Metabolic effects of resistant starch in patients with Type 2 diabetes(687 views) Giacco R, Mancini M, Clemente G, Coppola S, Lasorella G, D’Avanzo G, Rivieccio A M, Ruffa G, Brighenti F, Rivellese AA, Riccardi G
Affiliations: Institute of Food Science and Technology, National Research Council, Avellino, Italy
DISTAM University of Milan, Italy
S.Giuseppe Moscati Hospital, Avellino, Italy
Department of Clinical and Experimental Medicine, Medical School, University of Naples Federico II, Napoli, Italy
Istituto di Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche, Via Roma 52 A/C, 83100, Avellino, Italy
S. Giuseppe Moscati Hospital, Avellino, Italy
References: Not available.
Metabolic effects of resistant starch in patients with Type 2 diabetes
The aim of our study was to evaluate, in patients with Type 2 diabetes mellitus (T2DM): 1) the metabolic response to a meal rich in resistant starch (RS); 2) the effects of consumption of RS on the metabolic response to the subsequent meal. The study was randomized and placebo-controlled. Six men and 4 women with T2DM, age 50 ± 2 yr (Mean ± SE), BMI 27 ± 0.9 kg/m2, duration of diabetes 6 ± 1 yr, fasting plasma glucose 8.49 ± 0.21 mmol/l, treated with diet alone or diet + sulphonylurea, participated in the study. After a 12-hour overnight fast, the patients consumed, on different days and in random order, two meals with similar composition (protein 15%, fat 30%, carbohydrate 55%, fiber 3 g, kcal 797) but different in RS content (16 vs 1 g). Four hours after the first meal, patients were given a second meal, which was the same, independently of the first meal (protein 15%, fat 30%, carbohydrate 55%, fiber 3 g, kcal 593). Blood samples were collected in the fasting state and every hour for 4 hr after each meal, for measurement of plasma glucose, insulin, triglycerides and NEFA. Blood glucose response was lower after the high RS than after the low RS meal (-32%, f = 5.00; p < 0.03). Also, the triglyceride response was lower after the RS-rich meal (-26%, f = 4.96; p < 0.03). Conversely, plasma NEFA and insulin concentrations were similar after the two meals. Consumption of RS had no effect on the subsequent meal; in fact, there were no differences in plasma glucose, insulin, NEFA or triglyceride responses between the standard meals consumed 4 hours after either the high RS or the low RS meal. In conclusion, RS consumption improves the plasma glucose and triglyceride responses to a meal.
Metabolic effects of resistant starch in patients with Type 2 diabetes
No results.
Metabolic effects of resistant starch in patients with Type 2 diabetes
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