Synthetic and structural routes for the rational conversion of peptides into small molecules (476 views)
Methods Mol Biol (ISSN: 1064-3745, 1940-6029electronic, 1064-3745linking), 2015; 1268: 159-193.
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Paper type: Journal Article, Ser,
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Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84921781175&partnerID=40&md5=f58187099bfb4af2941e929be44892d3
Keywords: Backbone Modification, Conformational Constraints, Peptidomimetics, Macrocyclic Compound, Peptidomimetic Agent, Synthetic Peptide, Amino Acid Substitution, Article, Chemical Bond, Cyclization, Drug Design, Drug Structure, Drug Synthesis, Human, Medicinal Chemistry, Molecular Biology, Nonhuman, Priority Journal, Protein Conformation, Protein Modification, Biomimetic Materials, Small Molecule Libraries, Models,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, DFM-Scarl, University of Naples "Federico II", 80134, Naples, Italy, liana.sco@gmail.com.
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Hefti, F. F., Requirements for a lead compound to become a clinical candidate (2008) BMC Neurosci
Thaker, H. D., Sgolastra, F., Clements, D., Synthetic mimics of antimicrobial peptides from triaryl scaffolds (2011) J Med Chem, 54, pp. 2241-2254
Yang, S. Y., Pharmacophore modeling and applications in drug discovery: Challenges and recent advances (2010) Drug Discov Today, 15, pp. 444-450
Scognamiglio, P. L., Di Natale, C., Perretta, G., From peptides to small molecules: An intriguing but intricated way to new drugs (2013) Curr Med Chem, 20, pp. 3803-3817
Karle, I. L., Flexibility in peptide molecules and restraints imposed by hydrogen bonds, the AiB residue, and core inserts (1996) Biopolymers, 1, pp. 157-180
Ramachandran, G. N., Ramakrishnan, C., Sasisekharan, V., Stereochemistry of polypeptide chain configurations (1963) J Mol Biol, 4, pp. 95-99
Grauer, A., K nig, B., Peptidomimetics- a versatile route to biologically active compounds (2009) Eur J Org Chem, 30, pp. 5099-5111
Hruby, V. J., Li, G. G., Haskell Luevano, C., Design of peptides, proteins, and peptidomimetics in chi space (1997) Biopolymers, 3, pp. 219-266
Komarov, I. V., Grigorenko, A. O., Turov, A. V., Conformationally rigid cyclic -amino acids in the design of peptidomimetics, peptide models and biologically active compounds (2004) Usp Khim, 73, pp. 849-876
Silverman, R. B., Drug discovery design and development E7 peptidomimetics (2004) The organic chemistry of drug design and drug action, pp. 47-50. , In: Silver man RB, Elsevier Academic, Evanston, IL
Hruby, V. J., Balse, P. M., Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads (2000) Curr Med Chem, 7, pp. 945-970
Abdou, W. M., Barghash, R. F., Bekheit, M. S., Carbodiimides in the synthesis of enaminoand -aminophosphonates as peptidomimetics of analgesic/antiinfl ammatory and anticancer agents (2012) Arch Pharm, 345, pp. 884-895
Ibrahim, I. A. A., Shahzad, N., Al-joudi, F. S., In vitro and in vivo study of effect of -adrenergic agonist-methyldopa on the serum biochemical laboratory findings (2013) Clin Exp Pharmacol
Choi, W. T., Duggineni, S., Xu, Y., Targeting the CXC chemokine receptor 4 (CXCR4) (2012) J Med Chem, 55, pp. 977-994
Zuckermann, R. N., Kodadek, T., Peptoids as potential therapeutics (2009) Curr Opin Mol Ther, 11, pp. 299-307
Miller, S. M., Simon, R. J., Zuckermann, R. N., Comparison of the proteolytic susceptibilities of homologous L-amino acid, D-amino acid, and N-substituted glycine peptide and peptoid oligomers (1995) Drug Dev Res, 35, pp. 20-32
Bach, A. C., Eyermann, C. J., Groos, J. D., Structural studies of a family of high affinity ligands for IIb/IIIa (1994) J Am Chem Soc, 116, pp. 3207-3219
Huang, Z., He, Y. B., Raynor, K., Mainchain and side-chain chiral methylated somatostatin analogs: Synthesis and conformational analyses (1992) J Am Chem Soc, 114, pp. 9390-9401
Mosberg, H. I., Hurst, R., Hruby, V. J., Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors (1983) Proc Natl Acad Sci U S A, 80, pp. 5871-5874
Spear, K. L., Brown, M. S., Reinhard, E. J., Conformational restriction of angiotensin II: Cyclic analogues having high potency (1990) J Med Chem, 33, pp. 1935-1940
Lu, Y., Nguyen, T. M., Weltrowska, G., [2, 6 -Dimethyltyrosine] dynorphin A (1- 11) - NH2 analogues lacking an N-terminal amino group: Potent and selective kappa opioid antagonists (2001) J Med Chem, 44, pp. 3048-3053
Moussa, C. E. H., Mitrovic, A. D., Vandenberg, R. J., Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S, 1 S, 2 R) -2- (carboxycyclopropyl) glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy (2002) Neurochem Res, 27, pp. 27-35
Stewart, D. E., Sarkar, A., Wampler, J. E., Occurrence and role of cis peptide bonds in protein structures (1990) J Mol Biol, 214, pp. 253-260
Olsen, B. R., Ninomiya, Y., Collagens (1998) Guidebook to the extracellular matrix and adhesion proteins, p. 40. , In: Kreis T, Vale R, Oxford University Press, Oxford
Perni, R. B., Chandorkar, G., Cottrell, K. M., Inhibitors of hepatitis C virus NS3. 4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics (2007) Bioorg Med Chem Lett, 17, pp. 3406-3411
Chavan, A. S., Deng, J. C., Chuang, S. C., () -Michael addition of alkyl amines to dimethyl (E) -hex-2-en-4-ynedioate: Synthesis of, -dehydroamino acid derivatives (2013) Molecules, 18, pp. 2611-2622
Fisher, G. H., Berryer, P., Ryan, J. W., Dehydrophenylalanyl analogs of bradykinin: Synthesis and biological activities (1981) Arch Biochem Biophys, 211, pp. 269-275
Appella, D. H., Christianson, L. A., Karle, I. L., -peptide foldamers: Robust helix formation in a new family of amino acid oligomers (1996) J Am Chem Soc, 118, pp. 13071-13072
Weiner, B., Szyma ski, W., Janssen, D. B., Recent advances in the catalytic asymmetric synthesis of -amino acids (2010) Chem Soc Rev, 39, pp. 1656-1691
Murray, J. K., Farooqi, B., Sadowsky, J. D., Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation (2005) J Am Chem Soc, 127, pp. 13271-13280
Cheng, R. P., Gellman, S. H., Degrado, W. F., Beta-Peptides: From structure to function (2001) Chem Rev, 101, pp. 3219-3232
M ller, A., Vogt, C., Sewald, N., Synthesis of Fmoc- -homoamino acids by ultrasoundspromoted Wolff rearrangement (2006) Synthesis, pp. 837-841
Schiller, P. W., Nguyen, T. M., Weltrowska, G., Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: Development of a class of potent and highly deltaselective peptide antagonists (1993) Proc Natl Acad Sci U S A, 89, pp. 11871-11875
Hah, J. M., Mart sek, P., Roman, L. J., Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase (2003) J Med Chem, 46, pp. 1661-1669
Edwards, J. V., Spatola, A. F., Lemieux, C., In vitro activity profiles of cyclic and linear enkephalin pseudopeptide analogs (1986) Biochem Biophys Res Commun, 136, pp. 730-736
Fields, C. G., Fields, G. B., Solvents for solid-phase peptide synthesis (1994) Peptide synthesis protocols, 35, pp. 29-40. , In: Pennington MW, Dunn BM, Methods in molecular biology. Humana Press, Inc., Totowa, NJ
Hoffman, R. V., Tao, J., A simple, stereoselective synthesis of ketomethylene dipeptide isosteres (1997) Tetrahedron, 53, pp. 7119-7126
Fletcher, M. M., Campbell, M. M., Partially modified retro-inverso peptides: Development, synthesis, and conformational behavior (1998) Chem Rev, 98, pp. 763-796
P gorier, L., Larchev que, M., A general stereocontrolled synthesis of hydroxyethylene dipeptide isosteres (1995) Tetrahedron Lett, 36, pp. 2753-2756
Norman, B. H., Kroin, J. S., Alkylation studies of N-protected-5-substituted morpholin- 3-ones. A stereoselective approach to novel methylene ether dipeptide isosteres (1996) J Org Chem, 61, pp. 4990-4998
Angell, Y. L., Burgess, K., Peptidomimetics via copper-catalyzed azide-alkyne cycloadditions (2007) Chem Soc Rev, 36, pp. 1674-1689
Tron, G. C., Pirali, T., Billington, R. A., Click chemistry reactions in medicinal chemistry: Applications of the 1, 3-dipolar cycloaddition between azides and alkynes (2008) Med Res Rev, 28, pp. 278-308
Lipinski, C. A., Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings (1997) Adv Drug Deliv Rev, 23, pp. 3-25
White, C. J., Yudin, A. K., Contemporary strategies for peptide macrocyclization (2011) Nat Chem, 3, pp. 509-524
Hess, A. D., Colombani, P. M., Esa, A. H., Cyclosporine and the immune response: Basic aspects (1986) Crit Rev Immunol, 6, pp. 123-149
Walsh, C. T., Combinatorial biosynthesis of antibiotics: Challenges and opportunities (2002) Chembiochem, 3, pp. 125-134
Thomson, A. W., Starzl, T. E., FK 506 and autoimmune disease: Perspective and prospects (1992) Autoimmunity, 12, pp. 303-313
http: //www. pepscan. com/http: //www. ocerainc. com/technology/ MatchBlomberg, D., Hedenstr m, M., Kreye, P., Synthesis and conformational studies of a beta-turn mimetic incorporated in Leuenkephalin (2004) J Org Chem, 14, pp. 3500-3508
Ressurrei ao, A. S. M., Delatouche, R., Gennari, C., Bifunctional 2, 5- diketopiperazines as rigid three-dimensional scaffolds in receptors and peptidomimetics (2011) Eur J Org Chem, 2011, pp. 217-228
Whitby, L. R., Ando, Y., Setola, V., Design, synthesis, and validation of a -turn mimetic library targeting protein protein and peptide receptor interactions (2011) J Am Chem Soc, 133, pp. 10184-10194
Parkinson, G. N., Wu, Y., Fan, P., Crystal structure and NMR conformation of a cyclic pseudotetrapeptide containing urethane backbone linkages (1994) Biopolymers, 34, pp. 403-414
Dutta, A. S., Gormley, J. J., McLachlan, P. F., Novel inhibitors of human renin. Cyclic peptides based on the tetrapeptide sequence Glu-D-Phe-Lys-D-Trp (1990) J Med Chem, 33, pp. 2552-2560
Beck, J. G., Chatterjee, J., Laufer, B., Intestinal permeability of cyclic peptides: Common key backbone motifs identified (2012) J Am Chem Soc, 134, pp. 12125-12133
Hruby, V. J., Cai, M., Design of peptide and peptidomimetic ligands with novel pharmacological activity profiles (2013) Annu Rev Pharmacol Toxicol, 53, pp. 557-580
Methods Mol Biol (ISSN: 1064-3745, 1940-6029electronic, 1064-3745linking), 2015; 1268: 159-193.
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Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84921781175&partnerID=40&md5=f58187099bfb4af2941e929be44892d3
Keywords: Backbone Modification, Conformational Constraints, Peptidomimetics, Macrocyclic Compound, Peptidomimetic Agent, Synthetic Peptide, Amino Acid Substitution, Article, Chemical Bond, Cyclization, Drug Design, Drug Structure, Drug Synthesis, Human, Medicinal Chemistry, Molecular Biology, Nonhuman, Priority Journal, Protein Conformation, Protein Modification, Biomimetic Materials, Small Molecule Libraries, Models,
Affiliations:
*** IBB - CNR ***
Department of Pharmacy, CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, DFM-Scarl, University of Naples "Federico II", 80134, Naples, Italy, liana.sco@gmail.com.
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Ressurreiçao, A.S.M., Delatouche, R., Gennari, C., Bifunctional 2,5- diketopiperazines as rigid three-dimensional scaffolds in receptors and peptidomimetics (2011) Eur J Org Chem, 2011, pp. 217-228
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Dutta, A.S., Gormley, J.J., McLachlan, P.F., Novel inhibitors of human renin. Cyclic peptides based on the tetrapeptide sequence Glu-D-Phe-Lys-D-Trp (1990) J Med Chem, 33, pp. 2552-2560
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Nestor, J. J., Jr., The medicinal chemistry of peptides (2009) Curr Med Chem, 33, pp. 4399-441
Craik, D. J., Fairlie, D. P., Liras, S., The future of peptide-based drugs (2013) Chem Biol Drug Des, 81, pp. 136-147
Hefti, F. F., Requirements for a lead compound to become a clinical candidate (2008) BMC Neurosci
Thaker, H. D., Sgolastra, F., Clements, D., Synthetic mimics of antimicrobial peptides from triaryl scaffolds (2011) J Med Chem, 54, pp. 2241-2254
Yang, S. Y., Pharmacophore modeling and applications in drug discovery: Challenges and recent advances (2010) Drug Discov Today, 15, pp. 444-450
Scognamiglio, P. L., Di Natale, C., Perretta, G., From peptides to small molecules: An intriguing but intricated way to new drugs (2013) Curr Med Chem, 20, pp. 3803-3817
Karle, I. L., Flexibility in peptide molecules and restraints imposed by hydrogen bonds, the AiB residue, and core inserts (1996) Biopolymers, 1, pp. 157-180
Ramachandran, G. N., Ramakrishnan, C., Sasisekharan, V., Stereochemistry of polypeptide chain configurations (1963) J Mol Biol, 4, pp. 95-99
Grauer, A., K nig, B., Peptidomimetics- a versatile route to biologically active compounds (2009) Eur J Org Chem, 30, pp. 5099-5111
Hruby, V. J., Li, G. G., Haskell Luevano, C., Design of peptides, proteins, and peptidomimetics in chi space (1997) Biopolymers, 3, pp. 219-266
Komarov, I. V., Grigorenko, A. O., Turov, A. V., Conformationally rigid cyclic -amino acids in the design of peptidomimetics, peptide models and biologically active compounds (2004) Usp Khim, 73, pp. 849-876
Silverman, R. B., Drug discovery design and development E7 peptidomimetics (2004) The organic chemistry of drug design and drug action, pp. 47-50. , In: Silver man RB, Elsevier Academic, Evanston, IL
Hruby, V. J., Balse, P. M., Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads (2000) Curr Med Chem, 7, pp. 945-970
Abdou, W. M., Barghash, R. F., Bekheit, M. S., Carbodiimides in the synthesis of enaminoand -aminophosphonates as peptidomimetics of analgesic/antiinfl ammatory and anticancer agents (2012) Arch Pharm, 345, pp. 884-895
Ibrahim, I. A. A., Shahzad, N., Al-joudi, F. S., In vitro and in vivo study of effect of -adrenergic agonist-methyldopa on the serum biochemical laboratory findings (2013) Clin Exp Pharmacol
Choi, W. T., Duggineni, S., Xu, Y., Targeting the CXC chemokine receptor 4 (CXCR4) (2012) J Med Chem, 55, pp. 977-994
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Synthetic and structural routes for the rational conversion of peptides into small molecules
The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. The conversion of peptides into organic molecules, as traditional drugs, is a long and puzzled way. Many and versatile approaches have been described for designing peptide mimetics: the substitution of natural residues with modified amino acids and the rigidification and modifi- cation of the backbone are the main structural and chemical routes walked in medicinal chemistry. All of these strategies have been successfully applied to obtain active new compounds in molecular biology, drug discovery and design. Here we propose a panoramic review of the most common methods for the preparation of modified peptides and the most interesting findings of the last decade. © Springer Science+Business Media New York 2015.
The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. The conversion of peptides into organic molecules, as traditional drugs, is a long and puzzled way. Many and versatile approaches have been described for designing peptide mimetics: the substitution of natural residues with modified amino acids and the rigidification and modifi- cation of the backbone are the main structural and chemical routes walked in medicinal chemistry. All of these strategies have been successfully applied to obtain active new compounds in molecular biology, drug discovery and design. Here we propose a panoramic review of the most common methods for the preparation of modified peptides and the most interesting findings of the last decade. © Springer Science+Business Media New York 2015.
Synthetic and structural routes for the rational conversion of peptides into small molecules
Synthetic and structural routes for the rational conversion of peptides into small molecules
Other filter: ([btitle,keywords] "Backbone Modificatio ...
La Manna S, Leone M, Mercurio FA, Florio D, Marasco D
* Structure-Activity Relationship Investigations of Novel Constrained Chimeric Peptidomimetics of SOCS3 Protein Targeting JAK2 (13 views)
Pharmaceuticals (ISSN: 1424-8247linking), 2022 Apr 9; 15(4): N/D-N/D.
Impact Factor: 5.68
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La Manna S, Lopez-sanz L, Bernal S, Fortuna S, Mercurio FA, Leone M, Gomez-guerrero C, Marasco D
* Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics (23 views)
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Impact Factor: 5.572
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Fik-jaskółka MA, Pospieszna-markiewicz I, Roviello GN, Kubicki M, Radecka-paryzek W, Patroniak V
* Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect (102 views)
Inorg Chem (ISSN: 0020-1669linking, 1520-510x), 2021 Feb 15; 60(4): 2122-2126.
Impact Factor: 5.165
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La Manna S, Lopez-sanz L, Mercurio FA, Fortuna S, Leone M, Gomez-guerrero C, Marasco D
* Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds (55 views)
Acs Med Chem Lett (ISSN: 1948-5875linking), 2020 May 14; 11(5): 615-623.
Impact Factor: 3.975
View Export to BibTeX Export to EndNote
Satriano C, Munzone A, Cucci LM, Giacomelli C, Trincavelli ML, Martini C, Rizzarelli E, La Mendola D
* Angiogenin-mimetic peptide functionalised gold nanoparticles for cancer therapy applications (185 views)
Microchemical Journal (ISSN: 0026-265x), 2018; 136: 157-163.
Impact Factor: 2.579
View Export to BibTeX Export to EndNote
De Rosa L, Di Stasi R, D'Andrea LD
* Pro-angiogenic peptides in biomedicine (481 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
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La Manna S, Lopez-sanz L, Leone M, Brandi P, Scognamiglio PL, Morelli G, Novellino E, Gomez-guerrero C, Marasco D
* Structure-activity studies of peptidomimetics based on kinase-inhibitory region of suppressors of cytokine signaling (412 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2017 Nov 20; N/D: N/D-N/D.
Impact Factor: 1.99
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Sinopoli A, Giuffrida A, Tomasello MF, Giuffrida ML, Leone M, Attanasio F, Caraci F, De Bona P, Naletova I, Saviano M, Copani A, Pappalardo G, Rizzarelli E
* Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-beta Oligomer Formation and Cytotoxicity (453 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2016 Aug 17; 17(16): 1541-1549.
Impact Factor: 2.847
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Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (442 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Apr 11; 22(16): 5534-5537.
Impact Factor: 5.317
View Export to BibTeX Export to EndNote
Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L
* Straightforward entry to s-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics (490 views)
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2015; 17(3): 640-643.
Impact Factor: 6.732
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Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (437 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
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Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (370 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
Impact Factor: 2.406
View Export to BibTeX Export to EndNote
Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
* Cationic porphyrins are reversible proteasome inhibitors (447 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
View Export to BibTeX Export to EndNote
Celentano V, Diana D, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* beta-Hairpin stabilization through an interstrand triazole bridge (451 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012 Jan 18; 48(5): 762-764.
Impact Factor: 6.378
View Export to BibTeX Export to EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Monfregola L, De Luca S
* Synthetic strategy for side chain mono-N-alkylation of Fmoc-amino acids promoted by molecular sieves (538 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2011 Oct; 41(4): 981-990.
Impact Factor: 3.248
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Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (574 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
View Export to BibTeX Export to EndNote
Puglisi A, Purrello R, Rizzarelli E, Sortino S, Vecchio G
* Spectroscopic and self-association behavior of a porphyrin-β- cyclodextrin conjugate (376 views)
New J Chem (ISSN: 1144-0546), 2007; 31(8): 1499-1506.
Impact Factor: 2.651
View Export to BibTeX Export to EndNote
Angela M, Massimo De N, Rosaria L, Roberto P
* Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (417 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
Impact Factor: 2.286
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Formaggio F, Bonchio M, Crisma M, Peggion C, Mezzato S, Polese A, Barazza A, Antonello S, Maran F, Broxterman QB, Kaptein B, Kamphuis J, Vitale RM, Saviano M, Benedetti E, Toniolo C
* Nitroxyl peptides as catalysts of enantioselective oxidations (498 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002; 8(1): [d]84-93.
Impact Factor: 4.238
View Export to BibTeX Export to EndNote
De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (443 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001 Jul; 7(7): 386-394.
Impact Factor: 1.451
View Export to BibTeX Export to EndNote
* Structure-Activity Relationship Investigations of Novel Constrained Chimeric Peptidomimetics of SOCS3 Protein Targeting JAK2 (13 views)
Pharmaceuticals (ISSN: 1424-8247linking), 2022 Apr 9; 15(4): N/D-N/D.
Impact Factor: 5.68
View Export to BibTeX Export to EndNote
La Manna S, Lopez-sanz L, Bernal S, Fortuna S, Mercurio FA, Leone M, Gomez-guerrero C, Marasco D
* Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics (23 views)
Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254, 1768-3254electronic), 2021 Oct 5; 221: 113547-113547.
Impact Factor: 5.572
View Export to BibTeX Export to EndNote
Fik-jaskółka MA, Pospieszna-markiewicz I, Roviello GN, Kubicki M, Radecka-paryzek W, Patroniak V
* Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect (102 views)
Inorg Chem (ISSN: 0020-1669linking, 1520-510x), 2021 Feb 15; 60(4): 2122-2126.
Impact Factor: 5.165
View Export to BibTeX Export to EndNote
La Manna S, Lopez-sanz L, Mercurio FA, Fortuna S, Leone M, Gomez-guerrero C, Marasco D
* Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds (55 views)
Acs Med Chem Lett (ISSN: 1948-5875linking), 2020 May 14; 11(5): 615-623.
Impact Factor: 3.975
View Export to BibTeX Export to EndNote
Satriano C, Munzone A, Cucci LM, Giacomelli C, Trincavelli ML, Martini C, Rizzarelli E, La Mendola D
* Angiogenin-mimetic peptide functionalised gold nanoparticles for cancer therapy applications (185 views)
Microchemical Journal (ISSN: 0026-265x), 2018; 136: 157-163.
Impact Factor: 2.579
View Export to BibTeX Export to EndNote
De Rosa L, Di Stasi R, D'Andrea LD
* Pro-angiogenic peptides in biomedicine (481 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
View Export to BibTeX Export to EndNote
La Manna S, Lopez-sanz L, Leone M, Brandi P, Scognamiglio PL, Morelli G, Novellino E, Gomez-guerrero C, Marasco D
* Structure-activity studies of peptidomimetics based on kinase-inhibitory region of suppressors of cytokine signaling (412 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2017 Nov 20; N/D: N/D-N/D.
Impact Factor: 1.99
View Export to BibTeX Export to EndNote
Sinopoli A, Giuffrida A, Tomasello MF, Giuffrida ML, Leone M, Attanasio F, Caraci F, De Bona P, Naletova I, Saviano M, Copani A, Pappalardo G, Rizzarelli E
* Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-beta Oligomer Formation and Cytotoxicity (453 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2016 Aug 17; 17(16): 1541-1549.
Impact Factor: 2.847
View Export to BibTeX Export to EndNote
Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (442 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Apr 11; 22(16): 5534-5537.
Impact Factor: 5.317
View Export to BibTeX Export to EndNote
Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L
* Straightforward entry to s-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics (490 views)
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2015; 17(3): 640-643.
Impact Factor: 6.732
View Export to BibTeX Export to EndNote
Correale S, de Paola I, Morgillo CM, Federico A, Zaccaro L, Pallante P, Galeone A, Fusco A, Pedone E, Luque FJ, Catalanotti B
* Structural Model of the hUbA1-UbcH10 Quaternary Complex: In Silico and Experimental Analysis of the Protein-Protein Interactions between E1, E2 and Ubiquitin (437 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Nov 6; 9(11): e112082-e112082.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Ziaco B, Diana D, Capasso D, Palumbo R, Celentano V, Di Stasi R, Fattorusso R, D'Andrea LD
* C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties (370 views)
Biochem Biophys Res Commun (ISSN: 0006-291x), 2012 Jul 27; 424(2): 290-294.
Impact Factor: 2.406
View Export to BibTeX Export to EndNote
Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
* Cationic porphyrins are reversible proteasome inhibitors (447 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
View Export to BibTeX Export to EndNote
Celentano V, Diana D, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* beta-Hairpin stabilization through an interstrand triazole bridge (451 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2012 Jan 18; 48(5): 762-764.
Impact Factor: 6.378
View Export to BibTeX Export to EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
View Export to BibTeX Export to EndNote
Monfregola L, De Luca S
* Synthetic strategy for side chain mono-N-alkylation of Fmoc-amino acids promoted by molecular sieves (538 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2011 Oct; 41(4): 981-990.
Impact Factor: 3.248
View Export to BibTeX Export to EndNote
Gautier B, Goncalves V, Diana D, Di Stasi R, Teillet F, Lenoir C, Huguenot F, Garbay C, Fattorusso R, D'Andrea LD, Vidal M, Inguimbert N
* Biochemical and Structural Analysis of the Binding Determinants of a Vascular Endothelial Growth Factor Receptor Peptidic Antagonist (574 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jun 10; 53(11): 4428-4440.
Impact Factor: 5.207
View Export to BibTeX Export to EndNote
Puglisi A, Purrello R, Rizzarelli E, Sortino S, Vecchio G
* Spectroscopic and self-association behavior of a porphyrin-β- cyclodextrin conjugate (376 views)
New J Chem (ISSN: 1144-0546), 2007; 31(8): 1499-1506.
Impact Factor: 2.651
View Export to BibTeX Export to EndNote
Angela M, Massimo De N, Rosaria L, Roberto P
* Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (417 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
Impact Factor: 2.286
View Export to BibTeX Export to EndNote
Formaggio F, Bonchio M, Crisma M, Peggion C, Mezzato S, Polese A, Barazza A, Antonello S, Maran F, Broxterman QB, Kaptein B, Kamphuis J, Vitale RM, Saviano M, Benedetti E, Toniolo C
* Nitroxyl peptides as catalysts of enantioselective oxidations (498 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002; 8(1): [d]84-93.
Impact Factor: 4.238
View Export to BibTeX Export to EndNote
De Luca S, Tesauro D, Di Lello P, Fattorusso R, Saviano M, Pedone C, Morelli G
* Synthesis and solution characterization of a porphyrin-CCK8 conjugate (443 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2001 Jul; 7(7): 386-394.
Impact Factor: 1.451
View Export to BibTeX Export to EndNote
21 Records (20 excluding Abstracts).
Total impact factor: 94.35 (91.116 excluding Abstracts).
Total 5 year impact factor: 88.554 (84.852 excluding Abstracts).
Total impact factor: 94.35 (91.116 excluding Abstracts).
Total 5 year impact factor: 88.554 (84.852 excluding Abstracts).
476 views. Last view on Saturday 10 June 2023, 11:09:57
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