Synthetic peptides mimicking the interleukin-6/gp130 interaction: A two-helix bundle system. Design and confirmational studies(472 views) Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C
Keywords: Circular Dichroism, Cytokin, Gp130, Interleukin-6, Molecular Design, Nuclear Magnetic Resonance, Two-Helix Bundle, Glycoprotein Gp 130, Synthetic Peptide, Article, Binding Affinity, Complex Formation, Controlled Study, Data Analysis, Experimentation, Molecular Interaction, Molecular Mechanics, Molecular Recognition, Prediction, Priority Journal, Protein Binding, Protein Conformation, Protein Protein Interaction, Protein Structure, Stoichiometry, Titrimetry, Antigens, Cytokine Receptor Gp130, Membrane Glycoproteins, Models, Biomolecular, Secondary, Tertiary,
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture Bioimmagini, Dipartimento di Chimica Biologica, Universita Federico II di Napoli, via Mezzocannone 6, 80134 Napoli, Italy
Dipartimento di Scienze Ambientali, Seconda Università di Napoli, 81100 Caserta, Italy
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Karle, L. I., Flippen-Anderson, J. L., Uma, K., Balaram, P., Helix aggregation in peptide crystals: Occurrence of either all parallel or antiparallel packing motifs for -helices in polymorphs of Boc-Aib-Ala-Leu-Ala-Leu-Aib-Leu-Ala-Leu-Aib-OMe (1990) Biopolymers, 29, pp. 1835-1845
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Chou, C. K., Zhang, C. T., Maggiora, G. M., Disposition of amphiphilic helices in heteropolar environments (1997) Proteins, 28, pp. 99-108
Carpino, L. A., 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive (1993) J. Am. Chem. Soc., 115, pp. 4397-4398
Yang, J. T., Wu, C. S. C., Martinez, H. M., Calculation of protein conformation from circular dichroism (1986) Methods Enzymol., 130, pp. 208-269
M noz, V., Serrano, L., Elucidating the folding problem of helical peptides using empirical parameters (1994) Nature Struct. Biol., 1, pp. 399-409
Wisz, M. S., Garrett, C. Z., Hellinga, H. W., Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design (1998) Biochemistry, 37, pp. 8269-8277
W thrich, K., (1986) NMR of Proteins and Nucleic Acids, , Wiley: New York
Lee, M. S., Cao, B., Nuclear magnetic resonance chemical shift: Comparison of estimated secondary structures in peptides by nuclear magnetic resonance and circular dichroism (1996) Protein Eng., 9, pp. 15-25
Synthetic peptides mimicking the interleukin-6/gp130 interaction: A two-helix bundle system. Design and confirmational studies
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