Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases (498 views)
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2012 Mar; 7(2): 175-184.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.872, 5-year impact factor: 3.221
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84858715144&partnerID=40&md5=ad3b85ede72bc6ecbc524b4430f02a68
Keywords: Contrast Agent, Gadolinium, Matrix Metalloproteinase, Mouse Melanoma, Tumor, Albumin, Beta Cyclodextrin Derivative, Gelatinase A, Ilomastat, Macrophage Elastase, Tetrapeptide, Tetraxetan, Amino Acid Sequence, Animal Experiment, Animal Model, Antineoplastic Activity, Article, Cancer Cell, Controlled Study, In Vitro Study, In Vivo Study, Molecular Imaging, Nonhuman, Nuclear Magnetic Resonance Imaging, Priority Journal, Protein Cleavage, Tumor Microenvironment, Chromatography, High Pressure Liquid, Reverse-Phase, Disease Models, Magnetic Resonance Spectroscopy, Mass Spectrometry, Inbred C57bl, Molecular Probes, Solid-Phase Synthesis Techniques, Gadolinium Chemistry Diagnostic Use, Matrix Metalloproteinases Metabolism, Melanoma Enzymology Pathology, Molecular Imaging Methods, Molecular Probes Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Environmental and Life Sciences, Università del Piemonte Orientale 'A. Avogadro', Viale T. Michel 11, 15121 Alessandria, Italy
Institute for Biostructures and Bioimages (CNR), Molecular Biotechnology Center, University of Turin, Via Nizza 52, Torino, 10125, Italy
Department of Chemisty IFM, Center for Molecular Imaging, University of Turin, Via Nizza 52, Torino, 10125, Italy
San Raffaele Scientific Institute, INSPE-Division Neuroscience, Via Olgettina 58, Milan, 20132, Italy
References:
Nagase, H.H., Woessner Jr., J.F., Matrix metalloproteinases (1999) J Biol Chem, 274 (31), pp. 21491-2149
Massova, I., Kotra, L.P., Fridman, R., Mobashery, S., Matrix metalloproteinases: structures, evolution, and diversification (1998) FASEB J, 12, pp. 1075-1095
Sounni, N.E., Janssen, M., Foidart, J.M., Noel, A., Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis (2003) Matrix Biol, 22, pp. 55-61
Sternlicht, M.D., Bergers, G., Matrix metalloproteinases as emerging targets in anticancer therapy: status and prospects (2000) Emerging Ther Targets, 4, pp. 609-633
Deryugina, E.I., Quigley, J.P., Matrix metalloproteinases and tumor metastasis (2006) Cancer Metastasis Rev, 25, pp. 9-34
Lampert, K., Machein, U., Machein, M.R., Conca, W., Peter, H.H., Volk, B., Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors (1998) Am J Pathol, 153, pp. 429-437
Van de Wiele, C., Oltenfreiter, R., Imaging probes targeting matrix metalloproteinases (2006) Cancer Biother Radiopharm, 21 (5), pp. 409-417
auf dem Keller, U., Bellac, C.L., Li, Y., Lou, Y., Lange, F.P., Ting, R., Harwig, C., Overall, C.M., Novel MMP inhibitor [ 18F]-Marimastat-aryltrifluoroborate as a probe for in vivo PET imaging in cancer (2010) Cancer Res, 70 (19), pp. 7562-7569
Wagner, S., Breyholz, H.-J., Höltke, C., Faust, A., Schober, O., Schäfers, M., Kopka, K., A new 18F-labelled derivative of the MMP inhibitor CGS27023A for PET: radiosynthesis and initial small-animal PET studies (2009) Applied Radiat Isotopes, 67, pp. 606-610
Lancelot, E., Amirbekian, V., Brigger, I., Raynaud, J.-S., Ballet, S., David, C., Rousseaux, O., Fayad, Z.A., Evaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach (2008) Arterioscler Thromb Vasc Biol, 28, pp. 429-436
Turk, B.E., Huang, L.L., Piro, E.T., Cantley, L.C., Determination of protease cleavage site motifs using mixture-based oriented peptide libraries (2001) Nature Biotechnol, 19, pp. 661-667
Kridel, S.J., Chen, E., Kotra, L.P., Howard, E.W., Mobashery, S., Smith, J.W., Substrate hydrolysis by matrix metalloproteinase-9 (2001) J Biol Chem, 276 (23), pp. 20572-20578
Chen, E.I., Kridel, S.J., Howard, E.W., Li, W., Godzik, A., Smith, J.W., A unique substrate recognition profile for matrix metalloproteinase-2 (2002) J Biol Chem, 277 (6), pp. 4485-4491
Scherer, R.L., McIntyre, J.O., Matrisian, L.M., Imaging matrix metalloproteinases in cancer (2008) Cancer Metastasis Rev, 27, pp. 679-690
Lepage, M., Dow, W.C., Melchior, M., You, Y., Fingleton, B., Quarles, C.C., Pepin, C., McIntyre, J.O., Noninvasive detection of matrix metalloproteinase activity in vivo using a novel MRI contrast agent with a solubility switch (2007) Mol Imag, 6, pp. 393-403
Jastrzebska, B., Lebel, R., Therriault, H., McIntyre, J.O., Escher, E., Guerin, B., Paquette, B., Lepage, M., New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging (2009) J Med Chem, 52, pp. 1576-1581
Lebel, R., Jastrzebska, B., Therriault, H., Cournoyer, M.-M., McIntyre, J.O., Escher, E., Neugebauer, W., Lepage, M., Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model (2008) Magn Reson Med, 60, pp. 1056-1065
Mulder, W.J.M., Strijkers, G.J., Griffioen, A.W., van Bloois, L., Molema, G., Storm, G., Koning, G.A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjug Chem, 15, pp. 799-806
Park, K., Lee, S., Kang, E., Kim, K., Choi, K., Kwon, I.C., New generation of multifunctional nanoparticles for cancer imaging and therapy (2009) Adv Funct Mater, 19, pp. 1553-1566
Janib, S.M., Moses, A.S., MacKay, J.A., Imaging and drug delivery using theranostic nanoparticles (2010) Advanced Drug Deliv Rev, 62 (11), pp. 1052-1063
Sharon Stack, M., Gray, R.D., Comparison of vertebrate collagenase and gelatinase using new fluorogenic substrate peptide (1989) J Biol Chem, 264 (8), pp. 4277-4281
Berman, J., Green, M., Sugg, E., Anderegg, R., Millington, D.S., Norwood, D.L., McGeehan, J., Wiseman, J., Rapid optimization of enzyme substrates using defined substrate mixtures (1992) J Biol Chem, 267 (3), pp. 1434-1437
Deng, S.-J., Bickett, D.M., Mitchell, J.L., Lamberti, M.H., Blackburn, R.K., Carter, H.L., Neugebauer, J., Moss, M.L., Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide library (2000) J Biol Chem, 275 (40), pp. 31422-31427
Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E., Aime, S., Metal containing nanosized systems for MR-molecular imaging applications (2008) Coord Chem Rev, 252, p. 2424. , 2443
Falvey, P., Lim, C.W., Darcy, R., Revermann, T., Karst, U., Giesbers, M., Marcelis, A.T.M., Ravoo, B.J., Bilayer vesicles of amphiphilic cyclodextrins: host membranes that recognize guest molecules (2005) Chem Eur J, 11, pp. 1171-1180
Digilio, G., Menchise, V., Gianolio, E., Catanzaro, V., Carrera, C., Napolitano, R., Fedeli, F., Aime, S., Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for MRI cell labelling (2010) J Med Chem, 53, pp. 4877-4890
Carrera, C., Digilio, G., Baroni, S., Burgio, D., Consol, S., Fedeli, F., Longo, D., Aime, S., Synthesis and characterization of a Gd(III) based contrast agent responsive to thiol containing compounds (2007) Dalton Trans, (43), pp. 4980-4987
De Leòn-Rodrìguez, L.M., Ortiz, A., Weiner, A.L., Zhang, S., Kovacs, Z., Kodadek, T., Sherry, A.D., Magnetic resonance imaging detects a specific peptide-protein binding event (2002) J Am Chem Soc, 124, pp. 3514-3515
Aime, S., Botta, M., Terreno, E., Gd(III)-based contrast agents for MRI (2005) Adv Inorg Chem, 57, pp. 173-237
Caravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., Gadolinium(III) Chelates as MRI contrast agents: structure, dynamics, and applications (1999) Chem Rev, 99, pp. 2293-2352
Kielar, F., Tei, L., Terreno, E., Botta, M., Large relaxivity enhancement of paramagnetic lipid nanoparticles by restricting the local motions of the Gd III Chelates (2010) J Am Chem Soc, 132, pp. 7836-7837
Zhang, Z., Greenfield, M.T., Spiller, M., McMurry, T.J., Lauffer, R.B., Caravan, P., Multilocus binding increases the relaxivity of protein-bound MRI contrast agents (2005) Angew Chem Int Edn, 44, pp. 6766-6769
Aime, S., Chiaussa, M., Digilio, G., Gianolio, E., Terreno, E., 1H and 17O NMR relaxometric investigations on two gadolinium(III) DTPA-like chelates endowed with high binding affinity to human serum albumin (1999) J Biol Inorg Chem (JBIC), 4, pp. 766-774
Rasmussen, H.S., McCann, P.P., Matrix Metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat (1997) Pharmacol Ther, 75, pp. 69-75
Galardy, R.E., Cassabonne, M.E., Giese, C., Gilbert, J.H., Lapierre, F., Lopez Schaeffer, M.E., Stack, R., Holleran, W.M., Low molecular weight inhibitors in corneal ulceration (1994) Ann NY Acad Sci, 732, pp. 315-323
Watt, A.P., Mast cells and peptide induced histamine release (2002) Immunopharmacology, 9, pp. 421-434
Digilio, G., Bracco, C., Barbero, L., Chicco, D., Del Curto, M.D., Esposito, P., Traversa, S., Aime, S., NMR Conformational analysis of antide, a potent antagonist of the gonadotropin releasing hormone (2002) J Am Chem Soc, 124, pp. 3431-3442
Nicolle, G.M., Merbach, A.E., Destruction of perfluoroalkyl surfactant aggregates by β-cyclodextrin (2004) Chem Commun, (7), pp. 854-855
Meding, J., Urich, M., Licha, K., Reinhardt, M., Misselwitz, B., Fayad, Z.A., Weinmann, H.-J., Magnetic resonance imaging of atherosclerosis by targeting extracellular matrix deposition with gadofluorine M (2007) Contrast Media Mol Imag, 2, pp. 120-129
Nagase, H. H., Woessner Jr., J. F., Matrix metalloproteinases (1999) J Biol Chem, 274 (31), pp. 21491-2149
Sounni, N. E., Janssen, M., Foidart, J. M., Noel, A., Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis (2003) Matrix Biol, 22, pp. 55-61
Sternlicht, M. D., Bergers, G., Matrix metalloproteinases as emerging targets in anticancer therapy: status and prospects (2000) Emerging Ther Targets, 4, pp. 609-633
Deryugina, E. I., Quigley, J. P., Matrix metalloproteinases and tumor metastasis (2006) Cancer Metastasis Rev, 25, pp. 9-34
Turk, B. E., Huang, L. L., Piro, E. T., Cantley, L. C., Determination of protease cleavage site motifs using mixture-based oriented peptide libraries (2001) Nature Biotechnol, 19, pp. 661-667
Kridel, S. J., Chen, E., Kotra, L. P., Howard, E. W., Mobashery, S., Smith, J. W., Substrate hydrolysis by matrix metalloproteinase-9 (2001) J Biol Chem, 276 (23), pp. 20572-20578
Chen, E. I., Kridel, S. J., Howard, E. W., Li, W., Godzik, A., Smith, J. W., A unique substrate recognition profile for matrix metalloproteinase-2 (2002) J Biol Chem, 277 (6), pp. 4485-4491
Scherer, R. L., McIntyre, J. O., Matrisian, L. M., Imaging matrix metalloproteinases in cancer (2008) Cancer Metastasis Rev, 27, pp. 679-690
Mulder, W. J. M., Strijkers, G. J., Griffioen, A. W., van Bloois, L., Molema, G., Storm, G., Koning, G. A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjug Chem, 15, pp. 799-806
Janib, S. M., Moses, A. S., MacKay, J. A., Imaging and drug delivery using theranostic nanoparticles (2010) Advanced Drug Deliv Rev, 62 (11), pp. 1052-1063
Deng, S. -J., Bickett, D. M., Mitchell, J. L., Lamberti, M. H., Blackburn, R. K., Carter, H. L., Neugebauer, J., Moss, M. L., Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide library (2000) J Biol Chem, 275 (40), pp. 31422-31427
De Le n-Rodr guez, L. M., Ortiz, A., Weiner, A. L., Zhang, S., Kovacs, Z., Kodadek, T., Sherry, A. D., Magnetic resonance imaging detects a specific peptide-protein binding event (2002) J Am Chem Soc, 124, pp. 3514-3515
Rasmussen, H. S., McCann, P. P., Matrix Metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat (1997) Pharmacol Ther, 75, pp. 69-75
Galardy, R. E., Cassabonne, M. E., Giese, C., Gilbert, J. H., Lapierre, F., Lopez Schaeffer, M. E., Stack, R., Holleran, W. M., Low molecular weight inhibitors in corneal ulceration (1994) Ann NY Acad Sci, 732, pp. 315-323
Watt, A. P., Mast cells and peptide induced histamine release (2002) Immunopharmacology, 9, pp. 421-434
Nicolle, G. M., Merbach, A. E., Destruction of perfluoroalkyl surfactant aggregates by -cyclodextrin (2004) Chem Commun, (7), pp. 854-855
Contrast Media Mol Imaging (ISSN: 1555-4309, 1555-4309linking), 2012 Mar; 7(2): 175-184.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 2.872, 5-year impact factor: 3.221
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84858715144&partnerID=40&md5=ad3b85ede72bc6ecbc524b4430f02a68
Keywords: Contrast Agent, Gadolinium, Matrix Metalloproteinase, Mouse Melanoma, Tumor, Albumin, Beta Cyclodextrin Derivative, Gelatinase A, Ilomastat, Macrophage Elastase, Tetrapeptide, Tetraxetan, Amino Acid Sequence, Animal Experiment, Animal Model, Antineoplastic Activity, Article, Cancer Cell, Controlled Study, In Vitro Study, In Vivo Study, Molecular Imaging, Nonhuman, Nuclear Magnetic Resonance Imaging, Priority Journal, Protein Cleavage, Tumor Microenvironment, Chromatography, High Pressure Liquid, Reverse-Phase, Disease Models, Magnetic Resonance Spectroscopy, Mass Spectrometry, Inbred C57bl, Molecular Probes, Solid-Phase Synthesis Techniques, Gadolinium Chemistry Diagnostic Use, Matrix Metalloproteinases Metabolism, Melanoma Enzymology Pathology, Molecular Imaging Methods, Molecular Probes Metabolism,
Affiliations:
*** IBB - CNR ***
Department of Environmental and Life Sciences, Università del Piemonte Orientale 'A. Avogadro', Viale T. Michel 11, 15121 Alessandria, Italy
Institute for Biostructures and Bioimages (CNR), Molecular Biotechnology Center, University of Turin, Via Nizza 52, Torino, 10125, Italy
Department of Chemisty IFM, Center for Molecular Imaging, University of Turin, Via Nizza 52, Torino, 10125, Italy
San Raffaele Scientific Institute, INSPE-Division Neuroscience, Via Olgettina 58, Milan, 20132, Italy
References:
Nagase, H.H., Woessner Jr., J.F., Matrix metalloproteinases (1999) J Biol Chem, 274 (31), pp. 21491-2149
Massova, I., Kotra, L.P., Fridman, R., Mobashery, S., Matrix metalloproteinases: structures, evolution, and diversification (1998) FASEB J, 12, pp. 1075-1095
Sounni, N.E., Janssen, M., Foidart, J.M., Noel, A., Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis (2003) Matrix Biol, 22, pp. 55-61
Sternlicht, M.D., Bergers, G., Matrix metalloproteinases as emerging targets in anticancer therapy: status and prospects (2000) Emerging Ther Targets, 4, pp. 609-633
Deryugina, E.I., Quigley, J.P., Matrix metalloproteinases and tumor metastasis (2006) Cancer Metastasis Rev, 25, pp. 9-34
Lampert, K., Machein, U., Machein, M.R., Conca, W., Peter, H.H., Volk, B., Expression of matrix metalloproteinases and their tissue inhibitors in human brain tumors (1998) Am J Pathol, 153, pp. 429-437
Van de Wiele, C., Oltenfreiter, R., Imaging probes targeting matrix metalloproteinases (2006) Cancer Biother Radiopharm, 21 (5), pp. 409-417
auf dem Keller, U., Bellac, C.L., Li, Y., Lou, Y., Lange, F.P., Ting, R., Harwig, C., Overall, C.M., Novel MMP inhibitor [ 18F]-Marimastat-aryltrifluoroborate as a probe for in vivo PET imaging in cancer (2010) Cancer Res, 70 (19), pp. 7562-7569
Wagner, S., Breyholz, H.-J., Höltke, C., Faust, A., Schober, O., Schäfers, M., Kopka, K., A new 18F-labelled derivative of the MMP inhibitor CGS27023A for PET: radiosynthesis and initial small-animal PET studies (2009) Applied Radiat Isotopes, 67, pp. 606-610
Lancelot, E., Amirbekian, V., Brigger, I., Raynaud, J.-S., Ballet, S., David, C., Rousseaux, O., Fayad, Z.A., Evaluation of matrix metalloproteinases in atherosclerosis using a novel noninvasive imaging approach (2008) Arterioscler Thromb Vasc Biol, 28, pp. 429-436
Turk, B.E., Huang, L.L., Piro, E.T., Cantley, L.C., Determination of protease cleavage site motifs using mixture-based oriented peptide libraries (2001) Nature Biotechnol, 19, pp. 661-667
Kridel, S.J., Chen, E., Kotra, L.P., Howard, E.W., Mobashery, S., Smith, J.W., Substrate hydrolysis by matrix metalloproteinase-9 (2001) J Biol Chem, 276 (23), pp. 20572-20578
Chen, E.I., Kridel, S.J., Howard, E.W., Li, W., Godzik, A., Smith, J.W., A unique substrate recognition profile for matrix metalloproteinase-2 (2002) J Biol Chem, 277 (6), pp. 4485-4491
Scherer, R.L., McIntyre, J.O., Matrisian, L.M., Imaging matrix metalloproteinases in cancer (2008) Cancer Metastasis Rev, 27, pp. 679-690
Lepage, M., Dow, W.C., Melchior, M., You, Y., Fingleton, B., Quarles, C.C., Pepin, C., McIntyre, J.O., Noninvasive detection of matrix metalloproteinase activity in vivo using a novel MRI contrast agent with a solubility switch (2007) Mol Imag, 6, pp. 393-403
Jastrzebska, B., Lebel, R., Therriault, H., McIntyre, J.O., Escher, E., Guerin, B., Paquette, B., Lepage, M., New enzyme-activated solubility-switchable contrast agent for magnetic resonance imaging: from synthesis to in vivo imaging (2009) J Med Chem, 52, pp. 1576-1581
Lebel, R., Jastrzebska, B., Therriault, H., Cournoyer, M.-M., McIntyre, J.O., Escher, E., Neugebauer, W., Lepage, M., Novel solubility-switchable MRI agent allows the noninvasive detection of matrix metalloproteinase-2 activity in vivo in a mouse model (2008) Magn Reson Med, 60, pp. 1056-1065
Mulder, W.J.M., Strijkers, G.J., Griffioen, A.W., van Bloois, L., Molema, G., Storm, G., Koning, G.A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjug Chem, 15, pp. 799-806
Park, K., Lee, S., Kang, E., Kim, K., Choi, K., Kwon, I.C., New generation of multifunctional nanoparticles for cancer imaging and therapy (2009) Adv Funct Mater, 19, pp. 1553-1566
Janib, S.M., Moses, A.S., MacKay, J.A., Imaging and drug delivery using theranostic nanoparticles (2010) Advanced Drug Deliv Rev, 62 (11), pp. 1052-1063
Sharon Stack, M., Gray, R.D., Comparison of vertebrate collagenase and gelatinase using new fluorogenic substrate peptide (1989) J Biol Chem, 264 (8), pp. 4277-4281
Berman, J., Green, M., Sugg, E., Anderegg, R., Millington, D.S., Norwood, D.L., McGeehan, J., Wiseman, J., Rapid optimization of enzyme substrates using defined substrate mixtures (1992) J Biol Chem, 267 (3), pp. 1434-1437
Deng, S.-J., Bickett, D.M., Mitchell, J.L., Lamberti, M.H., Blackburn, R.K., Carter, H.L., Neugebauer, J., Moss, M.L., Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide library (2000) J Biol Chem, 275 (40), pp. 31422-31427
Delli Castelli, D., Gianolio, E., Geninatti Crich, S., Terreno, E., Aime, S., Metal containing nanosized systems for MR-molecular imaging applications (2008) Coord Chem Rev, 252, p. 2424. , 2443
Falvey, P., Lim, C.W., Darcy, R., Revermann, T., Karst, U., Giesbers, M., Marcelis, A.T.M., Ravoo, B.J., Bilayer vesicles of amphiphilic cyclodextrins: host membranes that recognize guest molecules (2005) Chem Eur J, 11, pp. 1171-1180
Digilio, G., Menchise, V., Gianolio, E., Catanzaro, V., Carrera, C., Napolitano, R., Fedeli, F., Aime, S., Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for MRI cell labelling (2010) J Med Chem, 53, pp. 4877-4890
Carrera, C., Digilio, G., Baroni, S., Burgio, D., Consol, S., Fedeli, F., Longo, D., Aime, S., Synthesis and characterization of a Gd(III) based contrast agent responsive to thiol containing compounds (2007) Dalton Trans, (43), pp. 4980-4987
De Leòn-Rodrìguez, L.M., Ortiz, A., Weiner, A.L., Zhang, S., Kovacs, Z., Kodadek, T., Sherry, A.D., Magnetic resonance imaging detects a specific peptide-protein binding event (2002) J Am Chem Soc, 124, pp. 3514-3515
Aime, S., Botta, M., Terreno, E., Gd(III)-based contrast agents for MRI (2005) Adv Inorg Chem, 57, pp. 173-237
Caravan, P., Ellison, J.J., McMurry, T.J., Lauffer, R.B., Gadolinium(III) Chelates as MRI contrast agents: structure, dynamics, and applications (1999) Chem Rev, 99, pp. 2293-2352
Kielar, F., Tei, L., Terreno, E., Botta, M., Large relaxivity enhancement of paramagnetic lipid nanoparticles by restricting the local motions of the Gd III Chelates (2010) J Am Chem Soc, 132, pp. 7836-7837
Zhang, Z., Greenfield, M.T., Spiller, M., McMurry, T.J., Lauffer, R.B., Caravan, P., Multilocus binding increases the relaxivity of protein-bound MRI contrast agents (2005) Angew Chem Int Edn, 44, pp. 6766-6769
Aime, S., Chiaussa, M., Digilio, G., Gianolio, E., Terreno, E., 1H and 17O NMR relaxometric investigations on two gadolinium(III) DTPA-like chelates endowed with high binding affinity to human serum albumin (1999) J Biol Inorg Chem (JBIC), 4, pp. 766-774
Rasmussen, H.S., McCann, P.P., Matrix Metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat (1997) Pharmacol Ther, 75, pp. 69-75
Galardy, R.E., Cassabonne, M.E., Giese, C., Gilbert, J.H., Lapierre, F., Lopez Schaeffer, M.E., Stack, R., Holleran, W.M., Low molecular weight inhibitors in corneal ulceration (1994) Ann NY Acad Sci, 732, pp. 315-323
Watt, A.P., Mast cells and peptide induced histamine release (2002) Immunopharmacology, 9, pp. 421-434
Digilio, G., Bracco, C., Barbero, L., Chicco, D., Del Curto, M.D., Esposito, P., Traversa, S., Aime, S., NMR Conformational analysis of antide, a potent antagonist of the gonadotropin releasing hormone (2002) J Am Chem Soc, 124, pp. 3431-3442
Nicolle, G.M., Merbach, A.E., Destruction of perfluoroalkyl surfactant aggregates by β-cyclodextrin (2004) Chem Commun, (7), pp. 854-855
Meding, J., Urich, M., Licha, K., Reinhardt, M., Misselwitz, B., Fayad, Z.A., Weinmann, H.-J., Magnetic resonance imaging of atherosclerosis by targeting extracellular matrix deposition with gadofluorine M (2007) Contrast Media Mol Imag, 2, pp. 120-129
Nagase, H. H., Woessner Jr., J. F., Matrix metalloproteinases (1999) J Biol Chem, 274 (31), pp. 21491-2149
Sounni, N. E., Janssen, M., Foidart, J. M., Noel, A., Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis (2003) Matrix Biol, 22, pp. 55-61
Sternlicht, M. D., Bergers, G., Matrix metalloproteinases as emerging targets in anticancer therapy: status and prospects (2000) Emerging Ther Targets, 4, pp. 609-633
Deryugina, E. I., Quigley, J. P., Matrix metalloproteinases and tumor metastasis (2006) Cancer Metastasis Rev, 25, pp. 9-34
Turk, B. E., Huang, L. L., Piro, E. T., Cantley, L. C., Determination of protease cleavage site motifs using mixture-based oriented peptide libraries (2001) Nature Biotechnol, 19, pp. 661-667
Kridel, S. J., Chen, E., Kotra, L. P., Howard, E. W., Mobashery, S., Smith, J. W., Substrate hydrolysis by matrix metalloproteinase-9 (2001) J Biol Chem, 276 (23), pp. 20572-20578
Chen, E. I., Kridel, S. J., Howard, E. W., Li, W., Godzik, A., Smith, J. W., A unique substrate recognition profile for matrix metalloproteinase-2 (2002) J Biol Chem, 277 (6), pp. 4485-4491
Scherer, R. L., McIntyre, J. O., Matrisian, L. M., Imaging matrix metalloproteinases in cancer (2008) Cancer Metastasis Rev, 27, pp. 679-690
Mulder, W. J. M., Strijkers, G. J., Griffioen, A. W., van Bloois, L., Molema, G., Storm, G., Koning, G. A., Nicolay, K., A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets (2004) Bioconjug Chem, 15, pp. 799-806
Janib, S. M., Moses, A. S., MacKay, J. A., Imaging and drug delivery using theranostic nanoparticles (2010) Advanced Drug Deliv Rev, 62 (11), pp. 1052-1063
Deng, S. -J., Bickett, D. M., Mitchell, J. L., Lamberti, M. H., Blackburn, R. K., Carter, H. L., Neugebauer, J., Moss, M. L., Substrate specificity of human collagenase 3 assessed using a phage-displayed peptide library (2000) J Biol Chem, 275 (40), pp. 31422-31427
De Le n-Rodr guez, L. M., Ortiz, A., Weiner, A. L., Zhang, S., Kovacs, Z., Kodadek, T., Sherry, A. D., Magnetic resonance imaging detects a specific peptide-protein binding event (2002) J Am Chem Soc, 124, pp. 3514-3515
Rasmussen, H. S., McCann, P. P., Matrix Metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat (1997) Pharmacol Ther, 75, pp. 69-75
Galardy, R. E., Cassabonne, M. E., Giese, C., Gilbert, J. H., Lapierre, F., Lopez Schaeffer, M. E., Stack, R., Holleran, W. M., Low molecular weight inhibitors in corneal ulceration (1994) Ann NY Acad Sci, 732, pp. 315-323
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Nicolle, G. M., Merbach, A. E., Destruction of perfluoroalkyl surfactant aggregates by -cyclodextrin (2004) Chem Commun, (7), pp. 854-855
Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases
Two novel Gd-based contrast agents (CAs) for the molecular imaging of matrix metalloproteinases (MMPs) were synthetized and characterized in vitro and in vivo. These probes were based on the PLG*LWAR peptide sequence, known to be hydrolyzed between Gly and Leu by a broad panel of MMPs. A Gd-DOTA chelate was conjugated to the N-terminal position through an amide bond, either directly to proline (compd Gd-K11) or through a hydrophilic spacer (compd Gd-K11N). Both CA were made strongly amphiphilic by conjugating an alkyl chain at the C-terminus of the peptide sequence. Gd-K11 and Gd-K11N have a good affinity for β-cyclodextrins (K D 310 and 670μ m respectively) and for serum albumin (K D 350 and 90μ m respectively), and can be efficiently cleaved in vitro at the expected site by MMP-2 and MMP-12. Upon MMP-dependent cleavage, the CAs lose the C-terminal tetrapeptide and the alkyl chain, thus undergoing to an amphiphilic-to-hydrophilic transformation that is expected to alter tissue pharmacokinetics. To prove this, Gd-K11 was systemically administered to mice bearing a subcutaneous B16.F10 melanoma, either pre-treated or not with the broad spectrum MMP inhibitor GM6001 (Ilomastat). The washout of the Gd-contrast enhancement in MR images was significantly faster for untreated subjects (displaying MMP activity) with respect to treated ones (MMP activity inhibited). The washout kinetics of Gd-contrast enhancement from the tumor microenvironment could be then interpreted in terms of the local activity of MMPs. © 2012 John Wiley & Sons, Ltd.
Two novel Gd-based contrast agents (CAs) for the molecular imaging of matrix metalloproteinases (MMPs) were synthetized and characterized in vitro and in vivo. These probes were based on the PLG*LWAR peptide sequence, known to be hydrolyzed between Gly and Leu by a broad panel of MMPs. A Gd-DOTA chelate was conjugated to the N-terminal position through an amide bond, either directly to proline (compd Gd-K11) or through a hydrophilic spacer (compd Gd-K11N). Both CA were made strongly amphiphilic by conjugating an alkyl chain at the C-terminus of the peptide sequence. Gd-K11 and Gd-K11N have a good affinity for β-cyclodextrins (K D 310 and 670μ m respectively) and for serum albumin (K D 350 and 90μ m respectively), and can be efficiently cleaved in vitro at the expected site by MMP-2 and MMP-12. Upon MMP-dependent cleavage, the CAs lose the C-terminal tetrapeptide and the alkyl chain, thus undergoing to an amphiphilic-to-hydrophilic transformation that is expected to alter tissue pharmacokinetics. To prove this, Gd-K11 was systemically administered to mice bearing a subcutaneous B16.F10 melanoma, either pre-treated or not with the broad spectrum MMP inhibitor GM6001 (Ilomastat). The washout of the Gd-contrast enhancement in MR images was significantly faster for untreated subjects (displaying MMP activity) with respect to treated ones (MMP activity inhibited). The washout kinetics of Gd-contrast enhancement from the tumor microenvironment could be then interpreted in terms of the local activity of MMPs. © 2012 John Wiley & Sons, Ltd.
Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases
| ▼ MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping perfluorocarbons based nanoparticles |
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Novel Gd(III)-based probes for MR molecular imaging of matrix metalloproteinases
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Longo DL, Carella A, Corrado A, Pirotta E, Mohanta Z, Singh A, Stabinska J, Liu G, Mcmahon MT
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Dastru W, Menchise V, Ferrauto G, Fabretto S, Carrera C, Terreno E, Aime S, Delli Castelli D
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
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Diaferia C, Gianolio E, Sibillano T, Mercurio FA, Leone M, Giannini C, Balasco N, Vitagliano L, Morelli G, Accardo A
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Oliveri V, Bellia F, Vecchio G
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Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S
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Anemone A, Consolino L, Longo DL
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Consolino L, Longo DL, Sciortino M, Dastru W, Cabodi S, Giovenzana GB, Aime S
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Filippi M, Boido M, Pasquino C, Garello F, Boffa C, Terreno E
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Tedeschi E, Palma G, Canna A, Cocozza S, Russo C, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Morra VB, Salvatore M, Brunetti A, Quarantelli M
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
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Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
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Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz HJ, Faust A, Hermann S, Kopka K, Faber C, Dolle F, Pappata S, Planas AM, Tavitian B, Schafers M, Sorokin LM, Kuhlmann MT, Jacobs AH
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Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-crich S, Giovenzana GB, Aime S
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Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
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Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
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Erra P, Puglia M, Ragozzino A, Maurea S, Liuzzi R, Sabino G, Barbuto L, Cuocolo A, Imbriaco M
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Romeo V, Esposito A, Maurea S, Camera L, Mainenti PP, Palmieri G, Buonerba C, Salvatore M
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Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S
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Tedeschi E, Russo C, Cocozza S, Palma G, Canna A, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Brescia Morra V, Brunetti A, Salvatore M
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Rsna 101st Scientific Assembly And Annual Meeting, 2015; N/D: N/D-N/D.
Impact Factor: 0
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Maurea S, Mainenti PP, Tambasco A, Imbriaco M, Mollica C, Laccetti E, Camera L, Liuzzi R, Salvatore M
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Impact Factor: 3.105
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
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Impact Factor: 1.865
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
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Ristori G, Romano S, Cannoni S, Visconti A, Tinelli E, Mendozzi L, Cecconi P, Lanzillo R, Quarantelli M, Buttinelli C, Gasperini C, Frontoni M, Coarelli G, Caputo D, Bresciamorra V, Vanacore N, Pozzilli C, Salvetti M
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Ciarmiello A, Gaeta MC, Meniconi M, Milano A, Alfano B, Del Vecchio S, Salvatore M
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Iodice D, Di Donato O, Liccardo I, Lamanna L, Segreto S, Salvatore M, Imbriaco M
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Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
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Gargiulo P, Dellegrottaglie S, Bruzzese D, Savarese G, Scala O, Ruggiero D, D'Amore C, Paolillo S, Agostoni P, Bossone E, Soricelli A, Cuocolo A, Trimarco B, Perrone Filardi P
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Impact Factor: 6.752
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Catanzaro V, Gringeri CV, Menchise V, Padovan S, Boffa C, Dastru W, Chaabane L, Digilio G, Aime S
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Castiglione F, Mainenti PP, De Palma GD, Testa A, Bucci L, Pesce G, Camera L, Diaferia M, Rea M, Caporaso N, Salvatore M, Rispo A
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Impact Factor: 5.475
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Mancini M, Di Donato O, Saldalamacchia G, Liuzzi R, Rivellese A, Salvatore M
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Impact Factor: 1.368
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Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
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Impact Factor: 8.535
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Grasso G, Giuffrida ML, Rizzarelli E
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Impact Factor: 4.099
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Maurea S, Fusari M, Imbriaco M, Camera L, Mainenti PP, Campione S, Santangelo M, Salvatore M
* Pitfalls in diagnostic imaging of cystic pancreatic masses: a case of true cystic lesion mimicking a mucinous cystadenoma (334 views)
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Impact Factor: 0
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Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* MR Contrast Agents (334 views)
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Impact Factor: 4.782
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Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A
* MR Contrast Agents (292 views)
Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555.
Impact Factor: 1.784
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (554 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (345 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* In vivo labeling of B16 melanoma tumor xenograft with a thiol-reactive gadolinium based MRI contrast agent (525 views)
Mol Pharm (ISSN: 1543-8384), 2011; 8(5): 1750-1756.
Impact Factor: 4.782
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (433 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (455 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (489 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (596 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Mainenti PP, Segreto S, Mancini M, Rispo A, Cozzolino I, Masone S, Rinaldi CR, Nardone G, Salvatore M
* Intestinal amyloidosis: two cases with different patterns of clinical and imaging presentation (386 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2010 May 28; 16(20): 2566-2570.
Impact Factor: 2.24
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Lanzillo R, Orefice G, Quarantelli M, Rinaldi C, Prinster A, Ventrella G, Spitaleri D, Lus G, Vacca G, Carotenuto B, Salvatore E, Brunetti A, Tedeschi G, Brescia Morra V
* Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: A longitudinal controlled trial of combination therapy (543 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2010 Apr; 16(4): 450-454.
Impact Factor: 4.23
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Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (415 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1227-1235.
Impact Factor: 2.605
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (591 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (14494 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (417 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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Maurea S, Caleo O, Mollica C, Imbriaco M, Mainenti PP, Palumbo C, Mancini M, Camera L, Salvatore M
* Comparative diagnostic evaluation with MR cholangiopancreatography, ultrasonography and CT in patients with pancreatobiliary disease (346 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2009 Apr; 114(3): 390-402.
Impact Factor: 1.454
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (402 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
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Digilio G, Catanzaro V, Fedeli F, Gianolio E, Menchise V, Napolitano R, Gringeri C, Aime S
* Targeting exofacial protein thiols with Gd-III complexes. An efficient procedure for MRI cell labelling (344 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2009 Feb 28; (8): 893-895.
Impact Factor: 5.504
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (528 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (254 views)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (458 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Imbriaco M, Caprio MG, Limite G, Pace L, De Falco T, Capuano E, Salvatore M
* Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions (290 views)
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2008 Nov; 191(5): 1323-1330.
Impact Factor: 2.94
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Fonti R, Salvatore B, Quarantelli M, Sirignano C, Segreto S, Petruzziello F, Catalano L, Liuzzi R, Rotoli B, Del Vecchio S, Pace L, Salvatore M
* F-18-FDG PET/CT, Tc-99m-MIBI, and MRI in evaluation of patients with multiple myeloma (546 views)
J Nucl Med (ISSN: 0161-5505, 0161-1550, 1535-5667), 2008 Feb; 49(2): 195-200.
Impact Factor: 6.662
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Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (367 views)
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.
Impact Factor: 0.481
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Frasca F, Nucera C, Pellegriti G, Gangemi P, Attard M, Stella M, Loda M, Vella V, Giordano C, Trimarchi F, Mazzoni E, Belfiore A, Vigneri R
* BRAF(V600E) mutation and the biology of papillary thyroid cancer (544 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2008; 15(1): 191-205.
Impact Factor: 5.236
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (573 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Ragozzino A, Lassandro F, De Ritis R, Imbriaco M
* Value of MRI in three patients with major vascular injuries after laparoscopic cholecystectomy (250 views)
Emergency Radiology (ISSN: 1070-3004), 2007 Nov; 14(6): 443-447.
Impact Factor: 6.214
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Pastore C, Franzese M, Sica F, Temussi P, Pastore A
* Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin (408 views)
Febs Journal (ISSN: 1742-464x), 2007 Sep; 274(16): 4199-4210.
Impact Factor: 3.396
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (351 views)
Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
Impact Factor: 3.664
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (321 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases (415 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.
Impact Factor: 2.945
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Del Giudice E, Bianchi MC, Tosetti M, Varrone A, Romano A, Crisanti AF, Titomanlio L, Imperati F
* Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment? (325 views)
Epileptic Disord (ISSN: 1294-9361), 2006 Dec; 8(4): 289-293.
Impact Factor: 1.202
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Maurea S, Imbriaco M, D'Angelillo M, Mollica C, Camera L, Salvatore M
* Diagnostic accuracy of chemical-shift MR imaging to differentiate between adrenal adenomas and non adenoma adrenal lesions (326 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2006 Sep; 111(5): 674-686.
Impact Factor: 1.368
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (441 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (575 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
Impact Factor: 3.574
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Cucinotta V, Giuffrida A, Maccarrone G, Messina M, Puglisi A, Rizzarelli E, Vecchio G
* Coordination properties of 3-functionalized β-cyclodextrins. Thermodynamic stereoselectivity of copper(II) complexes of the A, B-diamino derivative and its exploitation in LECE (356 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Sep 21; (16): 2731-2736.
Impact Factor: 3.003
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Impellizzeri G, D'Alessandro F, Pappalardo G, Tringali C
* Synthesis And Structural Characterisation Of Two Novel Diastereoisomeric Naproxen-Appended Beta-Cyclodextrin Derivatives (346 views)
J Incl Phenom (ISSN: 0923-0750), 2005; 51(3-4): 173-180.
Impact Factor: 1.02
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Puglisi A, Tabbì G, Vecchio G
* Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity (410 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jun; 98(6): 969-976.
Impact Factor: 2.225
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (452 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (414 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
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Maurea S, Caracò C, Klain M, Mainolfi C, Salvatore M
* Imaging characterization of non-hypersecreting adrenal masses. Comparison between MR and radionuclide techniques (348 views) (PDF 247 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2004; 48(3): 188-197.
Impact Factor: 1.724
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Camera L, Bresciani M, Soscia E, Percopo V, Mainenti PP, Salvatore M
* Morphological imaging of gastroenteropancreatic neuroendocrine tumours (256 views)
Minerva Endocrinol (ISSN: 0391-1977, 1827-1634electronic, 0391-1977linking), 2001 Sep; 26(3): 123-128.
Impact Factor: 1.464
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Imbriaco M, Del Vecchio S, Riccardi A, Pace L, Di Salle F, Di Gennaro F, Salvatore M, Sodano A
* Scintimammography with Tc-99m-MIBI versus dynamic MRI for non-invasive characterization of breast masses (606 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2001 Jan; 28(1): 56-63.
Impact Factor: 3.464
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Bonomo RP, Cucinotta V, D'Alessandro F, Impellizzeri G, Maccarrone G, Rizzarelli E, Vecchio G, Carima L, Corradini R, Sartor G, Marchelli R
Chiral recognition by the copper(ii) complex of 6-deoxy-6-n-(2 - methylaminopyridine)-β-cyclodextrin (378 views)
Chirality (ISSN: 0899-0042), 1997; 9(4): 341-349.
Impact Factor: 1.915
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Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (730 views) (PDF 245 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
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Di Blasio B, Galdiero S, Saviano M, Pedone C, Benedetti E, Rizzarelli E, Pedotti S, Vecchio G, Gibbons WA
Synthesis And Structural Characterization Of 6i, 6ii-Diamino-6i, 6ii-Dideoxy-Cyclomaltoheptaose, A Difunctionalized Beta-Cyclodextrin (426 views)
Carbohydr Res, 1996 Feb 28; 282(1): 41-52.
Impact Factor: 0
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DALESSANDRO F, GULINO F, IMPELLIZZERI G, PAPPALARDO G, RIZZARELLI E, SCIOTTO D, VECCHIO G
A new water soluble host compound possessing two different hydrophobic recognition cavities: Calix[4]arene derivative conjugated with monofunctionalized β-cyclodextrin (425 views)
Tetrahedron Lett (ISSN: 0040-4039), 1994 Jan 24; 35(4): 629-632.
Impact Factor: 2.5
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Cucinotta V, Mangano A, Nobile G, Santoro AM, Vecchio G
New platinum(II) complexes of β-cyclodextrin diamine derivatives and their antitumor activity (468 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Nov 15; 52(3): 183-190.
Impact Factor: 1.342
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Di Blasio B, Pavone V, Nastri F, Isernia C, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
Conformation for a β-cyclodextrin monosubstituted with a cyclic dipeptide (485 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 1992 Sep 1; 89(15): 7218-7221.
Impact Factor: 9.04
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* A snapshot of the vast array of diamagnetic CEST MRI contrast agents (6 views)
Nmr Biomed (ISSN: 0952-3480linking), 2022 Feb 20; N/D: e4715-N/D.
Impact Factor: 4.044
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Consolino L, Irrera P, Romdhane F, Anemone A, Longo DL
* Investigating plasma volume expanders as novel macromolecular MRI-CEST contrast agents for tumor contrast-enhanced imaging (20 views)
Magn Reson Med (ISSN: 0740-3194linking, 1522-2594electronic), 2021 Aug; 86(2): 995-1007.
Impact Factor: 3.635
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Garello F, Boido M, Miglietti M, Bitonto V, Zenzola M, Filippi M, Arena F, Consolino L, Ghibaudi M, Terreno E
* Imaging of Inflammation in Spinal Cord Injury: Novel Insights on the Usage of PFC-Based Contrast Agents (18 views)
Biomedicines (ISSN: 2227-9059linking), 2021 Apr 3; 9(4): N/D-N/D.
Impact Factor: 4.757
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Baroni S, Stefania R, Broche LM, Senn N, Lurie DJ, Ross PJ, Aime S, Geninatti Crich S
* A Novel Class of (1) H-MRI Contrast Agents Based on the Relaxation Enhancement Induced on Water Protons by (14) N-Containing Imidazole Moieties (74 views)
Angew Chem Int Ed (ISSN: 1433-7851linking, 1521-3773electronic), 2021 Feb 19; 60(8): 4208-4214.
Impact Factor: 12.959
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Zöllner FG, Dastrù W, Irrera P, Longo DL, Bennett KM, Beeman SC, Bretthorst GL, Garbow JR
* Analysis Protocol for Dynamic Contrast Enhanced (DCE) MRI of Renal Perfusion and Filtration (19 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 637-653.
Impact Factor: 1.17
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Kim H, Wu Y, Villano D, Longo DL, Mcmahon MT, Sun PZ
* Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI (23 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 667-688.
Impact Factor: 1.17
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Ponsiglione A, Nappi C, Imbriaco M, Ascione R, Megna R, Petretta M, Cuocolo A
* Cardiac magnetic resonance imaging during the COVID-19 pandemic: A southern Italian single-center experience (84 views)
Eur J Radiol Open (ISSN: 2352-0477electronic, 2352-0477linking), 2021; 8: 100319-100319.
Impact Factor: 0.654
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Irrera P, Consolino L, Dastrù W, Pedersen M, Zöllner FG, Longo DL
* Dynamic Contrast Enhanced (DCE) MRI-Derived Renal Perfusion and Filtration: Experimental Protocol (15 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 429-441.
Impact Factor: 1.17
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Pedersen M, Irrera P, Dastrù W, Zöllner FG, Bennett KM, Beeman SC, Bretthorst GL, Garbow JR, Longo DL
* Dynamic Contrast Enhancement (DCE) MRI-Derived Renal Perfusion and Filtration: Basic Concepts (26 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 205-227.
Impact Factor: 1.17
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Pavuluri KD, Consolino L, Longo DL, Irrera P, Sun PZ, Mcmahon MT
* Renal pH Mapping Using Chemical Exchange Saturation Transfer (CEST) MRI: Experimental Protocol (11 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 455-471.
Impact Factor: 1.17
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Tear LR, Carrera C, Gianolio E, Aime S
* Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues (73 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2020 May 12; 26(27): 6056-6063.
Impact Factor: 4.857
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Granato L, Longo D, Boutry S, Vander Elst L, Henoumont C, Aime S, Muller RN, Laurent S
* Synthesis and Relaxometric Characterization of New Poly[N, N-bis(3-aminopropyl)glycine] (PAPGly) Dendrons Gd-Based Contrast Agents and Their in Vivo Study by Using the Dynamic Contrast-Enhanced MRI Technique at Low Field (1 T) (135 views)
Chem Biodivers (ISSN: 1612-1872linking), 2019 Nov; 16(11): e1900322-e1900322.
Impact Factor: 1.449
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Cocozza S, Pontillo G, Lanzillo R, Russo C, Petracca M, Di Stasi M, Paolella C, Vola EA, Criscuolo C, Moccia M, Lamberti A, Monti S, Brescia Morra V, Elefante A, Palma G, Tedeschi E, Brunetti A
* MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis (282 views)
Neuroradiology (ISSN: 0028-3940linking, 1432-1920electronic), 2019 Feb; 61(2): 155-162.
Impact Factor: 1.287
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Baroni S, Ruggiero MR, Aime S, Geninatti Crich S
* Exploring the tumour extracellular matrix by in vivo Fast Field Cycling relaxometry after the administration of a Gadolinium-based MRI contrast agent (242 views)
Magn Reson Chem (ISSN: 0749-1581linking), 2019 Jan 24; N/D: N/D-N/D.
Impact Factor: 1.601
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Squeglia F, Ruggiero A, Berisio R
* Collagen degradation in tuberculosis pathogenesis: the biochemical consequences of hosting an undesired guest (387 views)
Biochem J (ISSN: 1470-8728electronic, 0264-6021linking, 0264-6021print), 2018 Oct 11; 475(19): 3123-3140.
Impact Factor: 4.897
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Ugga L, Romeo V, Tedeschi E, Brunetti A, Quarantelli M
* Superparamagnetic iron oxide nanocolloids in MRI studies of neuroinflammation (363 views)
J Neurosci Methods (ISSN: 0165-0270linking, 1872-678xelectronic), 2018 Jun 18; 310: 12-23.
Impact Factor: 2.668
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Dastru W, Menchise V, Ferrauto G, Fabretto S, Carrera C, Terreno E, Aime S, Delli Castelli D
* Modulation of the Prototropic Exchange Rate in pH-Responsive Yb-HPDO3A Derivatives as ParaCEST Agents (219 views)
Chemistryselect (ISSN: 2365-6549), 2018 Jun; 3(22): 6035-6041.
Impact Factor: 1.505
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Di Gregorio E, Ferrauto G, Furlan C, Lanzardo S, Nuzzi R, Gianolio E, Aime S
* The Issue of Gadolinium Retained in Tissues: Insights on the Role of Metal Complex Stability by Comparing Metal Uptake in Murine Tissues Upon the Concomitant Administration of Lanthanum- and Gadolinium-Diethylentriamminopentaacetate (200 views)
Invest Radiol (ISSN: 1536-0210electronic, 0020-9996linking), 2018 Mar; 53(3): 167-172.
Impact Factor: 4.85
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Arena F, Bardini P, Blasi F, Gianolio E, Marini G, Aime S
* Gadolinium deposition, MRI hyperintensities, and glucose uptake in the hypoperfused rat brain after repeated administrations of Gadodiamide (185 views)
Neuroradiolgy, 2018; N/D: N/D-N/D.
Impact Factor: 2.346
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Tedeschi E, Cocozza S, Borrelli P, Ugga L, Morra VB, Palma G
* Longitudinal assessment of dentate nuclei relaxometry during massive gadobutrol exposure (292 views)
Magn Reson Med Sci (ISSN: 1347-3182), 2018; 17(1): 100-104.
Impact Factor: 0
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (361 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
* Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (464 views)
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Impact Factor: 5.158
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Gianolio E, Bardini P, Arena F, Stefania R, Di Gregorio E, Iani R, Aime S
* Gadolinium Retention in the Rat Brain: Assessment of the Amounts of Insoluble Gadolinium-containing Species and Intact Gadolinium Complexes after Repeated Administration of Gadolinium-based Contrast Agents (317 views)
Radiology (ISSN: 0033-8419, 1527-1315), 2017 Dec; 285(3): 839-849.
Impact Factor: 7.469
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Srivastava K, Ferrauto G, Young Vg J, Aime S, Pierre VC
* Eight-Coordinate, Stable Fe(II) Complex as a Dual (19)F and CEST Contrast Agent for Ratiometric pH Imaging (197 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2017 Oct 16; 56(20): 12206-12213.
Impact Factor: 4.7
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Longo DL, Stefania R, Aime S, Oraevsky A
* Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications (319 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2017 Aug 7; 18(8): N/D-N/D.
Impact Factor: 3.687
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Diaferia C, Gianolio E, Sibillano T, Mercurio FA, Leone M, Giannini C, Balasco N, Vitagliano L, Morelli G, Accardo A
* Cross-beta nanostructures based on dinaphthylalanine Gd-conjugates loaded with doxorubicin (413 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Mar 22; 7(1): 307-307.
Impact Factor: 4.122
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (737 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
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Longo DL, Moustaghfir FZ, Zerbo A, Consolino L, Anemone A, Bracesco M, Aime S
* EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging (454 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
Impact Factor: 3.862
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Anemone A, Consolino L, Longo DL
* MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent (180 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2017; 27(5): 2170-2179.
Impact Factor: 4.027
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Consolino L, Longo DL, Sciortino M, Dastru W, Cabodi S, Giovenzana GB, Aime S
* Assessing tumor vascularization as a potential biomarker of imatinib resistance in gastrointestinal stromal tumors by dynamic contrast-enhanced magnetic resonance imaging (263 views)
Gastric Cancer (ISSN: 1436-3291, 1436-3291linking), 2016 Dec 19; 20(4): 629-639.
Impact Factor: 5.454
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Filippi M, Boido M, Pasquino C, Garello F, Boffa C, Terreno E
* Successful in vivo MRI tracking of MSCs labeled with Gadoteridol in a Spinal Cord Injury experimental model (277 views)
Exp Neurol (ISSN: 0014-4886), 2016 Aug; 282: 66-77.
Impact Factor: 4.706
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Tedeschi E, Palma G, Canna A, Cocozza S, Russo C, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Morra VB, Salvatore M, Brunetti A, Quarantelli M
* In vivo dentate nucleus MRI relaxometry correlates with previous administration of Gadolinium-based contrast agents (442 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2016 Feb 23; 26(12): 4577-4584.
Impact Factor: 3.967
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Accardo A, Arena F, Gianolio E, Marasco D, Ringhieri P, Boffa C, Bardini P, Aime S, Morelli G
* Diolein based nanostructures as targeted theranostics (446 views)
J Biomed Nanotechnol (ISSN: 1550-7033), 2016; 12(5): 1076-1088.
Impact Factor: 4.521
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Consolino L, Longo DL, Dastrù W, Cutrin JC, Dettori D, Lanzardo S, Oliviero S, Cavallo F, Aime S
* Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer by dynamic contrast enhanced magnetic resonance imaging (308 views)
Int J Cancer (ISSN: 0020-7136), 2016; N/D: N/D-N/D.
Impact Factor: 6.513
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Zinnhardt B, Viel T, Wachsmuth L, Vrachimis A, Wagner S, Breyholz HJ, Faust A, Hermann S, Kopka K, Faber C, Dolle F, Pappata S, Planas AM, Tavitian B, Schafers M, Sorokin LM, Kuhlmann MT, Jacobs AH
* Multimodal imaging reveals temporal and spatial microglia and matrix metalloproteinase activity after experimental stroke (318 views)
J Cerebr Blood F Met (ISSN: 0271-678x), 2015 Nov; 35(11): 1711-1721.
Impact Factor: 4.929
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Longo DL, Arena F, Consolino L, Minazzi P, Geninatti-crich S, Giovenzana GB, Aime S
* Gd-AAZTA-MADEC, an improved blood pool agent for DCE-MRI studies on mice on 1 T scanners (418 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2015 Oct 16; 75: 47-57.
Impact Factor: 8.387
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Delli Castelli D, Ferrauto G, Di Gregorio E, Terreno E, Aime S
* Sensitive MRI detection of internalized T contrast agents using magnetization transfer contrast (247 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2015 Oct 16; N/D: N/D-N/D.
Impact Factor: 2.983
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Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
* In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (284 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
Impact Factor: 4.887
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Erra P, Puglia M, Ragozzino A, Maurea S, Liuzzi R, Sabino G, Barbuto L, Cuocolo A, Imbriaco M
* Appearance of hepatocellular carcinoma on gadoxetic acid-enhanced hepato-biliary phase MR imaging: a systematic review (259 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 0033-8362linking), 2015 Apr 22; 120(11): 1002-1011.
Impact Factor: 1.523
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Romeo V, Esposito A, Maurea S, Camera L, Mainenti PP, Palmieri G, Buonerba C, Salvatore M
* Correlative Imaging in a Patient with Cystic Thymoma: CT, MR and PET/CT Comparison (393 views)
Pol J Radiol (ISSN: 0137-7183, 1733-134x, 1733-134xlinking), 2015 Jan 13; 80(1): 22-26.
Impact Factor: 0.567
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Longo DL, Dastrù W, Consolino L, Espak M, Arigoni M, Cavallo F, Aime S
* Cluster analysis of quantitative parametric maps from DCE-MRI: Application in evaluating heterogeneity of tumor response to antiangiogenic treatment (488 views)
Magn Reson Imaging (ISSN: 0730-725x), 2015; 33(6): 725-736.
Impact Factor: 1.98
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Tedeschi E, Russo C, Cocozza S, Palma G, Canna A, Borrelli P, Lanzillo R, Angelini V, Postiglione E, Brescia Morra V, Brunetti A, Salvatore M
* Does Gadolinium Change the Relaxometry of the Dentate Nuclei? A Quantitative Multi-parametric MRI Study (321 views)
Rsna 101st Scientific Assembly And Annual Meeting, 2015; N/D: N/D-N/D.
Impact Factor: 0
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Maurea S, Mainenti PP, Tambasco A, Imbriaco M, Mollica C, Laccetti E, Camera L, Liuzzi R, Salvatore M
* Diagnostic accuracy of MR imaging to identify and characterize focal liver lesions: comparison between gadolinium and superparamagnetic iron oxide contrast media (292 views)
Quant Imaging Med Surg (ISSN: 2223-4292, 2223-4292print, 2223-4306linking), 2014 Jun; 4(3): 181-189.
Impact Factor: 3.105
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Accardo A, Ringhieri P, Szekely N, Pipich V, Luchini A, Paduano L, Tesauro D
* Structural insights on nanoparticles containing gadolinium complexes as potential theranostic (454 views)
Colloid Polym Sci (ISSN: 0303-402x), 2014 May; 292(5): 1121-1127.
Impact Factor: 1.865
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (768 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
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Ristori G, Romano S, Cannoni S, Visconti A, Tinelli E, Mendozzi L, Cecconi P, Lanzillo R, Quarantelli M, Buttinelli C, Gasperini C, Frontoni M, Coarelli G, Caputo D, Bresciamorra V, Vanacore N, Pozzilli C, Salvetti M
* Effects of Bacille Calmette-Guerin after the first demyelinating event in the CNS (527 views)
Neurology (ISSN: 0028-3878, 1526-632x, 0028-3878linking), 2014 Jan 7; 82(1): 41-48.
Impact Factor: 8.185
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Ciarmiello A, Gaeta MC, Meniconi M, Milano A, Alfano B, Del Vecchio S, Salvatore M
* Parametric MR dynamic imaging for breast lesions characterization and prediction of lymph nodes involvement (341 views)
Curr Radiopharm (ISSN: 1874-4710, 1874-4729), 2014; 7(2): 91-99.
Impact Factor: 0.643
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Iodice D, Di Donato O, Liccardo I, Lamanna L, Segreto S, Salvatore M, Imbriaco M
* Prevalence of extramammary findings on breast MRI: a large retrospective single-centre study (362 views)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 2013 Oct; 118(7): 1109-1118.
Impact Factor: 1.368
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Mancini M, Greco A, Salvatore G, Liuzzi R, Di Maro G, Vergara E, Chiappetta G, Pasquinelli R, Brunetti A, Salvatore M
* Imaging of thyroid tumor angiogenesis with microbubbles targeted to vascular endothelial growth factor receptor type 2 in mice (481 views)
Bmc Med Imaging (ISSN: 1471-2342, 1471-2342electronic), 2013 Sep 12; 13(1): 31-31.
Impact Factor: 0.983
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Gargiulo P, Dellegrottaglie S, Bruzzese D, Savarese G, Scala O, Ruggiero D, D'Amore C, Paolillo S, Agostoni P, Bossone E, Soricelli A, Cuocolo A, Trimarco B, Perrone Filardi P
* The prognostic value of normal stress cardiac magnetic resonance in patients with known or suspected coronary artery disease: a meta-analysis (467 views)
Circ Cardiovasc Imaging (ISSN: 1942-0080, 1941-9651), 2013 Jul; 6(4): 574-582.
Impact Factor: 6.752
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Catanzaro V, Gringeri CV, Menchise V, Padovan S, Boffa C, Dastru W, Chaabane L, Digilio G, Aime S
* A R2p/R1p ratiometric procedure to assess matrix metalloproteinase-2 activity by magnetic resonance imaging (395 views)
Angew Chem Int Ed (ISSN: 1433-7851, 1521-3773electronic, 1433-7851linking), 2013 Apr 2; 52(14): 3926-3930.
Impact Factor: 11.336
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Castiglione F, Mainenti PP, De Palma GD, Testa A, Bucci L, Pesce G, Camera L, Diaferia M, Rea M, Caporaso N, Salvatore M, Rispo A
* Noninvasive diagnosis of small bowel crohn's disease: Direct comparison of bowel sonography and magnetic resonance enterography (471 views)
Inflamm Bowel Dis (ISSN: 1078-0998, 1536-4844electronic, 1078-0998linking), 2013 Apr; 19(4): 991-998.
Impact Factor: 5.475
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Mancini M, Di Donato O, Saldalamacchia G, Liuzzi R, Rivellese A, Salvatore M
* Contrast-enhanced ultrasound evaluation of peripheral microcirculation in diabetic patients: effects of cigarette smoking (408 views)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 2013 Mar; 118(2): 206-214.
Impact Factor: 1.368
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Accardo A, Gianolio E, Arena F, Barnert S, Schubert R, Tesauro D, Morelli G
* Nanostructures based on monoolein or diolein and amphiphilic gadolinium complexes as MRI contrast agents (412 views)
J Mater Chem B (ISSN: 2050-7518, 2050-750x), 2013; 1(5): 617-628.
Impact Factor: 8.535
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (932 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Maurea S, Fusari M, Imbriaco M, Camera L, Mainenti PP, Campione S, Santangelo M, Salvatore M
* Pitfalls in diagnostic imaging of cystic pancreatic masses: a case of true cystic lesion mimicking a mucinous cystadenoma (334 views)
Jop (ISSN: 1590-8577, 1590-0857), 2012 Jan 10; 13(1): 83-86.
Impact Factor: 0
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Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* MR Contrast Agents (334 views)
Mol Pharm (ISSN: 1543-8384), 2011 Sep; 8(5): 1750-1756.
Impact Factor: 4.782
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Malvindi MA, Greco A, Conversano F, Figuerola A, Corti M, Bonora M, Lascialfari A, Doumari HA, Moscardini M, Cingolani R, Gigli G, Casciaro S, Pellegrino T, Ragusa A
* MR Contrast Agents (292 views)
Small Animal Imaging, 2011 Jul 8; 21(13): 2548-2555.
Impact Factor: 1.784
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (554 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (345 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Accardo A, Morisco A, Tesauro D, Pedone C, Morelli G
* Naposomes: A new class of peptide-derivatized, target-selective multimodal nanoparticles for imaging and therapeutic applications (408 views)
Ther Deliv (ISSN: 2041-5990), 2011 Feb; 2(2): 235-257.
Impact Factor: 0
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Menchise V, Digilio G, Gianolio E, Cittadino E, Catanzaro V, Carrera C, Aime S
* In vivo labeling of B16 melanoma tumor xenograft with a thiol-reactive gadolinium based MRI contrast agent (525 views)
Mol Pharm (ISSN: 1543-8384), 2011; 8(5): 1750-1756.
Impact Factor: 4.782
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (433 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Digilio G, Menchise V, Gianolio E, Catanzaro V, Carrera C, Napolitano R, Fedeli F, Aime S
* Exofacial protein thiols as a route for the internalization of Gd(III)-based complexes for magnetic resonance imaging cell labeling (455 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2010 Jul 8; 53(13): 4877-4890.
Impact Factor: 5.207
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (489 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (596 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Mainenti PP, Segreto S, Mancini M, Rispo A, Cozzolino I, Masone S, Rinaldi CR, Nardone G, Salvatore M
* Intestinal amyloidosis: two cases with different patterns of clinical and imaging presentation (386 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2010 May 28; 16(20): 2566-2570.
Impact Factor: 2.24
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Lanzillo R, Orefice G, Quarantelli M, Rinaldi C, Prinster A, Ventrella G, Spitaleri D, Lus G, Vacca G, Carotenuto B, Salvatore E, Brunetti A, Tedeschi G, Brescia Morra V
* Atorvastatin combined to interferon to verify the efficacy (ACTIVE) in relapsing-remitting active multiple sclerosis patients: A longitudinal controlled trial of combination therapy (543 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2010 Apr; 16(4): 450-454.
Impact Factor: 4.23
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Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (415 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1227-1235.
Impact Factor: 2.605
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Accardo A, Tesauro D, Aloj L, Pedone C, Morelli G
* Supramolecular aggregates containing lipophilic Gd(III) complexes as contrast agents in MRI (591 views)
Coord Chem Rev (ISSN: 0010-8545), 2009 Sep; 253(17-18): 2193-2213.
Impact Factor: 11.225
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (14494 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (417 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Accardo A, Tesauro D, Morisco A, Mangiapia G, Vaccaro M, Gianolio E, Heenan RK, Paduano L, Morelli G
* Micelles obtained by aggregation of gemini surfactants containing the CCK8 peptide and a gadolinium complex (398 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257linking), 2009 May; 14(4): 587-599.
Impact Factor: 3.415
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Maurea S, Caleo O, Mollica C, Imbriaco M, Mainenti PP, Palumbo C, Mancini M, Camera L, Salvatore M
* Comparative diagnostic evaluation with MR cholangiopancreatography, ultrasonography and CT in patients with pancreatobiliary disease (346 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2009 Apr; 114(3): 390-402.
Impact Factor: 1.454
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (402 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
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Digilio G, Catanzaro V, Fedeli F, Gianolio E, Menchise V, Napolitano R, Gringeri C, Aime S
* Targeting exofacial protein thiols with Gd-III complexes. An efficient procedure for MRI cell labelling (344 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2009 Feb 28; (8): 893-895.
Impact Factor: 5.504
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Vaccaro M, Mangiapia G, Radulescu A, Schillen K, D'Errico G, Morelli G, Paduano L
* Colloidal particles composed of amphiphilic molecules binding gadolinium complexes and peptides as tumor-specific contrast agents in MRI: physico-chemical characterization (528 views)
Soft Matter (ISSN: 1744-683x), 2009; 5(13): 2504-2512.
Impact Factor: 4.869
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Mancini M, Speranza A, Greco A, Salvatore M
* Effects Of High Frequency Ultrasound On Echogenicity Of Ultrasound Contrast Agents Solutions (254 views)
Endocrinology, 2009; 35(8S): 221-221.
Impact Factor: 4.503
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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (458 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Vaccaro M, Mangiapia G, Accardo A, Tesauro D, Gianolio E, Frielinghaus H, Morelli G, Paduano L
* Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide (423 views)
Colloid Polym Sci (ISSN: 0303-402x), 2008 Dec; 286(14-15): 1643-1652.
Impact Factor: 1.736
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Imbriaco M, Caprio MG, Limite G, Pace L, De Falco T, Capuano E, Salvatore M
* Dual-time-point 18F-FDG PET/CT versus dynamic breast MRI of suspicious breast lesions (290 views)
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2008 Nov; 191(5): 1323-1330.
Impact Factor: 2.94
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Fonti R, Salvatore B, Quarantelli M, Sirignano C, Segreto S, Petruzziello F, Catalano L, Liuzzi R, Rotoli B, Del Vecchio S, Pace L, Salvatore M
* F-18-FDG PET/CT, Tc-99m-MIBI, and MRI in evaluation of patients with multiple myeloma (546 views)
J Nucl Med (ISSN: 0161-5505, 0161-1550, 1535-5667), 2008 Feb; 49(2): 195-200.
Impact Factor: 6.662
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Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (367 views)
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.
Impact Factor: 0.481
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Frasca F, Nucera C, Pellegriti G, Gangemi P, Attard M, Stella M, Loda M, Vella V, Giordano C, Trimarchi F, Mazzoni E, Belfiore A, Vigneri R
* BRAF(V600E) mutation and the biology of papillary thyroid cancer (544 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2008; 15(1): 191-205.
Impact Factor: 5.236
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Vaccaro M, Mangiapia G, Paduano L, Gianolio E, Accardo A, Tesauro D, Morelli G
* Structural and relaxometric characterization of peptide aggregates containing gadolinium complexes as potential selective contrast agents in MRI (573 views)
Chemphyschem (ISSN: 1439-4235, 1439-7641, 1439-7641electronic), 2007 Dec 3; 8(17): 2526-2538.
Impact Factor: 3.502
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Ragozzino A, Lassandro F, De Ritis R, Imbriaco M
* Value of MRI in three patients with major vascular injuries after laparoscopic cholecystectomy (250 views)
Emergency Radiology (ISSN: 1070-3004), 2007 Nov; 14(6): 443-447.
Impact Factor: 6.214
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Vaccaro M, Accardo A, D'Errico G, Schillen K, Radulescu A, Tesauro D, Morelli G, Paduano L
* Peptides and gd complexes containing colloidal assemblies as tumor-specific contrast agents in MRI: Physicochemical characterization (399 views)
Biophysical Journal (ISSN: 0006-3495, 1542-0086), 2007 Sep; 93(5): 1736-1746.
Impact Factor: 4.627
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Pastore C, Franzese M, Sica F, Temussi P, Pastore A
* Understanding the binding properties of an unusual metal-binding protein - a study of bacterial frataxin (408 views)
Febs Journal (ISSN: 1742-464x), 2007 Sep; 274(16): 4199-4210.
Impact Factor: 3.396
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Tesauro D, Accardo A, Gianolio E, Paduano L, Teixeira J, Schillén K, Aime S, Morelli G
* Peptide derivatized lamellar aggregates as target-specific MRI contrast agents (580 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 950-955.
Impact Factor: 3.446
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (351 views)
Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
Impact Factor: 3.664
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Accardo A, Tesauro D, Morelli G, Gianolio E, Aime S, Vaccaro M, Mangiapia G, Paduano L, Schillén K
* High-relaxivity supramolecular aggregates containing peptides and Gd complexes as contrast agents in MRI (423 views)
J Biol Inorg Chem (ISSN: 0949-8257, 1432-1327electronic, 0949-8257print), 2007 Feb; 12(2): 267-276.
Impact Factor: 3.325
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (321 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases (415 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2006 Dec; 41(12): 1561-1569.
Impact Factor: 2.945
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Del Giudice E, Bianchi MC, Tosetti M, Varrone A, Romano A, Crisanti AF, Titomanlio L, Imperati F
* Taylor-type focal cortical dysplasia: is the epilepsy always resistant to medical treatment? (325 views)
Epileptic Disord (ISSN: 1294-9361), 2006 Dec; 8(4): 289-293.
Impact Factor: 1.202
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Maurea S, Imbriaco M, D'Angelillo M, Mollica C, Camera L, Salvatore M
* Diagnostic accuracy of chemical-shift MR imaging to differentiate between adrenal adenomas and non adenoma adrenal lesions (326 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2006 Sep; 111(5): 674-686.
Impact Factor: 1.368
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Vaccaro M, Accardo A, Tesauro D, Mangiapia G, Loef D, Schillen K, Soederman O, Morelli G, Paduan L
* Supramolecular aggregates of amphiphilic gadolinium complexes as blood pool MRI/MRA contrast agents: Physicochemical characterization (441 views)
Langmuir (ISSN: 0743-7463), 2006 Jul 18; 22(15): 6635-6643.
Impact Factor: 3.902
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Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (575 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
Impact Factor: 3.574
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Cucinotta V, Giuffrida A, Maccarrone G, Messina M, Puglisi A, Rizzarelli E, Vecchio G
* Coordination properties of 3-functionalized β-cyclodextrins. Thermodynamic stereoselectivity of copper(II) complexes of the A, B-diamino derivative and its exploitation in LECE (356 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Sep 21; (16): 2731-2736.
Impact Factor: 3.003
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Morelli G, Accardo A, Tesauro D, Pedone C, Mangiapia G, Paduano L, Gianolio E
* Multicomponent aggregates containing the CCK8 bioactive peptide and Gd complexes as target-specific MRI contrast agents (279 views)
Peptides 2004 Proceedings, 2005; N/D: N/D-N/D.
Impact Factor: 0
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Impellizzeri G, D'Alessandro F, Pappalardo G, Tringali C
* Synthesis And Structural Characterisation Of Two Novel Diastereoisomeric Naproxen-Appended Beta-Cyclodextrin Derivatives (346 views)
J Incl Phenom (ISSN: 0923-0750), 2005; 51(3-4): 173-180.
Impact Factor: 1.02
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Puglisi A, Tabbì G, Vecchio G
* Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity (410 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jun; 98(6): 969-976.
Impact Factor: 2.225
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Accardo A, Tesauro D, Roscigno P, Gianolio E, Paduano L, D'Errico G, Pedone C, Morelli G
* Physicochemical Properties of Mixed Micellar Aggregates Containing CCK Peptides and Gd Complexes Designed as Tumor Specific Contrast Agents in MRI (452 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2004 Mar 17; 126(10): 3097-3107.
Impact Factor: 6.903
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Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (414 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
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Maurea S, Caracò C, Klain M, Mainolfi C, Salvatore M
* Imaging characterization of non-hypersecreting adrenal masses. Comparison between MR and radionuclide techniques (348 views) (PDF 247 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2004; 48(3): 188-197.
Impact Factor: 1.724
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Mangiapia G, Accardo A, Celso FL, Tesauro D, Morelli G, Radulescu A, Paduano L
* Mixed micelles composed of peptides and gadolinium complexes as tumor-specific contrast agents in MRI: A sans study (587 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2004; 108(45): 17611-17617.
Impact Factor: 3.834
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Camera L, Bresciani M, Soscia E, Percopo V, Mainenti PP, Salvatore M
* Morphological imaging of gastroenteropancreatic neuroendocrine tumours (256 views)
Minerva Endocrinol (ISSN: 0391-1977, 1827-1634electronic, 0391-1977linking), 2001 Sep; 26(3): 123-128.
Impact Factor: 1.464
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Imbriaco M, Del Vecchio S, Riccardi A, Pace L, Di Salle F, Di Gennaro F, Salvatore M, Sodano A
* Scintimammography with Tc-99m-MIBI versus dynamic MRI for non-invasive characterization of breast masses (606 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2001 Jan; 28(1): 56-63.
Impact Factor: 3.464
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Bonomo RP, Cucinotta V, D'Alessandro F, Impellizzeri G, Maccarrone G, Rizzarelli E, Vecchio G, Carima L, Corradini R, Sartor G, Marchelli R
Chiral recognition by the copper(ii) complex of 6-deoxy-6-n-(2 - methylaminopyridine)-β-cyclodextrin (378 views)
Chirality (ISSN: 0899-0042), 1997; 9(4): 341-349.
Impact Factor: 1.915
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Brunetti A, Alfano B, Soricelli A, Tedeschi E, Mainolfi C, Covelli EM, Aloj L, Panico M, Bazzicalupo L, Salvatore M
Functional characterization of brain tumors: An overview of the potential clinical value (730 views) (PDF 245 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 699-715.
Impact Factor: 1.042
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Di Blasio B, Galdiero S, Saviano M, Pedone C, Benedetti E, Rizzarelli E, Pedotti S, Vecchio G, Gibbons WA
Synthesis And Structural Characterization Of 6i, 6ii-Diamino-6i, 6ii-Dideoxy-Cyclomaltoheptaose, A Difunctionalized Beta-Cyclodextrin (426 views)
Carbohydr Res, 1996 Feb 28; 282(1): 41-52.
Impact Factor: 0
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DALESSANDRO F, GULINO F, IMPELLIZZERI G, PAPPALARDO G, RIZZARELLI E, SCIOTTO D, VECCHIO G
A new water soluble host compound possessing two different hydrophobic recognition cavities: Calix[4]arene derivative conjugated with monofunctionalized β-cyclodextrin (425 views)
Tetrahedron Lett (ISSN: 0040-4039), 1994 Jan 24; 35(4): 629-632.
Impact Factor: 2.5
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Cucinotta V, Mangano A, Nobile G, Santoro AM, Vecchio G
New platinum(II) complexes of β-cyclodextrin diamine derivatives and their antitumor activity (468 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Nov 15; 52(3): 183-190.
Impact Factor: 1.342
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Di Blasio B, Pavone V, Nastri F, Isernia C, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
Conformation for a β-cyclodextrin monosubstituted with a cyclic dipeptide (485 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 1992 Sep 1; 89(15): 7218-7221.
Impact Factor: 9.04
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114 Records (111 excluding Abstracts).
Total impact factor: 396.643 (389.157 excluding Abstracts).
Total 5 year impact factor: 424.474 (416.48 excluding Abstracts).
Total impact factor: 396.643 (389.157 excluding Abstracts).
Total 5 year impact factor: 424.474 (416.48 excluding Abstracts).
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