Influence of left ventricular asynchrony on systolic and diastolic function in patients with nonischemic heart failure(299 views) Della Morte AM, Storto G, Varrone A, Pace L, Cuocolo A, Perrone-Filardi P, Betocchi S, Chiariello M, Salvatore M
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1998; 96(1-2): 68-72.
Affiliations: Cattedra di Medicina Nucleare, Dipartimento di Scienze Radiologiche, Università Federico II, Napoli, Italy
Centro C N R Medicina Nucleare, Università Federico II, Napoli, Italy
Ist. Med. Int. - Cardiol. C., Facoltà di Medicina, Università Federico II, Napoli, Italy
Istituto Nazionale Tumori, Fondazione Pascale, Via Mariano Semmola, 80131 Napoli NA, Italy
Dipto. Sci. Biomorfologiche F., Facoltà di Medicina, Università Federico II, Via Pansini 5, 80131 Napoli NA, Italy
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Bonow, R. O., Udelson, J. E., Left ventricular diastolic dysfunction as a cause of congestive heart failure (1992) Ann Intern Med, 117, pp. 502-510
Bonow, R. O., Vitale, D. F., Bacharach, S. L., Asynchronous left ventricular regional function and impaired global diastolic filling in patients with coronary artery disease: Reversal after coronary angioplasty (1985) Circulation, 71, pp. 297-307
Bonow, R. O., Regional left ventricular non uniformity: Effects on left ventricular diastolic function in ischemic heart disease, hypertrophic cardiomyopathy, and the normal heart (1990) Circulation, 81 (3 SUPPL.), pp. 54-65
Brutsaert, D. L., Rademakers, F. E., Sys, F. U., Analysis of relaxation in the evaluation of ventricular function of the heart (1985) Prog Cardiovasc Dis, 28, pp. 143-163
Brutsaert, D. L., Nonuniformity a physiologic modulator of contraction and relaxation in normal heart (1987) J Am Coll Cardiol, 9, pp. 341-348
Wallis, D. E., O'Connel, J. B., Henkin, R. E., Segmental wall motion abnormalities in dilated cardiomyopathy: A common finding and good prognostic sign (1984) J Am Coll Cardiol, 4, pp. 674-679
Weber, K. T., Janicki, J. S., Pick, R., Collagen in the hypertrophied pressure-overload myocardium (1987) Circulation, 75 (1 SUPPL.), pp. 40-47
Influence of left ventricular asynchrony on systolic and diastolic function in patients with nonischemic heart failure
Introduction. The asynchrony of the left ventricle - ie. its nonuniform contraction and relaxation - is an important factor for left ventricular function. Heart failure is often related to abnormal systolic function, sometimes associated with a diastolic dysfunction. We studied the relationship of left ventricular asynchrony to left ventricular function in patients with nonischemic heart failure. Material and methods. Radionuclide angiography at rest was performed in 25 patients with nonischemic heart failure and in 26 age and sex matched normal subjects. In addition to ejection fraction and peak filling rate, two indices of left ventricular asynchrony were calculated: the coefficient of variation of regional time to end systole and the coefficient of variation of regional time to peak filling rate. These factors indicate how disperse are the regional values of time to end systole and of time to peak filling rate. In fact, the higher the value, the greater the asynchrony. Results. A significant (r=.46, p
Influence of left ventricular asynchrony on systolic and diastolic function in patients with nonischemic heart failure
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