuromodulatory synaptic transmission using PET: A review of relevant neurophysiology (1995) Human Brain Mapping, 3, pp. 24-34
Garris, P.A., Wightman, R.M., Different kinetics govern dopaminergic transmission in amygdala, prefrontal cortex and striatum: An in vivo voltammetric study (1994) J Neurosci, 14, pp. 442-450
Ginovart, N., Farde, L., Halldin, C., Swahn, C.G., Effect of reserpine-induced depletion of synaptic dopamine on C11-raclopride binding to D2-dopamine receptors in the monkey brain (1997) Synapse, 24, pp. 321-325
Guidotti, A., Forchetti, C.M., Corda, M.G., Konkel, D., Benett, K.D., Costa, E., Isolation, characterization, and purification of an endogenous polypeptide with agonistic action on benzodiazepine receptors (1983) Proc Nat Acad Sci USA, 80, pp. 3531-3535
Huang, S.C., Barrio, J.R., Phelps, M.E., Neuroreceptor assay with positron emission tomography: Equilibrium versus dynamic approach (1986) J Cereb Blood Flow Metab, 6, pp. 515-521
Kawagoe, K.T., Garris, P.A., Wiedemann, D.J., Wightman, R.M., Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum (1992) Neuroscience, 51, pp. 55-64
Klotz, U., Occurrence of "natural" benzodiazepine (1991) Life Sci, 48, pp. 209-215
Koepp, M.J., Gunn, R.N., Lawrence, A.D., Cunningham, V.J., Dagher, A., Jones, T., Brooks, D.J., Grasby, P.M., Evidence for striatal dopamine release during a video game (1998) Nature, 393, pp. 266-268
Kuczenski, R., Segal, D.S., Effects of methylphenidate on extracellular dopamine serotonin, and norepinephrine: Comparison with amphetamine (1977) J Neurochem, 68, pp. 2032-2037
Laruelle, M., D'Souza, C.D., Baldwin, R.M., Abi-Dargham, A., Kanes, S.J., Fingado, C.L., Seibyl, J.P., Innis, R.B., Imaging D2 receptor occupancy by endogenous dopamine in humans (1997) Neuropshychopharmacology, 13, pp. 162-174
Laruelle, M., Iyer, R.N., Al-Tikriti, M.S., Zea-Ponce, Y., Malison, R.T., Zoghbi, S.S., Baldwin, R.M., Bradberry, C.W., Microdialysis and SPECT measurements of amphetamine-induced dopamine release in non-human primates (1997) Synapse, 25, pp. 1-14
Laruelle, M., Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review (2000) J Cereb Blood Flow Metab, 20, pp. 423-451
Logan, J., Dewey, S.L., Wolf, A.P., Fowler, J.S., Brodie, J.D., Angrist, B., Volkow, N.D., Gatley, S.J., Effects of endogenous dopamine on measures of [18F]N-methylspiroperidol binding in the basal ganglia: Comparison of simulations and experimental results from PET studies in baboons (1991) Synapse, 9, pp. 195-207
Millet, P.H., Delforge, J., Mauguière, F., Pappata, S., Cinotti, L., Frouin, V., Samson, Y., Syrota, A., Parametric images of benzodiazepine receptor concentration in human brain: Comparison with the distribution volume approach (1995) J Nucl Med, 36, pp. 1462-1471
Mintun, M.A., Raichle, M.E., Kilbourn, M.R., Wooten, G.F., Welch, M.J., A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography (1984) Ann Neurol, 15, pp. 217-227
Morris, E.D., Fisher, R.E., Alpert, N.M., Rauch, S.L., Fischman, A.J., In vivo imaging of neuromodulation using positron emission tomography: Optimal ligand characteristics and task length for detection of activation (1995) Hum Brain Mapp, 3, pp. 35-55
Naudon, L., Leroux-Nicollet, I., Raisman-Vozari, R., Botton, D., Costentin, J., Time-course of modifications elicited by reserpine on the density of mRNA synthesis of the vesicular monoamine transporter and on the density of the membrane dopamine uptake complex (1995) Synapse, 21, pp. 29-36
Price, J.C., Mason, N.S., Lopresti, B., Holt, D., Simpson, N.R., Drevets, W., Smith, G.S., Mathis, C.A., PET measurement of endogenous neurotransmitter activity using high and low affinity radiotracers (1998) Quantitative functional brain imaging with positron emission tomography, pp. 441-448. , (Carson RE, Daube-Witherspoon M, Herscovitch P, eds), San Diego: Academic Press
Ross, S.B., Jackson, D.M., Kinetic properties of the in vivo accumulation of 3H-(-)-N-n-propylnorapomorphine in mouse brain (1989) Naunyn Schmiedebergs Arch Pharmacol, 340, pp. 6-12
Ross, S.B., Synaptic concentration of dopamine in the mouse striatum in relationship to the kinetic properties of the dopamine receptors and uptake mechanism (1991) J Neurochem, 56, pp. 22-29
Seeman, P., Guan, H.-C., Niznik, H.B., Endogenous dopamine lowers the dopamine D2 receptor density as measured by [3H]raclopride: Implications for positron emission tomography of the human brain (1989) Synapse, 3, pp. 96-97
Seeman, P., Sunahara, R.K., Niznik, H.B., Receptor-receptor link in membranes revealed by ligand competition: Example for dopamine D1 and D2 receptors (1994) Synapse, 17, pp. 62-64
Swahn, C.-G., Halldin, C., Farde, L., Sedvall, G., Metabolism of the PET ligand [11C]SCH 23390. Identification of two radiolabeled metabolites with HPLC (1994) Human Psychopharmacology, 9, pp. 25-31
Syrota, A., Paillotin, G., Davy, J.M., Aumont, M.C., Kinetics of in vivo binding of antagonist to muscarinic cholinergic receptor in the human heart studied by positron emission tomography (1984) Life Sci, 35, pp. 937-945
Volkow, N.D., Wang, G.-J., Fowler, J., Logan, J., Schlyer, D., Hitzemann, R., Lieberman, J., Wolf, A., Imaging endogenous dopamine competition with 11C raclopride in the human brain (1994) Synapse, 16, pp. 255-262
Volkow, N.D., Fowler, J.S., Gatley, S.J., Logan, J., Wang, G.W., Ding, Y.S., Dewey, S., PET evaluation of the dopamine system of the human brain (1996) J Nucl Med, 37, pp. 1242-1256
Breier, A., Su, T. P., Saunders, R., Carson, R. E., Kolachana, B. S., De Bartolomeis, A., Weinberger, D. R., Pickar, D., Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentration (1997) Proc Nat Acad Sci USA, 94, pp. 2569-2574
Carson, R. E., Breier, A., De Bartolomeis, A., Saunders, R. C., Su, T. P., Schmall, B., Der, M. G., Eckelman, W. C., Quantification of amphetamine-induced changes in [11C] raclopride binding with continuous infusion (1997) J Cereb Blood Flow Metab, 17, pp. 437-447
Dewey, S. L., Smith, G. S., Logan, J., Brodie, J., Yu, D. W., Ferrieri, R., King, P., Meller, E., Gabaergic inhibition of endogeneous dopamine release measured in vivo with 11C-raclopride and positron emission tomography (1992) Neuroscience, 12, pp. 3773-3780
Endres, C. J., Kolachana, B. S., Saunders, R. C., Su, T., Weinberger, D., Breier, A., Eckelman, W. C., Carson, R. E., Kinetic modeling of [11C] raclopride: Combined PET-microdialysis studies (1997) J Cereb Blood Flow Metab, 17, pp. 932-942
Fisher, R. E., Morris, E. D., Alpert, N., Fischman, A. J., In vivo imaging of neuromodulatory synaptic transmission using PET: A review of relevant neurophysiology (1995) Human Brain Mapping, 3, pp. 24-34
Garris, P. A., Wightman, R. M., Different kinetics govern dopaminergic transmission in amygdala, prefrontal cortex and striatum: An in vivo voltammetric study (1994) J Neurosci, 14, pp. 442-450
Huang, S. C., Barrio, J. R., Phelps, M. E., Neuroreceptor assay with positron emission tomography: Equilibrium versus dynamic approach (1986) J Cereb Blood Flow Metab, 6, pp. 515-521
Kawagoe, K. T., Garris, P. A., Wiedemann, D. J., Wightman, R. M., Regulation of transient dopamine concentration gradients in the microenvironment surrounding nerve terminals in the rat striatum (1992) Neuroscience, 51, pp. 55-64
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Grasby, P. M., Evidence for striatal dopamine release during a video game (1998) Nature, 393, pp. 266-268
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Absolute quantification by positron emission tomography of the endogenous ligand
The results of several recent papers have shown a significant influence of the endogenous neurotransmitters on the exogenous ligand kinetics measured by positron emission tomography. For example, several groups found that the percentage of D2 receptor sites occupied by the endogenous dopamine ranged from 25% to 40% at basal level. An obvious consequence of this significant occupancy is that the ligand-receptor model parameters, usually estimated by a model that does not take into account the endogenous ligand (EL) kinetics, can be significantly biased. In the current work, the authors studied the biases obtained by using the multiinjection approach. The results showed that in the classical ligand-receptor model, the receptor concentration is correctly estimated and that only the apparent affinity is biased by not taking the EL into account. At present, all absolute quantifications of the EL have been obtained through pharmacologic manipulation of the endogenous transmitter concentration, which is often too invasive a method to be used in patients. A theoretical reasoning showed that a noninvasive approach is necessarily based on both the apparent affinity measurement and on a multiregion approach. The correlation between the receptor concentration and the apparent affinity, previously observed with some ligands, verifies these two conditions; thus, the authors suggest that this correlation could be the result of the EL effect. To test this assumption experimentally, the effect of reserpine-induced dopamine depletion on the interactions between the D2 receptor sites and the FLB 457 is studied. With untreated baboons, the apparent FLB 457 affinity was smaller in the receptor-rich regions (striatum) than in the receptor-poor regions. This discrepancy disappeared after dopamine depletion, strongly suggesting that this affinity difference was related to the EL effect. Therefore, the purpose of the current study was to test the ability to quantify the EL based on the observed correlation between the receptor concentration and the apparent affinity. This approach offers a method for estimating the percentage of receptor sites occupied by the EL and, if its affinity is known, the free EL concentration. From the data obtained using FLB 457 with baboons, the authors found that approximately 53% of the D2 receptor sites are occupied by dopamine in the striatum and that the free dopamine concentration is approximately 120 nmol/L at basal level. This approach is transferable to patients, because the experimental data are obtained without pharmacologically induced modification of the EL.
The results of several recent papers have shown a significant influence of the endogenous neurotransmitters on the exogenous ligand kinetics measured by positron emission tomography. For example, several groups found that the percentage of D2 receptor sites occupied by the endogenous dopamine ranged from 25% to 40% at basal level. An obvious consequence of this significant occupancy is that the ligand-receptor model parameters, usually estimated by a model that does not take into account the endogenous ligand (EL) kinetics, can be significantly biased. In the current work, the authors studied the biases obtained by using the multiinjection approach. The results showed that in the classical ligand-receptor model, the receptor concentration is correctly estimated and that only the apparent affinity is biased by not taking the EL into account. At present, all absolute quantifications of the EL have been obtained through pharmacologic manipulation of the endogenous transmitter concentration, which is often too invasive a method to be used in patients. A theoretical reasoning showed that a noninvasive approach is necessarily based on both the apparent affinity measurement and on a multiregion approach. The correlation between the receptor concentration and the apparent affinity, previously observed with some ligands, verifies these two conditions; thus, the authors suggest that this correlation could be the result of the EL effect. To test this assumption experimentally, the effect of reserpine-induced dopamine depletion on the interactions between the D2 receptor sites and the FLB 457 is studied. With untreated baboons, the apparent FLB 457 affinity was smaller in the receptor-rich regions (striatum) than in the receptor-poor regions. This discrepancy disappeared after dopamine depletion, strongly suggesting that this affinity difference was related to the EL effect. Therefore, the purpose of the current study was to test the ability to quantify the EL based on the observed correlation between the receptor concentration and the apparent affinity. This approach offers a method for estimating the percentage of receptor sites occupied by the EL and, if its affinity is known, the free EL concentration. From the data obtained using FLB 457 with baboons, the authors found that approximately 53% of the D2 receptor sites are occupied by dopamine in the striatum and that the free dopamine concentration is approximately 120 nmol/L at basal level. This approach is transferable to patients, because the experimental data are obtained without pharmacologically induced modification of the EL.
Absolute quantification by positron emission tomography of the endogenous ligand
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Absolute quantification by positron emission tomography of the endogenous ligand
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Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (470 views)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
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Cervenka S, Varrone A, Fransen E, Halldin C, Farde L
* PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans (550 views)
Synapse (ISSN: 0887-4476), 2010 Jun; 64(6): 478-485.
Impact Factor: 2.925
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Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (604 views) (PDF 259 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
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Fujita M, Varrone A, Kim KM, Watabe H, Zoghbi SS, Seneca N, Tipre D, Seibyl JP, Innis RB, Iida H
* Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET (353 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 May; 31(5): 644-654.
Impact Factor: 3.935
View Export to BibTeX Export to EndNote
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (470 views)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
Impact Factor: 5.88
View Export to BibTeX Export to EndNote
Cervenka S, Varrone A, Fransen E, Halldin C, Farde L
* PET studies of D2-receptor binding in striatal and extrastriatal brain regions: Biochemical support in vivo for separate dopaminergic systems in humans (550 views)
Synapse (ISSN: 0887-4476), 2010 Jun; 64(6): 478-485.
Impact Factor: 2.925
View Export to BibTeX Export to EndNote
Varrone A, Sjoholm N, Eriksson L, Gulyas B, Halldin C, Farde L
* Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT (604 views) (PDF 259 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Oct; 36(10): 1639-1650.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Fujita M, Varrone A, Kim KM, Watabe H, Zoghbi SS, Seneca N, Tipre D, Seibyl JP, Innis RB, Iida H
* Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET (353 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 May; 31(5): 644-654.
Impact Factor: 3.935
View Export to BibTeX Export to EndNote
4 Records (4 excluding Abstracts).
Total impact factor: 17.271 (17.271 excluding Abstracts).
Total 5 year impact factor: 17.978 (17.978 excluding Abstracts).
Total impact factor: 17.271 (17.271 excluding Abstracts).
Total 5 year impact factor: 17.978 (17.978 excluding Abstracts).
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