Whole grain intake in relation to body weight: From epidemiological evidence to clinical trials (679 views)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2011 Dec; 21(12): 901-908.
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Paper type: Journal Article, Research Support, Review,
Impact factor: 3.731, 5-year impact factor: 3.622
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-81055156602&partnerID=40&md5=37006310ee29335de9ebf333f38be9ce
Keywords: Body Weight, Cereal Fiber, Weight Gain, Whole Grain And Satiety, Animal, Body Mass, Chemistry, Diet Therapy, Dietary Fiber, Evidence Based Medicine, Food Handling, Health Promotion, Human, Metabolism, Obesity, Psychophysiology, Short Survey, Body Mass Index, Evidence-Based Medicine, Overweight, Satiety Response, Cereals Chemistry, Dietary Fiber Administration, Dosage, Therapeutic Use, Epidemiology, Etiology, Prevention, Control,
Affiliations:
*** IBB - CNR ***
CNR-Institute of Food Science, Via Roma 64, 83100 Avellino, Italy
Department of Clinical and Experimental Medicine, School of Medicine, Federico II University, Naples, Italy
CNR-Institute of Biostructures and Bioimaging, Naples, Italy
References:
Not available.
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2011 Dec; 21(12): 901-908.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Review,
Impact factor: 3.731, 5-year impact factor: 3.622
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-81055156602&partnerID=40&md5=37006310ee29335de9ebf333f38be9ce
Keywords: Body Weight, Cereal Fiber, Weight Gain, Whole Grain And Satiety, Animal, Body Mass, Chemistry, Diet Therapy, Dietary Fiber, Evidence Based Medicine, Food Handling, Health Promotion, Human, Metabolism, Obesity, Psychophysiology, Short Survey, Body Mass Index, Evidence-Based Medicine, Overweight, Satiety Response, Cereals Chemistry, Dietary Fiber Administration, Dosage, Therapeutic Use, Epidemiology, Etiology, Prevention, Control,
Affiliations:
*** IBB - CNR ***
CNR-Institute of Food Science, Via Roma 64, 83100 Avellino, Italy
Department of Clinical and Experimental Medicine, School of Medicine, Federico II University, Naples, Italy
CNR-Institute of Biostructures and Bioimaging, Naples, Italy
References:
Not available.
Whole grain intake in relation to body weight: From epidemiological evidence to clinical trials
This viewpoint aims to 1) review the available scientific literature on the relationship between whole grain consumption and body weight regulation; 2) evaluate the potential mechanisms whereby whole grain intake may help reduce overweight and 3) try to understand why epidemiological studies and clinical trials provide diverging results on this topic. All the prospective epidemiological studies demonstrate that a higher intake of whole grains is associated with lower BMI and body weight gain. However, these results do not clarify whether whole grain consumption is simply a marker of a healthier lifestyle or a factor favoring "per se" lower body weight. Habitual whole grain consumption seems to cause lower body weight by multiple mechanisms such as lower energy density of whole grain based products, lower glycemic index, fermentation of non digestible carbohydrates (satiety signals) and finally by modulating intestinal microflora. In contrast with epidemiological evidence, the results of few clinical trials do not confirm that a whole grain low-calorie diet is more effective in reducing body weight than a refined cereal diet, but their results may have been affected by small sample size or short duration of the intervention. Therefore, further intervention studies with adequate methodology are needed to clarify this question. For the time being, whole grain consumption can be recommended as one of the features of the diet that may help control body weight but also because is associated with a lower risk to develop type 2 diabetes, cardiovascular diseases and cancer. © 2011 Elsevier B.V.
This viewpoint aims to 1) review the available scientific literature on the relationship between whole grain consumption and body weight regulation; 2) evaluate the potential mechanisms whereby whole grain intake may help reduce overweight and 3) try to understand why epidemiological studies and clinical trials provide diverging results on this topic. All the prospective epidemiological studies demonstrate that a higher intake of whole grains is associated with lower BMI and body weight gain. However, these results do not clarify whether whole grain consumption is simply a marker of a healthier lifestyle or a factor favoring "per se" lower body weight. Habitual whole grain consumption seems to cause lower body weight by multiple mechanisms such as lower energy density of whole grain based products, lower glycemic index, fermentation of non digestible carbohydrates (satiety signals) and finally by modulating intestinal microflora. In contrast with epidemiological evidence, the results of few clinical trials do not confirm that a whole grain low-calorie diet is more effective in reducing body weight than a refined cereal diet, but their results may have been affected by small sample size or short duration of the intervention. Therefore, further intervention studies with adequate methodology are needed to clarify this question. For the time being, whole grain consumption can be recommended as one of the features of the diet that may help control body weight but also because is associated with a lower risk to develop type 2 diabetes, cardiovascular diseases and cancer. © 2011 Elsevier B.V.
Whole grain intake in relation to body weight: From epidemiological evidence to clinical trials
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Whole grain intake in relation to body weight: From epidemiological evidence to clinical trials
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 8.57
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 6.31
View Export to BibTeX Export to EndNote
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Impact Factor: 7.735
View Export to BibTeX Export to EndNote
Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi G
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Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2010 Mar; 20(3): 186-194.
Impact Factor: 3.438
View Export to BibTeX Export to EndNote
Sciacca MFM, Pappalardo M, Milardi D, Grasso DM, La Rosa C
* Calcium-Activated Membrane Interaction Of The Islet Amyloid Polypeptide: Implications In The Pathogenesis Of Type Ii Diabetes Mellitus (1073 views)
Arch Biochem Biophys, 2008 Sep 15; 65(1-2): 291-298.
Impact Factor: 3.043
View Export to BibTeX Export to EndNote
De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (497 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
View Export to BibTeX Export to EndNote
De Simone G, Supuran CT
* Antiobesity carbonic anhydrase inhibitors (529 views)
Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884.
Impact Factor: 4.325
View Export to BibTeX Export to EndNote
Cittadini A, Monti MG, Iaccarino G, Di Rella F, Tsichlis PN, Di Gianni A, Strömer H, Sorriento D, Peschle C, Trimarco B, Saccà L, Condorelli G
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Gene Ther (ISSN: 0969-7128, 0969-7128linking), 2006; 13(1): 8-19.
Impact Factor: 4.782
View Export to BibTeX Export to EndNote
Leosco D, Iaccarino G, Cipolletta E, De Santis D, Pisani E, Trimarco V, Ferrara N, Abete P, Sorriento D, Rengo F, Trimarco B
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Am J Physiol Heart Circ Physiol American Journal Of Physiology Heart And Circulatory Physiology (ISSN: 0363-6135), 2003; 285(154-1): H369-H369.
Impact Factor: 3.658
View Export to BibTeX Export to EndNote
Marino M, Rossi M, Ruvo M, Fassina G
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Impact Factor: 3.597
View Export to BibTeX Export to EndNote
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Diabetes Nutr Metab Clin Exp (ISSN: 0394-3402), 1998; 11(6): 330-335.
Impact Factor: 0.629
View Export to BibTeX Export to EndNote
Ferrara LA, Marotta T, Mainenti G, Borrelli R, Mancini M, Soro S
Resting blood pressure and cardiovascular response to sympathetic stimulation in adolescents (357 views)
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic), 1992 Sep; 36(2): 197-201.
Impact Factor: 0.61
View Export to BibTeX Export to EndNote
Ferrara LA, Mancini M, De Simone GD, Turco S, Iovine C, Marotta T, Mainenti G, Mancini M
Responses of serum insulin and blood pressure to cold and handgrip in obese patients (366 views)
Int J Cardiol (ISSN: 0167-5273, 1874-1754electronic), 1991 Sep; 32(3): 353-359.
Impact Factor: 0.61
View Export to BibTeX Export to EndNote
Ferrara LA, Soro S, Mainenti G, Mancini M, Pisanti N, Borrelli R, Moscato TS
Body weight and cardiovascular response to sympathetic stimulation in childhood (566 views)
Int J Obes (ISSN: 0307-0565, 0307-0565linking), 1989; 13(3): 271-277.
Impact Factor: 2.476
View Export to BibTeX Export to EndNote
Alberghina M, Brogna A, Mangiameli A, Marletta F, Rizzarelli E, Sammartano S
Copper(II) complexes of aminoacids: Gastric acid antisecretory activity in rats (2116 views)
Farmaco Ed Sci, 1982 Dec; 37(12): 805-814.
Impact Factor: 0
View Export to BibTeX Export to EndNote
22 Records (21 excluding Abstracts).
Total impact factor: 81.321 (77.646 excluding Abstracts).
Total 5 year impact factor: 78.485 (78.485 excluding Abstracts).
Total impact factor: 81.321 (77.646 excluding Abstracts).
Total 5 year impact factor: 78.485 (78.485 excluding Abstracts).
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