Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET (772 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 May; 31(5): 644-654.
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Paper type: Journal Article,
Impact factor: 3.935, 5-year impact factor: 4.728
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-2442473862&partnerID=40&md5=64c4aebf017ffd90d5efda847ec4d58a
Keywords: Nonlinear Least-Squares Analysis, Ordered Subsets Expectation Maximization, Putamen, Temporal Cortex, Thalamus, Dopamine 2 Receptor, Epidepride I 123, Fallypride F 18, Tracer, Unclassified Drug, Adult, Article, Brain Region, Cerebellum, Controlled Study, Corpus Striatum, Diagnostic Accuracy, Dopaminergic System, Female, Geometry, Human, Human Experiment, Image Analysis, In Vivo Study, Normal Human, Phantom, Protein Localization, Single Photon Emission Computer Tomography, Benzamides, Image Enhancement, Image Interpretation, Computer-Assisted, Iodine Radioisotopes, Metabolic Clearance Rate, Middle Aged, Pyrrolidines, Radiopharmaceuticals, Reproducibility Of Results, Scattering, Radiation, Sensitivity And Specificity, Tissue Distribution,
Affiliations:
*** IBB - CNR ***
Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT, United States
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, United States
Biostructure and Bioimaging Inst., National Research Council, Napoli, Italy
Dept. of Investigative Radiology, Natl. Cardiovasc. Ctr. Res. Inst., Osaka, Japan
Department of Radiology, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT, United States
Inst. for Neurodeg. Disorders, New Haven, CT, United States
Building 1, MSC-0135, United States
References:
Not available.
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 May; 31(5): 644-654.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.935, 5-year impact factor: 4.728
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-2442473862&partnerID=40&md5=64c4aebf017ffd90d5efda847ec4d58a
Keywords: Nonlinear Least-Squares Analysis, Ordered Subsets Expectation Maximization, Putamen, Temporal Cortex, Thalamus, Dopamine 2 Receptor, Epidepride I 123, Fallypride F 18, Tracer, Unclassified Drug, Adult, Article, Brain Region, Cerebellum, Controlled Study, Corpus Striatum, Diagnostic Accuracy, Dopaminergic System, Female, Geometry, Human, Human Experiment, Image Analysis, In Vivo Study, Normal Human, Phantom, Protein Localization, Single Photon Emission Computer Tomography, Benzamides, Image Enhancement, Image Interpretation, Computer-Assisted, Iodine Radioisotopes, Metabolic Clearance Rate, Middle Aged, Pyrrolidines, Radiopharmaceuticals, Reproducibility Of Results, Scattering, Radiation, Sensitivity And Specificity, Tissue Distribution,
Affiliations:
*** IBB - CNR ***
Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT, United States
Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD, United States
Biostructure and Bioimaging Inst., National Research Council, Napoli, Italy
Dept. of Investigative Radiology, Natl. Cardiovasc. Ctr. Res. Inst., Osaka, Japan
Department of Radiology, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT, United States
Inst. for Neurodeg. Disorders, New Haven, CT, United States
Building 1, MSC-0135, United States
References:
Not available.
Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET
Prior studies with anthropomorphic phantoms and single, static in vivo brain images have demonstrated that scatter correction significantly improves the accuracy of regional quantitation of single-photon emission tomography (SPET) brain images. Since the regional distribution of activity changes following a bolus injection of a typical neuroreceptor ligand, we examined the effect of scatter correction on the compartmental modeling of serial dynamic images of striatal and extrastriatal dopamine D2 receptors using [123I]epidepride. Eight healthy human subjects [age 30±8 (range 22-46) years] participated in a study with a bolus injection of 373±12 (354-389) MBq [123I]epidepride and data acquisition over a period of 14 h. A transmission scan was obtained in each study for attenuation and scatter correction. Distribution volumes were calculated by means of compartmental nonlinear least-squares analysis using metabolite-corrected arterial input function and brain data processed with scatter correction using narrow-beam geometry μ (SC) and without scatter correction using broad-beam μ (NoSC). Effects of SC were markedly different among brain regions. SC increased activities in the putamen and thalamus after 1-1.5 h while it decreased activity during the entire experiment in the temporal cortex and cerebellum. Compared with NoSC, SC significantly increased specific distribution volume in the putamen (58%, P=0.0001) and thalamus (23%, P=0.0297). Compared with NoSC, SC made regional distribution of the specific distribution volume closer to that of [18F]fallypride. It is concluded that SC is required for accurate quantification of distribution volumes of receptor ligands in SPET studies.
Prior studies with anthropomorphic phantoms and single, static in vivo brain images have demonstrated that scatter correction significantly improves the accuracy of regional quantitation of single-photon emission tomography (SPET) brain images. Since the regional distribution of activity changes following a bolus injection of a typical neuroreceptor ligand, we examined the effect of scatter correction on the compartmental modeling of serial dynamic images of striatal and extrastriatal dopamine D2 receptors using [123I]epidepride. Eight healthy human subjects [age 30±8 (range 22-46) years] participated in a study with a bolus injection of 373±12 (354-389) MBq [123I]epidepride and data acquisition over a period of 14 h. A transmission scan was obtained in each study for attenuation and scatter correction. Distribution volumes were calculated by means of compartmental nonlinear least-squares analysis using metabolite-corrected arterial input function and brain data processed with scatter correction using narrow-beam geometry μ (SC) and without scatter correction using broad-beam μ (NoSC). Effects of SC were markedly different among brain regions. SC increased activities in the putamen and thalamus after 1-1.5 h while it decreased activity during the entire experiment in the temporal cortex and cerebellum. Compared with NoSC, SC significantly increased specific distribution volume in the putamen (58%, P=0.0001) and thalamus (23%, P=0.0297). Compared with NoSC, SC made regional distribution of the specific distribution volume closer to that of [18F]fallypride. It is concluded that SC is required for accurate quantification of distribution volumes of receptor ligands in SPET studies.
Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET
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Effect of scatter correction on the compartmental measurement of striatal and extrastriatal dopamine D2 receptors using [ 123I]epidepride SPET
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 2.692
View Export to BibTeX Export to EndNote
18 Records (18 excluding Abstracts).
Total impact factor: 70.061 (70.061 excluding Abstracts).
Total 5 year impact factor: 75.045 (75.045 excluding Abstracts).
Total impact factor: 70.061 (70.061 excluding Abstracts).
Total 5 year impact factor: 75.045 (75.045 excluding Abstracts).
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