Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder (362 views)
J Sci Med Sport (ISSN: 1440-2440), 2010; 13(6): 174-179.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.194, 5-year impact factor: 3.834
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77958451506&doi=10.1016%2fj.pio.2010.09.007&partnerID=40&md5=6ade4f3b14b37ed6995e87f6f3e1a473
Keywords: Comt Gene, Disc Displacement Without Reduction, Mutation, Pain Sensitivity, Temporomandibular Joint Disorders, Catechol Methyltransferase, Genomic Dna, Adult, Article, Case Report, Clinical Assessment, Crystallography, Dna Sequence, Female, Gene Expression, Gene Mutation, Human, Jaw Disease, Masticatory Muscle, Myofascial Pain, Nociception, Nuclear Magnetic Resonance Imaging, Pain Assessment, Visual Analog Scale, Adenine, Agents Interacting With Transmitter, Hormone Or Drug Receptors, Arginine, Cytosine, Serine, Codon, Dislocation, Genetics, Joint Characteristics And Functions, Pathology, Physiology, Catechol O-Methyltransferase, Neurotransmitter Agents, Pain Measurement, Range Of Motion, Articular, Temporomandibular Joint Dysfunction Syndrome,
Affiliations:
*** IBB - CNR ***
Department of Oral and Maxillofacial Surgery, University of Naples Federico II, Italy
Institute of biostructure and bioimaging, CNR, Naples, Italy
CEINGE Biotecnologie Avanzate S.C.a R.L, Naples, Italy
Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, Italy
References:
Cairns, B.E., Pathophysiology of TMD pain - basic mechanisms and their implications for pharmacotherapy (2010) J Oral Rehabil, 37, pp. 391-41
Scrivani, S.J., Keith, D.A., Kaban, L.B., Temporomandibular disorders (2008) N Engl J Med, 359, pp. 2693-2705
Von Korff, M., Le Resche, L., Dworkin, S.F., First onset of common pain symptoms: a prospective study of depression as a risk factor (1993) Pain, 55, pp. 251-258
John, M.T., Miglioretti, D.L., LeResche, L., Von Korff, M., Critchlow, C.W., Widespread pain as a risk factor for dysfunctional temporomandibular disorder pain (2003) Pain, 102, pp. 257-263
Maixner, W., Fillingim, R., Booker, D., Sigurdsson, A., Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain (1995) Pain, 63, pp. 341-351
Von Korff, M.R., Dworkin, S.F., Le Resche, L., Kriger, A., An epidemiologic comparison of pain complaints (1988) Pain, 32, pp. 173-183
Dworkin, S.F., LeResche, L., Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique (1992) J Craniomandib Disord, 6, pp. 301-355
Marbach, J.J., Lipton, J.A., Treatment of patients with temporomandibular joint and other facial pain by otolaryngologist (1982) Arch Otolaryngol, 108, pp. 102-107
Svensson, P., Craniofacial muscle pain: review of mechanisms and clinical manifestations (2001) J Orofacial Pain, 15, pp. 117-145
DeBoever, J.A., Carlsson, G.E., Etiology and differential diagnosis (1994) Temporomandibular joint and masticatory muscle disorders, , Munksgaard, Copenhagen, G.A. Zarb, G.E. Carlsson, B.J. Sessle, N.D. Mohl (Eds.)
Diatchenko, L., Nackley, A.G., Slade, G.D., Fillingim, R.B., Maixner, W., Idiopathic pain disorders-pathways of vulnerability (2006) Pain, 123, pp. 226-230
Nagasako, E.M., Oaklander, A.L., Dworkin, R.H., Congenital insensitivity to pain: an update (2003) Pain, 101, pp. 213-219
Slade, G.D., Diatchenko, L., Ohrbach, R., Maixner, W., Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder (2008) Semin Orthod, 14, pp. 146-156
Zubieta, J.K., Heitzeg, M.M., Smith, Y.R., Bueller, J.A., Xu, K., Xu, Y., Koeppe, R.A., Goldman, D., COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor (2003) Science, 299, pp. 1240-1243
Diatchenko, L., Slade, G.D., Nackley, A.G., Bhalang, K., Sigurdsson, A., Belfer, I., Goldman, D., Maixner, W., Genetic basis for individual variations in pain perception and the development of a chronic pain condition (2005) Hum Mol Genet, 14, pp. 135-143
Melzack, R., The McGill Pain Questionnaire: Major properties and scoring methods (1975) Pain, 1, pp. 277-299
Rutherford, K., Le Trong, I., Stenkamp, R.E., Parson, W.W., Crystal structures of human 108V and 108M catechol O-methyltransferase (2008) J Mol Biol., 380, pp. 120-130
Raphael, K.G., Marbach, J.J., Widespread pain and the effectiveness of oral splints in myofascial face pain (2001) J Am Dent Assoc, 132, pp. 305-316
Vassend, O., Krogstad, B.S., Dahl, B.L., Negative affectivity, somatic complaints, and symptoms of temporomandibular disorders (1995) J Psychosom Res, 39, pp. 889-899
Beaton, R.D., Egan, K.J., Nakagawa-Kogan, H., Morrison, K.N., Selfreported symptoms of stress with temporomandibular disorders: comparisons to healthy men and women (1991) J Prosthet Dent, 65, pp. 289-293
Piedrafita, F.J., Elorriaga, C., Fernández-Alvarez, E., Nieto, O., Inhibition of catechol-O-methyltransferase by N-(3,4-dihydroxyphenyl) maleimide (1990) J Enzyme Inhib, 4, pp. 43-50
Pérez, R.A., Fernández-Alvarez, E., Nieto, O., Piedrafita, F.J., Kinetics of the reversible tight-binding inhibition of pig liver catechol-O-methyltransferase by [2-(3,4-dihydroxy-2- nitrophenyl)vinyl]phenyl ketone (1994) J Enzyme Inhib, 8, pp. 123-131
Bai, H.W., Shim, J.Y., Yu, J., Zhu, B.T., Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound catechol-O-methyltransferases (2007) Chem Res Toxicol., 20, pp. 1409-1425
Li, P.P., Warsh, J.J., Godse, D.D., Formation and clearance of norepinephrine glycol metabolites in mouse brain (1984) J Neurochem., 43, pp. 1425-1433
Pertovaara, A., Noradrenergic pain modulation (2006) Prog Neurobiol, 80, pp. 53-83
Wood, P.B., Role of central dopamine in pain and analgesia (2008) Expert Rev Neurother, 8, pp. 781-797
George, S.R., Kertesz, M., Met-enkephalin concentrations in striatum respond reciprocally to alterations in dopamine neurotransmission (1987) Peptides., 8, pp. 487-492
Chen, J.F., Aloyo, V.J., Weiss, B., Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum (1993) Neuroscience., 54, pp. 669-680
Tchivileva, I.E., Lim, P.F., Smith, S.B., Slade, G.D., Diatchenko, L., McLean, S.A., Maixner, W., Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study (2010) Pharmacogenet Genomics, 20, pp. 239-248
Cairns, B. E., Pathophysiology of TMD pain - basic mechanisms and their implications for pharmacotherapy (2010) J Oral Rehabil, 37, pp. 391-41
Scrivani, S. J., Keith, D. A., Kaban, L. B., Temporomandibular disorders (2008) N Engl J Med, 359, pp. 2693-2705
John, M. T., Miglioretti, D. L., LeResche, L., Von Korff, M., Critchlow, C. W., Widespread pain as a risk factor for dysfunctional temporomandibular disorder pain (2003) Pain, 102, pp. 257-263
Von Korff, M. R., Dworkin, S. F., Le Resche, L., Kriger, A., An epidemiologic comparison of pain complaints (1988) Pain, 32, pp. 173-183
Dworkin, S. F., LeResche, L., Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique (1992) J Craniomandib Disord, 6, pp. 301-355
Marbach, J. J., Lipton, J. A., Treatment of patients with temporomandibular joint and other facial pain by otolaryngologist (1982) Arch Otolaryngol, 108, pp. 102-107
DeBoever, J. A., Carlsson, G. E., Etiology and differential diagnosis (1994) Temporomandibular joint and masticatory muscle disorders, , Munksgaard, Copenhagen, G. A. Zarb, G. E. Carlsson, B. J. Sessle, N. D. Mohl (Eds.)
Nagasako, E. M., Oaklander, A. L., Dworkin, R. H., Congenital insensitivity to pain: an update (2003) Pain, 101, pp. 213-219
Slade, G. D., Diatchenko, L., Ohrbach, R., Maixner, W., Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder (2008) Semin Orthod, 14, pp. 146-156
Zubieta, J. K., Heitzeg, M. M., Smith, Y. R., Bueller, J. A., Xu, K., Xu, Y., Koeppe, R. A., Goldman, D., COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor (2003) Science, 299, pp. 1240-1243
Raphael, K. G., Marbach, J. J., Widespread pain and the effectiveness of oral splints in myofascial face pain (2001) J Am Dent Assoc, 132, pp. 305-316
Beaton, R. D., Egan, K. J., Nakagawa-Kogan, H., Morrison, K. N., Selfreported symptoms of stress with temporomandibular disorders: comparisons to healthy men and women (1991) J Prosthet Dent, 65, pp. 289-293
Piedrafita, F. J., Elorriaga, C., Fern ndez-Alvarez, E., Nieto, O., Inhibition of catechol-O-methyltransferase by N- (3, 4-dihydroxyphenyl) maleimide (1990) J Enzyme Inhib, 4, pp. 43-50
P rez, R. A., Fern ndez-Alvarez, E., Nieto, O., Piedrafita, F. J., Kinetics of the reversible tight-binding inhibition of pig liver catechol-O-methyltransferase by [2- (3, 4-dihydroxy-2- nitrophenyl) vinyl] phenyl ketone (1994) J Enzyme Inhib, 8, pp. 123-131
Bai, H. W., Shim, J. Y., Yu, J., Zhu, B. T., Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound catechol-O-methyltransferases (2007) Chem Res Toxicol., 20, pp. 1409-1425
Li, P. P., Warsh, J. J., Godse, D. D., Formation and clearance of norepinephrine glycol metabolites in mouse brain (1984) J Neurochem., 43, pp. 1425-1433
Wood, P. B., Role of central dopamine in pain and analgesia (2008) Expert Rev Neurother, 8, pp. 781-797
George, S. R., Kertesz, M., Met-enkephalin concentrations in striatum respond reciprocally to alterations in dopamine neurotransmission (1987) Peptides., 8, pp. 487-492
Chen, J. F., Aloyo, V. J., Weiss, B., Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum (1993) Neuroscience., 54, pp. 669-680
Tchivileva, I. E., Lim, P. F., Smith, S. B., Slade, G. D., Diatchenko, L., McLean, S. A., Maixner, W., Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study (2010) Pharmacogenet Genomics, 20, pp. 239-248
J Sci Med Sport (ISSN: 1440-2440), 2010; 13(6): 174-179.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.194, 5-year impact factor: 3.834
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-77958451506&doi=10.1016%2fj.pio.2010.09.007&partnerID=40&md5=6ade4f3b14b37ed6995e87f6f3e1a473
Keywords: Comt Gene, Disc Displacement Without Reduction, Mutation, Pain Sensitivity, Temporomandibular Joint Disorders, Catechol Methyltransferase, Genomic Dna, Adult, Article, Case Report, Clinical Assessment, Crystallography, Dna Sequence, Female, Gene Expression, Gene Mutation, Human, Jaw Disease, Masticatory Muscle, Myofascial Pain, Nociception, Nuclear Magnetic Resonance Imaging, Pain Assessment, Visual Analog Scale, Adenine, Agents Interacting With Transmitter, Hormone Or Drug Receptors, Arginine, Cytosine, Serine, Codon, Dislocation, Genetics, Joint Characteristics And Functions, Pathology, Physiology, Catechol O-Methyltransferase, Neurotransmitter Agents, Pain Measurement, Range Of Motion, Articular, Temporomandibular Joint Dysfunction Syndrome,
Affiliations:
*** IBB - CNR ***
Department of Oral and Maxillofacial Surgery, University of Naples Federico II, Italy
Institute of biostructure and bioimaging, CNR, Naples, Italy
CEINGE Biotecnologie Avanzate S.C.a R.L, Naples, Italy
Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, Italy
References:
Cairns, B.E., Pathophysiology of TMD pain - basic mechanisms and their implications for pharmacotherapy (2010) J Oral Rehabil, 37, pp. 391-41
Scrivani, S.J., Keith, D.A., Kaban, L.B., Temporomandibular disorders (2008) N Engl J Med, 359, pp. 2693-2705
Von Korff, M., Le Resche, L., Dworkin, S.F., First onset of common pain symptoms: a prospective study of depression as a risk factor (1993) Pain, 55, pp. 251-258
John, M.T., Miglioretti, D.L., LeResche, L., Von Korff, M., Critchlow, C.W., Widespread pain as a risk factor for dysfunctional temporomandibular disorder pain (2003) Pain, 102, pp. 257-263
Maixner, W., Fillingim, R., Booker, D., Sigurdsson, A., Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain (1995) Pain, 63, pp. 341-351
Von Korff, M.R., Dworkin, S.F., Le Resche, L., Kriger, A., An epidemiologic comparison of pain complaints (1988) Pain, 32, pp. 173-183
Dworkin, S.F., LeResche, L., Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique (1992) J Craniomandib Disord, 6, pp. 301-355
Marbach, J.J., Lipton, J.A., Treatment of patients with temporomandibular joint and other facial pain by otolaryngologist (1982) Arch Otolaryngol, 108, pp. 102-107
Svensson, P., Craniofacial muscle pain: review of mechanisms and clinical manifestations (2001) J Orofacial Pain, 15, pp. 117-145
DeBoever, J.A., Carlsson, G.E., Etiology and differential diagnosis (1994) Temporomandibular joint and masticatory muscle disorders, , Munksgaard, Copenhagen, G.A. Zarb, G.E. Carlsson, B.J. Sessle, N.D. Mohl (Eds.)
Diatchenko, L., Nackley, A.G., Slade, G.D., Fillingim, R.B., Maixner, W., Idiopathic pain disorders-pathways of vulnerability (2006) Pain, 123, pp. 226-230
Nagasako, E.M., Oaklander, A.L., Dworkin, R.H., Congenital insensitivity to pain: an update (2003) Pain, 101, pp. 213-219
Slade, G.D., Diatchenko, L., Ohrbach, R., Maixner, W., Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder (2008) Semin Orthod, 14, pp. 146-156
Zubieta, J.K., Heitzeg, M.M., Smith, Y.R., Bueller, J.A., Xu, K., Xu, Y., Koeppe, R.A., Goldman, D., COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor (2003) Science, 299, pp. 1240-1243
Diatchenko, L., Slade, G.D., Nackley, A.G., Bhalang, K., Sigurdsson, A., Belfer, I., Goldman, D., Maixner, W., Genetic basis for individual variations in pain perception and the development of a chronic pain condition (2005) Hum Mol Genet, 14, pp. 135-143
Melzack, R., The McGill Pain Questionnaire: Major properties and scoring methods (1975) Pain, 1, pp. 277-299
Rutherford, K., Le Trong, I., Stenkamp, R.E., Parson, W.W., Crystal structures of human 108V and 108M catechol O-methyltransferase (2008) J Mol Biol., 380, pp. 120-130
Raphael, K.G., Marbach, J.J., Widespread pain and the effectiveness of oral splints in myofascial face pain (2001) J Am Dent Assoc, 132, pp. 305-316
Vassend, O., Krogstad, B.S., Dahl, B.L., Negative affectivity, somatic complaints, and symptoms of temporomandibular disorders (1995) J Psychosom Res, 39, pp. 889-899
Beaton, R.D., Egan, K.J., Nakagawa-Kogan, H., Morrison, K.N., Selfreported symptoms of stress with temporomandibular disorders: comparisons to healthy men and women (1991) J Prosthet Dent, 65, pp. 289-293
Piedrafita, F.J., Elorriaga, C., Fernández-Alvarez, E., Nieto, O., Inhibition of catechol-O-methyltransferase by N-(3,4-dihydroxyphenyl) maleimide (1990) J Enzyme Inhib, 4, pp. 43-50
Pérez, R.A., Fernández-Alvarez, E., Nieto, O., Piedrafita, F.J., Kinetics of the reversible tight-binding inhibition of pig liver catechol-O-methyltransferase by [2-(3,4-dihydroxy-2- nitrophenyl)vinyl]phenyl ketone (1994) J Enzyme Inhib, 8, pp. 123-131
Bai, H.W., Shim, J.Y., Yu, J., Zhu, B.T., Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound catechol-O-methyltransferases (2007) Chem Res Toxicol., 20, pp. 1409-1425
Li, P.P., Warsh, J.J., Godse, D.D., Formation and clearance of norepinephrine glycol metabolites in mouse brain (1984) J Neurochem., 43, pp. 1425-1433
Pertovaara, A., Noradrenergic pain modulation (2006) Prog Neurobiol, 80, pp. 53-83
Wood, P.B., Role of central dopamine in pain and analgesia (2008) Expert Rev Neurother, 8, pp. 781-797
George, S.R., Kertesz, M., Met-enkephalin concentrations in striatum respond reciprocally to alterations in dopamine neurotransmission (1987) Peptides., 8, pp. 487-492
Chen, J.F., Aloyo, V.J., Weiss, B., Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum (1993) Neuroscience., 54, pp. 669-680
Tchivileva, I.E., Lim, P.F., Smith, S.B., Slade, G.D., Diatchenko, L., McLean, S.A., Maixner, W., Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study (2010) Pharmacogenet Genomics, 20, pp. 239-248
Cairns, B. E., Pathophysiology of TMD pain - basic mechanisms and their implications for pharmacotherapy (2010) J Oral Rehabil, 37, pp. 391-41
Scrivani, S. J., Keith, D. A., Kaban, L. B., Temporomandibular disorders (2008) N Engl J Med, 359, pp. 2693-2705
John, M. T., Miglioretti, D. L., LeResche, L., Von Korff, M., Critchlow, C. W., Widespread pain as a risk factor for dysfunctional temporomandibular disorder pain (2003) Pain, 102, pp. 257-263
Von Korff, M. R., Dworkin, S. F., Le Resche, L., Kriger, A., An epidemiologic comparison of pain complaints (1988) Pain, 32, pp. 173-183
Dworkin, S. F., LeResche, L., Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique (1992) J Craniomandib Disord, 6, pp. 301-355
Marbach, J. J., Lipton, J. A., Treatment of patients with temporomandibular joint and other facial pain by otolaryngologist (1982) Arch Otolaryngol, 108, pp. 102-107
DeBoever, J. A., Carlsson, G. E., Etiology and differential diagnosis (1994) Temporomandibular joint and masticatory muscle disorders, , Munksgaard, Copenhagen, G. A. Zarb, G. E. Carlsson, B. J. Sessle, N. D. Mohl (Eds.)
Nagasako, E. M., Oaklander, A. L., Dworkin, R. H., Congenital insensitivity to pain: an update (2003) Pain, 101, pp. 213-219
Slade, G. D., Diatchenko, L., Ohrbach, R., Maixner, W., Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder (2008) Semin Orthod, 14, pp. 146-156
Zubieta, J. K., Heitzeg, M. M., Smith, Y. R., Bueller, J. A., Xu, K., Xu, Y., Koeppe, R. A., Goldman, D., COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor (2003) Science, 299, pp. 1240-1243
Raphael, K. G., Marbach, J. J., Widespread pain and the effectiveness of oral splints in myofascial face pain (2001) J Am Dent Assoc, 132, pp. 305-316
Beaton, R. D., Egan, K. J., Nakagawa-Kogan, H., Morrison, K. N., Selfreported symptoms of stress with temporomandibular disorders: comparisons to healthy men and women (1991) J Prosthet Dent, 65, pp. 289-293
Piedrafita, F. J., Elorriaga, C., Fern ndez-Alvarez, E., Nieto, O., Inhibition of catechol-O-methyltransferase by N- (3, 4-dihydroxyphenyl) maleimide (1990) J Enzyme Inhib, 4, pp. 43-50
P rez, R. A., Fern ndez-Alvarez, E., Nieto, O., Piedrafita, F. J., Kinetics of the reversible tight-binding inhibition of pig liver catechol-O-methyltransferase by [2- (3, 4-dihydroxy-2- nitrophenyl) vinyl] phenyl ketone (1994) J Enzyme Inhib, 8, pp. 123-131
Bai, H. W., Shim, J. Y., Yu, J., Zhu, B. T., Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound catechol-O-methyltransferases (2007) Chem Res Toxicol., 20, pp. 1409-1425
Li, P. P., Warsh, J. J., Godse, D. D., Formation and clearance of norepinephrine glycol metabolites in mouse brain (1984) J Neurochem., 43, pp. 1425-1433
Wood, P. B., Role of central dopamine in pain and analgesia (2008) Expert Rev Neurother, 8, pp. 781-797
George, S. R., Kertesz, M., Met-enkephalin concentrations in striatum respond reciprocally to alterations in dopamine neurotransmission (1987) Peptides., 8, pp. 487-492
Chen, J. F., Aloyo, V. J., Weiss, B., Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum (1993) Neuroscience., 54, pp. 669-680
Tchivileva, I. E., Lim, P. F., Smith, S. B., Slade, G. D., Diatchenko, L., McLean, S. A., Maixner, W., Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study (2010) Pharmacogenet Genomics, 20, pp. 239-248
Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder
We report a case of temporomandibular disorder patient with disc displacement without reduction, myofascial pain, limited opening and a novel, never described, nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene. COMT is one of the enzymes that metabolizes catecholamines, thereby acting as a key modulator of dopaminergic and adrenergic/noradrenergic neurotransmissions, which play a key role in pain modulation. This novel mutation, p.R58S, changed a codon (58 from arginine to serine) in the COMT protein. The introduction of a serine residue in a highly organised secondary structure, in critical regions of the protein, results in a structural alteration. Therefore, we speculate an influence of the mutation on the high pain sensitivity of the patient. © 2010 Società Italiana di Ortodonzia SIDO.
We report a case of temporomandibular disorder patient with disc displacement without reduction, myofascial pain, limited opening and a novel, never described, nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene. COMT is one of the enzymes that metabolizes catecholamines, thereby acting as a key modulator of dopaminergic and adrenergic/noradrenergic neurotransmissions, which play a key role in pain modulation. This novel mutation, p.R58S, changed a codon (58 from arginine to serine) in the COMT protein. The introduction of a serine residue in a highly organised secondary structure, in critical regions of the protein, results in a structural alteration. Therefore, we speculate an influence of the mutation on the high pain sensitivity of the patient. © 2010 Società Italiana di Ortodonzia SIDO.
Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder
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Nonsynonimous mutation of catechol-O-methyl-transferase (COMT) gene in a patient with temporomandibular disorder
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* Surface Plasmon Resonance Imaging (SPR-I), peptide nucleic acid (PNA) probes and nanoparticle-enhancement for PCR-free ultrasensitive detection of beta-thalassemia mutations in human genomic DNA (298 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2010; 26: N/D-N/D.
Impact Factor: 1.814
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* Park20 Caused By Synj1 Homozygous Arg258gln Mutation In A New Italian Family (492 views)
Neurogenetics (ISSN: 1364-6745, 1364-6753), 2014 Aug; 15(3): 183-188.
Impact Factor: 2.884
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Quadri M, Fang M, Picillo M, Olgiati S, Breedveld Gj Graafland J, Wu B, Xu F, Erro R, Amboni M, Pappata S, Quarantelli M, Annesi G, Quattrone A, Chien Hf Barbosa ER, International Parkinsonism Genetics Network Oostra Ba Barone P, Wang J, Bonifati V
* Mutation in the SYNJ1 gene associated with autosomal recessive, early-onset Parkinsonism (401 views)
Hum Mutat (ISSN: 1059-7794, 1098-1004, 1098-1004electronic), 2013 Sep; 34(9): 1208-1215.
Impact Factor: 5.122
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D'Agata R, Spoto G
* Artificial DNA and surface plasmon resonance (554 views)
Artificial Dna Pna & Xna (ISSN: 1949-095x), 2012 Apr; 3(2): N/D-N/D.
Impact Factor: 0
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D'Agata R, Breveglieri G, Zanoli LM, Borgatti M, Spoto G, Gambari R
* Direct Detection of Point Mutations in Nonamplified Human Genomic DNA (807 views)
Analytical Chemistry (ISSN: 0003-2700), 2011 Nov 15; 83(22): 8711-8717.
Impact Factor: 5.856
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA (434 views)
Lect Notes Electr Eng, 2010 May 15; 91LNEE: 485-488.
Impact Factor: 0
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Ultrasensitive detection of non-amplified genomic DNA by nanoparticle-enhanced surface plasmon resonance imaging (425 views)
Biosens Bioelectron (ISSN: 0956-5663, 1873-4235electronic), 2010 May 15; 25(9): 2095-2100.
Impact Factor: 5.361
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D'Agata R, Corradini R, Ferretti C, Zanoli L, Gatti M, Marchelli R, Spoto G
* Detection Of Non Amplified Genomic Dna By Advanced Spri Methods (224 views)
Chimica & L Industria, 2010; 7: 140-145.
Impact Factor: 0
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D'Agata R, Breveglieri G, Zanoli L, Borgatti M, Spoto G, Gambari R
* Surface Plasmon Resonance Imaging (SPR-I), peptide nucleic acid (PNA) probes and nanoparticle-enhancement for PCR-free ultrasensitive detection of beta-thalassemia mutations in human genomic DNA (298 views)
International Journal Of Molecular Medicine (ISSN: 1107-3756), 2010; 26: N/D-N/D.
Impact Factor: 1.814
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8 Records (6 excluding Abstracts).
Total impact factor: 21.037 (19.223 excluding Abstracts).
Total 5 year impact factor: 21.198 (19.379 excluding Abstracts).
Total impact factor: 21.037 (19.223 excluding Abstracts).
Total 5 year impact factor: 21.198 (19.379 excluding Abstracts).
362 views. Last view on Tuesday 11 April 2023, 20:15:11
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