Characterization of hypersecreting or non-hypersecreting adrenal adenomas: Comparison between iodine-131 nor-cholesterol scintigraphy and magnetic resonance imaging (490 views) (PDF public 288 views)
Curr Radiopharm (ISSN: 1874-4710, 1874-4729), 2009; 2(1): 56-62.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0.643, 5-year impact factor: 0.874
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77953733368&partnerID=40&md5=1aa46bef8d69eb9cc8de3adbc9d53932
Keywords: Adenomas, Adrenals, Imaging Characterization, Nor-Cholesterol, Iodocholesterol I 131, Acth Secreting Adenoma, Adrenal Cortex Adenoma, Adrenal Cortex Carcinoma, Adrenal Cyst, Adult, Article, Clinical Article, Controlled Study, Diagnostic Accuracy, Female, Follow Up, Histopathology, Human, Metastasis, Myelolipoma, Nuclear Magnetic Resonance Imaging, Pheochromocytoma, Priority Journal, Qualitative Analysis, Quantitative Analysis, Scintigraphy, Tumor Volume,
Affiliations:
*** IBB - CNR ***
Radiologia e Medicina Nucleare, Dipartimento di Scienze Biomorfologiche e Funzionali (DSBMF), Napoli, Italy
Università degli Studi di Napoli Federico II (UNINA), Napoli, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale delle Ricerche (CNR), Napoli, Italy
Fondazione SDN (IRCCS), Napoli, Italy
Universit degli Studi di Napoli Federico II (UNINA), Napoli, Italy
References:
Not available.
Curr Radiopharm (ISSN: 1874-4710, 1874-4729), 2009; 2(1): 56-62.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0.643, 5-year impact factor: 0.874
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77953733368&partnerID=40&md5=1aa46bef8d69eb9cc8de3adbc9d53932
Keywords: Adenomas, Adrenals, Imaging Characterization, Nor-Cholesterol, Iodocholesterol I 131, Acth Secreting Adenoma, Adrenal Cortex Adenoma, Adrenal Cortex Carcinoma, Adrenal Cyst, Adult, Article, Clinical Article, Controlled Study, Diagnostic Accuracy, Female, Follow Up, Histopathology, Human, Metastasis, Myelolipoma, Nuclear Magnetic Resonance Imaging, Pheochromocytoma, Priority Journal, Qualitative Analysis, Quantitative Analysis, Scintigraphy, Tumor Volume,
Affiliations:
*** IBB - CNR ***
Radiologia e Medicina Nucleare, Dipartimento di Scienze Biomorfologiche e Funzionali (DSBMF), Napoli, Italy
Università degli Studi di Napoli Federico II (UNINA), Napoli, Italy
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale delle Ricerche (CNR), Napoli, Italy
Fondazione SDN (IRCCS), Napoli, Italy
Universit degli Studi di Napoli Federico II (UNINA), Napoli, Italy
References:
Not available.
Characterization of hypersecreting or non-hypersecreting adrenal adenomas: Comparison between iodine-131 nor-cholesterol scintigraphy and magnetic resonance imaging
The aim of this study was to compare the results of nor-cholesterol scintigraphy and those of magnetic resonance imaging (MRI) in characterizing adrenal adenomas and differentiating between hypersecreting and non-hypersecreting lesions. We studied 41 patients (18 M and 23 F, mean age 47±15 years) with hypersecreting (n=19) or non-hypersecreting (n=22) unilateral adrenal tumors; all patients underwent iodine-131 nor-cholesterol adrenal scintigraphy and MRI studies. Pathology examinations (n=26) or follow-up data (n=15) were obtained showing 34 adenomas, 2 cysts, 1 myelolipoma, 1 pheochromocytoma, 1 carcinoma and 2 metastases. Imaging studies were qualitatively evaluated and the corresponding results were classified as true-positive, true-negative, false-positive and false-negative calculating diagnostic accuracy of each test. Imaging studies were also quantitatively assessed comparing nor-cholesterol uptake and MRI signal intensity ratios (SIRs) in hypersecreting and non-hypersecreting adenomas. The diagnostic accuracies of norcholesterol scintigraphy (95%) and MRI (93%) to identify adrenal adenomas were comparable; however, while a significantly (p=0.01) higher nor-cholesterol uptake was observed in hypersecreting (n=19) adenomas compared to non-hypersecreting (n=15) lesions, no significant differences in MRI SIRs were found in this comparative analysis; furthermore, no significant difference in tumor size occurred between hypersecreting and non-hypersecreting adenomas. In conclusion, adrenal scintigraphy using nor-cholesterol and MRI are both able to accurately identify cortical adenomas; in particular, while quantitative analysis of nor-cholesterol uptake is effective to differentiate between hypersecreting and non-hypersecreting adenomas, MRI SIRs evaluation is not useful for this purpose. These findings have relevant clinical implications particularly in patients with non-hypersecreting adenomas; in such patients, laboratory data are not helpful for lesion diagnosis, while imaging findings allow tumor characterization; in particular, the lower nor-cholesterol uptake observed in non-hypersecreting adenomas might reflect the normal hormone synthesis status of these lesions and, thus, regular secretion. © 2009 Bentham Science Publishers Ltd.
The aim of this study was to compare the results of nor-cholesterol scintigraphy and those of magnetic resonance imaging (MRI) in characterizing adrenal adenomas and differentiating between hypersecreting and non-hypersecreting lesions. We studied 41 patients (18 M and 23 F, mean age 47±15 years) with hypersecreting (n=19) or non-hypersecreting (n=22) unilateral adrenal tumors; all patients underwent iodine-131 nor-cholesterol adrenal scintigraphy and MRI studies. Pathology examinations (n=26) or follow-up data (n=15) were obtained showing 34 adenomas, 2 cysts, 1 myelolipoma, 1 pheochromocytoma, 1 carcinoma and 2 metastases. Imaging studies were qualitatively evaluated and the corresponding results were classified as true-positive, true-negative, false-positive and false-negative calculating diagnostic accuracy of each test. Imaging studies were also quantitatively assessed comparing nor-cholesterol uptake and MRI signal intensity ratios (SIRs) in hypersecreting and non-hypersecreting adenomas. The diagnostic accuracies of norcholesterol scintigraphy (95%) and MRI (93%) to identify adrenal adenomas were comparable; however, while a significantly (p=0.01) higher nor-cholesterol uptake was observed in hypersecreting (n=19) adenomas compared to non-hypersecreting (n=15) lesions, no significant differences in MRI SIRs were found in this comparative analysis; furthermore, no significant difference in tumor size occurred between hypersecreting and non-hypersecreting adenomas. In conclusion, adrenal scintigraphy using nor-cholesterol and MRI are both able to accurately identify cortical adenomas; in particular, while quantitative analysis of nor-cholesterol uptake is effective to differentiate between hypersecreting and non-hypersecreting adenomas, MRI SIRs evaluation is not useful for this purpose. These findings have relevant clinical implications particularly in patients with non-hypersecreting adenomas; in such patients, laboratory data are not helpful for lesion diagnosis, while imaging findings allow tumor characterization; in particular, the lower nor-cholesterol uptake observed in non-hypersecreting adenomas might reflect the normal hormone synthesis status of these lesions and, thus, regular secretion. © 2009 Bentham Science Publishers Ltd.
Characterization of hypersecreting or non-hypersecreting adrenal adenomas: Comparison between iodine-131 nor-cholesterol scintigraphy and magnetic resonance imaging
No results. |
Characterization of hypersecreting or non-hypersecreting adrenal adenomas: Comparison between iodine-131 nor-cholesterol scintigraphy and magnetic resonance imaging
Other filter: ([btitle,keywords] "Imaging Characteriza ...
Dell'Aversana S, Coppola M, Balestrieri U, Mainenti PP, Pascale C, Imbriaco M, Chianca V, Romeo V, Pellegrino T, Mainolfi C, Maurea S
* Integrated Imaging Characterization of Adrenal Adenoma: False-Positive Metaiodobenzylguanidine (MIBG) Findings of Adrenal Scintigraphy (230 views)
Pol J Radiol (ISSN: 1733-134xlinking), 2017 Aug 4; 82: 422-425.
Impact Factor: 0.567
View Export to BibTeX Export to EndNote
Maurea S, Mainenti PP, Romeo V, Mollica C, Salvatore M
* Nuclear imaging to characterize adrenal tumors: Comparison with MRI (327 views)
World J Radiol (ISSN: 1949-8470, 1949-8470electronic, 1949-8470linking), 2014 Jul 28; 6(7): 493-501.
Impact Factor: 0.567
View Export to BibTeX Export to EndNote
Maurea S, Cuocolo A, Imbriaco M, Pellegrino T, Fusari M, Cuocolo R, Liuzzi R, Salvatore M
* Imaging characterization of benign and malignant pheochromocytoma or paraganglioma: comparison between MIBG uptake and MR signal intensity ratio (504 views)
Ann Nucl Med (ISSN: 1864-6433, 0914-7187, 1864-6433electronic), 2012 Oct; 26(8): 670-675.
Impact Factor: 1.41
View Export to BibTeX Export to EndNote
Maurea S, Imbriaco M, Mollica C, Pace L, Salvatore M
* Quantitative Imaging Characterization Of Hypersecreting Or Non-Hypersecreting Adrenal Adenomas: Comparison Between Iodine-131 Nor-Cholesterol Uptake And Magnetic Resonance Signal Intensity Ratios (413 views)
Nuclear Medicine Communications (ISSN: 1473-5628, 0143-3636), 2011 Jun; 32(6): 535-541.
Impact Factor: 1.404
View Export to BibTeX Export to EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (471 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
View Export to BibTeX Export to EndNote
Maurea S, Imbriaco M, D'Angelillo M, Mollica C, Camera L, Salvatore M
* Diagnostic accuracy of chemical-shift MR imaging to differentiate between adrenal adenomas and non adenoma adrenal lesions (1403 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2006 Sep; 111(5): 674-686.
Impact Factor: 1.368
View Export to BibTeX Export to EndNote
Tauchmanovà L, Pivonello R, Di Somma C, Rossi R, De Martino MC, Camera L, Klain M, Salvatore M, Lombardi G, Colao A
* Bone demineralization and vertebral fractures in endogenous cortisol excess: Role of disease etiology and gonadal status (795 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2006 May; 91(5): 1779-1784.
Impact Factor: 5.799
View Export to BibTeX Export to EndNote
Maurea S, Salvatore M
* I-131 Nor-Cholesterol Nuclear imaging in Patients with Hypersecreting or Non-Hypersecreting Adrenal Adenomas (493 views)
Trends In Cholesterol Research, 2005; N/D: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Maurea S, Caracò C, Klain M, Mainolfi C, Salvatore M
* Imaging characterization of non-hypersecreting adrenal masses. Comparison between MR and radionuclide techniques (546 views) (PDF 288 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2004; 48(3): 188-197.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Maurea S, Klain M, Mainolfi C, Ziviello M, Salvatore M
* The diagnostic role of radionuclide imaging in evaluation of patients with nonhypersecreting adrenal masses (402 views) (PDF 288 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2001 Jun; 42(6): 884-892.
Impact Factor: 4.51
View Export to BibTeX Export to EndNote
* Integrated Imaging Characterization of Adrenal Adenoma: False-Positive Metaiodobenzylguanidine (MIBG) Findings of Adrenal Scintigraphy (230 views)
Pol J Radiol (ISSN: 1733-134xlinking), 2017 Aug 4; 82: 422-425.
Impact Factor: 0.567
View Export to BibTeX Export to EndNote
Maurea S, Mainenti PP, Romeo V, Mollica C, Salvatore M
* Nuclear imaging to characterize adrenal tumors: Comparison with MRI (327 views)
World J Radiol (ISSN: 1949-8470, 1949-8470electronic, 1949-8470linking), 2014 Jul 28; 6(7): 493-501.
Impact Factor: 0.567
View Export to BibTeX Export to EndNote
Maurea S, Cuocolo A, Imbriaco M, Pellegrino T, Fusari M, Cuocolo R, Liuzzi R, Salvatore M
* Imaging characterization of benign and malignant pheochromocytoma or paraganglioma: comparison between MIBG uptake and MR signal intensity ratio (504 views)
Ann Nucl Med (ISSN: 1864-6433, 0914-7187, 1864-6433electronic), 2012 Oct; 26(8): 670-675.
Impact Factor: 1.41
View Export to BibTeX Export to EndNote
Maurea S, Imbriaco M, Mollica C, Pace L, Salvatore M
* Quantitative Imaging Characterization Of Hypersecreting Or Non-Hypersecreting Adrenal Adenomas: Comparison Between Iodine-131 Nor-Cholesterol Uptake And Magnetic Resonance Signal Intensity Ratios (413 views)
Nuclear Medicine Communications (ISSN: 1473-5628, 0143-3636), 2011 Jun; 32(6): 535-541.
Impact Factor: 1.404
View Export to BibTeX Export to EndNote
Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (471 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
View Export to BibTeX Export to EndNote
Maurea S, Imbriaco M, D'Angelillo M, Mollica C, Camera L, Salvatore M
* Diagnostic accuracy of chemical-shift MR imaging to differentiate between adrenal adenomas and non adenoma adrenal lesions (1403 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2006 Sep; 111(5): 674-686.
Impact Factor: 1.368
View Export to BibTeX Export to EndNote
Tauchmanovà L, Pivonello R, Di Somma C, Rossi R, De Martino MC, Camera L, Klain M, Salvatore M, Lombardi G, Colao A
* Bone demineralization and vertebral fractures in endogenous cortisol excess: Role of disease etiology and gonadal status (795 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2006 May; 91(5): 1779-1784.
Impact Factor: 5.799
View Export to BibTeX Export to EndNote
Maurea S, Salvatore M
* I-131 Nor-Cholesterol Nuclear imaging in Patients with Hypersecreting or Non-Hypersecreting Adrenal Adenomas (493 views)
Trends In Cholesterol Research, 2005; N/D: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Maurea S, Caracò C, Klain M, Mainolfi C, Salvatore M
* Imaging characterization of non-hypersecreting adrenal masses. Comparison between MR and radionuclide techniques (546 views) (PDF 288 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2004; 48(3): 188-197.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Maurea S, Klain M, Mainolfi C, Ziviello M, Salvatore M
* The diagnostic role of radionuclide imaging in evaluation of patients with nonhypersecreting adrenal masses (402 views) (PDF 288 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2001 Jun; 42(6): 884-892.
Impact Factor: 4.51
View Export to BibTeX Export to EndNote
10 Records (9 excluding Abstracts).
Total impact factor: 18.497 (18.497 excluding Abstracts).
Total 5 year impact factor: 15.876 (15.876 excluding Abstracts).
Total impact factor: 18.497 (18.497 excluding Abstracts).
Total 5 year impact factor: 15.876 (15.876 excluding Abstracts).
490 views. Last view on Sunday 08 December 2024, 0:57:11
ibb.cnr.it
