Characterization of hypersecreting or non-hypersecreting adrenal adenomas: Comparison between iodine-131 nor-cholesterol scintigraphy and magnetic resonance imaging (360 views) (PDF public 254 views)
Curr Radiopharm (ISSN: 1874-4710, 1874-4729), 2009; 2(1): 56-62.
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Paper type: Journal Article,
Impact factor: 0.643, 5-year impact factor: 0.874
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77953733368&partnerID=40&md5=1aa46bef8d69eb9cc8de3adbc9d53932
Keywords: Adenomas, Adrenals, Imaging Characterization, Nor-Cholesterol, Iodocholesterol I 131, Acth Secreting Adenoma, Adrenal Cortex Adenoma, Adrenal Cortex Carcinoma, Adrenal Cyst, Adult, Article, Clinical Article, Controlled Study, Diagnostic Accuracy, Female, Follow Up, Histopathology, Human, Metastasis, Myelolipoma, Nuclear Magnetic Resonance Imaging, Pheochromocytoma, Priority Journal, Qualitative Analysis, Quantitative Analysis, Scintigraphy, Tumor Volume,
Affiliations:
*** IBB - CNR ***
Radiologia e Medicina Nucleare, Dipartimento di Scienze Biomorfologiche e Funzionali (DSBMF), Napoli, Italy
Università degli Studi di Napoli Federico II (UNINA), Napoli, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale delle Ricerche (CNR), Napoli, Italy
Fondazione SDN (IRCCS), Napoli, Italy
Universit degli Studi di Napoli Federico II (UNINA), Napoli, Italy
References:
Not available.
Curr Radiopharm (ISSN: 1874-4710, 1874-4729), 2009; 2(1): 56-62.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0.643, 5-year impact factor: 0.874
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77953733368&partnerID=40&md5=1aa46bef8d69eb9cc8de3adbc9d53932
Keywords: Adenomas, Adrenals, Imaging Characterization, Nor-Cholesterol, Iodocholesterol I 131, Acth Secreting Adenoma, Adrenal Cortex Adenoma, Adrenal Cortex Carcinoma, Adrenal Cyst, Adult, Article, Clinical Article, Controlled Study, Diagnostic Accuracy, Female, Follow Up, Histopathology, Human, Metastasis, Myelolipoma, Nuclear Magnetic Resonance Imaging, Pheochromocytoma, Priority Journal, Qualitative Analysis, Quantitative Analysis, Scintigraphy, Tumor Volume,
Affiliations:
*** IBB - CNR ***
Radiologia e Medicina Nucleare, Dipartimento di Scienze Biomorfologiche e Funzionali (DSBMF), Napoli, Italy
Università degli Studi di Napoli Federico II (UNINA), Napoli, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale delle Ricerche (CNR), Napoli, Italy
Fondazione SDN (IRCCS), Napoli, Italy
Universit degli Studi di Napoli Federico II (UNINA), Napoli, Italy
References:
Not available.
Characterization of hypersecreting or non-hypersecreting adrenal adenomas: Comparison between iodine-131 nor-cholesterol scintigraphy and magnetic resonance imaging
The aim of this study was to compare the results of nor-cholesterol scintigraphy and those of magnetic resonance imaging (MRI) in characterizing adrenal adenomas and differentiating between hypersecreting and non-hypersecreting lesions. We studied 41 patients (18 M and 23 F, mean age 47±15 years) with hypersecreting (n=19) or non-hypersecreting (n=22) unilateral adrenal tumors; all patients underwent iodine-131 nor-cholesterol adrenal scintigraphy and MRI studies. Pathology examinations (n=26) or follow-up data (n=15) were obtained showing 34 adenomas, 2 cysts, 1 myelolipoma, 1 pheochromocytoma, 1 carcinoma and 2 metastases. Imaging studies were qualitatively evaluated and the corresponding results were classified as true-positive, true-negative, false-positive and false-negative calculating diagnostic accuracy of each test. Imaging studies were also quantitatively assessed comparing nor-cholesterol uptake and MRI signal intensity ratios (SIRs) in hypersecreting and non-hypersecreting adenomas. The diagnostic accuracies of norcholesterol scintigraphy (95%) and MRI (93%) to identify adrenal adenomas were comparable; however, while a significantly (p=0.01) higher nor-cholesterol uptake was observed in hypersecreting (n=19) adenomas compared to non-hypersecreting (n=15) lesions, no significant differences in MRI SIRs were found in this comparative analysis; furthermore, no significant difference in tumor size occurred between hypersecreting and non-hypersecreting adenomas. In conclusion, adrenal scintigraphy using nor-cholesterol and MRI are both able to accurately identify cortical adenomas; in particular, while quantitative analysis of nor-cholesterol uptake is effective to differentiate between hypersecreting and non-hypersecreting adenomas, MRI SIRs evaluation is not useful for this purpose. These findings have relevant clinical implications particularly in patients with non-hypersecreting adenomas; in such patients, laboratory data are not helpful for lesion diagnosis, while imaging findings allow tumor characterization; in particular, the lower nor-cholesterol uptake observed in non-hypersecreting adenomas might reflect the normal hormone synthesis status of these lesions and, thus, regular secretion. © 2009 Bentham Science Publishers Ltd.
The aim of this study was to compare the results of nor-cholesterol scintigraphy and those of magnetic resonance imaging (MRI) in characterizing adrenal adenomas and differentiating between hypersecreting and non-hypersecreting lesions. We studied 41 patients (18 M and 23 F, mean age 47±15 years) with hypersecreting (n=19) or non-hypersecreting (n=22) unilateral adrenal tumors; all patients underwent iodine-131 nor-cholesterol adrenal scintigraphy and MRI studies. Pathology examinations (n=26) or follow-up data (n=15) were obtained showing 34 adenomas, 2 cysts, 1 myelolipoma, 1 pheochromocytoma, 1 carcinoma and 2 metastases. Imaging studies were qualitatively evaluated and the corresponding results were classified as true-positive, true-negative, false-positive and false-negative calculating diagnostic accuracy of each test. Imaging studies were also quantitatively assessed comparing nor-cholesterol uptake and MRI signal intensity ratios (SIRs) in hypersecreting and non-hypersecreting adenomas. The diagnostic accuracies of norcholesterol scintigraphy (95%) and MRI (93%) to identify adrenal adenomas were comparable; however, while a significantly (p=0.01) higher nor-cholesterol uptake was observed in hypersecreting (n=19) adenomas compared to non-hypersecreting (n=15) lesions, no significant differences in MRI SIRs were found in this comparative analysis; furthermore, no significant difference in tumor size occurred between hypersecreting and non-hypersecreting adenomas. In conclusion, adrenal scintigraphy using nor-cholesterol and MRI are both able to accurately identify cortical adenomas; in particular, while quantitative analysis of nor-cholesterol uptake is effective to differentiate between hypersecreting and non-hypersecreting adenomas, MRI SIRs evaluation is not useful for this purpose. These findings have relevant clinical implications particularly in patients with non-hypersecreting adenomas; in such patients, laboratory data are not helpful for lesion diagnosis, while imaging findings allow tumor characterization; in particular, the lower nor-cholesterol uptake observed in non-hypersecreting adenomas might reflect the normal hormone synthesis status of these lesions and, thus, regular secretion. © 2009 Bentham Science Publishers Ltd.
Characterization of hypersecreting or non-hypersecreting adrenal adenomas: Comparison between iodine-131 nor-cholesterol scintigraphy and magnetic resonance imaging
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Characterization of hypersecreting or non-hypersecreting adrenal adenomas: Comparison between iodine-131 nor-cholesterol scintigraphy and magnetic resonance imaging
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10 Records (9 excluding Abstracts).
Total impact factor: 18.497 (18.497 excluding Abstracts).
Total 5 year impact factor: 15.876 (15.876 excluding Abstracts).
Total impact factor: 18.497 (18.497 excluding Abstracts).
Total 5 year impact factor: 15.876 (15.876 excluding Abstracts).
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