Resuscitation-promoting Factors (Rpf): In Search of Inhibitors(495 views) Kaprelyants AS, Mukamolova GV, Ruggiero A, Makarov VA, Demina GR, Shleeva MO, Potapov VD, Shramko PA
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1026-1034.
A. N. Bach Institute of Biochemistry, RAS, Leninsky pr., 33, 119071, Moscow, Russian Federation
Department of Infection, Immunity and Inflammation, University of Leicester Medical School, Leicester, United Kingdom
Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone 16, I-80134 Naples, Italy
Scientific Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, Russian Federation
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Wayne, L. G., Hayes, L. G., An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of nonreplicating persistence (1996) Infect. Immun, 64, pp. 2062-2069
Hu, Y., Mangan, J. A., Dhillon, J., Sole, K. M., Mitchison, D. A., Butcher, P. D., Coates, A. R., Detection of mRNA transcripts and active transcription in persistent Mycobacterium tuberculosis induced by exposure to rifampin or pyrazinamide (2000) J. Bacteriol, 182, pp. 6358-6365
Shleeva, M. O., Bagramyan, K., Telkov, M. V., Mukamolova, G. V., Young, M., Kell, D. B., Kaprelyants, A. S., Formation and resuscitation of non-culturable cells of Rhodococcus rhodochrous and Mycobacterium tuberculosis in prolonged stationary phase (2002) Microbiology, 148, pp. 1581-1591
Orme, I. M., The mouse as a useful model of tuberculosis (2003) Tuberculosis, 83, pp. 112-115
Karakousis, P. C., Yoshimatsu, T., Lamichhane, G., Woolwine, S. C., Nuermberger, E. L., Grosset, J., Bishai, W. R., Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice (2004) J. Exp. Med, 200, pp. 647-657
Deb, C., Lee, C. M., Dubey, V. S., Daniel, J., Abomoelak, B., Sirakova, T. D., Pawar, S., Kolattukudy, P. E., A novel in vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen (2009) PLoS ONE, 4, pp. e6077
Rustad, T. R., Harrell, M. I., Liao, R., Sherman, D. R., The Enduring Hypoxic Response of Mycobacterium tuberculosis (2008) PLoS ONE, 3, pp. e1502
Barer, M. R., Kaprelyants, A. S., Weichart, D. H., Harwood, C. R., Kell, D. B., Microbial stress and culturability: Conceptual and operational domains (1998) Microbiology, 144, pp. 2009-2010
Gill, W. P., Harik, N. S., Whiddon, M. R., Liao, R. P., Mittler, J. E., Sherman, D. R., A replication clock for Mycobacterium tuberculosis (2009) Nat. Med, 15, pp. 211-214
Mukamolova, G. V., Turapov, O. A., Kazarian, K., Telkov, M., Kaprelyants, A. S., Kell, D. B., Young, M., The rpf gene of Micrococcus luteus encodes an essential secreted growth factor (2002) Mol. Microbiol, 46, pp. 611-621
Downing, K. J., Betts, J. C., Young, D. I., McAdam, R. A., Kelly, F., Young, M., Mizrahi, V., Global expression profiling of strains harbouring null mutations reveals that the five rpf like genes of Mycobacterium tuberculosis show functional redundancy (2004) Tuberculosis, 84, pp. 167-179
Tufariello, J. M., Jacobs Jr., W. R., Chan, J., Individual Mycobacterium tuberculosis resuscitation-promoting factor homologues are dispensable for growth in vitro and in vivo (2004) Infect. Immun, 72, pp. 515-526
Dahl, J. L., Kraus, C. N., Boshoff, H. I., Doan, B., Foley, K., Avarbock, D., Kaplan, G., Barry III, C. E., The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 10026-10031
Downing, K. J., Mischenko, V. V., Shleeva, M. O., Young, D. I., Young, M., Kaprelyants, A. S., Apt, A. S., Mizrahi, V., Mutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro (2005) Infect. Immun, 73, pp. 3038-3304
Kana, B. D., Gordhan, B. G., Downing, K. J., Sung, N., Vostroktunova, G., MacHowski, E. E., Tsenova, L., Mizrahi, V., The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro (2008) Mol. Microbiol, 67, pp. 672-684
Gupta, R. K., Srivastava, B. S., Srivastava, R., Comparative expression analysis of rpf-like genes of Mycobacterium tuberculosis H37Rv under different physiological stress and growth conditions (2010) Microbiology, 156, pp. 2714-2722
Davies, A. P., Dhillon, A. P., Young, M., Henderson, B., McHugh, T. D., Gillspie, S. H., Resuscitation-promoting factors are expressed in Mycobacterium tuberculosis-infected human tissue (2008) Tuberculosis, 88, pp. 462-468
Garton, N. J., Waddell, S. J., Sherratt, A. L., Lee, S. M., Smith, R. J., Senner, C., Hinds, J., Barer, M. R., Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum (2008) PLoS Med, 5, pp. e75
Finan, C. L., (2003) Autocrine Growth Factors in Streptomycetes, , PhD Thesis, University of Wales: Aberystwyth
Hett, E. C., Chao, M. C., Deng, L. L., Rubin, E. J., A mycobacterial enzyme essential for cell division synergizes with resuscitationpromoting factor (2008) PLoS Pathog, 4, pp. e1000001
Meroueh, S. O., Bencze, K. Z., Hesek, D., Lee, M., Fisher, J. F., Stemmler, T. L., Mobashery, S., Three-dimensional structure of the bacterial cell wall peptidoglycan (2006) Proc. Natl. Acad. Sci. USA, 103, pp. 4404-4409
Van Asselt, E. J., Kalk, K. H., Dijstra, B. W., Crystallographic studies of the interaction of Escherichia coli lytic transglycosylase Slt35 with peptidoglycan (2000) Biochemistry, 39, pp. 1924-1934
Haiser, H. J., Yousef, M. R., Elliot, M. A., Cell wall hydrolases affect germination, vegetative growth, and sporulation in Streptomyces coelicolor (2009) J. Bacteriol, 191, pp. 6501-6512
Boneca, I. G., The role of peptidoglycan in pathogenesis (2005) Curr. Opin. Microbiol, 8, pp. 46-53
Keep, N. H., Ward, J. M., Cohen-Gonsaud, M., Henderson, B., Wake up! Peptidoglycan lysis and bacterial non-growth states (2006) Trends Microbiol, 14, pp. 271-276
Shah, I. M., Laaberki, M. H., Popham, D. L., Dworkin, J., A eukaryotic- like Ser/Thr kinase signals bacteria to exit dormancy in response to peptidoglycan fragments (2008) Cell, 135, pp. 486-496
Shah, I. M., Dworkin, J., Induction and regulation of a secreted peptidoglycan hydrolase by a membrane Ser/Thr kinase that detects muropeptides (2010) Mol. Microbiol, 75, pp. 1232-1243
Reid, C. W., Blackburn, N. T., Legaree, B. A., Auzanneau, F. I., Clarke, A. J., Inhibition of membrane - Bound lytic transglycosylase B by NAG - Thiazoline (2004) FEBS Lett, 574, pp. 73-79
Templin, M. F., Edwards, D. H., H ltje, J. V., A murein hydrolase is the specific target of bulgecin in Escherichia coli (1992) J. Biol. Chem, 267, pp. 20039-20043
Qazi, S. S., Khachatourians, G. G., Addition of exogenous carbon and nitrogen sources to aphid exuviae modulates synthesis of proteases and chitinase by germinating conidia of Beauveria bassiana (2008) Arch. Microbiol, 189, pp. 589-596
Demina, G. R., Makarov, V. A., Nikitushkin, V. D., Ryabova, O. B., Vostroknutova, G. N., Salina, E. G., Shleeva, M. O., Kaprelyants, A. S., Finding of the low molecular weight ihibitors of resuscitation promoting factor enzymatic and resuscitation activity (2009) PLoS ONE, 4, pp. e8174
Dhillon, J. L., Lowrie, D. B., Mitchison, D. A., Mycobacterium tuberculosis from chronic murine infections that grows in liquid but not on solid medium (2004) BMC Infect. Dis, 4, p. 51
Mohan, V. P., Scanga, C. A., Yu, K., Scott, H. M., Tanaka, K. E., Tsang, E., Tsai, M. M., Chan, J., Effects of tumor necrosis factor alpha on host immune response in chronic persistent tuberculosis: Possible role for limiting pathology (2001) Infect. Immun, 69, pp. 1847-1855
Resuscitation-promoting Factors (Rpf): In Search of Inhibitors
Resuscitation promoting factors (Rpf) are a family of proteins secreted by actively growing actinobacteria, including Mycobacterium tuberculosis. Experimental evidence suggests that Rpfs play a distinct role in bacterial resuscitation and re-growth as well as reactivation of chronic tuberculosis in mice. The striking similarity of the Rpfs structure to cell wall hydrolysing enzymes has provided a basis for the development of novel low molecular weight inhibitors of Rpfs activity. In particular, recently characterised nitrophenylthiocyanate compounds could be considered as a promising scaffold for generation of therapeutic agents targeting reactivation of latent tuberculosis. This review describes recent progress in understanding of molecular mechanisms of Rpf biological activity.
Resuscitation-promoting Factors (Rpf): In Search of Inhibitors
Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ * Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer(297 views) N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756. Impact Factor:59.558 ViewExport to BibTeXExport to EndNote