A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis (505 views)
J Clin Gastroenterol (ISSN: 0192-0790), 2009 Jan; 43(1): 81-87.
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Paper type: Journal Article,
Impact factor: 2.207, 5-year impact factor: 2.64
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-67651174428&partnerID=40&md5=eb5f45de2c589d58e1218cb515e93811
Keywords: Ast Alt Ratio, Cirrhosis, Endoscopy, Platelet Count, Portal Hypertension, Alanine Aminotransferase, Albumin, Aspartate Aminotransferase, Adult, Aged, Article, Chronic Liver Disease, Controlled Study, Diagnostic Accuracy, Esophagus Varices, Female, Gastrointestinal Endoscopy, Hepatitis B, Human, Human Tissue, Liver Biopsy, Liver Cirrhosis, Major Clinical Study, Patient Identification, Priority Journal, Scoring System, Stomach Varices, Thrombocyte Count, Age Factors, Digestive System, Esophageal And Gastric Varices, Logistic Models, Middle Aged, Practice Guidelines As Topic, Predictive Value Of Tests, Retrospective Studies, Risk Factors, Severity Of Illness Index, Young Adult,
Affiliations:
*** IBB - CNR ***
Department of Public Medicine and Social Security, Section of Infectious Diseases, University of Naples Federico II, Naples, Italy
Department of Physical Science, University of Naples Federico II, Naples, Italy
Institution of Biostructure and Bioimaging, National Research Council (CNR), via S. Pansini, Naples, Italy
References:
Not available.
J Clin Gastroenterol (ISSN: 0192-0790), 2009 Jan; 43(1): 81-87.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.207, 5-year impact factor: 2.64
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-67651174428&partnerID=40&md5=eb5f45de2c589d58e1218cb515e93811
Keywords: Ast Alt Ratio, Cirrhosis, Endoscopy, Platelet Count, Portal Hypertension, Alanine Aminotransferase, Albumin, Aspartate Aminotransferase, Adult, Aged, Article, Chronic Liver Disease, Controlled Study, Diagnostic Accuracy, Esophagus Varices, Female, Gastrointestinal Endoscopy, Hepatitis B, Human, Human Tissue, Liver Biopsy, Liver Cirrhosis, Major Clinical Study, Patient Identification, Priority Journal, Scoring System, Stomach Varices, Thrombocyte Count, Age Factors, Digestive System, Esophageal And Gastric Varices, Logistic Models, Middle Aged, Practice Guidelines As Topic, Predictive Value Of Tests, Retrospective Studies, Risk Factors, Severity Of Illness Index, Young Adult,
Affiliations:
*** IBB - CNR ***
Department of Public Medicine and Social Security, Section of Infectious Diseases, University of Naples Federico II, Naples, Italy
Department of Physical Science, University of Naples Federico II, Naples, Italy
Institution of Biostructure and Bioimaging, National Research Council (CNR), via S. Pansini, Naples, Italy
References:
Not available.
A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis
BACKGROUND: Guidelines recommend upper endoscopic screening of cirrhotic patients for gastroesophageal varices. Cirrhosis is not always distinguishable from chronic hepatitis. GOALS: To identify low-risk patients who can be spared upper endoscopy irrespective of a diagnosis of cirrhosis. STUDY: We evaluated 13 nonendoscopic variables as predictors of esophagogastric varices in 254 patients with hepatitis B or hepatitis C-related chronic liver disease who underwent upper endoscopy. RESULTS: Any size varices occurred in 30.3% (77/254), and large varices in 12.2% of patients (31/254). Age >50 years [odds ratio (OR): 11.29; 95% confidence interval (CI): 2.33-54.67], platelet count <150,000/mmc (OR: 4.40; 95% CI: 1.85-10.45), albumin <3.6 g/dL (OR: 2.99; 95% CI: 1.31-6.79), and aspartate aminotransferase/alanine aminotransferase ratio >1 (OR: 2.83; 95% CI: 1.26-6.34) independently predicted varices by logistic regression. Using a score based on age >50 years, platelets <150,000/mmc, and aspartate aminotransferase/alanine aminotransferase ratio >1 (1 point/predictor), only 3.2% of patients with a score <2 had varices, all small. CONCLUSIONS: Patients with chronic viral hepatitis and a score <2 need not undergo upper endoscopy, as they are unlikely to have large varices. Because about 50% of our patients had this score, 50% of upper endoscopies may be safely avoided. © 2009 Lippincott Williams & Wilkins, Inc.
BACKGROUND: Guidelines recommend upper endoscopic screening of cirrhotic patients for gastroesophageal varices. Cirrhosis is not always distinguishable from chronic hepatitis. GOALS: To identify low-risk patients who can be spared upper endoscopy irrespective of a diagnosis of cirrhosis. STUDY: We evaluated 13 nonendoscopic variables as predictors of esophagogastric varices in 254 patients with hepatitis B or hepatitis C-related chronic liver disease who underwent upper endoscopy. RESULTS: Any size varices occurred in 30.3% (77/254), and large varices in 12.2% of patients (31/254). Age >50 years [odds ratio (OR): 11.29; 95% confidence interval (CI): 2.33-54.67], platelet count <150,000/mmc (OR: 4.40; 95% CI: 1.85-10.45), albumin <3.6 g/dL (OR: 2.99; 95% CI: 1.31-6.79), and aspartate aminotransferase/alanine aminotransferase ratio >1 (OR: 2.83; 95% CI: 1.26-6.34) independently predicted varices by logistic regression. Using a score based on age >50 years, platelets <150,000/mmc, and aspartate aminotransferase/alanine aminotransferase ratio >1 (1 point/predictor), only 3.2% of patients with a score <2 had varices, all small. CONCLUSIONS: Patients with chronic viral hepatitis and a score <2 need not undergo upper endoscopy, as they are unlikely to have large varices. Because about 50% of our patients had this score, 50% of upper endoscopies may be safely avoided. © 2009 Lippincott Williams & Wilkins, Inc.
A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis
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A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis
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Impact Factor: 0.936
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10 Records (9 excluding Abstracts).
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Total 5 year impact factor: 20.785 (15.91 excluding Abstracts).
Total impact factor: 20.953 (16.455 excluding Abstracts).
Total 5 year impact factor: 20.785 (15.91 excluding Abstracts).
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