The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime?(541 views) Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
Front Endocrinol (ISSN: 1664-2392, 1664-2392linking, 1664-2392print), 2014; 5(DEC): 216-216.
Keywords: Amyloid, Calcium, Free Fatty Acids, Genetic Predisposition, Membranes, Obesity, Type Ii Diabetes Mellitus, Calpain 10, Cholesterol, Glucokinase Regulatory Protein, Insulin Receptor, Peptides And Proteins, Somatomedin C, Transcription Factor 7, Unclassified Drug, Article, Biological Phenomena And Functions Concerning The Entire Organism, Calcium Homeostasis, Cell Death, Channel Gating, Cytotoxicity, Dyshomeostasis, Familial Hypercalciuric Hypercalcemia, Gene Mutation, Human, Insulin Resistance, Lipid Membrane, Membrane Damage, Non Insulin Dependent Diabetes Mellitus, Nonhuman, Protein Aggregation, Risk Factor, Weight Gain,
Affiliations: *** IBB - CNR ***
Istituto CNR di Biostrutture e Bioimmagini-Sezione di CataniaCatania, Italy
Dipartimento di Scienze Chimiche Viale Andrea Doria 6, Università Degli Studi di CataniaCatania, Italy
References: Chen, L., Magliano, D.J., Zimmet, P.Z., The worldwide epidemiology of type 2 diabetes mellitus -present and future perspectives (2012) Nat Rev Endocrinol, 8, pp. 228-23
Shaw, J.E., Sicree, R.A., Zimmet, P.Z., Global estimates of the prevalence of diabetes for 2010 and 2030 (2010) Diabetes Res Clin Pract, 87, pp. 4-14
Wimalawansa, S.J., Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily (1997) Crit Rev Neurobiol, 11, pp. 167-239
Höppener, J.W.M., Ahrén, B., Lips, C.J.M., Islet amyloid and type 2 diabetes mellitus (2000) N Engl J Med, 343, pp. 411-419
Hull, R.L., Westermark, G.T., Westermark, P., Kahn, S.E., Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes (2004) J Clin Endocrinol Metab, 89, pp. 3629-3643
Aitken, J.F., Loomes, K.M., Scott, D.W., Reddy, S., Phillips, A.R.J., Prijic, G., Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice (2010) Diabetes, 59, pp. 161-171
Knight, J.D., Hebda, J.A., Miranker, A.D., Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide (2006) Biochemistry (Mosc), 45, pp. 9496-9508
Zhang, Y., Luo, Y., Deng, Y., Mu, Y., Wei, G., Lipid interaction and membrane perturbation of human islet amyloid polypeptide monomer and dimer by molecular dynamics simulations (2012) PLoS One, 7
Anguiano, M., Nowak, R.J., Lansbury, P.T., Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes (2002) Biochemistry (Mosc), 41, pp. 11338-11343
Sciacca, M.F.M., Milardi, D., Messina, G.M.L., Marletta, G., Brender, J.R., Ramamoorthy, A., Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP (2013) Biophys J, 104, pp. 173-184
Zhao, J., Hu, R., Sciacca, M.F.M., Brender, J.R., Chen, H., Ramamoorthy, A., Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels (2014) Phys Chem Chem Phys, 16, pp. 2368-2377
Scalisi, S., Sciacca, M.F.M., Zhavnerko, G., Grasso, D.M., Marletta, G., La Rosa, C., Self-assembling pathway of HiApp fibrils within lipid bilayers (2010) Chembiochemistry, 11, pp. 1856-1859
Milardi, D., Sciacca, M.F.M., Pappalardo, M., Grasso, D.M., Rosa, C.L., The role of aromatic side-chains in amyloid growth and membrane interaction of the islet amyloid polypeptide fragment LANFLVH (2011) Eur Biophys J, 40, pp. 1-12
Pannuzzo, M., Milardi, D., Raudino, A., Karttunen, M., La Rosa, C., Analytical model and multiscale simulations of Aß peptide aggregation in lipid membranes: towards a unifying description of conformational transitions, oligomerization and membrane damage (2013) Phys Chem Chem Phys PCCP, 15, pp. 8940-8951
Sciacca, M.F.M., Kotler, S.A., Brender, J.R., Chen, J., Lee, D., Ramamoorthy, A., Two-step mechanism of membrane disruption by Aß through membrane fragmentation and pore formation (2012) Biophys J, 103, pp. 702-710
Sakagashira, S., Sanke, T., Hanabusa, T., Shimomura, H., Ohagi, S., Kumagaye, K.Y., Missense mutation of amylin gene (S20G) in Japanese NIDDM patients (1996) Diabetes, 45, pp. 1279-1281
Hiddinga, H.J., Sakagashira, S., Ishigame, M., Madde, P., Sanke, T., Nanjo, K., Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance (2012) J Diabetes Investig, 3, pp. 138-147
Ahlqvist, E., Ahluwalia, T.S., Groop, L., Genetics of type 2 diabetes (2011) Clin Chem, 57, pp. 241-254
Choi, J.M., Seo, M-H., Kyeong, H-H., Kim, E., Kim, H-S., Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase (2013) Proc Natl Acad Sci U S A, 110, pp. 10171-10176
Beardsall, K., Vanhaesebrouck, S., Frystyk, J., Ogilvy-Stuart, A.L., Vanhole, C., van Weissenbruch, M., Relationship between insulin-like growth factor I levels, early insulin treatment, and clinical outcomes of very low birth weight infants (2014) J Pediatr, 164, p. 1038. , e-44.e
Horikawa, Y., Oda, N., Cox, N.J., Li, X., Orho-Melander, M., Hara, M., Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus (2000) Nat Genet, 26, pp. 163-175
Chattopadhyay, N., Brown, E.M., (2003) Calcium-Sensing Receptor, , Springer Science & Business Media
Resnick, L.M., Cellular calcium and magnesium metabolism in the pathophysiology and treatment of hypertension and related metabolic disorders (1992) Am J Med, 93, pp. 11S-20S
Barbagallo, M., Gupta, R.K., Resnick, L.M., Cellular ions in NIDDM: relation of calcium to hyperglycemia and cardiac mass (1996) Diabetes Care, 19, pp. 1393-1398
Squier, T.C., Bigelow, D.J., Protein oxidation and age-dependent alterations in calcium homeostasis (2000) Front Biosci J Virtual Libr, 5, pp. D504-D526
Nitahara, J.A., Cheng, W., Liu, Y., Li, B., Leri, A., Li, P., Intracellular calcium, DNase activity and myocyte apoptosis in aging Fischer 344 rats (1998) J Mol Cell Cardiol, 30, pp. 519-535
Astrup, A., The role of calcium in energy balance and obesity: the search for mechanisms (2008) Am J Clin Nutr, 88, pp. 873-874
Rescher, U., Gerke, V., Annexins -unique membrane binding proteins with diverse functions (2004) J Cell Sci, 117, pp. 2631-2639
Kuczmarski, R.J., Flegal, K.M., Campbell, S.M., Johnson, C.L., Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991 (1994) JAMA J Am Med Assoc, 272, pp. 205-211
Meier, D.T., Morcos, M., Samarasekera, T., Zraika, S., Hull, R.L., Kahn, S.E., Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice (2014) Diabetologia, 57, pp. 1884-1888
Steyn, N.P., Mann, J., Bennett, P.H., Temple, N., Zimmet, P., Tuomilehto, J., Diet, nutrition and the prevention of type 2 diabetes (2004) Public Health Nutr, 7, pp. 147-165
Knowler, W.C., Pettitt, D.J., Savage, P.J., Bennett, P.H., Diabetes incidence in Pima indians: contributions of obesity and parental diabetes (1981) Am J Epidemiol, 113, pp. 144-156
Kahn, S.E., Hull, R.L., Utzschneider, K.M., Mechanisms linking obesity to insulin resistance and type 2 diabetes (2006) Nature, 444, pp. 840-846
Swinburn, B.A., Metcalf, P.A., Ley, S.J., Long-term (5-year) effects of a reduced-fat diet intervention in individuals with glucose intolerance (2001) Diabetes Care, 24, pp. 619-624
Astrup, A., Grunwald, G.K., Melanson, E.L., Saris, W.H., Hill, J.O., The role of low-fat diets in body weight control: a meta-analysis of ad libitum dietary intervention studies (2000) Int J Obes Relat Metab Disord, 24, pp. 1545-1552
Boden, G., Role of fatty acids in the pathogenesis of insulin resistance and NIDDM (1997) Diabetes, 46, pp. 3-10
Boden, G., Chen, X., Ruiz, J., White, J.V., Rossetti, L., Mechanisms of fatty acid-induced inhibition of glucose uptake (1994) J Clin Invest, 93, pp. 2438-2446
Reaven, G.M., Hollenbeck, C., Jeng, C.Y., Wu, M.S., Chen, Y.D., Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM (1988) Diabetes, 37, pp. 1020-1024
Tanner, J.M., The relation between serum cholesterol and physique in healthy young men (1951) J Physiol, 115, pp. 371-390
Montoye, H.J., Epstein, F.H., Kjelsberg, M.O., Relationship between serum cholesterol and body fatness. An epidemiologic study (1966) Am J Clin Nutr, 18, pp. 397-406
Sasahara, K., Morigaki, K., Shinya, K., Amyloid aggregation and deposition of human islet amyloid polypeptide at membrane interfaces (2014) FEBS J, 281, pp. 2597-2612
Wakabayashi, M., Matsuzaki, K., Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts (2009) FEBS Lett, 583, pp. 2854-2858
Yang, H., Li, X., The role of fatty acid metabolism and lipotoxicity in pancreatic ß-cell injury: identification of potential therapeutic targets (2012) Acta Pharm Sin B, 2, pp. 396-402
Björntorp, P., Bergman, H., Varnauskas, E., Plasma free fatty acid turnover rate in obesity (1969) Acta Med Scand, 185, pp. 351-356
Ma, Z., Westermark, G.T., Effects of free fatty acid on polymerization of islet amyloid polypeptide (IAPP) in vitro and on amyloid fibril formation in cultivated isolated islets of transgenic mice overexpressing human IAPP (2002) Mol Med, 8, pp. 863-868
Westermark, P., Andersson, A., Westermark, G.T., Islet amyloid polypeptide, islet amyloid, and diabetes mellitus (2011) Physiol Rev, 91, pp. 795-826
MacDonald, M.J., Dobrzyn, A., Ntambi, J., Stoker, S.W., The role of rapid lipogenesis in insulin secretion: insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells (2008) Arch Biochem Biophys, 470, pp. 153-162
Stefani, M., Rigacci, S., Protein folding and aggregation into amyloid: the interference by natural phenolic compounds (2013) Int J Mol Sci, 14, pp. 12411-12457
Shaw, J. E., Sicree, R. A., Zimmet, P. Z., Global estimates of the prevalence of diabetes for 2010 and 2030 (2010) Diabetes Res Clin Pract, 87, pp. 4-14
Wimalawansa, S. J., Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily (1997) Crit Rev Neurobiol, 11, pp. 167-239
H ppener, J. W. M., Ahr n, B., Lips, C. J. M., Islet amyloid and type 2 diabetes mellitus (2000) N Engl J Med, 343, pp. 411-419
Hull, R. L., Westermark, G. T., Westermark, P., Kahn, S. E., Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes (2004) J Clin Endocrinol Metab, 89, pp. 3629-3643
Aitken, J. F., Loomes, K. M., Scott, D. W., Reddy, S., Phillips, A. R. J., Prijic, G., Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice (2010) Diabetes, 59, pp. 161-171
Knight, J. D., Hebda, J. A., Miranker, A. D., Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide (2006) Biochemistry (Mosc), 45, pp. 9496-9508
Sciacca, M. F. M., Milardi, D., Messina, G. M. L., Marletta, G., Brender, J. R., Ramamoorthy, A., Cations as switches of amyloid-mediated membrane disruption mechanisms: calcium and IAPP (2013) Biophys J, 104, pp. 173-184
Hiddinga, H. J., Sakagashira, S., Ishigame, M., Madde, P., Sanke, T., Nanjo, K., Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance (2012) J Diabetes Investig, 3, pp. 138-147
Choi, J. M., Seo, M-H., Kyeong, H-H., Kim, E., Kim, H-S., Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase (2013) Proc Natl Acad Sci U S A, 110, pp. 10171-10176
Resnick, L. M., Cellular calcium and magnesium metabolism in the pathophysiology and treatment of hypertension and related metabolic disorders (1992) Am J Med, 93, pp. 11S-20S
Squier, T. C., Bigelow, D. J., Protein oxidation and age-dependent alterations in calcium homeostasis (2000) Front Biosci J Virtual Libr, 5, pp. D504-D526
Nitahara, J. A., Cheng, W., Liu, Y., Li, B., Leri, A., Li, P., Intracellular calcium, DNase activity and myocyte apoptosis in aging Fischer 344 rats (1998) J Mol Cell Cardiol, 30, pp. 519-535
Kuczmarski, R. J., Flegal, K. M., Campbell, S. M., Johnson, C. L., Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991 (1994) JAMA J Am Med Assoc, 272, pp. 205-211
Meier, D. T., Morcos, M., Samarasekera, T., Zraika, S., Hull, R. L., Kahn, S. E., Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice (2014) Diabetologia, 57, pp. 1884-1888
Steyn, N. P., Mann, J., Bennett, P. H., Temple, N., Zimmet, P., Tuomilehto, J., Diet, nutrition and the prevention of type 2 diabetes (2004) Public Health Nutr, 7, pp. 147-165
Knowler, W. C., Pettitt, D. J., Savage, P. J., Bennett, P. H., Diabetes incidence in Pima indians: contributions of obesity and parental diabetes (1981) Am J Epidemiol, 113, pp. 144-156
Kahn, S. E., Hull, R. L., Utzschneider, K. M., Mechanisms linking obesity to insulin resistance and type 2 diabetes (2006) Nature, 444, pp. 840-846
Swinburn, B. A., Metcalf, P. A., Ley, S. J., Long-term (5-year) effects of a reduced-fat diet intervention in individuals with glucose intolerance (2001) Diabetes Care, 24, pp. 619-624
Reaven, G. M., Hollenbeck, C., Jeng, C. Y., Wu, M. S., Chen, Y. D., Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM (1988) Diabetes, 37, pp. 1020-1024
Tanner, J. M., The relation between serum cholesterol and physique in healthy young men (1951) J Physiol, 115, pp. 371-390
Montoye, H. J., Epstein, F. H., Kjelsberg, M. O., Relationship between serum cholesterol and body fatness. An epidemiologic study (1966) Am J Clin Nutr, 18, pp. 397-406
Bj rntorp, P., Bergman, H., Varnauskas, E., Plasma free fatty acid turnover rate in obesity (1969) Acta Med Scand, 185, pp. 351-356
MacDonald, M. J., Dobrzyn, A., Ntambi, J., Stoker, S. W., The role of rapid lipogenesis in insulin secretion: insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells (2008) Arch Biochem Biophys, 470, pp. 153-162
The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime?
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The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime?
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The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime?
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