HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens(390 views) Tagliamonte M, Marasco D, Ruggiero A, de Stradis A, Tornesello ML, Totrov M, Buonaguro FM, Buonaguro L
Keywords: Env Antigen, Epitope, Gag Protein, Human Immunodeficiency Virus Antigen, Human Immunodeficiency Virus Protein, Monoclonal Antibody, Scaffold Protein, Unclassified Drug, Article, Enzyme Activity, Nonhuman, Protein Analysis, Protein Binding, Protein Conformation, Protein Expression, Protein Function, Protein Structure, Structure Analysis, Antibodies, Neutralizing, Enzyme-Linked Immunosorbent Assay, Hiv Core Protein P24, Hiv Envelope Protein Gp120, Microscopy, Electron, Peptide Fragments,
Affiliations: *** IBB - CNR ***
Laboratory of Molecular Biology and Viral Oncogenesis, AIDS Reference Center, Istituto Nazionale Tumori Fond. G. Pascale, Naples, Italy
Department of Biological Science-School of Biotechnological Sciences, University of Naples Federico II, Naples, Italy
National Resource Council, Institute of Biostructure and Bioimaging, Naples, Italy
Molsoft LLC, La Jolla, CA, United States
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Dhillon, A. K., Donners, H., Pantophlet, R., Johnson, W. E., Decker, J. M., Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors (2007) Journal of Virology, 81, pp. 6548-6562
Sather, D. N., Stamatatos, L., Epitope specificities of broadly neutralizing plasmas from HIV-1 infected subjects (2010) Vaccine, 28, pp. B8-12
Burton, D. R., Pyati, J., Koduri, R., Sharp, S. J., Thornton, G. B., Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody (1994) Science, 266, pp. 1024-1027
Walker, L. M., Phogat, S. K., Chan-Hui, P. Y., Wagner, D., Phung, P., Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target (2009) Science, 326, pp. 285-289
Wu, X., Yang, Z. Y., Li, Y., Hogerkorp, C. M., Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1 (2010) Science, 329, pp. 856-861. , Schief WR, et al
Gorny, M. K., Williams, C., Volsky, B., Revesz, K., Wang, X. H., Cross-clade neutralizing activity of human anti-V3 monoclonal antibodies derived from the cells of individuals infected with non-B clades of human immunodeficiency virus type 1 (2006) Journal of Virology, 80, pp. 6865-6872
Bell, C. H., Pantophlet, R., Schiefner, A., Cavacini, L. A., Stanfield, R. L., Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization (2008) J. Mol. Biol, 375, pp. 969-978
Brunel, F. M., Zwick, M. B., Cardoso, R. M., Nelson, J. D., Wilson, I. A., Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody (2006) Journal of Virology, 80, pp. 1680-1687
Stanfield, R. L., Gorny, M. K., Williams, C., Zolla-Pazner, S., Wilson, I. A., Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D (2004) Structure, 12, pp. 193-204
Zinkernagel, R. M., LaMarre, A., Ciurea, A., Hunziker, L., Ochsenbein, A. F., Neutralizing antiviral antibody responses (2001) Adv. Immunol, 79, pp. 1-53
Bachmann, M. F., Hengartner, H., Zinkernagel, R. M., T helper cell-independent neutralizing B cell response against vesicular stomatitis virus: role of antigen patterns in B cell induction (1995) European Joutnal of Immunology, 25, pp. 3445-3451
Netter, H. J., Macnaughton, T. B., Woo, W. P., Tindle, R., Gowans, E. J., Antigenicity and immunogenicity of novel chimeric hepatitis B surface antigen particles with exposed hepatitis C virus epitopes (2001) Journal of Virology, 75, pp. 2130-2141
Nardin, E. H., Oliveira, G. A., Calvo-Calle, J. M., Wetzel, K., Maier, C., Phase I testing of a malaria vaccine composed of hepatitis B virus core particles expressing Plasmodium falciparum circumsporozoite epitopes (2004) Infection and Immunity, 72, pp. 6519-6527
Vietheer, P. T., Boo, I., Drummer, H. E., Netter, H. J., Immunizations with chimeric hepatitis B virus-like particles to induce potential anti-hepatitis C virus neutralizing antibodies (2007) Antivir. Ther, 12, pp. 477-487
Crooks, E. T., Moore, P. L., Franti, M., Cayanan, C. S., Zhu, P., A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120 (2007) Virology, 366, pp. 245-262
Wang, B. Z., Liu, W., Kang, S. M., Alam, M., Huang, C., Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles (2007) Journal of Virology, 81, pp. 10869-10878
Huang, C. C., Tang, M., Zhang, M. Y., Majeed, S., Montabana, E., Structure of a V3-containing HIV-1 gp120 core (2005) Science, 310, pp. 1025-1028
von Schwedler, U. K., Stemmler, T. L., Klishko, V. Y., Li, S., Albertine, K. H., Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly (1998) EMBO J, 17, pp. 1555-1568
Martelli, G. P., Russo, M., Use of thin sectioning for the visualization and identification of plant virus (1984) Methods in Virology, 8, pp. 143-224
Gorny, M. K., Conley, A. J., Karwowska, S., Buchbinder, A., Xu, J. Y., Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody (1992) Journal of Virology, 66, pp. 7538-7542
Ehrlich, L. S., Agresta, B. E., Carter, C. A., Assembly of recombinant human immunodeficiency virus type 1 capsid protein in vitro (1992) Journal of Virology, 66, pp. 4874-4883
Cardoso, R. M., Zwick, M. B., Stanfield, R. L., Kunert, R., Binley, J. M., Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41 (2005) Immunity, 22, pp. 163-173
Hinton, H. J., Jegerlehner, A., Bachmann, M. F., Pattern recognition by B cells: the role of antigen repetitiveness versus Toll-like receptors (2008) Curr Top Microbiol Immunol, 319, pp. 1-15
Bachmann, M. F., Lutz, M. B., Layton, G. T., Harris, S. J., Fehr, T., Dendritic cells process exogenous viral proteins and virus-like particles for class I presentation to CD8+ cytotoxic T lymphocytes (1996) European Joutnal of Immunology, 26, pp. 2595-2600
HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens