Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback (668 views)
Psychol Med (ISSN: 0033-2917), 2015 Jan 12; 45(8): 1765-1778.
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Paper type: Journal Article,
Impact factor: 5.491, 5-year impact factor: 5.969
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988258835&doi=10.1017%2fS0033291714002943&partnerID=40&md5=88fcadffbf1b15b682071af5b065f619
Keywords: Avolition, Deficit Schizophrenia, Dorsal Caudate, Reward Anticipation, Ventral Striatum, Adaptive Behavior, Adult, Brain, Brain Mapping, Female, Human, Motivation, Nuclear Magnetic Resonance Imaging, Pathophysiology, Psychological, Feedback,
Affiliations:
*** IBB - CNR ***
Department of Psychiatry,University of Naples SUN,Naples,Italy.
Psychosis Research Program,Department of Psychiatry,Icahn School of Medicine at Mount SinaiNew York,USA.
Biostructure and Bioimaging Institute,National Research Council,Naples,Italy.
Department of Biomorphological and Functional Studies,University of Naples 'Federico II',Naples,Italy.
MRC Social Genetic and Developmental Psychiatry, Institute of Psychiatry, King's College London, United Kingdom
References:
Not available.
Psychol Med (ISSN: 0033-2917), 2015 Jan 12; 45(8): 1765-1778.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.491, 5-year impact factor: 5.969
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988258835&doi=10.1017%2fS0033291714002943&partnerID=40&md5=88fcadffbf1b15b682071af5b065f619
Keywords: Avolition, Deficit Schizophrenia, Dorsal Caudate, Reward Anticipation, Ventral Striatum, Adaptive Behavior, Adult, Brain, Brain Mapping, Female, Human, Motivation, Nuclear Magnetic Resonance Imaging, Pathophysiology, Psychological, Feedback,
Affiliations:
*** IBB - CNR ***
Department of Psychiatry,University of Naples SUN,Naples,Italy.
Psychosis Research Program,Department of Psychiatry,Icahn School of Medicine at Mount SinaiNew York,USA.
Biostructure and Bioimaging Institute,National Research Council,Naples,Italy.
Department of Biomorphological and Functional Studies,University of Naples 'Federico II',Naples,Italy.
MRC Social Genetic and Developmental Psychiatry, Institute of Psychiatry, King's College London, United Kingdom
References:
Not available.
Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback
Background The neurobiological underpinnings of avolition in schizophrenia remain unclear. Most brain imaging research has focused on reward prediction deficit and on ventral striatum dysfunction, but findings are not consistent. In the light of accumulating evidence that both ventral striatum and dorsal caudate play a key role in motivation, we investigated ventral striatum and dorsal caudate activation during processing of reward or loss in patients with schizophrenia. Method We used functional magnetic resonance imaging to study brain activation during a Monetary Incentive Delay task in patients with schizophrenia, treated with second-generation antipsychotics only, and in healthy controls (HC). We also assessed the relationships of ventral striatum and dorsal caudate activation with measures of hedonic experience and motivation. Results The whole patient group had lower motivation but comparable hedonic experience and striatal activation than HC. Patients with high avolition scores showed lower dorsal caudate activation than both HC and patients with low avolition scores. A lower dorsal caudate activation was also observed in patients with deficit schizophrenia compared to HC and patients with non-deficit schizophrenia. Dorsal caudate activity during reward anticipation was significantly associated with avolition, but not with anhedonia in the patient group. Conclusions These findings suggest that avolition in schizophrenia is linked to dorsal caudate hypoactivation. © Cambridge University Press 2015.
Background The neurobiological underpinnings of avolition in schizophrenia remain unclear. Most brain imaging research has focused on reward prediction deficit and on ventral striatum dysfunction, but findings are not consistent. In the light of accumulating evidence that both ventral striatum and dorsal caudate play a key role in motivation, we investigated ventral striatum and dorsal caudate activation during processing of reward or loss in patients with schizophrenia. Method We used functional magnetic resonance imaging to study brain activation during a Monetary Incentive Delay task in patients with schizophrenia, treated with second-generation antipsychotics only, and in healthy controls (HC). We also assessed the relationships of ventral striatum and dorsal caudate activation with measures of hedonic experience and motivation. Results The whole patient group had lower motivation but comparable hedonic experience and striatal activation than HC. Patients with high avolition scores showed lower dorsal caudate activation than both HC and patients with low avolition scores. A lower dorsal caudate activation was also observed in patients with deficit schizophrenia compared to HC and patients with non-deficit schizophrenia. Dorsal caudate activity during reward anticipation was significantly associated with avolition, but not with anhedonia in the patient group. Conclusions These findings suggest that avolition in schizophrenia is linked to dorsal caudate hypoactivation. © Cambridge University Press 2015.
Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback
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Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback
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Impact Factor: 3.439
View Export to BibTeX Export to EndNote
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Impact Factor: 3.552
View Export to BibTeX Export to EndNote
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Impact Factor: 6.592
View Export to BibTeX Export to EndNote
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Impact Factor: 4.128
View Export to BibTeX Export to EndNote
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7 Records (4 excluding Abstracts).
Total impact factor: 24.526 (15.768 excluding Abstracts).
Total 5 year impact factor: 28.681 (16.794 excluding Abstracts).
Total impact factor: 24.526 (15.768 excluding Abstracts).
Total 5 year impact factor: 28.681 (16.794 excluding Abstracts).
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