Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications (539 views)
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
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Paper type: Journal Article,
Impact factor: 2.76, 5-year impact factor: 2.79
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84923165976&partnerID=40&md5=89fab1b27b11d1f8ea1684046db28847
Keywords: Akt, P53, Chemoradiotherapy, Epidermal Growth Factor Receptor (egfr), Head And Neck Squamous Cell Carcinoma, Intracellular Pathway, Radioresistance, Adenovirus Vector, Amphiregulin, Bevacizumab, Cetuximab, Contusugene Ladenovec, Cyclin D1, Dactolisib, Docetaxel, Erlotinib, Initiation Factor 4e, K Ras Protein, Lontucirev, Mammalian Target Of Rapamycin, Methotrexate, Perifosine, Phosphatidylinositol 3 Kinase, Protein Bax, Protein Kinase B, Protein P53, Puma Protein, Temsirolimus, Tipifarnib, Transforming Growth Factor, Unindexed Drug, Uvomorulin, Vorinostat, [1 (4 Oxo 8 Phenyl 4h 1 Benzopyran 2 Yl)morpholinio]methoxysuccinylarginylglycylaspartylserine Acetate, Advanced Cancer, Apoptosis, Article, Autophosphorylation, Cancer Radiotherapy, Cancer Recurrence, Cell Migration, Cell Proliferation, Cell Survival, Dna Damage, Dna Repair, Down Regulation, Enzyme Inhibition, Enzyme Phosphorylation, Epithelial Mesenchymal Transition, G1 Phase Cell Cycle Checkpoint, Gene Mutation, Gene Overexpression, Human, Immunohistochemistry, Ionizing Radiation, Papillomavirus Infection, Priority Journal, Radiation Dose Fractionation, Radiosensitivity, Signal Transduction, T Lymphocyte Activation, Upregulation, Viral Gene Therapy, Virus Replication, Wild Type, Egfr Protein, Mtor Protein, Target Of Rapamycin Kinase, Drug Effects, Female, Head And Neck Neoplasms, Molecularly Targeted Therapy, Pathology, Physiology, Procedures, Prognosis, Radiation Response, Risk Assessment, Treatment Outcome, Molecular Targeted Therapy, Radiation Tolerance, Radiotherapy Dosage, Tor Serine-Threonine Kinases,
Affiliations:
*** IBB - CNR ***
Head and Neck Medical Oncology Unit, National Tumor Institute of Naples, Naples, Italy.
Institute of Biostructures and Bioimaging, National Council of Research (CNR)Naples Italy
Department of Advanced Biomedical SciencesUniversity Federico IINaples Italy
Department of Clinical Medicine and SurgeryUniversity Federico IINaples Italy
Lester and Sue Smith Breast Center, Baylor College of MedicineHouston Texas
Department of Medical OncologyUniversity of SalernoSalerno Italy
References:
Not available.
Head Neck-J Sci Spec (ISSN: 1043-3074), 2015; 37(5): 763-770.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.76, 5-year impact factor: 2.79
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84923165976&partnerID=40&md5=89fab1b27b11d1f8ea1684046db28847
Keywords: Akt, P53, Chemoradiotherapy, Epidermal Growth Factor Receptor (egfr), Head And Neck Squamous Cell Carcinoma, Intracellular Pathway, Radioresistance, Adenovirus Vector, Amphiregulin, Bevacizumab, Cetuximab, Contusugene Ladenovec, Cyclin D1, Dactolisib, Docetaxel, Erlotinib, Initiation Factor 4e, K Ras Protein, Lontucirev, Mammalian Target Of Rapamycin, Methotrexate, Perifosine, Phosphatidylinositol 3 Kinase, Protein Bax, Protein Kinase B, Protein P53, Puma Protein, Temsirolimus, Tipifarnib, Transforming Growth Factor, Unindexed Drug, Uvomorulin, Vorinostat, [1 (4 Oxo 8 Phenyl 4h 1 Benzopyran 2 Yl)morpholinio]methoxysuccinylarginylglycylaspartylserine Acetate, Advanced Cancer, Apoptosis, Article, Autophosphorylation, Cancer Radiotherapy, Cancer Recurrence, Cell Migration, Cell Proliferation, Cell Survival, Dna Damage, Dna Repair, Down Regulation, Enzyme Inhibition, Enzyme Phosphorylation, Epithelial Mesenchymal Transition, G1 Phase Cell Cycle Checkpoint, Gene Mutation, Gene Overexpression, Human, Immunohistochemistry, Ionizing Radiation, Papillomavirus Infection, Priority Journal, Radiation Dose Fractionation, Radiosensitivity, Signal Transduction, T Lymphocyte Activation, Upregulation, Viral Gene Therapy, Virus Replication, Wild Type, Egfr Protein, Mtor Protein, Target Of Rapamycin Kinase, Drug Effects, Female, Head And Neck Neoplasms, Molecularly Targeted Therapy, Pathology, Physiology, Procedures, Prognosis, Radiation Response, Risk Assessment, Treatment Outcome, Molecular Targeted Therapy, Radiation Tolerance, Radiotherapy Dosage, Tor Serine-Threonine Kinases,
Affiliations:
*** IBB - CNR ***
Head and Neck Medical Oncology Unit, National Tumor Institute of Naples, Naples, Italy.
Institute of Biostructures and Bioimaging, National Council of Research (CNR)Naples Italy
Department of Advanced Biomedical SciencesUniversity Federico IINaples Italy
Department of Clinical Medicine and SurgeryUniversity Federico IINaples Italy
Lester and Sue Smith Breast Center, Baylor College of MedicineHouston Texas
Department of Medical OncologyUniversity of SalernoSalerno Italy
References:
Not available.
Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications
Head and neck squamous cell carcinoma (HNSCC) is strongly associated with alcohol and tobacco consumption. Lately, the incidence of human papillomavirus (HPV)-related tumors has shown a significant increase, and HPV-related tumors show distinctive features if compared with the HPV-negative counterpart. Locally advanced HNSCC can be treated with concomitant chemoradiotherapy, but early recurrences sometimes occur. Relapses are often related to an intrinsic radioresistance of the tumors. Alterations in intracellular pathways, primarily involved in cell proliferation, apoptosis, and DNA repair, can lead to radioresistance. Preclinical and clinical evidence highlighted that 3 main pathways, including the epidermal growth factor receptor (EGFR), the phosphotidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR), and the p53 signaling cascades, play a crucial role in radioresistance development. A future approach may consist in the association of radiotherapy (RT) and selective inhibition of the key pathways involved in radioresistance. Phase I, II, and III clinical trials are currently testing these novel treatment strategies. © 2015 Wiley Periodicals, Inc. Head Neck 37: 763-770, 2015 © 2015 Wiley Periodicals, Inc.
Head and neck squamous cell carcinoma (HNSCC) is strongly associated with alcohol and tobacco consumption. Lately, the incidence of human papillomavirus (HPV)-related tumors has shown a significant increase, and HPV-related tumors show distinctive features if compared with the HPV-negative counterpart. Locally advanced HNSCC can be treated with concomitant chemoradiotherapy, but early recurrences sometimes occur. Relapses are often related to an intrinsic radioresistance of the tumors. Alterations in intracellular pathways, primarily involved in cell proliferation, apoptosis, and DNA repair, can lead to radioresistance. Preclinical and clinical evidence highlighted that 3 main pathways, including the epidermal growth factor receptor (EGFR), the phosphotidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR), and the p53 signaling cascades, play a crucial role in radioresistance development. A future approach may consist in the association of radiotherapy (RT) and selective inhibition of the key pathways involved in radioresistance. Phase I, II, and III clinical trials are currently testing these novel treatment strategies. © 2015 Wiley Periodicals, Inc. Head Neck 37: 763-770, 2015 © 2015 Wiley Periodicals, Inc.
Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications
| ▼ Biomolecules able to modulate the VEGF-dependent angiogenesis |
Radioresistance in head and neck squamous cell carcinoma: Biological bases and therapeutic implications
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* Modeling the risk of radiation-induced lung fibrosis: Irradiated heart tissue is as important as irradiated lung (482 views) (PDF 201 views)
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 2.997
View Export to BibTeX Export to EndNote
Pedicini P, Fiorentino A, Improta G, Nappi A, Salvatore M, Storto G
* Estimate of the accelerated proliferation by protein tyrosine phosphatase (PTEN) over expression in postoperative radiotherapy of head and neck squamous cell carcinoma (301 views)
Clin Transl Oncol (ISSN: 1699-048x), 2013 Nov; 15(11): 919-924.
Impact Factor: 1.6
View Export to BibTeX Export to EndNote
Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
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Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2013 Oct 1; 87(2): 304-310.
Impact Factor: 4.176
View Export to BibTeX Export to EndNote
Cella L, Conson M, Liuzzi R, Pacelli R
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Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2013 Jan 1; 85(1): 11-11.
Impact Factor: 4.176
View Export to BibTeX Export to EndNote
Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Development of multivariate NTCP models for radiation-induced hypothyroidism: A comparative analysis (490 views) (PDF 240 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2012 Dec 27; 7(1): 224-224.
Impact Factor: 2.107
View Export to BibTeX Export to EndNote
Pedicini P, Nappi A, Strigari L, Jereczek-Fossa BA, Alterio D, Cremonesi M, Botta F, Vischioni B, Caivano R, Fiorentino A, Improta G, Storto G, Benassi M, Orecchia R, Salvatore M
* Correlation between EGFr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma (499 views)
Radiation Oncology (ISSN: 1748-717x), 2012 Sep 24; 7: 143-143.
Impact Factor: 2.107
View Export to BibTeX Export to EndNote
Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R
* Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma (523 views) (PDF 240 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2012 Apr 1; 82(5): 1802-1808.
Impact Factor: 4.524
View Export to BibTeX Export to EndNote
Zannetti A, Iommelli F, Speranza A, Salvatore M, Del Vecchio S
* 3'-deoxy-3'-18F-fluorothymidine (FLT) PET/CT to guide therapy with epidermal growth factor receptor (EGFR) antagonists and Bcl-xL inhibitors in non-small cell lung cancer (651 views)
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Impact Factor: 5.774
View Export to BibTeX Export to EndNote
Orditura M, Galizia G, Morgillo F, Martinelli E, Lieto E, Vitiello F, Di Martino N, Pacelli R, Renda A, Ciardiello F, De Vita F
* Complete Response To Preoperative Chemoradiation And Survival In Esophageal Cancer: A Pooled Analysis Of Three Single-Institution Phase Ii Trials (405 views)
Diseases Of The Esophagus, 2012 Feb; 142(5): 130-136.
Impact Factor: 2.057
View Export to BibTeX Export to EndNote
Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (632 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
View Export to BibTeX Export to EndNote
Cella L, Liuzzi R, Conson M, Torre G, Caterino M, De Rosa N, Picardi M, Camera L, Solla R, Farella A, Salvatore M, Pacelli R
* Dosimetric predictors of asymptomatic heart valvular dysfunction following mediastinal irradiation for Hodgkin's lymphoma (513 views)
Radiother Oncol (ISSN: 0167-8140, 1879-0887, 1879-0887electronic), 2011 Nov; 101(2): 316-321.
Impact Factor: 5.58
View Export to BibTeX Export to EndNote
Orditura M, Galizia G, Napolitano V, Martinelli E, Pacelli R, Lieto E, Aurilio G, Vecchione L, Morgillo F, Catalano G, Ciardiello F, Del Genio A, Di Martino N, De Vita F
* Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study (398 views)
Cancer Investigation (ISSN: 0735-7907), 2010 Oct; 28(8): 820-827.
Impact Factor: 2.39
View Export to BibTeX Export to EndNote
Carlomagno C, Farella A, Bucci L, D'Armiento FP, Pesce G, Pepe S, Cannella L, Pacelli R, De Stefano A, Solla R, D'Armiento MR, De Placido S
* Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: A phase II study (797 views)
Annals Of Oncology (ISSN: 0923-7534), 2009 May; 20(5): 906-912.
Impact Factor: 5.647
View Export to BibTeX Export to EndNote
19 Records (18 excluding Abstracts).
Total impact factor: 68.622 (66.515 excluding Abstracts).
Total 5 year impact factor: 64.635 (62.149 excluding Abstracts).
Total impact factor: 68.622 (66.515 excluding Abstracts).
Total 5 year impact factor: 64.635 (62.149 excluding Abstracts).
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