HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens (731 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Sep 17; 7(8): N/D-N/D.
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Paper type: Journal Article, Abstract, Conference,
Impact factor: 3.73, 5-year impact factor: 4.244
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84865094442&partnerID=40&md5=da2968418492c10caff0bafe91f2d318
Keywords: Env Antigen, Epitope, Gag Protein, Human Immunodeficiency Virus Antigen, Human Immunodeficiency Virus Protein, Monoclonal Antibody, Scaffold Protein, Unclassified Drug, Article, Enzyme Activity, Nonhuman, Protein Analysis, Protein Binding, Protein Conformation, Protein Expression, Protein Function, Protein Structure, Structure Analysis, Antibodies, Neutralizing, Enzyme-Linked Immunosorbent Assay, Hiv Core Protein P24, Hiv Envelope Protein Gp120, Microscopy, Electron, Peptide Fragments,
Affiliations:
*** IBB - CNR ***
Laboratory of Molecular Biology and Viral Oncogenesis, AIDS Reference Center, Istituto Nazionale Tumori Fond. G. Pascale, Naples, Italy
Department of Biological Science-School of Biotechnological Sciences, University of Naples Federico II, Naples, Italy
National Resource Council, Institute of Biostructure and Bioimaging, Naples, Italy
Molsoft LLC, La Jolla, CA, United States
References:
Not available.
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Sep 17; 7(8): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Abstract, Conference,
Impact factor: 3.73, 5-year impact factor: 4.244
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84865094442&partnerID=40&md5=da2968418492c10caff0bafe91f2d318
Keywords: Env Antigen, Epitope, Gag Protein, Human Immunodeficiency Virus Antigen, Human Immunodeficiency Virus Protein, Monoclonal Antibody, Scaffold Protein, Unclassified Drug, Article, Enzyme Activity, Nonhuman, Protein Analysis, Protein Binding, Protein Conformation, Protein Expression, Protein Function, Protein Structure, Structure Analysis, Antibodies, Neutralizing, Enzyme-Linked Immunosorbent Assay, Hiv Core Protein P24, Hiv Envelope Protein Gp120, Microscopy, Electron, Peptide Fragments,
Affiliations:
*** IBB - CNR ***
Laboratory of Molecular Biology and Viral Oncogenesis, AIDS Reference Center, Istituto Nazionale Tumori Fond. G. Pascale, Naples, Italy
Department of Biological Science-School of Biotechnological Sciences, University of Naples Federico II, Naples, Italy
National Resource Council, Institute of Biostructure and Bioimaging, Naples, Italy
Molsoft LLC, La Jolla, CA, United States
References:
Not available.
HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens
Heterologous protein scaffolds engrafted with structurally defined HIV Env epitopes recognized by broadly neutralizing monoclonal antibodies (MAbs) represent a promising strategy to elicit broad neutralizing antibodies. In such regards, a protein scaffold based on the HIV p24 CA protein is a highly attractive approach, providing also Gag epitopes for eliciting HIV non-neutralizing protective antibodies and specific CD4+ and CD8+ T cell responses. In the present study, computational techniques were employed to verify the presence of acceptor sites for conformational HIV Env epitopes and, as proof of concept, the analysis of HIV p24 CA-based scaffolds using a complete V3 loop in a MAb-bound conformation is presented. The V3-p24 epitope-scaffold proteins show the formation of capsomers made of hexamers similarly to the p24 wild type protein. Moreover, the conformational V3 loop presented on p24 scaffold is recognized by a panel of anti-V3 MAbs. The results suggest that HIV p24 CA protein has suitable acceptor sites for engrafting foreign epitopes, without disrupting the formation of capsomer hexamer structures, and that the V3 epitope does retain its antibody-bound conformation. This strongly support the feasibility of developing a scaffolding strategy based on p24 CA proteins displaying conformational minimal structural, antigenic HIV Env epitopes. © 2012 Tagliamonte et al.
Heterologous protein scaffolds engrafted with structurally defined HIV Env epitopes recognized by broadly neutralizing monoclonal antibodies (MAbs) represent a promising strategy to elicit broad neutralizing antibodies. In such regards, a protein scaffold based on the HIV p24 CA protein is a highly attractive approach, providing also Gag epitopes for eliciting HIV non-neutralizing protective antibodies and specific CD4+ and CD8+ T cell responses. In the present study, computational techniques were employed to verify the presence of acceptor sites for conformational HIV Env epitopes and, as proof of concept, the analysis of HIV p24 CA-based scaffolds using a complete V3 loop in a MAb-bound conformation is presented. The V3-p24 epitope-scaffold proteins show the formation of capsomers made of hexamers similarly to the p24 wild type protein. Moreover, the conformational V3 loop presented on p24 scaffold is recognized by a panel of anti-V3 MAbs. The results suggest that HIV p24 CA protein has suitable acceptor sites for engrafting foreign epitopes, without disrupting the formation of capsomer hexamer structures, and that the V3 epitope does retain its antibody-bound conformation. This strongly support the feasibility of developing a scaffolding strategy based on p24 CA proteins displaying conformational minimal structural, antigenic HIV Env epitopes. © 2012 Tagliamonte et al.
HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens
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HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens
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Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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d'Onofrio G, Menichella G, Zini G, Rumi C, Pierelli L, Quarantelli M, Puggioni PL, Mango G
Lymphocyte subset counting by immunoperoxidase using an automated routine hematologic analyzer (611 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1989 Mar; 74(2): 137-142.
Impact Factor: 2.56
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Reynolds JC, Del Vecchio S, Sakahara H, Lora ME, Carrasquillo JA, Neumann RD, Larson SM
ANTI-MURINE ANTIBODY RESPONSE TO MOUSE MONOCLONAL ANTIBODIES CLINICAL FINDINGS AND IMPLICATIONS (1149 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 121-125.
Impact Factor: 1.042
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (550 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (524 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (485 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (474 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
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Del Vecchio S, Reynolds JC, Blasberg RG, Neumann RD, Carrasquillo JA, Hellström I, Larson SM
Measurement of local Mr 97, 000 and 250, 000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (711 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1988; 48(19): 5475-5481.
Impact Factor: 8.426
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* Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry (176 views)
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Impact Factor: 4.556
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Sivaccumar J, Sandomenico A, Vitagliano L, Ruvo M
* Monoclonal Antibodies: A Prospective and Retrospective View (273 views)
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Impact Factor: 4.184
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Camorani S, Passariello M, Agnello L, Esposito S, Collina F, Cantile M, Di Bonito M, Ulasov IV, Fedele M, Zannetti A, De Lorenzo C, Cerchia L
* Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer (203 views) (PDF 82 views)
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Impact Factor: 7.068
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Alterio V, Kellner M, Esposito D, Liesche-starnecker F, Bua S, Supuran CT, Monti SM, Zeidler R, De Simone G
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Impact Factor: 5.067
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Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (872 views)
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Impact Factor: 8.29
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Calvanese L, Foca A, Sandomenico A, Foca G, Caporale A, Doti N, Iaccarino E, Leonardi A, D'Auria G, Ruvo M, Falcigno L
* Structural insights into the interaction of a monoclonal antibody and Nodal peptides by STD-NMR spectroscopy (684 views)
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Impact Factor: 2.881
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Berisio R, Squeglia F, Ruggiero A
* Editorial: Molecular Scenarios Behind Infectious Diseases (600 views)
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Impact Factor: 3.469
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
* A Synthetic MUC1 Glycopeptide Bearing betaGalNAc-Thr as a Tn Antigen Isomer Induces the Production of Antibodies against Tumor Cells (1773 views)
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Impact Factor: 2.774
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Di Matteo A, Franceschini M, Paiardini A, Grottesi A, Chiarella S, Rocchio S, Di Natale C, Marasco D, Vitagliano L, Travaglini-allocatelli C, Federici L
* Structural investigation of Nucleophosmin interaction with the tumor suppressor Fbw7γ (521 views)
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Impact Factor: 4.722
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Strizzi L, Sandomenico A, Margaryan NV, Foca A, Sanguigno L, Bodenstine TM, Chandler GS, Reed DW, Gilgur A, Seftor EA, Seftor RE, Khalkhali-ellis Z, Leonardi A, Ruvo M, Hendrix MJ
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Impact Factor: 5.008
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Foca A, Sanguigno L, Foca G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A
* New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (912 views) (PDF 312 views)
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Impact Factor: 3.257
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (983 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
* F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (888 views)
Eur J Haematol (ISSN: 0902-4441), 2014 May; 92(5): 382-389.
Impact Factor: 2.066
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
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Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
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Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (606 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
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Monti SM, Supuran CT, De Simone G
* Carbonic anhydrase IX as a target for designing novel anticancer drugs (912 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 821-830.
Impact Factor: 4.07
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Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, Puca A, Pedone C, Scala G, Quinto I, Marasco D
* Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (802 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
Impact Factor: 3.022
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (1021 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (869 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (536 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (820 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (597 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (886 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (904 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (913 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Mar; 34(3): 433-436.
Impact Factor: 4.101
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Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (595 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (867 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (771 views)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (1079 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (690 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
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Fonti R, Del Vecchio S, Zannetti A, De Renzo A, Catalano L, Pace L, Rotoli B, Salvatore M
* Functional Imaging Of Multidrug Resistant Phenotype By 99mtc-Mibi Scan In Patients With Multiple Myeloma (654 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004; 19(2): 165-170.
Impact Factor: 1.091
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (877 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (671 views)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (579 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (593 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (425 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Impact Factor: 1.623
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Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (717 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
Impact Factor: 1.623
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Fonti R, Cheung NKV, Bridger GJ, Shen SQ, Finn RD, Abrams RJ, Larson SM
Technetium-99m-Monoclonal Antibody Radio-Labeled Via Hydrazino Nicotinamide Derivative For Imaging Ganglioside Gd2-Positive Tumors (487 views)
Nucl Med Biol, 1999; 26: 681-686.
Impact Factor: 0
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (471 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
Fractional retention of technetium-99m-sestamibi as an index of P- glycoprotein expression in untreated breast cancer patients (1670 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Sep; 38(9): 1348-1351.
Impact Factor: 3.491
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (428 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (608 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
Characterization of the mucins produced by normal human colonocytes in primary culture (509 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
Impact Factor: 0.732
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (739 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (443 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Sofia M, Del Vecchio S, Petrillo A, Mormile M, Salvatore M, Carratù L
Endobronchial deposition of radioactive monoclonal antibody in patients with inoperable non-small-cell carcinoma of the lung [4] (419 views)
Chest (ISSN: 0012-3692), 1992 Nov; 102(5): 1632-1634.
Impact Factor: 2.341
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D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (801 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 1991 Oct 31; 77(5): 449-451.
Impact Factor: 0.408
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (663 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (859 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (415 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
Impact Factor: 2.692
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Valenza V, Maussier ML, D'Errico G, Lemmo GF, Frontera D, Ferrante A, Saletnich I, Valli A, Quarantelli M
Cancer of the pancreas and the periampullary region: The usefulness of tumor marker products with the monoclonal antibody technique (558 views)
J Nucl Med Allied Sci (ISSN: 0392-0208), 1990 Oct; 34(4SUPPL.): 131-134.
Impact Factor: 1.91
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Del Vecchio S, Reynolds JC
NONUNIFORM DISTRIBUTION OF RADIOLABELED MONOCLONAL-ANTIBODY IN TUMOR (414 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1990 Jul; 31(7): 1252-1252.
Impact Factor: 3.491
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Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (427 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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d'Onofrio G, Menichella G, Zini G, Rumi C, Pierelli L, Quarantelli M, Puggioni PL, Mango G
Lymphocyte subset counting by immunoperoxidase using an automated routine hematologic analyzer (611 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1989 Mar; 74(2): 137-142.
Impact Factor: 2.56
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Reynolds JC, Del Vecchio S, Sakahara H, Lora ME, Carrasquillo JA, Neumann RD, Larson SM
ANTI-MURINE ANTIBODY RESPONSE TO MOUSE MONOCLONAL ANTIBODIES CLINICAL FINDINGS AND IMPLICATIONS (1149 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 121-125.
Impact Factor: 1.042
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (550 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
View Export to BibTeX Export to EndNote
Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (524 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (485 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (474 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
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Del Vecchio S, Reynolds JC, Blasberg RG, Neumann RD, Carrasquillo JA, Hellström I, Larson SM
Measurement of local Mr 97, 000 and 250, 000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (711 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1988; 48(19): 5475-5481.
Impact Factor: 8.426
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60 Records (57 excluding Abstracts).
Total impact factor: 225.988 (218.344 excluding Abstracts).
Total 5 year impact factor: 243.443 (232.408 excluding Abstracts).
Total impact factor: 225.988 (218.344 excluding Abstracts).
Total 5 year impact factor: 243.443 (232.408 excluding Abstracts).
731 views. Last view on Sunday 26 January 2025, 7:07:58
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