Exit from mycobacterial dormancy: a structural perspective
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Exit from mycobacterial dormancy: a structural perspective
(
696 views
)
Squeglia F
,
Ruggiero A
,
Berisio R
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic)
,
2015 Feb 9;
22(14): 1698-1709.
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Paper type:
Journal Article, Research Support, Non-U. S. Gov'T , Review,
Impact factor:
3.455,
5-year impact factor:
3.792
Url:
http://www.scopus.com/inward/record.url?eid=2-s2.0-84931263248&partnerID=40&md5=5f13be67b488ba0d92b93a7d6b46e581
Keywords:
Dormancy, Mycobacteria, Resuscitation, Structure, Hydrolase, Peptidoglycan, Article, Bacterial Cell Wall, Bacterial Growth, Bacterial Phenomena And Functions, Bacterial Resuscitation, Bacterial Survival, Cell Growth, Chemical Composition, Chemical Structure, Gram Negative Bacterium, Gram Positive Bacterium, Molecular Interaction, Nonhuman, Protein Structure, Cell Wall Chemistry , Mycobacterium Tuberculosis Chemistry Cytology Growth, Development Physiology,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR, Naples, Italy.. alessia.ruggiero@unina.it.
References:
Not available.
Exit from mycobacterial dormancy: a structural perspective
Dormancy in mycobacteria is defined as a stable but reversible non-replicating state in response to stresses. In Mycobacterium tuberculosis, an important human pathogen, this state is responsible for latent Tuberculosis. The current chemotherapy to defeat Tuberculosis while effective in killing growing tubercle bacilli is largely ineffective in killing dormant bacilli. For this reason there is a recent interest to develop new drugs against this disease in the latent form. To this aim, the knowledge of the molecular basis of bacterial resuscitation from dormancy is necessary and of paramount importance. This review summarizes the current knowledge on the complex mechanism of exit from mycobacterial dormancy; the main molecular players responsible for mycobacterial resuscitation from dormancy are described and their role is discussed from a structural perspective. © 2015 Bentham Science Publishers.
Exit from mycobacterial dormancy: a structural perspective
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Cell wall recognition events for biosensors development
Squeglia Flavia
Ruggiero Alessia
Romano Maria
Berisio Rita
▼
Structural and functional studies of virulence factors in Mycobacterium tuberculosis infection
Pedone EmiliaMaria
Berisio Rita
Exit from mycobacterial dormancy: a structural perspective
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Squeglia F
,
Marasco D
,
Ruggiero A
, Testa G,
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,
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*
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*
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Squeglia F
, Moreira M,
Ruggiero A
,
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*
The Cell Wall Hydrolytic NlpC/P60 Endopeptidases in Mycobacterial Cytokinesis: A Structural Perspective
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De Maio F,
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, Goletti D, Delogu G
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Squeglia F
,
Ruggiero A
,
Berisio R
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Chemistry of Peptidoglycan in Mycobacterium tuberculosis Life Cycle: An off-the-wall Balance of Synthesis and Degradation
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Squeglia F
,
Ruggiero A
, De Simone A,
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A structural overview of mycobacterial adhesins: Key biomarkers for diagnostics and therapeutics
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Squeglia F
,
Ruggiero A
,
Berisio R
*
Chemistry of Peptidoglycan in Mycobacterium tuberculosis life style: an off-the-wall balance of synthesis and degradation
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558 views
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Chemistry (ISSN: 1521-3765electronic, 0947-6539linking)
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2018;
24: 2533-2546.
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Berisio R
,
Squeglia F
,
Ruggiero A
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Editorial: Molecular Scenarios Behind Infectious Diseases
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Ruggiero A
,
Squeglia F
,
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,
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, De Simone A,
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*
Structure and dynamics of the multi-domain resuscitation promoting factor RpfB from Mycobacterium tuberculosis
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Dennehy R, RomanoM,
Ruggiero A
, Mohamed YF, Dignam SL, Mujica Troncoso C, Callaghan M, Valvano MA,
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2017 May;
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Dennehy R,
Romano M
,
Ruggiero A
, Troncoso CM, Fathy Y, Callaghan M, Valvano M,
Berisio R
, Mcclean S
*
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341 views
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Cellular Microbiology
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2016;
inpress: N/D-N/D.
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Maione V,
Ruggiero A
, Russo L, De Simone A, Pedone PV, Malgieri G,
Berisio R
, Isernia C
*
NMR Structure and Dynamics of the Resuscitation Promoting Factor RpfC Catalytic Domain
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2015 Nov 17;
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Ruggiero A
,
Squeglia F
,
Romano M
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Vitagliano L
, De Simone A,
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*
The structure of Resuscitation promoting factor B from M. tuberculosis reveals unexpected ubiquitin-like domains
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2015 Nov 5;
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Nikitushkin VD, Demina GR, Shleeva MO, Guryanova SV,
Ruggiero A
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, Kaprelyants AS
*
A product of RpfB and RipA joint enzymatic action promotes the resuscitation of dormant mycobacteria
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2015 Apr 3;
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Calce E, Mignogna E, Bugatti V, Galdiero M, Vittoria V,
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Pectin functionalized with natural fatty acids as antimicrobial agent
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Calvanese L,
Falcigno L
, Maglione C,
Marasco D
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Ruggiero A
,
Squeglia F
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Berisio R
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Romano M
, Van De Weerd R, Brouwer FCC,
Roviello GN
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Cantisani M,
Leone M
, Mignogna E, Kampanaraki K, Falanga A,
Morelli G
, Galdiero M,
Galdiero S
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Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish
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2013 Nov;
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Correale S,
Ruggiero A
, Capparelli R,
Pedone E
,
Berisio R
*
Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis
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Correale S,
Ruggiero A
,
Pedone E
,
Berisio R
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Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the l, d-transpeptidase LdtMt1 from Mycobacterium tuberculosis
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2013 Mar 1;
69(3): 253-256.
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Ruggiero A
, Marchant J,
Squeglia F
, Makarov V, De Simone A,
Berisio R
*
Molecular determinants of inactivation of the resuscitation promoting factor B from Mycobacterium tuberculosis
(
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2013 Feb 1;
31(2): 195-205.
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Ruggiero A
, De Simone P, Smaldone G,
Squeglia F
,
Berisio R
*
Bacterial cell division regulation by Ser/Thr kinases: A structural perspective
(
681 views
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Berisio R
*
Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development
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Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking)
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2012 Dec;
13(8): 697-698.
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Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L,
De Luca S
, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A
*
Antimicrobial properties of distinctin in an experimental model of MRSA-infected wounds
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Eur J Clin Microbiol Infect Dis (ISSN: 0934-9723, 0934-9723linking)
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2012 Nov;
31(11): 3047-3055.
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Berisio R
*
Editorial: cell processes in bacterial diseases
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Protein Pept Lett (ISSN: 0929-8665, 1875-5305)
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2012 Oct;
19(10): 1011-1012.
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Kaprelyants AS, Mukamolova GV,
Ruggiero A
, Makarov VA, Demina GR, Shleeva MO, Potapov VD, Shramko PA
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Resuscitation-promoting Factors (Rpf): In Search of Inhibitors
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632 views
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Protein Pept Lett (ISSN: 0929-8665, 1875-5305)
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2012 Oct;
19(10): 1026-1034.
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Esposito C, Cantisani M,
D'Auria G
,
Falcigno L
,
Pedone E
,
Galdiero S
,
Berisio R
*
Mapping key interactions in the dimerization process of HBHA from Mycobacterium tuberculosis, insights into bacterial agglutination
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Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic)
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2012 Mar 23;
586(6): 659-667.
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De Simone G
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Editorial: Zinc Metallo-Enzymes As Target For Drug Design
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Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic)
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2012 Feb;
19(6): 820-1012.
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Squeglia F
, Marchetti R,
Ruggiero A
, Lanzetta R,
Marasco D
, Dworkin J, Petoukhov M,
Molinaro A
,
Berisio R
, Silipo A
*
Chemical basis of peptidoglycan discrimination by PrkC, a key kinase involved in bacterial resuscitation from dormancy
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438 views
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J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126)
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2011 Dec 28;
133(51): 20676-20679.
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Ruggiero A
,
Squeglia F
,
Marasco D
, Marchetti R,
Molinaro A
,
Berisio R
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X-ray structural studies of the entire extracellular region of the serine/threonine kinase PrkC from Staphylococcus aureus
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1005 views
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Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking)
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2011 Apr 1;
435(1): 33-41.
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Ruggiero A
,
Squeglia F
,
Pirone L
, Correale S,
Berisio R
*
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a major fragment of the resuscitation-promoting factor RpfB from Mycobacterium tuberculosis
(
496 views
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Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309)
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2011 Jan 1;
67(1): 164-168.
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Ruggiero A
,
Squeglia F
, Izzo V, Silipo A,
Vitagliano L
,
Molinaro A
,
Berisio R
*
Expression, purification, crystallization and preliminary x-ray crystallographic analysis of the peptidoglycan binding region of the ser/thr kinase PrkC from staphylococcus aureus
(
656 views
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Protein Pept Lett (ISSN: 0929-8665, 1875-5305)
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2010 Oct;
17(10): 1296-1299.
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Ruggiero A
,
Marasco D
,
Squeglia F
, Soldini S,
Pedone E
,
Pedone C
,
Berisio R
*
Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation
(
635 views
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Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking)
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2010 Sep 8;
18(9): 1184-1190.
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Ruggiero A
,
Squeglia F
, Esposito C,
Marasco D
,
Pedone E
,
Pedone C
,
Berisio R
*
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the resuscitation promoting factor interacting protein RipA from M. tuberculosis
(
475 views
)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305)
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2010 Jan;
17(1): 70-73.
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Ruggiero A
, Tizzano B,
Pedone E
,
Pedone C
, Wilmanns M,
Berisio R
*
Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis
(
758 views
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J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic)
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2009 Jan 9;
385(1): 153-162.
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Cirioni O, Ghiselli R, Orlando F, Silvestri C,
De Luca S
, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A
*
Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis
(
472 views
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Critical Care Medicine (ISSN: 0090-3493)
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2008 Sep;
36(9): 2629-2633.
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Limauro D,
Pedone E
, Galdi I, Bartolucci S
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Peroxiredoxins as cellular guardians in Sulfolobus solfataricus - characterization of Bcp1, Bcp3 and Bcp4
(
460 views
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Febs Journal (ISSN: 1742-464x)
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2008 May;
275(9): 2067-2077.
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Ruggiero A
, Tizzano B, Geerlof A,
Pedone E
,
Pedone C
, Wilmanns M,
Berisio R
*
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of a resuscitation-promoting factor from Mycobacterium tuberculosis
(
516 views
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Nucleosides Nucleotides Nucleic Acids (ISSN: 1744-3091, 1744-4309)
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2007 Oct 1;
63(10): 870-873.
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Leone M
, Di Lello P, Ohlenschläger O,
Pedone E
, Bartolucci S, Rossi M, Di Blasio B,
Pedone C
, Saviano M, Isernia C, Fattorusso R
*
Solution structure and backbone dynamics of the K18G/R82E Alicyclobacillus acidocaldarius thioredoxin mutant: A molecular analysis of its reduced thermal stability
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1068 views
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Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic)
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2004 May 25;
43(20): 6043-6058.
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4.008
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Ogawa R,
Pacelli R
, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
*
Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress
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904 views
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2001 Feb 1;
30(3): 268-276.
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40
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40
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Total impact factor:
152.084
(
152.084
excluding Abstracts).
Total 5 year impact factor:
155.333
(
155.333
excluding Abstracts).
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Marco Comerci
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