Structural modifications induced by the switch from an endogenous bis-histidyl to an exogenous cyanomet hexa-coordination in a tetrameric haemoglobin (419 views)
Rsc Adv (ISSN: 2046-2069, 2046-2069electronic), 2014; 4(49): 25852-25856.
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Paper type: Journal Article,
Impact factor: 3.84, 5-year impact factor: 3.907
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84902981233&partnerID=40&md5=b1893d2203b1f9f47a4151ee0d690c58
Keywords: Cyanidation, Haemoglobins, Structural Modifications, Tetrameric, X Ray Crystal Structures,
Affiliations:
*** IBB - CNR ***
Dept of Chemical Sciences, University of Naples Federico II, Naples, Italy
Institute of Biostructures and Bioimaging, CNR, Naples, Italy
Institute of Biosciences and BioResources, CNR, Naples, Italy
Roma 3 University, Dept of Biology, Rome, Italy
Dept of Biophysics and Physiology, Albert Einstein College of Medicine, New York NY, United States
References:
Not available.
Rsc Adv (ISSN: 2046-2069, 2046-2069electronic), 2014; 4(49): 25852-25856.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.84, 5-year impact factor: 3.907
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84902981233&partnerID=40&md5=b1893d2203b1f9f47a4151ee0d690c58
Keywords: Cyanidation, Haemoglobins, Structural Modifications, Tetrameric, X Ray Crystal Structures,
Affiliations:
*** IBB - CNR ***
Dept of Chemical Sciences, University of Naples Federico II, Naples, Italy
Institute of Biostructures and Bioimaging, CNR, Naples, Italy
Institute of Biosciences and BioResources, CNR, Naples, Italy
Roma 3 University, Dept of Biology, Rome, Italy
Dept of Biophysics and Physiology, Albert Einstein College of Medicine, New York NY, United States
References:
Not available.
Structural modifications induced by the switch from an endogenous bis-histidyl to an exogenous cyanomet hexa-coordination in a tetrameric haemoglobin
Ferric cold-adapted fish haemoglobins exhibit heterogeneous coordination at the alpha (aquo-met) and beta (bis-histidyl) subunits. Herein we report two EPR-distinct bis-histidyl conformers (I and II) of the beta subunits of ferric haemoglobin from Trematomus bernacchii which react differently with CN-. An EPR titration reveals that upon cyanidation the most distorted conformer I reacts faster than II, producing both a cyanided and penta-coordinate ferric forms in the b subunits. The X-ray crystal structure of the partially cyanided conformer I reveals both an order-disorder transition and details of a communication between alpha and beta subunits.
Ferric cold-adapted fish haemoglobins exhibit heterogeneous coordination at the alpha (aquo-met) and beta (bis-histidyl) subunits. Herein we report two EPR-distinct bis-histidyl conformers (I and II) of the beta subunits of ferric haemoglobin from Trematomus bernacchii which react differently with CN-. An EPR titration reveals that upon cyanidation the most distorted conformer I reacts faster than II, producing both a cyanided and penta-coordinate ferric forms in the b subunits. The X-ray crystal structure of the partially cyanided conformer I reveals both an order-disorder transition and details of a communication between alpha and beta subunits.
Structural modifications induced by the switch from an endogenous bis-histidyl to an exogenous cyanomet hexa-coordination in a tetrameric haemoglobin
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Structural modifications induced by the switch from an endogenous bis-histidyl to an exogenous cyanomet hexa-coordination in a tetrameric haemoglobin
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Vitagliano L, Mazzarella L, Merlino A, Vergara A
* Fine Sampling of the R--> T Quaternary-Structure Transition of a Tetrameric Hemoglobin (421 views)
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (784 views)
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Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D
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Vergara A, Verde C, Di Prisco G, Mazzarella L
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Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
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Biophys J, 2008; 94: 4031-4040.
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Vergara A, Vitagliano L, Verde C, di Prisco G, Mazzarella L
* Spectroscopic and crystallographic characterization of bis-histidyl adducts in tetrameric hemoglobins (505 views)
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Vergara A, Vitagliano L, Di Prisco G, Verde C, Mazzarella L
* Spectroscopic And Crystallographic Characterization Of Hemichromes In Tetrameric Hemoglobins (437 views)
Methods In Enzymology, 2008; 436: 421-440.
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Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* The crystal structure of a tetrameric hemoglobin in a partial hemichrome state (1161 views)
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Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* Liganded and unliganded forms of Antarctic fish haemoglobins in polyethylene glycol: crystallization of an R-state haemichrome intermediate (557 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2001 Sep; 57: 1144-1146.
Impact Factor: 2.124
View Export to BibTeX Export to EndNote
* Oral Delivery of a Tetrameric Tripeptide Inhibitor of VEGFR1 Suppresses Pathological Choroid Neovascularization (332 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2020 Jan 9; 21 (2 ): N/D-N/D.
Impact Factor: 2.598
View Export to BibTeX Export to EndNote
Mazzarella L, Merlino A, Balasco N, Balsamo A, Vergara A
* Crystal structure of the ferric homotetrameric beta4 human hemoglobin (348 views)
Biophys Chem (ISSN: 0301-4622linking), 2018 Sep; 240: 9-14.
Impact Factor: 1.87
View Export to BibTeX Export to EndNote
Vitagliano L, Mazzarella L, Merlino A, Vergara A
* Fine Sampling of the R--> T Quaternary-Structure Transition of a Tetrameric Hemoglobin (421 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 Jan 12; 23(3): 605-613.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Coppola D, Abbruzzetti S, Nicoletti F, Merlino A, Gambacurta A, Giordano D, Howes BD, De Sanctis G, Vitagliano L, Bruno S, di Prisco G, Mazzarella L, Smulevich G, Coletta M, Viappiani C, Vergara A, Verde C
* ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus (557 views)
Molecular Biosystems (ISSN: 1742-206x), 2012 Oct 30; 8(12): 3295-3304.
Impact Factor: 3.35
View Export to BibTeX Export to EndNote
Vergara A, Franzese M, Merlino A, Bonomi G, Verde C, Giordano D, Di Prisco G, Lee HC, Peisach J, Mazzarella L
* Correlation between Hemichrome Stability and the Root Effect in Tetrameric Hemoglobins (503 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2009 Sep 5; 97(3): 866-874.
Impact Factor: 4.39
View Export to BibTeX Export to EndNote
Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (1066 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state (784 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2008 Sep 13; 130(32): 10527-10535.
Impact Factor: 8.091
View Export to BibTeX Export to EndNote
Ponticelli S, Takeda A, Mitola S, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S, Marasco D
* Angiogenesis modulation: identification of tetrameric tripeptide as inhibitor of VEGFR-1 by the screening of peptide combinatiorial libraries (466 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2008 Sep; 14(8): N/D-N/D.
Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Vergara A, Verde C, Di Prisco G, Mazzarella L
* Bis-histidyl Ferric Adducts in Tetrameric Haemoglobins (292 views)
Protein Reviews, 2008; 9: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Vitagliano L, Vergara A, Bonomi G, Merlino A, Verde C, Di Prisco G, Howes BD, Smulevich G, Mazzarella L
* Spectroscopic And Crystallographic Characterization Of A Tetrameric Hemoglobin Oxidation Pathway Reveals Structural Features Of A Functional Intermediate R/T State (357 views)
Biophys J, 2008; 94: 4031-4040.
Impact Factor: 3.832
View Export to BibTeX Export to EndNote
Vergara A, Vitagliano L, Verde C, di Prisco G, Mazzarella L
* Spectroscopic and crystallographic characterization of bis-histidyl adducts in tetrameric hemoglobins (505 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic), 2008; 436: 425-444.
Impact Factor: 2.312
View Export to BibTeX Export to EndNote
Vergara A, Vitagliano L, Di Prisco G, Verde C, Mazzarella L
* Spectroscopic And Crystallographic Characterization Of Hemichromes In Tetrameric Hemoglobins (437 views)
Methods In Enzymology, 2008; 436: 421-440.
Impact Factor: 2.194
View Export to BibTeX Export to EndNote
Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* The crystal structure of a tetrameric hemoglobin in a partial hemichrome state (1161 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2002 Jul 23; 99(15): 9801-9806.
Impact Factor: 10.7
View Export to BibTeX Export to EndNote
Riccio A, Vitagliano L, Di Prisco G, Zagari A, Mazzarella L
* Liganded and unliganded forms of Antarctic fish haemoglobins in polyethylene glycol: crystallization of an R-state haemichrome intermediate (557 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2001 Sep; 57: 1144-1146.
Impact Factor: 2.124
View Export to BibTeX Export to EndNote
14 Records (12 excluding Abstracts).
Total impact factor: 53.795 (52.141 excluding Abstracts).
Total 5 year impact factor: 62.049 (60.267 excluding Abstracts).
Total impact factor: 53.795 (52.141 excluding Abstracts).
Total 5 year impact factor: 62.049 (60.267 excluding Abstracts).
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