Synthetic and structural routes for the rational conversion of peptides into small molecules (487 views)
Methods Mol Biol (ISSN: 1064-3745, 1940-6029electronic, 1064-3745linking), 2015; 1268: 159-193.
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Paper type: Journal Article, Ser,
Impact factor: 3.221, 5-year impact factor: 4.197
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84921781175&partnerID=40&md5=f58187099bfb4af2941e929be44892d3
Keywords: Backbone Modification, Conformational Constraints, Peptidomimetics, Macrocyclic Compound, Peptidomimetic Agent, Synthetic Peptide, Amino Acid Substitution, Article, Chemical Bond, Cyclization, Drug Design, Drug Structure, Drug Synthesis, Human, Medicinal Chemistry, Molecular Biology, Nonhuman, Priority Journal, Protein Conformation, Protein Modification, Biomimetic Materials, Small Molecule Libraries, Models,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, DFM-Scarl, University of Naples "Federico II", 80134, Naples, Italy, liana.sco@gmail.com.
References:
Not available.
Methods Mol Biol (ISSN: 1064-3745, 1940-6029electronic, 1064-3745linking), 2015; 1268: 159-193.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Ser,
Impact factor: 3.221, 5-year impact factor: 4.197
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84921781175&partnerID=40&md5=f58187099bfb4af2941e929be44892d3
Keywords: Backbone Modification, Conformational Constraints, Peptidomimetics, Macrocyclic Compound, Peptidomimetic Agent, Synthetic Peptide, Amino Acid Substitution, Article, Chemical Bond, Cyclization, Drug Design, Drug Structure, Drug Synthesis, Human, Medicinal Chemistry, Molecular Biology, Nonhuman, Priority Journal, Protein Conformation, Protein Modification, Biomimetic Materials, Small Molecule Libraries, Models,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, DFM-Scarl, University of Naples "Federico II", 80134, Naples, Italy, liana.sco@gmail.com.
References:
Not available.
Synthetic and structural routes for the rational conversion of peptides into small molecules
The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. The conversion of peptides into organic molecules, as traditional drugs, is a long and puzzled way. Many and versatile approaches have been described for designing peptide mimetics: the substitution of natural residues with modified amino acids and the rigidification and modifi- cation of the backbone are the main structural and chemical routes walked in medicinal chemistry. All of these strategies have been successfully applied to obtain active new compounds in molecular biology, drug discovery and design. Here we propose a panoramic review of the most common methods for the preparation of modified peptides and the most interesting findings of the last decade. © Springer Science+Business Media New York 2015.
The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. The conversion of peptides into organic molecules, as traditional drugs, is a long and puzzled way. Many and versatile approaches have been described for designing peptide mimetics: the substitution of natural residues with modified amino acids and the rigidification and modifi- cation of the backbone are the main structural and chemical routes walked in medicinal chemistry. All of these strategies have been successfully applied to obtain active new compounds in molecular biology, drug discovery and design. Here we propose a panoramic review of the most common methods for the preparation of modified peptides and the most interesting findings of the last decade. © Springer Science+Business Media New York 2015.
Synthetic and structural routes for the rational conversion of peptides into small molecules
Synthetic and structural routes for the rational conversion of peptides into small molecules
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View Export to BibTeX Export to EndNote
* Structure-Activity Relationship Investigations of Novel Constrained Chimeric Peptidomimetics of SOCS3 Protein Targeting JAK2 (20 views)
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Impact Factor: 5.68
View Export to BibTeX Export to EndNote
La Manna S, Lopez-sanz L, Bernal S, Fortuna S, Mercurio FA, Leone M, Gomez-guerrero C, Marasco D
* Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics (60 views)
Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254, 1768-3254electronic), 2021 Oct 5; 221: 113547-113547.
Impact Factor: 5.572
View Export to BibTeX Export to EndNote
Fik-jaskółka MA, Pospieszna-markiewicz I, Roviello GN, Kubicki M, Radecka-paryzek W, Patroniak V
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Inorg Chem (ISSN: 0020-1669linking, 1520-510x), 2021 Feb 15; 60(4): 2122-2126.
Impact Factor: 5.165
View Export to BibTeX Export to EndNote
La Manna S, Lopez-sanz L, Mercurio FA, Fortuna S, Leone M, Gomez-guerrero C, Marasco D
* Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds (62 views)
Acs Med Chem Lett (ISSN: 1948-5875linking), 2020 May 14; 11(5): 615-623.
Impact Factor: 3.975
View Export to BibTeX Export to EndNote
Satriano C, Munzone A, Cucci LM, Giacomelli C, Trincavelli ML, Martini C, Rizzarelli E, La Mendola D
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Impact Factor: 2.579
View Export to BibTeX Export to EndNote
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Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
View Export to BibTeX Export to EndNote
La Manna S, Lopez-sanz L, Leone M, Brandi P, Scognamiglio PL, Morelli G, Novellino E, Gomez-guerrero C, Marasco D
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Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2017 Nov 20; N/D: N/D-N/D.
Impact Factor: 1.99
View Export to BibTeX Export to EndNote
Sinopoli A, Giuffrida A, Tomasello MF, Giuffrida ML, Leone M, Attanasio F, Caraci F, De Bona P, Naletova I, Saviano M, Copani A, Pappalardo G, Rizzarelli E
* Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-beta Oligomer Formation and Cytotoxicity (459 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2016 Aug 17; 17(16): 1541-1549.
Impact Factor: 2.847
View Export to BibTeX Export to EndNote
Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (461 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Apr 11; 22(16): 5534-5537.
Impact Factor: 5.317
View Export to BibTeX Export to EndNote
Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L
* Straightforward entry to s-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics (552 views)
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2015; 17(3): 640-643.
Impact Factor: 6.732
View Export to BibTeX Export to EndNote
Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
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Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (373 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
Impact Factor: 2.406
View Export to BibTeX Export to EndNote
Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
* Cationic porphyrins are reversible proteasome inhibitors (454 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
View Export to BibTeX Export to EndNote
Celentano V, Diana D, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* beta-Hairpin stabilization through an interstrand triazole bridge (454 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012 Jan 18; 48(5): 762-764.
Impact Factor: 6.378
View Export to BibTeX Export to EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (414 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
View Export to BibTeX Export to EndNote
Monfregola L, De Luca S
* Synthetic strategy for side chain mono-N-alkylation of Fmoc-amino acids promoted by molecular sieves (561 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2011 Oct; 41(4): 981-990.
Impact Factor: 3.248
View Export to BibTeX Export to EndNote
Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (591 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
View Export to BibTeX Export to EndNote
Puglisi A, Purrello R, Rizzarelli E, Sortino S, Vecchio G
* Spectroscopic and self-association behavior of a porphyrin-β- cyclodextrin conjugate (389 views)
New J Chem (ISSN: 1144-0546), 2007; 31(8): 1499-1506.
Impact Factor: 2.651
View Export to BibTeX Export to EndNote
Angela M, Massimo De N, Rosaria L, Roberto P
* Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (481 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
Impact Factor: 2.286
View Export to BibTeX Export to EndNote
Formaggio F, Bonchio M, Crisma M, Peggion C, Mezzato S, Polese A, Barazza A, Antonello S, Maran F, Broxterman QB, Kaptein B, Kamphuis J, Vitale RM, Saviano M, Benedetti E, Toniolo C
* Nitroxyl peptides as catalysts of enantioselective oxidations (506 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002; 8(1): [d]84-93.
Impact Factor: 4.238
View Export to BibTeX Export to EndNote
De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (460 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001 Jul; 7(7): 386-394.
Impact Factor: 1.451
View Export to BibTeX Export to EndNote
21 Records (20 excluding Abstracts).
Total impact factor: 94.35 (91.116 excluding Abstracts).
Total 5 year impact factor: 88.554 (84.852 excluding Abstracts).
Total impact factor: 94.35 (91.116 excluding Abstracts).
Total 5 year impact factor: 88.554 (84.852 excluding Abstracts).
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