Technetium-99m MIBI SPECT to identify viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction(300 views) Maurea S, Cuocolo A, Soricelli A, Castelli L, Nappi A, Trimarco B, Salvatore M
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1996; 92(3): 289-296.
Affiliations: Cattedra di Medicina Nucleare, Centro per la Medicina Nucleare, CNR, Italy
I Clinica Medica, Univ. degli Studi Federico II, Istituto Nazionale dei Tumori, Napoli, Italy
Via Raffaele De Cesare, 7, 80132 Napoli NA, Italy
References: Altehoefer, C., Kaiser, H.J., Dorr, R., Fluorine-18 deoxyglucose PET for assessment of viable myocardium in perfusion defects in 99mTc-MIBI SPECT. a comparative study in patients with coronary artery disease (1992) Eur J Nucl Med, 19, pp. 334-34
Altehoefer, C., Von Dahl, J., Biedermann, M., Significance of defect severity in technetium-99m-MIBI SPECT at rest to assess myocardial viability: Comparison with fluorine-18-FDG PET (1994) J Nucl Med, 35, pp. 569-574
Beaulans, R., Dawood, F., Wan, W.H., Are the kinetics of technetium-99m methoxy isobutyl isonitrile affected by cell metabolism and viability? (1990) Circulation, 82, pp. 1802-1814
Bisi, G., Sciagrà, R., Santoro, G.M., Rest technetium-99m sestamibi tomography in combination with short-term administration of nitrates feasibility and reliability for prediction of postrevascularization outcome of asynergic territories (1994) J Am Coll Cardiol, 24, pp. 1282-1289
Braunwald, E., Rutherford, J.D., Reversible ischemic left ventricular dysfunction evidence foi "hibernating" myocaidium (1986) J Am Coll Cardiol, 8, pp. 1467-1470
Cuocolo, A., Pace, L., Ricciardelli, B., Identification of viable myocardium in patients with chronic coronary artery disease: Comparison of thallium-201 scintigraphy with reinjection and technetium-99m-methoxy isobutyl isonitrile (1992) J Nucl Med, 33, pp. 505-511
Cuocolo, A., Maurea, S., Pace, L., Resting technetium-99m methoxy isobutyl isonitrile cardiac imaging in chronic coronary artery disease, comparison with rest-redistribution thallium-201 scintigraphy (1993) Eur J Nucl Med, 20, pp. 1186-1192
Dilsizian, V., Bonow, R.O., Current diagnostic techniques of assessing myocardial viability in patients with hibernating and stunned myocardium (1993) Circulation, 87, pp. 1-20
Dilsizian, V., Arrighi, J.A., Diodati, J.G., Myocardial viability in patients with chronic coronary artery disease. Companson of 99mTc-Sestamibi with thallium reinjection and [18F]fluorodeoxyglucose (1994) Circulation, 89, pp. 578-587
Dilsizian, V., Perrone-Filardi, P., Arrighi, J.A., Concordance and discordance between stress-redistribution-reinjection and rest-redistribution thallium imaging for assessing viable myocardium. Comparison with metabolic activity by positron emission tomoaraphy (1993) Circulation, 88, pp. 941-952
Dondi, M., Tartagni, F., Fallani, F., A comparison of rest sestamibi and rest-redistribution thallium single photon emission tomography: Possible implications for myocardial viability detection in infarcted patients (1993) Eur J Nucl Med, 20, pp. 26-31
Fuijita, M., Ohno, A., Wada, O., Collateral circulation as a marker of the presence of viable myocardium in patient with recent myocardial infarction (1991) Am Heart J, 122, pp. 409-414
Galli, M., Marcassa, C., Imparato, A., Effects of nitroglycerin by technetium-99m sestamibi tomoscintigraphy on resting regional myocardial hypoperfusion in stable patients with healed myocardial infarction (1994) Am J Cardiol, 74, pp. 843-848
Gropler, R.J., Imaging to distinguish between viable and nonviable myocardium: Pathophysiologic basis and importance of positron emission tomography (1993) Am J Roentenol, 161, pp. 497-506
Henry, W.L., De Maria, A., Feigenbaum, H., (1982) Report of the American Society of Echocardiography Committee on Nomenclature and Standards: Identification of Myocardial Wall Segments, , Atti: American Society Echocardiography, Durham, North Carolina
Jones, R.H., Borges-Neto, S., Potts, J.M., Simultaneous measurement of myocardial perfusion and ventricular function during exercise from a single injection of technetium-99m sestamibi in coronary artery disease (1990) Am J Cardiol, 66, pp. 68E-71E
Liu, P.P., Technetium-99m-sestamibi. Another window on myocardial viability? (1991) J Nucl Med, 32, pp. 298-299
Mahac, J., Technetium-99m isonitrile: A perfusion or a viability agent? (1989) J Am Coll Cardiol, 14, pp. 1685-1688
Marshall, R.C., Tillish, J.H., Phelps, M.E., Identification and differentiation of resting myocardial ischemia and infarction in man with positron computed tomography, 18-F-labeled fluorodeoxyglucose and N-13 ammonia (1983) Circulation, 67, pp. 766-778
Marzullo, P., Sambuceti, G., Parodi, O., The role of sestamibi scintigraphy in the radioisotopie assessment of myocardial viability (1992) J Nucl Med, 33, pp. 1925-1930
Marzullo, P., Parodi, O., Reisenhofer, B., Value of rest thallium-201/technetium-99m sestamibi scans and dobutamine echocardiography for detecting myocardial viability (1993) Am J Cardiol, 71, pp. 166-172
Maurea, S., Cuocolo, A., Pace, L., Rest-injected thallium-201 redistribution and resting technetium-99m methoxy isobutyl isonitrile uptake in coronary artery disease: Relation to the seventy of coronary artery stenosis (1993) Eur J Nucl Med, 20, pp. 502-510
Okada, R.D., Glover, D., Gaffney, T., Myocardial kinetics of technetium-99m-hesakis-2-methoxy-2-methyl-propyl-isonitrile (1988) Circulation, 77, pp. 491-498
Pozzoli, M.M.A., Fioretti, P.M., Salustri, A., Exercise echocardiography and technetium-99m MIBI single photon emission Computed Tomography in the detection of coronary artery disease (1991) Am J Cardiol, 67, pp. 350-355
Rahimtoola, S.H., The hibernating myocardium (1989) Am Heart J, 117, pp. 211-213
Rocco, T.P., Dilsizian, V., Strauss, H.W., Technetium-99m isonitrile myocardial uptake at rest. II. Relation to clinical markers of potential viability (1989) J Am Coll Cardiol, 14, pp. 1678-1684
Sawada, S.G., Allman, K.C., Muzik, O., Positron emission tomography detects evidence of viability in rest technetium-99m sestamibi defects (1994) J Am Coll Cardiol, 23, pp. 92-98
Schelbert, H.R., Phelps, M.E., Hoffman, E., Regional myocardial blood flow, metabolism, and function assessed noninvasively with positron emission tomography (1980) Am J Cardiol, 80, pp. 1269-1277
Shiller, N.B., Shah, P.M., Crawford, M., American Society of Echocardiography Committe on Standards. Subcommittee on Quantitation of Two-dimensional Echocardiograms: Recommendations for quantitation of the left ventricle by two-dimensional echocardiography (1989) J Am Soc Echo, 2, pp. 358-367
Sinusas, A.J., Bergin, J.D., Edwards, N.C., Redistribution of 99mTc sestamibi and 201Tl in the presence of a severe coronary artery stenosis (1994) Circulation, 89, pp. 2332-2341
Udelson, J.E., Coleman, P.S., Metherall, J., Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201Tl and 99mTc sestamibi (1994) Circulation, 89, pp. 2552-2561
Bisi, G., Sciagr, R., Santoro, G. M., Rest technetium-99m sestamibi tomography in combination with short-term administration of nitrates feasibility and reliability for prediction of postrevascularization outcome of asynergic territories (1994) J Am Coll Cardiol, 24, pp. 1282-1289
Gropler, R. J., Imaging to distinguish between viable and nonviable myocardium: Pathophysiologic basis and importance of positron emission tomography (1993) Am J Roentenol, 161, pp. 497-506
Henry, W. L., De Maria, A., Feigenbaum, H., (1982) Report of the American Society of Echocardiography Committee on Nomenclature and Standards: Identification of Myocardial Wall Segments, , Atti: American Society Echocardiography, Durham, North Carolina
Jones, R. H., Borges-Neto, S., Potts, J. M., Simultaneous measurement of myocardial perfusion and ventricular function during exercise from a single injection of technetium-99m sestamibi in coronary artery disease (1990) Am J Cardiol, 66, pp. 68E-71E
Liu, P. P., Technetium-99m-sestamibi. Another window on myocardial viability? (1991) J Nucl Med, 32, pp. 298-299
Marshall, R. C., Tillish, J. H., Phelps, M. E., Identification and differentiation of resting myocardial ischemia and infarction in man with positron computed tomography, 18-F-labeled fluorodeoxyglucose and N-13 ammonia (1983) Circulation, 67, pp. 766-778
Okada, R. D., Glover, D., Gaffney, T., Myocardial kinetics of technetium-99m-hesakis-2-methoxy-2-methyl-propyl-isonitrile (1988) Circulation, 77, pp. 491-498
Pozzoli, M. M. A., Fioretti, P. M., Salustri, A., Exercise echocardiography and technetium-99m MIBI single photon emission Computed Tomography in the detection of coronary artery disease (1991) Am J Cardiol, 67, pp. 350-355
Rahimtoola, S. H., The hibernating myocardium (1989) Am Heart J, 117, pp. 211-213
Rocco, T. P., Dilsizian, V., Strauss, H. W., Technetium-99m isonitrile myocardial uptake at rest. II. Relation to clinical markers of potential viability (1989) J Am Coll Cardiol, 14, pp. 1678-1684
Sawada, S. G., Allman, K. C., Muzik, O., Positron emission tomography detects evidence of viability in rest technetium-99m sestamibi defects (1994) J Am Coll Cardiol, 23, pp. 92-98
Schelbert, H. R., Phelps, M. E., Hoffman, E., Regional myocardial blood flow, metabolism, and function assessed noninvasively with positron emission tomography (1980) Am J Cardiol, 80, pp. 1269-1277
Shiller, N. B., Shah, P. M., Crawford, M., American Society of Echocardiography Committe on Standards. Subcommittee on Quantitation of Two-dimensional Echocardiograms: Recommendations for quantitation of the left ventricle by two-dimensional echocardiography (1989) J Am Soc Echo, 2, pp. 358-367
Sinusas, A. J., Bergin, J. D., Edwards, N. C., Redistribution of 99mTc sestamibi and 201Tl in the presence of a severe coronary artery stenosis (1994) Circulation, 89, pp. 2332-2341
Udelson, J. E., Coleman, P. S., Metherall, J., Predicting recovery of severe regional ventricular dysfunction. Comparison of resting scintigraphy with 201Tl and 99mTc sestamibi (1994) Circulation, 89, pp. 2552-2561
Technetium-99m MIBI SPECT to identify viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction
Resting 99mTc-MIBI cardiac imaging may be poorly accurate in identifying the presence of viable myocardium in patients with chronic coronary artery disease (CAD). In this study, we directly compared the results of resting 99mTc-MIBI SPECT with initial (1 hr) and delayed (5 hrs) images with those of 99mTc-MIBI SPECT after nitroglycerine (NTG) administration in 31 patients with chronic CAD. All patients also underwent rest-redistribution thallium-201 ( 201Tl) SPECT. In 8 patients, echocardiography was performed before and after coronary revascularization (Rev). Of 682 myocardial segments, 197 showed a marked reduction (<50% of peak) in MIBI uptake on initial images. MIBI uptake (≤10%) was increased in 47 (24%) segments on delayed images (from 43 ± 8% to 60 ± 8%, p < 0.001) and in 54 (27%) segments after NTG (from 42 ± 8% to 60 ± 8%, p < 0.001). The results of delayed and NTG MIBI images were in agreement in most segments (n = 160, 81%). The results of delayed and NTG MIBI images were in disagreement in the remaining 37 (19%) segments. In particular, 15 segments showed reversible defects on delayed, but not on NTG MIBI images, while 22 on NTG, but not on delayed MIBI images. All the segments with reversible MIBI defects on delayed and/or NTG images were identified as viable on Tl-201. In the 8 pts examined before and after Rev, 83% of segments with reversible MIBI defects on delayed images and 87% of those with reversible defects after NTG showed functional recovery after Rev; furthermore, in these patients a significant improvement in global left ventricular function was observed after Rev, as shown by ejection fraction values (from 42 ± 7% to 47 ± 7%, p < 0.01). These comparative results show that resting delayed and NTG MIBI imaging provide similar information to identify viable myocardium and to predict functional recovery after coronary Rev in chronic CAD.
Technetium-99m MIBI SPECT to identify viable myocardium in patients with chronic coronary artery disease and left ventricular dysfunction
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(731 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote