HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens (361 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Sep 17; 7(8): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Abstract, Conference,
Impact factor: 3.73, 5-year impact factor: 4.244
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84865094442&partnerID=40&md5=da2968418492c10caff0bafe91f2d318
Keywords: Env Antigen, Epitope, Gag Protein, Human Immunodeficiency Virus Antigen, Human Immunodeficiency Virus Protein, Monoclonal Antibody, Scaffold Protein, Unclassified Drug, Article, Enzyme Activity, Nonhuman, Protein Analysis, Protein Binding, Protein Conformation, Protein Expression, Protein Function, Protein Structure, Structure Analysis, Antibodies, Neutralizing, Enzyme-Linked Immunosorbent Assay, Hiv Core Protein P24, Hiv Envelope Protein Gp120, Microscopy, Electron, Peptide Fragments,
Affiliations:
*** IBB - CNR ***
Laboratory of Molecular Biology and Viral Oncogenesis, AIDS Reference Center, Istituto Nazionale Tumori Fond. G. Pascale, Naples, Italy
Department of Biological Science-School of Biotechnological Sciences, University of Naples Federico II, Naples, Italy
National Resource Council, Institute of Biostructure and Bioimaging, Naples, Italy
Molsoft LLC, La Jolla, CA, United States
References:
Ross, A.L., Brave, A., Scarlatti, G., Manrique, A., Buonaguro, L., Progress towards development of an HIV vaccine: report of the AIDS Vaccine 2009 Conference (2010) Lancet Infect.Dis, 10, pp. 305-31
Boutwell, C.L., Rolland, M.M., Herbeck, J.T., Mullins, J.I., Allen, T.M., Viral evolution and escape during acute HIV-1 infection (2010) J.Infect.Dis, 202, pp. S309-S314
Doria-Rose, N.A., Klein, R.M., Daniels, M.G., O'Dell, S., Nason, M., Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables (2010) Journal of Virology, 84, pp. 1631-1636
Walker, L.M., Simek, M.D., Priddy, F., Gach, J.S., Wagner, D., A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals (2010) PLoS.Pathog, 6
Cheng-Mayer, C., Homsy, J., Evans, L.A., Levy, J.A., Identification of human immunodeficiency virus subtypes with distinct patterns of sensitivity to serum neutralization (1988) Proceedings of National Academy of Science USA, 85, pp. 2815-2819
Dhillon, A.K., Donners, H., Pantophlet, R., Johnson, W.E., Decker, J.M., Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors (2007) Journal of Virology, 81, pp. 6548-6562
Sather, D.N., Stamatatos, L., Epitope specificities of broadly neutralizing plasmas from HIV-1 infected subjects (2010) Vaccine, 28, pp. B8-12
Burton, D.R., Pyati, J., Koduri, R., Sharp, S.J., Thornton, G.B., Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody (1994) Science, 266, pp. 1024-1027
Trkola, A., Purtscher, M., Muster, T., Ballaun, C., Buchacher, A., Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of Human Immunodeficiency Virus type 1 (1996) Journal of Virology, 70, pp. 1100-1108
Muster, T., Steindl, F., Purtscher, M., Trkola, A., Klima, A., A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1 (1993) Journal of Virology, 67, pp. 6642-6647
Stiegler, G., Kunert, R., Purtscher, M., Wolbank, S., Voglauer, R., A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1 (2001) AIDS Research and Human Retroviruses, 17, pp. 1757-1765
Walker, L.M., Phogat, S.K., Chan-Hui, P.Y., Wagner, D., Phung, P., Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target (2009) Science, 326, pp. 285-289
Wu, X., Yang, Z.Y., Li, Y., Hogerkorp, C.M., Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1 (2010) Science, 329, pp. 856-861. , Schief WR, et al
Corti, D., Langedijk, J.P., Hinz, A., Seaman, M.S., Vanzetta, F., Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals (2010) PLoS.One, 5, pp. e8805-
Gorny, M.K., Williams, C., Volsky, B., Revesz, K., Wang, X.H., Cross-clade neutralizing activity of human anti-V3 monoclonal antibodies derived from the cells of individuals infected with non-B clades of human immunodeficiency virus type 1 (2006) Journal of Virology, 80, pp. 6865-6872
Bell, C.H., Pantophlet, R., Schiefner, A., Cavacini, L.A., Stanfield, R.L., Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization (2008) J.Mol.Biol, 375, pp. 969-978
Pantophlet, R., Wrin, T., Cavacini, L.A., Robinson, J.E., Burton, D.R., Neutralizing activity of antibodies to the V3 loop region of HIV-1 gp120 relative to their epitope fine specificity (2008) Virology, 381, pp. 251-260
Ofek, G., Tang, M., Sambor, A., Katinger, H., Mascola, J.R., Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope (2004) Journal of Virology, 78, pp. 10724-10737
Brunel, F.M., Zwick, M.B., Cardoso, R.M., Nelson, J.D., Wilson, I.A., Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody (2006) Journal of Virology, 80, pp. 1680-1687
Zhou, T., Xu, L., Dey, B., Hessell, A.J., van, R.D., Structural definition of a conserved neutralization epitope on HIV-1 gp120 (2007) Nature, 445, pp. 732-737
Stanfield, R.L., Gorny, M.K., Williams, C., Zolla-Pazner, S., Wilson, I.A., Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D (2004) Structure, 12, pp. 193-204
Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Elicitation of structure-specific antibodies by epitope scaffolds (2010) Proc.Natl.Acad.Sci.U.S.A, 107, pp. 17880-17887
Guenaga, J., Dosenovic, P., Ofek, G., Baker, D., Schief, W.R., Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant (2011) PLoS.One, 6, pp. e16074-
Chakraborty, K., Durani, V., Miranda, E.R., Citron, M., Liang, X., Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies (2006) Biochem.J, 399, pp. 483-491
Totrov, M., Jiang, X., Kong, X.P., Cohen, S., Krachmarov, C., Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold (2010) Virology, 405, pp. 513-523
Zinkernagel, R.M., LaMarre, A., Ciurea, A., Hunziker, L., Ochsenbein, A.F., Neutralizing antiviral antibody responses (2001) Adv.Immunol, 79, pp. 1-53
Bachmann, M.F., Hengartner, H., Zinkernagel, R.M., T helper cell-independent neutralizing B cell response against vesicular stomatitis virus: role of antigen patterns in B cell induction (1995) European Joutnal of Immunology, 25, pp. 3445-3451
Netter, H.J., Macnaughton, T.B., Woo, W.P., Tindle, R., Gowans, E.J., Antigenicity and immunogenicity of novel chimeric hepatitis B surface antigen particles with exposed hepatitis C virus epitopes (2001) Journal of Virology, 75, pp. 2130-2141
Nardin, E.H., Oliveira, G.A., Calvo-Calle, J.M., Wetzel, K., Maier, C., Phase I testing of a malaria vaccine composed of hepatitis B virus core particles expressing Plasmodium falciparum circumsporozoite epitopes (2004) Infection and Immunity, 72, pp. 6519-6527
Schellenbacher, C., Roden, R., Kirnbauer, R., Chimeric L1-L2 virus-like particles as potential broad-spectrum human papillomavirus vaccines (2009) Journal of Virology, 83, pp. 10085-10095
Buonaguro, L., Tornesello, M.L., Buonaguro, F.M., Virus-Like Particles as Particulate Vaccines (2010) Curr.HIV Res, 8, pp. 299-399
Vietheer, P.T., Boo, I., Drummer, H.E., Netter, H.J., Immunizations with chimeric hepatitis B virus-like particles to induce potential anti-hepatitis C virus neutralizing antibodies (2007) Antivir.Ther, 12, pp. 477-487
Buonaguro, L., Buonaguro, F.M., Tornesello, M.L., Mantas, D., Beth-Giraldo, E., High efficient production of Pr55gag Virus-like Particles expressing multiple HIV-1 epitopes, including a gp120 protein derived from an Ugandan HIV-1 isolate of subtype A (2001) Antiviral Research, 49, pp. 35-47
Crooks, E.T., Moore, P.L., Franti, M., Cayanan, C.S., Zhu, P., A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120 (2007) Virology, 366, pp. 245-262
Wang, B.Z., Liu, W., Kang, S.M., Alam, M., Huang, C., Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles (2007) Journal of Virology, 81, pp. 10869-10878
Pornillos, O., Ganser-Pornillos, B.K., Kelly, B.N., Hua, Y., Whitby, F.G., X-ray structures of the hexameric building block of the HIV capsid (2009) Cell, 137, pp. 1282-1292
Buonaguro, L., Tagliamonte, M., Tornesello, M.L., Buonaguro, F.M., Can HIV p24 Be a Suitable Scaffold for Presenting Env Antigens? (2011) Clin.Vaccine Immunol, 18, pp. 2003-2004
Huang, C.C., Tang, M., Zhang, M.Y., Majeed, S., Montabana, E., Structure of a V3-containing HIV-1 gp120 core (2005) Science, 310, pp. 1025-1028
Abagyan, R., Totrov, M., Kuznetsov, D., ICM-A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation (1994) J.Comp.Chem, 15, pp. 488-506
von Schwedler, U.K., Stemmler, T.L., Klishko, V.Y., Li, S., Albertine, K.H., Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly (1998) EMBO J, 17, pp. 1555-1568
Gross, I., Hohenberg, H., Krausslich, H.G., In vitro assembly properties of purified bacterially expressed capsid proteins of human immunodeficiency virus (1997) Eur.J.Biochem, 249, pp. 592-600
Martelli, G.P., Russo, M., Use of thin sectioning for the visualization and identification of plant virus (1984) Methods in Virology, 8, pp. 143-224
Johnsson, B., Lofas, S., Lindquist, G., Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors (1991) Anal.Biochem, 198, pp. 268-277
Gorny, M.K., Conley, A.J., Karwowska, S., Buchbinder, A., Xu, J.Y., Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody (1992) Journal of Virology, 66, pp. 7538-7542
Ehrlich, L.S., Agresta, B.E., Carter, C.A., Assembly of recombinant human immunodeficiency virus type 1 capsid protein in vitro (1992) Journal of Virology, 66, pp. 4874-4883
Cardoso, R.M., Zwick, M.B., Stanfield, R.L., Kunert, R., Binley, J.M., Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41 (2005) Immunity, 22, pp. 163-173
Hinton, H.J., Jegerlehner, A., Bachmann, M.F., Pattern recognition by B cells: the role of antigen repetitiveness versus Toll-like receptors (2008) Curr Top Microbiol Immunol, 319, pp. 1-15
Vos, Q., Lees, A., Wu, Z.Q., Snapper, C.M., Mond, J.J., B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms (2000) Immunol.Rev, 176, pp. 154-170
Ruedl, C., Storni, T., Lechner, F., Bachi, T., Bachmann, M.F., Cross-presentation of virus-like particles by skin-derived CD8(-) dendritic cells: a dispensable role for TAP (2002) European Joutnal of Immunology, 32, pp. 818-825
Bachmann, M.F., Lutz, M.B., Layton, G.T., Harris, S.J., Fehr, T., Dendritic cells process exogenous viral proteins and virus-like particles for class I presentation to CD8+ cytotoxic T lymphocytes (1996) European Joutnal of Immunology, 26, pp. 2595-2600
Ross, A. L., Brave, A., Scarlatti, G., Manrique, A., Buonaguro, L., Progress towards development of an HIV vaccine: report of the AIDS Vaccine 2009 Conference (2010) Lancet Infect. Dis, 10, pp. 305-31
Boutwell, C. L., Rolland, M. M., Herbeck, J. T., Mullins, J. I., Allen, T. M., Viral evolution and escape during acute HIV-1 infection (2010) J. Infect. Dis, 202, pp. S309-S314
Doria-Rose, N. A., Klein, R. M., Daniels, M. G., O'Dell, S., Nason, M., Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables (2010) Journal of Virology, 84, pp. 1631-1636
Walker, L. M., Simek, M. D., Priddy, F., Gach, J. S., Wagner, D., A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals (2010) PLoS. Pathog, 6
Dhillon, A. K., Donners, H., Pantophlet, R., Johnson, W. E., Decker, J. M., Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors (2007) Journal of Virology, 81, pp. 6548-6562
Sather, D. N., Stamatatos, L., Epitope specificities of broadly neutralizing plasmas from HIV-1 infected subjects (2010) Vaccine, 28, pp. B8-12
Burton, D. R., Pyati, J., Koduri, R., Sharp, S. J., Thornton, G. B., Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody (1994) Science, 266, pp. 1024-1027
Walker, L. M., Phogat, S. K., Chan-Hui, P. Y., Wagner, D., Phung, P., Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target (2009) Science, 326, pp. 285-289
Wu, X., Yang, Z. Y., Li, Y., Hogerkorp, C. M., Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1 (2010) Science, 329, pp. 856-861. , Schief WR, et al
Gorny, M. K., Williams, C., Volsky, B., Revesz, K., Wang, X. H., Cross-clade neutralizing activity of human anti-V3 monoclonal antibodies derived from the cells of individuals infected with non-B clades of human immunodeficiency virus type 1 (2006) Journal of Virology, 80, pp. 6865-6872
Bell, C. H., Pantophlet, R., Schiefner, A., Cavacini, L. A., Stanfield, R. L., Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization (2008) J. Mol. Biol, 375, pp. 969-978
Brunel, F. M., Zwick, M. B., Cardoso, R. M., Nelson, J. D., Wilson, I. A., Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody (2006) Journal of Virology, 80, pp. 1680-1687
Stanfield, R. L., Gorny, M. K., Williams, C., Zolla-Pazner, S., Wilson, I. A., Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D (2004) Structure, 12, pp. 193-204
Zinkernagel, R. M., LaMarre, A., Ciurea, A., Hunziker, L., Ochsenbein, A. F., Neutralizing antiviral antibody responses (2001) Adv. Immunol, 79, pp. 1-53
Bachmann, M. F., Hengartner, H., Zinkernagel, R. M., T helper cell-independent neutralizing B cell response against vesicular stomatitis virus: role of antigen patterns in B cell induction (1995) European Joutnal of Immunology, 25, pp. 3445-3451
Netter, H. J., Macnaughton, T. B., Woo, W. P., Tindle, R., Gowans, E. J., Antigenicity and immunogenicity of novel chimeric hepatitis B surface antigen particles with exposed hepatitis C virus epitopes (2001) Journal of Virology, 75, pp. 2130-2141
Nardin, E. H., Oliveira, G. A., Calvo-Calle, J. M., Wetzel, K., Maier, C., Phase I testing of a malaria vaccine composed of hepatitis B virus core particles expressing Plasmodium falciparum circumsporozoite epitopes (2004) Infection and Immunity, 72, pp. 6519-6527
Vietheer, P. T., Boo, I., Drummer, H. E., Netter, H. J., Immunizations with chimeric hepatitis B virus-like particles to induce potential anti-hepatitis C virus neutralizing antibodies (2007) Antivir. Ther, 12, pp. 477-487
Crooks, E. T., Moore, P. L., Franti, M., Cayanan, C. S., Zhu, P., A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120 (2007) Virology, 366, pp. 245-262
Wang, B. Z., Liu, W., Kang, S. M., Alam, M., Huang, C., Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles (2007) Journal of Virology, 81, pp. 10869-10878
Huang, C. C., Tang, M., Zhang, M. Y., Majeed, S., Montabana, E., Structure of a V3-containing HIV-1 gp120 core (2005) Science, 310, pp. 1025-1028
von Schwedler, U. K., Stemmler, T. L., Klishko, V. Y., Li, S., Albertine, K. H., Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly (1998) EMBO J, 17, pp. 1555-1568
Martelli, G. P., Russo, M., Use of thin sectioning for the visualization and identification of plant virus (1984) Methods in Virology, 8, pp. 143-224
Gorny, M. K., Conley, A. J., Karwowska, S., Buchbinder, A., Xu, J. Y., Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody (1992) Journal of Virology, 66, pp. 7538-7542
Ehrlich, L. S., Agresta, B. E., Carter, C. A., Assembly of recombinant human immunodeficiency virus type 1 capsid protein in vitro (1992) Journal of Virology, 66, pp. 4874-4883
Cardoso, R. M., Zwick, M. B., Stanfield, R. L., Kunert, R., Binley, J. M., Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41 (2005) Immunity, 22, pp. 163-173
Hinton, H. J., Jegerlehner, A., Bachmann, M. F., Pattern recognition by B cells: the role of antigen repetitiveness versus Toll-like receptors (2008) Curr Top Microbiol Immunol, 319, pp. 1-15
Bachmann, M. F., Lutz, M. B., Layton, G. T., Harris, S. J., Fehr, T., Dendritic cells process exogenous viral proteins and virus-like particles for class I presentation to CD8+ cytotoxic T lymphocytes (1996) European Joutnal of Immunology, 26, pp. 2595-2600
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Sep 17; 7(8): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Abstract, Conference,
Impact factor: 3.73, 5-year impact factor: 4.244
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84865094442&partnerID=40&md5=da2968418492c10caff0bafe91f2d318
Keywords: Env Antigen, Epitope, Gag Protein, Human Immunodeficiency Virus Antigen, Human Immunodeficiency Virus Protein, Monoclonal Antibody, Scaffold Protein, Unclassified Drug, Article, Enzyme Activity, Nonhuman, Protein Analysis, Protein Binding, Protein Conformation, Protein Expression, Protein Function, Protein Structure, Structure Analysis, Antibodies, Neutralizing, Enzyme-Linked Immunosorbent Assay, Hiv Core Protein P24, Hiv Envelope Protein Gp120, Microscopy, Electron, Peptide Fragments,
Affiliations:
*** IBB - CNR ***
Laboratory of Molecular Biology and Viral Oncogenesis, AIDS Reference Center, Istituto Nazionale Tumori Fond. G. Pascale, Naples, Italy
Department of Biological Science-School of Biotechnological Sciences, University of Naples Federico II, Naples, Italy
National Resource Council, Institute of Biostructure and Bioimaging, Naples, Italy
Molsoft LLC, La Jolla, CA, United States
References:
Ross, A.L., Brave, A., Scarlatti, G., Manrique, A., Buonaguro, L., Progress towards development of an HIV vaccine: report of the AIDS Vaccine 2009 Conference (2010) Lancet Infect.Dis, 10, pp. 305-31
Boutwell, C.L., Rolland, M.M., Herbeck, J.T., Mullins, J.I., Allen, T.M., Viral evolution and escape during acute HIV-1 infection (2010) J.Infect.Dis, 202, pp. S309-S314
Doria-Rose, N.A., Klein, R.M., Daniels, M.G., O'Dell, S., Nason, M., Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables (2010) Journal of Virology, 84, pp. 1631-1636
Walker, L.M., Simek, M.D., Priddy, F., Gach, J.S., Wagner, D., A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals (2010) PLoS.Pathog, 6
Cheng-Mayer, C., Homsy, J., Evans, L.A., Levy, J.A., Identification of human immunodeficiency virus subtypes with distinct patterns of sensitivity to serum neutralization (1988) Proceedings of National Academy of Science USA, 85, pp. 2815-2819
Dhillon, A.K., Donners, H., Pantophlet, R., Johnson, W.E., Decker, J.M., Dissecting the neutralizing antibody specificities of broadly neutralizing sera from human immunodeficiency virus type 1-infected donors (2007) Journal of Virology, 81, pp. 6548-6562
Sather, D.N., Stamatatos, L., Epitope specificities of broadly neutralizing plasmas from HIV-1 infected subjects (2010) Vaccine, 28, pp. B8-12
Burton, D.R., Pyati, J., Koduri, R., Sharp, S.J., Thornton, G.B., Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody (1994) Science, 266, pp. 1024-1027
Trkola, A., Purtscher, M., Muster, T., Ballaun, C., Buchacher, A., Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of Human Immunodeficiency Virus type 1 (1996) Journal of Virology, 70, pp. 1100-1108
Muster, T., Steindl, F., Purtscher, M., Trkola, A., Klima, A., A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1 (1993) Journal of Virology, 67, pp. 6642-6647
Stiegler, G., Kunert, R., Purtscher, M., Wolbank, S., Voglauer, R., A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1 (2001) AIDS Research and Human Retroviruses, 17, pp. 1757-1765
Walker, L.M., Phogat, S.K., Chan-Hui, P.Y., Wagner, D., Phung, P., Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target (2009) Science, 326, pp. 285-289
Wu, X., Yang, Z.Y., Li, Y., Hogerkorp, C.M., Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1 (2010) Science, 329, pp. 856-861. , Schief WR, et al
Corti, D., Langedijk, J.P., Hinz, A., Seaman, M.S., Vanzetta, F., Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals (2010) PLoS.One, 5, pp. e8805-
Gorny, M.K., Williams, C., Volsky, B., Revesz, K., Wang, X.H., Cross-clade neutralizing activity of human anti-V3 monoclonal antibodies derived from the cells of individuals infected with non-B clades of human immunodeficiency virus type 1 (2006) Journal of Virology, 80, pp. 6865-6872
Bell, C.H., Pantophlet, R., Schiefner, A., Cavacini, L.A., Stanfield, R.L., Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization (2008) J.Mol.Biol, 375, pp. 969-978
Pantophlet, R., Wrin, T., Cavacini, L.A., Robinson, J.E., Burton, D.R., Neutralizing activity of antibodies to the V3 loop region of HIV-1 gp120 relative to their epitope fine specificity (2008) Virology, 381, pp. 251-260
Ofek, G., Tang, M., Sambor, A., Katinger, H., Mascola, J.R., Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope (2004) Journal of Virology, 78, pp. 10724-10737
Brunel, F.M., Zwick, M.B., Cardoso, R.M., Nelson, J.D., Wilson, I.A., Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody (2006) Journal of Virology, 80, pp. 1680-1687
Zhou, T., Xu, L., Dey, B., Hessell, A.J., van, R.D., Structural definition of a conserved neutralization epitope on HIV-1 gp120 (2007) Nature, 445, pp. 732-737
Stanfield, R.L., Gorny, M.K., Williams, C., Zolla-Pazner, S., Wilson, I.A., Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D (2004) Structure, 12, pp. 193-204
Ofek, G., Guenaga, F.J., Schief, W.R., Skinner, J., Baker, D., Elicitation of structure-specific antibodies by epitope scaffolds (2010) Proc.Natl.Acad.Sci.U.S.A, 107, pp. 17880-17887
Guenaga, J., Dosenovic, P., Ofek, G., Baker, D., Schief, W.R., Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant (2011) PLoS.One, 6, pp. e16074-
Chakraborty, K., Durani, V., Miranda, E.R., Citron, M., Liang, X., Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies (2006) Biochem.J, 399, pp. 483-491
Totrov, M., Jiang, X., Kong, X.P., Cohen, S., Krachmarov, C., Structure-guided design and immunological characterization of immunogens presenting the HIV-1 gp120 V3 loop on a CTB scaffold (2010) Virology, 405, pp. 513-523
Zinkernagel, R.M., LaMarre, A., Ciurea, A., Hunziker, L., Ochsenbein, A.F., Neutralizing antiviral antibody responses (2001) Adv.Immunol, 79, pp. 1-53
Bachmann, M.F., Hengartner, H., Zinkernagel, R.M., T helper cell-independent neutralizing B cell response against vesicular stomatitis virus: role of antigen patterns in B cell induction (1995) European Joutnal of Immunology, 25, pp. 3445-3451
Netter, H.J., Macnaughton, T.B., Woo, W.P., Tindle, R., Gowans, E.J., Antigenicity and immunogenicity of novel chimeric hepatitis B surface antigen particles with exposed hepatitis C virus epitopes (2001) Journal of Virology, 75, pp. 2130-2141
Nardin, E.H., Oliveira, G.A., Calvo-Calle, J.M., Wetzel, K., Maier, C., Phase I testing of a malaria vaccine composed of hepatitis B virus core particles expressing Plasmodium falciparum circumsporozoite epitopes (2004) Infection and Immunity, 72, pp. 6519-6527
Schellenbacher, C., Roden, R., Kirnbauer, R., Chimeric L1-L2 virus-like particles as potential broad-spectrum human papillomavirus vaccines (2009) Journal of Virology, 83, pp. 10085-10095
Buonaguro, L., Tornesello, M.L., Buonaguro, F.M., Virus-Like Particles as Particulate Vaccines (2010) Curr.HIV Res, 8, pp. 299-399
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HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens
Heterologous protein scaffolds engrafted with structurally defined HIV Env epitopes recognized by broadly neutralizing monoclonal antibodies (MAbs) represent a promising strategy to elicit broad neutralizing antibodies. In such regards, a protein scaffold based on the HIV p24 CA protein is a highly attractive approach, providing also Gag epitopes for eliciting HIV non-neutralizing protective antibodies and specific CD4+ and CD8+ T cell responses. In the present study, computational techniques were employed to verify the presence of acceptor sites for conformational HIV Env epitopes and, as proof of concept, the analysis of HIV p24 CA-based scaffolds using a complete V3 loop in a MAb-bound conformation is presented. The V3-p24 epitope-scaffold proteins show the formation of capsomers made of hexamers similarly to the p24 wild type protein. Moreover, the conformational V3 loop presented on p24 scaffold is recognized by a panel of anti-V3 MAbs. The results suggest that HIV p24 CA protein has suitable acceptor sites for engrafting foreign epitopes, without disrupting the formation of capsomer hexamer structures, and that the V3 epitope does retain its antibody-bound conformation. This strongly support the feasibility of developing a scaffolding strategy based on p24 CA proteins displaying conformational minimal structural, antigenic HIV Env epitopes. © 2012 Tagliamonte et al.
Heterologous protein scaffolds engrafted with structurally defined HIV Env epitopes recognized by broadly neutralizing monoclonal antibodies (MAbs) represent a promising strategy to elicit broad neutralizing antibodies. In such regards, a protein scaffold based on the HIV p24 CA protein is a highly attractive approach, providing also Gag epitopes for eliciting HIV non-neutralizing protective antibodies and specific CD4+ and CD8+ T cell responses. In the present study, computational techniques were employed to verify the presence of acceptor sites for conformational HIV Env epitopes and, as proof of concept, the analysis of HIV p24 CA-based scaffolds using a complete V3 loop in a MAb-bound conformation is presented. The V3-p24 epitope-scaffold proteins show the formation of capsomers made of hexamers similarly to the p24 wild type protein. Moreover, the conformational V3 loop presented on p24 scaffold is recognized by a panel of anti-V3 MAbs. The results suggest that HIV p24 CA protein has suitable acceptor sites for engrafting foreign epitopes, without disrupting the formation of capsomer hexamer structures, and that the V3 epitope does retain its antibody-bound conformation. This strongly support the feasibility of developing a scaffolding strategy based on p24 CA proteins displaying conformational minimal structural, antigenic HIV Env epitopes. © 2012 Tagliamonte et al.
HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens
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HIV p24 as Scaffold for Presenting Conformational HIV Env Antigens
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (465 views)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (346 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (373 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (253 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Impact Factor: 1.623
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Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (323 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
Impact Factor: 1.623
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Fonti R, Cheung NKV, Bridger GJ, Shen SQ, Finn RD, Abrams RJ, Larson SM
Technetium-99m-Monoclonal Antibody Radio-Labeled Via Hydrazino Nicotinamide Derivative For Imaging Ganglioside Gd2-Positive Tumors (249 views)
Nucl Med Biol, 1999; 26: 681-686.
Impact Factor: 0
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (259 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
Fractional retention of technetium-99m-sestamibi as an index of P- glycoprotein expression in untreated breast cancer patients (821 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Sep; 38(9): 1348-1351.
Impact Factor: 3.491
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (251 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (441 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
Characterization of the mucins produced by normal human colonocytes in primary culture (260 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
Impact Factor: 0.732
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (455 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (298 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Sofia M, Del Vecchio S, Petrillo A, Mormile M, Salvatore M, Carratù L
Endobronchial deposition of radioactive monoclonal antibody in patients with inoperable non-small-cell carcinoma of the lung [4] (268 views)
Chest (ISSN: 0012-3692), 1992 Nov; 102(5): 1632-1634.
Impact Factor: 2.341
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D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (598 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 1991 Oct 31; 77(5): 449-451.
Impact Factor: 0.408
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (451 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (380 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (274 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
Impact Factor: 2.692
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Valenza V, Maussier ML, D'Errico G, Lemmo GF, Frontera D, Ferrante A, Saletnich I, Valli A, Quarantelli M
Cancer of the pancreas and the periampullary region: The usefulness of tumor marker products with the monoclonal antibody technique (264 views)
J Nucl Med Allied Sci (ISSN: 0392-0208), 1990 Oct; 34(4SUPPL.): 131-134.
Impact Factor: 1.91
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Del Vecchio S, Reynolds JC
NONUNIFORM DISTRIBUTION OF RADIOLABELED MONOCLONAL-ANTIBODY IN TUMOR (239 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1990 Jul; 31(7): 1252-1252.
Impact Factor: 3.491
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Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (308 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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d'Onofrio G, Menichella G, Zini G, Rumi C, Pierelli L, Quarantelli M, Puggioni PL, Mango G
Lymphocyte subset counting by immunoperoxidase using an automated routine hematologic analyzer (370 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1989 Mar; 74(2): 137-142.
Impact Factor: 2.56
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Reynolds JC, Del Vecchio S, Sakahara H, Lora ME, Carrasquillo JA, Neumann RD, Larson SM
ANTI-MURINE ANTIBODY RESPONSE TO MOUSE MONOCLONAL ANTIBODIES CLINICAL FINDINGS AND IMPLICATIONS (566 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 121-125.
Impact Factor: 1.042
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (292 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (288 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (322 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (292 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
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Del Vecchio S, Reynolds JC, Blasberg RG, Neumann RD, Carrasquillo JA, Hellström I, Larson SM
Measurement of local Mr 97, 000 and 250, 000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (501 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1988; 48(19): 5475-5481.
Impact Factor: 8.426
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* Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry (11 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2021 Mar 20; 22(6): N/D-N/D.
Impact Factor: 4.556
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Sivaccumar J, Sandomenico A, Vitagliano L, Ruvo M
* Monoclonal Antibodies: A Prospective and Retrospective View (52 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2021; 28(3): 435-471.
Impact Factor: 4.184
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Camorani S, Passariello M, Agnello L, Esposito S, Collina F, Cantile M, Di Bonito M, Ulasov IV, Fedele M, Zannetti A, De Lorenzo C, Cerchia L
* Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer (94 views) (PDF 45 views)
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Impact Factor: 7.068
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Alterio V, Kellner M, Esposito D, Liesche-starnecker F, Bua S, Supuran CT, Monti SM, Zeidler R, De Simone G
* Biochemical and structural insights into Carbonic Anhydrase XII/Fab6A10 complex (151 views)
J Mol Biol (ISSN: 0022-2836linking, 1089-8638), 2019 Dec 6; 431(24): 4910-4921.
Impact Factor: 5.067
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Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (450 views)
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
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Calvanese L, Foca A, Sandomenico A, Foca G, Caporale A, Doti N, Iaccarino E, Leonardi A, D'Auria G, Ruvo M, Falcigno L
* Structural insights into the interaction of a monoclonal antibody and Nodal peptides by STD-NMR spectroscopy (473 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017 Dec 15; 25(24): 6589-6596.
Impact Factor: 2.881
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Berisio R, Squeglia F, Ruggiero A
* Editorial: Molecular Scenarios Behind Infectious Diseases (300 views)
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Impact Factor: 3.469
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Leiria Campo V, Riul TB, Oliveira Bortot L, Martins-teixeira MB, Fiori Marchiori M, Iaccarino E, Ruvo M, Dias-baruffi M, Carvalho I
* A Synthetic MUC1 Glycopeptide Bearing betaGalNAc-Thr as a Tn Antigen Isomer Induces the Production of Antibodies against Tumor Cells (1221 views)
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Impact Factor: 2.774
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Di Matteo A, Franceschini M, Paiardini A, Grottesi A, Chiarella S, Rocchio S, Di Natale C, Marasco D, Vitagliano L, Travaglini-allocatelli C, Federici L
* Structural investigation of Nucleophosmin interaction with the tumor suppressor Fbw7γ (216 views)
Oncogenesis (ISSN: 2157-9024), 2017; 6(9): N/D-N/D.
Impact Factor: 4.722
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Strizzi L, Sandomenico A, Margaryan NV, Foca A, Sanguigno L, Bodenstine TM, Chandler GS, Reed DW, Gilgur A, Seftor EA, Seftor RE, Khalkhali-ellis Z, Leonardi A, Ruvo M, Hendrix MJ
* Effects of a novel Nodal-targeting monoclonal antibody in melanoma (369 views) (PDF 207 views)
Oncotarget (ISSN: 1949-2553, 1949-2553electronic), 2015 Oct 27; 6(33): 34071-34086.
Impact Factor: 5.008
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Foca A, Sanguigno L, Foca G, Strizzi L, Iannitti R, Palumbo R, Hendrix MJ, Leonardi A, Ruvo M, Sandomenico A
* New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding (665 views) (PDF 260 views)
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Impact Factor: 3.257
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Calce E, Monfregola L, Saviano M, De Luca S
* HER2-mediated anticancer drug delivery: strategies to prepare targeting ligands highly specific for the receptor (538 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2015 May 20; 22(21): 2525-2538.
Impact Factor: 3.455
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
* F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (453 views)
Eur J Haematol (ISSN: 0902-4441), 2014 May; 92(5): 382-389.
Impact Factor: 2.066
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1435 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
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Pedicini P, Caivano R, Jereczek-Fossa BA, Strigari L, Vischioni B, Alterio D, Cremonesi M, Botta F, Nappi A, Improta G, Storto G, Benassi M, Orecchia R
* Modelling the correlation between EGFr expression and tumour cell radiosensitivity, and combined treatments of radiation and monoclonal antibody EGFr inhibitors (361 views)
Theor Biol Med Model (ISSN: 1742-4682), 2012 Jun 19; 9(1): 23-23.
Impact Factor: 1.461
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Monti SM, Supuran CT, De Simone G
* Carbonic anhydrase IX as a target for designing novel anticancer drugs (481 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 821-830.
Impact Factor: 4.07
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Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, Puca A, Pedone C, Scala G, Quinto I, Marasco D
* Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction (548 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2011 Sep; 93(9): 1592-1600.
Impact Factor: 3.022
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (521 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (557 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (351 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (558 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Storto G, De Renzo A, Pellegrino T, Perna F, De Falco T, Erra P, Nardelli A, Speranza A, Klain M, Rotoli B, Pace L
* Assessment of Metabolic Response to Radioimmunotherapy with (90)Y-Ibritumomab Tiuxetan in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma (381 views)
Radiology (ISSN: 0033-8419, 1527-1315, 0033-8419linking), 2010 Jan; 254(1): 245-252.
Impact Factor: 6.069
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (392 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Del Vecchio S, Zannetti A, Fonti R, Pace L, Salvatore M
* Nuclear imaging in cancer theranostics (592 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2007 Jun; 51(2): 152-163.
Impact Factor: 1.724
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (325 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Mar; 34(3): 433-436.
Impact Factor: 4.101
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Palmieri G, Marino M, Salvatore M, Budillon A, Meo G, Caraglia M, Montella L
* Cetuximab is an active treatment of metastatic and chemorefractory thymoma (361 views)
Frontiers In Bioscience (ISSN: 1093-9946, 1093-4715), 2007 Jan 1; 12(2): 757-761.
Impact Factor: 2.989
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (505 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Palumbo R, Capasso D, Brescia F, Mita P, Sarti M, Bersani F, Scarfi MR
* Effects on apoptosis and reactive oxygen species formation by Jurkat cells exposed to 50 Hz electromagnetic fields (555 views)
Bioelectromagnetics (ISSN: 0197-8462), 2006 Feb; 27(2): 159-162.
Impact Factor: 1.514
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (729 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (454 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
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Fonti R, Del Vecchio S, Zannetti A, De Renzo A, Catalano L, Pace L, Rotoli B, Salvatore M
* Functional Imaging Of Multidrug Resistant Phenotype By 99mtc-Mibi Scan In Patients With Multiple Myeloma (446 views)
Cancer Biotherapy And Radiopharmaceuticals (ISSN: 1084-9785, 1084-4978), 2004; 19(2): 165-170.
Impact Factor: 1.091
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (364 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (465 views)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (346 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (373 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Fonti R, Levchenko A, Mehta BM, Zhang J, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in human neuroblastoma xenografts using in vitro quantitative autoradiography (253 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999 Jan; 26(1): 35-41.
Impact Factor: 1.623
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Fonti R, Cheung N-KV, Bridger GJ, Guo H-F, Abrams MJ, Larson SM
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors (323 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1999; 26(6): 681-686.
Impact Factor: 1.623
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Fonti R, Cheung NKV, Bridger GJ, Shen SQ, Finn RD, Abrams RJ, Larson SM
Technetium-99m-Monoclonal Antibody Radio-Labeled Via Hydrazino Nicotinamide Derivative For Imaging Ganglioside Gd2-Positive Tumors (249 views)
Nucl Med Biol, 1999; 26: 681-686.
Impact Factor: 0
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Renda A, Iovino F, Capasso L, Ricciardelli L, Tammaro V, Acampa W
Radioimmunoguided surgery in colorectal cancer: A 6-year experience with four different technical solutions (259 views)
Semin Surg Oncol Wiley Liss Inc (ISSN: 8756-0437), 1998 Dec; 15(4): 226-230.
Impact Factor: 1.045
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Del Vecchio S, Ciarmiello A, Pace L, Potena MI, Carriero MV, Mainolfi C, Thomas R, D'Aiuto G, Tsuruo T, Salvatore M
Fractional retention of technetium-99m-sestamibi as an index of P- glycoprotein expression in untreated breast cancer patients (821 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1997 Sep; 38(9): 1348-1351.
Impact Factor: 3.491
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Levchenko A, Mehta B, Spengler BA, Narkar A, Fonti R, Biedler JL, Tsuruo T, Larson SM
Measurement of P-glycoprotein expression in multidrug-resistant human neuroblastoma cell lines using self-competitive binding assay (251 views)
Anal Biochem (ISSN: 0003-2697, 1096-0309electronic, 0003-2697linking), 1996 May 1; 236(2): 338-343.
Impact Factor: 2.017
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Li PY, Del Vecchio S, Fonti R, Carriero MV, Potena MI, Botti G, Miotti S, Lastoria S, Menard S, Colnaghi MI, Salvatore M
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography (441 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1996 Apr; 37(4-6): 665-672.
Impact Factor: 3.491
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Latella G, Fonti R, Caprilli R, Marcheggiano A, Magliocca F, Das KM, Gambús G, Sambuy Y
Characterization of the mucins produced by normal human colonocytes in primary culture (260 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 1996; 11(2): 76-83.
Impact Factor: 0.732
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (455 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Caraglia M, Tagliaferri P, Correale P, Genua G, Pinto A, Del Vecchio S, Esposito G, Bianco AR
CYTOSINE-ARABINOSIDE INCREASES THE BINDING OF I-125 LABELED EPIDERMAL GROWTH-FACTOR AND I-125 TRANSFERRIN AND ENHANCES THE IN-VITRO TARGETING OF HUMAN TUMOR-CELLS WITH ANTI-(GROWTH FACTOR-RECEPTOR) MAB (298 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 1993 Sep; 37(3): 150-156.
Impact Factor: 1.269
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Sofia M, Del Vecchio S, Petrillo A, Mormile M, Salvatore M, Carratù L
Endobronchial deposition of radioactive monoclonal antibody in patients with inoperable non-small-cell carcinoma of the lung [4] (268 views)
Chest (ISSN: 0012-3692), 1992 Nov; 102(5): 1632-1634.
Impact Factor: 2.341
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D'Aiuto G, Del Vecchio S, Mansi L, D'Aprile M, Botti G, Salvatore M
Malignant melanoma of the nipple: A case studied with radiolabeled monoclonal antibody (598 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 1991 Oct 31; 77(5): 449-451.
Impact Factor: 0.408
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Camera L, Del Vecchio S, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Evaluation of therapeutic response using iodine-131-B72. 3 monoclonal antibody in patients with ovarian carcinoma (451 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991 Apr; 18(4): 269-273.
Impact Factor: 2.692
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Del Vecchio S, Camera L, Petrillo A, Esposito G, Frasci G, Iaffaioli RV, Bianco AR, Salvatore M
Clinical studies with B72. 3 in ovarian cancer and probe-guided tumor localization (380 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1991; 18(1): 85-87.
Impact Factor: 1.042
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Del Vecchio S, Mansi L, Petrillo A, Camera L, Sofia M, Marra A, Carratú L, Salvatore M
Endobronchial administration of iodine-131 B72. 3 monoclonal antibody in patients with lung cancer (274 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1991; 18(2): 129-132.
Impact Factor: 2.692
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Valenza V, Maussier ML, D'Errico G, Lemmo GF, Frontera D, Ferrante A, Saletnich I, Valli A, Quarantelli M
Cancer of the pancreas and the periampullary region: The usefulness of tumor marker products with the monoclonal antibody technique (264 views)
J Nucl Med Allied Sci (ISSN: 0392-0208), 1990 Oct; 34(4SUPPL.): 131-134.
Impact Factor: 1.91
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Del Vecchio S, Reynolds JC
NONUNIFORM DISTRIBUTION OF RADIOLABELED MONOCLONAL-ANTIBODY IN TUMOR (239 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1990 Jul; 31(7): 1252-1252.
Impact Factor: 3.491
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Trischitta V, Wong KY, Brunetti A, Scalisi R, Vigneri R, Goldfine ID
Endocytosis, recycling, and degradation of the insulin receptor. Studies with monoclonal antireceptor antibodies that do not activate receptor kinase (308 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 1989 Mar 25; 264(9): 5041-5046.
Impact Factor: 6.963
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d'Onofrio G, Menichella G, Zini G, Rumi C, Pierelli L, Quarantelli M, Puggioni PL, Mango G
Lymphocyte subset counting by immunoperoxidase using an automated routine hematologic analyzer (370 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1989 Mar; 74(2): 137-142.
Impact Factor: 2.56
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Reynolds JC, Del Vecchio S, Sakahara H, Lora ME, Carrasquillo JA, Neumann RD, Larson SM
ANTI-MURINE ANTIBODY RESPONSE TO MOUSE MONOCLONAL ANTIBODIES CLINICAL FINDINGS AND IMPLICATIONS (566 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 121-125.
Impact Factor: 1.042
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Salvatore M, Lastoria S, Del Vecchio S, Mansi L
Detection of colon cancer with radiolabelled monoclonal antibodies (292 views)
Nucl Med Biol (ISSN: 0883-2897, 0969-8051), 1989; 16(2): 103-104.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC
DETERMINATION OF ANTIGEN CONCENTRATION AND DISTRIBUTION IN HUMAN TUMORS THE QUANTITATIVE AUTORADIOGRAPHIC APPROACH (288 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1989; 16(2): 143-145.
Impact Factor: 1.042
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Del Vecchio S, Reynolds JC, Carrasquillo JA, Blasberg RG, Neumann RD, Lotze MT, Bryant GJ, Farkas RJ, Larson SM
Local distribution and concentration of intravenously injected 131I-9. 2. 27 monoclonal antibody in human malignant melanoma (322 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1989; 49(10): 2783-2789.
Impact Factor: 8.426
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DEL VECCHIO S, MANSI L, GAGLIARDI N, PETRILLO A, SOFIA M, CARRATU L, SALVATORE M
INTRABRONCHIAL ADMINISTRATION OF IODINE-131 B72. 3 MONOCLONAL ANTIBODY IN PATIENTS WITH LUNG CANCER (292 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1988; 14(5-6): N/D-N/D.
Impact Factor: 2.692
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Del Vecchio S, Reynolds JC, Blasberg RG, Neumann RD, Carrasquillo JA, Hellström I, Larson SM
Measurement of local Mr 97, 000 and 250, 000 protein antigen concentration in sections of human melanoma tumor using in vitro quantitative autoradiography (501 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1988; 48(19): 5475-5481.
Impact Factor: 8.426
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60 Records (57 excluding Abstracts).
Total impact factor: 225.988 (218.344 excluding Abstracts).
Total 5 year impact factor: 243.443 (232.408 excluding Abstracts).
Total impact factor: 225.988 (218.344 excluding Abstracts).
Total 5 year impact factor: 243.443 (232.408 excluding Abstracts).
361 views. Last view on Tuesday 20 September 2022, 16:57:32
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