Hairpin ODN-based ligands as potential inhibitors of HMGB1 cytokine activity (435 views)
Rsc Adv (ISSN: 2046-2069), 2013; 3(30): 12176-12184.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.708, 5-year impact factor: 3.708
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84881523430&partnerID=40&md5=e5083493c20f9c665f62871ad3952f20
Keywords: Cytokine Activity, Enzymatic Stability, High-Mobility Groups, Hydrodynamic Volumes, Inflammatory Disease, Nuclear Proteins, Pharmacokinetic Properties, Potential Inhibitors, Bioactivity, Biosynthesis, Ethylene Glycol, Optimization, Plasma Stability, Polyols, Ligands,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario di Monte, via Cintia 21, Sant'Angelo, Napoli I-80126, Italy
Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, I-80134 Napoli, Italy
Bionucleon Srl, via Ribes 5, I-10010 Colleretto Giacosa (TO), Italy
References:
Musumeci, D., Valente, M., Bucci, E.M., (2006) Screening, 2, p. 3
Bucci, E.M., Valente, M., Musumeci, D., Sapio, R., Anrò, V., Roviello, G.N., Moccia, M., (2007) Nucleosides, Nucleotides Nucleic Acids, 26, p. 1047
Agresti, A., Bianchi, M.E., (2003) Curr. Opin. Genet. Dev., 13, p. 170
Muller, S., Ronfani, L., Bianchi, M.E., (2004) J. Intern. Med., 255, p. 332
Andersson, U., Erlandsson-Harris, H., Yang, H., Tracey, K.J., (2002) J. Leukoc. Biol., 72, p. 1084
Shingo, Y., Ikuro, M., (2007) Clin. Chim. Acta, 375, p. 36
Scaffidi, P., Misteli, T., Bianchi, M.E., (2002) Nature, 418, p. 191
Palumbo, R., Sampaolesi, M., De Marchis, F., Tonlorenzi, R., Colombetti, S., Mondino, A., Cossu, G., Bianchi, M.E., (2004) J. Cell Biol., 164, p. 441
Wang, H., Yang, H., Tracey, K.J., (2004) J. Intern. Med., 255, p. 320
Voll, R.E., Urbonaviciute, V., Furnrohr, B., Herrmann, M., Kalden, J.R., (2008) Curr. Rheumatol. Rep., 10, p. 341
Pisetsky, D.S., Erlandsson-Harris, H., Andersson, U., (2008) Arthritis Res. Ther., 10, p. 209
Andersson, U., Harris, H.E., (2010) Biochim. Biophys. Acta, 1799, p. 141
Sunden-Cullberg, J., Norrby-Teglund, A., Rouhiainen, A., Rauvala, H., Herman, G., Tracey, K.J., Lee, M.L., Treutiger, C.J., (2005) Crit. Care Med., 33, p. 564
Goldstein, R.S., Bruchfeld, A., Yang, L., Qureshi, A.R., Gallowitsch-Puerta, M., Patel, N.B., Huston, B.J., Tracey, K.J., (2007) Mol. Med., 13, p. 210
Li, W., Sama, A.E., Wang, H., (2006) Curr. Opin. Pharmacol., 6, p. 130
Bruchfeld, A., Qureshi, A.R., Lindholm, B., Barany, P., Yang, L., Stenvinkel, P., Tracey, K.J., (2008) Mol. Med., 14, p. 109
Jiang, W., Pisetsky, D.S., (2008) Ann. Rheum. Dis., 67, p. 727
Li, J., Xie, H., Wen, T., Liu, H., Zhu, W., Chen, X., (2010) J. Rheumatol., 37, p. 766
Ellerman, J.E., Brown, C.K., De Vera, M., Zeh, H.J., Billiar, T., Rubartelli, A., Lotze, M.T., (2007) Clin. Cancer Res., 13, p. 2836
Tang, D., Kang, R., Zeh III, H.J., Lotze, M.T., (2010) Biochim. Biophys. Acta, 1799 (12), p. 131
Kokkola, R., Andersson, A., Mullins, G., Ostberg, T., Treutiger, C.J., Arnold, B., Nawroth, P., Harris, H.E., (2005) Scand. J. Immunol., 61, p. 1
Todorova, J., Pasheva, E., (2012) Oncol. Lett., 3, p. 214
Kokkola, R., Li, J., Sundberg, E., Aveberger, A.C., Palmblad, K., Yang, H., Tracey, K.J., Harris, H.E., (2003) Arthritis Rheum., 48, p. 2052
Yang, H., Ochani, M., Li, J., Qiang, X., Tanovic, M., Harris, H.E., Susarla, S.M., Diraimo, R., (2004) Proc. Natl. Acad. Sci. USA, 101, p. 296
Gong, W., Zheng, Y., Chao, F., Li, Y., Xu, Z., Huang, G., Gao, X., He, F., (2010) J. Biomed. Biotechnol., 2010, p. 915234
Arumugam, T., Ramachandran, V., Gomez, S.B., Schmidt, A.M., Logsdon, C.D., (2012) Clin. Cancer Res., 18, p. 4356
Schierbeck, H., Lundbäck, P., Palmblad, K., Klevenvall, L., Erlandsson-Harris, H., Andersson, U., Ottosson, L., (2011) Mol. Med., 17, p. 1039
Mollica, L., De Marchis, F., Spitaleri, A., Dallacosta, C., Pennacchini, D., Zamai, M., Agresti, A., Bianchi, M.E., (2007) Chem. Biol., 14, p. 431
Smolarczyk, R., Cichoń, T., Matuszczak, S., Mitrus, I., Lesiak, M., Kobusińska, M., Kamysz, W., Szala, S., (2012) Arch. Immunol. Ther. Exp., 60, p. 391
Du, D., Yan, J., Ren, J., Lv, H., Li, Y., Xu, S., Wang, Y., Yu, S., (2013) J. Med. Chem., 56, p. 97
Li, J., Kokkola, R., Tabibzadeh, S., Yang, R., Ochani, M., Qiang, X., Harris, H.E., Yang, H., (2003) Mol. Med., 9, p. 37
Bianchi, M.E., Beltrame, M., Paonessa, G., (1989) Science, 243, p. 1056
Musumeci, D., Bucci, E.M., Roviello, G.N., Sapio, R., Valente, M., Moccia, M., Bianchi, M.E., Pedone, C., (2011) Mol. BioSyst., 7, p. 1742
De Napoli, L., Di Fabio, G., Messere, A., Montesarchio, D., Musumeci, D., Piccialli, G., (1999) Tetrahedron, 55, p. 9899
De Napoli, L., Messere, A., Montesarchio, D., Pepe, A., Piccialli, G., Varra, M., (1997) J. Org. Chem., 62, p. 9024
Xodo, L.E., Manzini, G., Quadrifoglio, F., Van Der Marel, G., Van Boom, J., (1991) Nucleic Acids Res., 19, p. 1505
White, R.R., Sullenger, B.A., Rusconi, C.P., (2000) J. Clin. Invest., 106, p. 929
Keefe, A.D., Pai, S., Ellington, A., (2010) Nat. Rev. Drug Discovery, 9, p. 537
Cavaluzzi, J.M., Borer, P.N., (2004) Nucleic Acids Res., 32, p. 13
Bucci, E. M., Valente, M., Musumeci, D., Sapio, R., Anr, V., Roviello, G. N., Moccia, M., (2007) Nucleosides, Nucleotides Nucleic Acids, 26, p. 1047
Voll, R. E., Urbonaviciute, V., Furnrohr, B., Herrmann, M., Kalden, J. R., (2008) Curr. Rheumatol. Rep., 10, p. 341
Pisetsky, D. S., Erlandsson-Harris, H., Andersson, U., (2008) Arthritis Res. Ther., 10, p. 209
Goldstein, R. S., Bruchfeld, A., Yang, L., Qureshi, A. R., Gallowitsch-Puerta, M., Patel, N. B., Huston, B. J., Tracey, K. J., (2007) Mol. Med., 13, p. 210
Li, W., Sama, A. E., Wang, H., (2006) Curr. Opin. Pharmacol., 6, p. 130
Ellerman, J. E., Brown, C. K., De Vera, M., Zeh, H. J., Billiar, T., Rubartelli, A., Lotze, M. T., (2007) Clin. Cancer Res., 13, p. 2836
Bianchi, M. E., Beltrame, M., Paonessa, G., (1989) Science, 243, p. 1056
Xodo, L. E., Manzini, G., Quadrifoglio, F., Van Der Marel, G., Van Boom, J., (1991) Nucleic Acids Res., 19, p. 1505
White, R. R., Sullenger, B. A., Rusconi, C. P., (2000) J. Clin. Invest., 106, p. 929
Keefe, A. D., Pai, S., Ellington, A., (2010) Nat. Rev. Drug Discovery, 9, p. 537
Cavaluzzi, J. M., Borer, P. N., (2004) Nucleic Acids Res., 32, p. 13
Rsc Adv (ISSN: 2046-2069), 2013; 3(30): 12176-12184.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.708, 5-year impact factor: 3.708
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84881523430&partnerID=40&md5=e5083493c20f9c665f62871ad3952f20
Keywords: Cytokine Activity, Enzymatic Stability, High-Mobility Groups, Hydrodynamic Volumes, Inflammatory Disease, Nuclear Proteins, Pharmacokinetic Properties, Potential Inhibitors, Bioactivity, Biosynthesis, Ethylene Glycol, Optimization, Plasma Stability, Polyols, Ligands,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario di Monte, via Cintia 21, Sant'Angelo, Napoli I-80126, Italy
Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, I-80134 Napoli, Italy
Bionucleon Srl, via Ribes 5, I-10010 Colleretto Giacosa (TO), Italy
References:
Musumeci, D., Valente, M., Bucci, E.M., (2006) Screening, 2, p. 3
Bucci, E.M., Valente, M., Musumeci, D., Sapio, R., Anrò, V., Roviello, G.N., Moccia, M., (2007) Nucleosides, Nucleotides Nucleic Acids, 26, p. 1047
Agresti, A., Bianchi, M.E., (2003) Curr. Opin. Genet. Dev., 13, p. 170
Muller, S., Ronfani, L., Bianchi, M.E., (2004) J. Intern. Med., 255, p. 332
Andersson, U., Erlandsson-Harris, H., Yang, H., Tracey, K.J., (2002) J. Leukoc. Biol., 72, p. 1084
Shingo, Y., Ikuro, M., (2007) Clin. Chim. Acta, 375, p. 36
Scaffidi, P., Misteli, T., Bianchi, M.E., (2002) Nature, 418, p. 191
Palumbo, R., Sampaolesi, M., De Marchis, F., Tonlorenzi, R., Colombetti, S., Mondino, A., Cossu, G., Bianchi, M.E., (2004) J. Cell Biol., 164, p. 441
Wang, H., Yang, H., Tracey, K.J., (2004) J. Intern. Med., 255, p. 320
Voll, R.E., Urbonaviciute, V., Furnrohr, B., Herrmann, M., Kalden, J.R., (2008) Curr. Rheumatol. Rep., 10, p. 341
Pisetsky, D.S., Erlandsson-Harris, H., Andersson, U., (2008) Arthritis Res. Ther., 10, p. 209
Andersson, U., Harris, H.E., (2010) Biochim. Biophys. Acta, 1799, p. 141
Sunden-Cullberg, J., Norrby-Teglund, A., Rouhiainen, A., Rauvala, H., Herman, G., Tracey, K.J., Lee, M.L., Treutiger, C.J., (2005) Crit. Care Med., 33, p. 564
Goldstein, R.S., Bruchfeld, A., Yang, L., Qureshi, A.R., Gallowitsch-Puerta, M., Patel, N.B., Huston, B.J., Tracey, K.J., (2007) Mol. Med., 13, p. 210
Li, W., Sama, A.E., Wang, H., (2006) Curr. Opin. Pharmacol., 6, p. 130
Bruchfeld, A., Qureshi, A.R., Lindholm, B., Barany, P., Yang, L., Stenvinkel, P., Tracey, K.J., (2008) Mol. Med., 14, p. 109
Jiang, W., Pisetsky, D.S., (2008) Ann. Rheum. Dis., 67, p. 727
Li, J., Xie, H., Wen, T., Liu, H., Zhu, W., Chen, X., (2010) J. Rheumatol., 37, p. 766
Ellerman, J.E., Brown, C.K., De Vera, M., Zeh, H.J., Billiar, T., Rubartelli, A., Lotze, M.T., (2007) Clin. Cancer Res., 13, p. 2836
Tang, D., Kang, R., Zeh III, H.J., Lotze, M.T., (2010) Biochim. Biophys. Acta, 1799 (12), p. 131
Kokkola, R., Andersson, A., Mullins, G., Ostberg, T., Treutiger, C.J., Arnold, B., Nawroth, P., Harris, H.E., (2005) Scand. J. Immunol., 61, p. 1
Todorova, J., Pasheva, E., (2012) Oncol. Lett., 3, p. 214
Kokkola, R., Li, J., Sundberg, E., Aveberger, A.C., Palmblad, K., Yang, H., Tracey, K.J., Harris, H.E., (2003) Arthritis Rheum., 48, p. 2052
Yang, H., Ochani, M., Li, J., Qiang, X., Tanovic, M., Harris, H.E., Susarla, S.M., Diraimo, R., (2004) Proc. Natl. Acad. Sci. USA, 101, p. 296
Gong, W., Zheng, Y., Chao, F., Li, Y., Xu, Z., Huang, G., Gao, X., He, F., (2010) J. Biomed. Biotechnol., 2010, p. 915234
Arumugam, T., Ramachandran, V., Gomez, S.B., Schmidt, A.M., Logsdon, C.D., (2012) Clin. Cancer Res., 18, p. 4356
Schierbeck, H., Lundbäck, P., Palmblad, K., Klevenvall, L., Erlandsson-Harris, H., Andersson, U., Ottosson, L., (2011) Mol. Med., 17, p. 1039
Mollica, L., De Marchis, F., Spitaleri, A., Dallacosta, C., Pennacchini, D., Zamai, M., Agresti, A., Bianchi, M.E., (2007) Chem. Biol., 14, p. 431
Smolarczyk, R., Cichoń, T., Matuszczak, S., Mitrus, I., Lesiak, M., Kobusińska, M., Kamysz, W., Szala, S., (2012) Arch. Immunol. Ther. Exp., 60, p. 391
Du, D., Yan, J., Ren, J., Lv, H., Li, Y., Xu, S., Wang, Y., Yu, S., (2013) J. Med. Chem., 56, p. 97
Li, J., Kokkola, R., Tabibzadeh, S., Yang, R., Ochani, M., Qiang, X., Harris, H.E., Yang, H., (2003) Mol. Med., 9, p. 37
Bianchi, M.E., Beltrame, M., Paonessa, G., (1989) Science, 243, p. 1056
Musumeci, D., Bucci, E.M., Roviello, G.N., Sapio, R., Valente, M., Moccia, M., Bianchi, M.E., Pedone, C., (2011) Mol. BioSyst., 7, p. 1742
De Napoli, L., Di Fabio, G., Messere, A., Montesarchio, D., Musumeci, D., Piccialli, G., (1999) Tetrahedron, 55, p. 9899
De Napoli, L., Messere, A., Montesarchio, D., Pepe, A., Piccialli, G., Varra, M., (1997) J. Org. Chem., 62, p. 9024
Xodo, L.E., Manzini, G., Quadrifoglio, F., Van Der Marel, G., Van Boom, J., (1991) Nucleic Acids Res., 19, p. 1505
White, R.R., Sullenger, B.A., Rusconi, C.P., (2000) J. Clin. Invest., 106, p. 929
Keefe, A.D., Pai, S., Ellington, A., (2010) Nat. Rev. Drug Discovery, 9, p. 537
Cavaluzzi, J.M., Borer, P.N., (2004) Nucleic Acids Res., 32, p. 13
Bucci, E. M., Valente, M., Musumeci, D., Sapio, R., Anr, V., Roviello, G. N., Moccia, M., (2007) Nucleosides, Nucleotides Nucleic Acids, 26, p. 1047
Voll, R. E., Urbonaviciute, V., Furnrohr, B., Herrmann, M., Kalden, J. R., (2008) Curr. Rheumatol. Rep., 10, p. 341
Pisetsky, D. S., Erlandsson-Harris, H., Andersson, U., (2008) Arthritis Res. Ther., 10, p. 209
Goldstein, R. S., Bruchfeld, A., Yang, L., Qureshi, A. R., Gallowitsch-Puerta, M., Patel, N. B., Huston, B. J., Tracey, K. J., (2007) Mol. Med., 13, p. 210
Li, W., Sama, A. E., Wang, H., (2006) Curr. Opin. Pharmacol., 6, p. 130
Ellerman, J. E., Brown, C. K., De Vera, M., Zeh, H. J., Billiar, T., Rubartelli, A., Lotze, M. T., (2007) Clin. Cancer Res., 13, p. 2836
Bianchi, M. E., Beltrame, M., Paonessa, G., (1989) Science, 243, p. 1056
Xodo, L. E., Manzini, G., Quadrifoglio, F., Van Der Marel, G., Van Boom, J., (1991) Nucleic Acids Res., 19, p. 1505
White, R. R., Sullenger, B. A., Rusconi, C. P., (2000) J. Clin. Invest., 106, p. 929
Keefe, A. D., Pai, S., Ellington, A., (2010) Nat. Rev. Drug Discovery, 9, p. 537
Cavaluzzi, J. M., Borer, P. N., (2004) Nucleic Acids Res., 32, p. 13
Hairpin ODN-based ligands as potential inhibitors of HMGB1 cytokine activity
We here report the design, synthesis, and biological activity of a kinked hairpin-loop DNA acting at low nM concentrations as a strong inhibitor of HMGB1 (High-Mobility Group Box-1), a nuclear protein with cytokine activity in a number of inflammatory diseases. Lead compound optimization has been realized by inserting different oligo-ethylene glycol spacers at the 5′-end and loop positions of the natural hairpin DNA, in order to improve its enzymatic stability and structuring capability, as well as its overall pharmacokinetic properties. Thermal stability data as well as activity assays proved that the ODN which contained two hexa-ethylene glycol spacers, one at the 5′-end and the other in the loop, was the best candidate to inhibit HMGB1. Plasma stability assays and hydrodynamic volume measurements afforded further encouraging results in view of future in vivo evaluation of the optimized ligand. This journal is © The Royal Society of Chemistry 2013.
We here report the design, synthesis, and biological activity of a kinked hairpin-loop DNA acting at low nM concentrations as a strong inhibitor of HMGB1 (High-Mobility Group Box-1), a nuclear protein with cytokine activity in a number of inflammatory diseases. Lead compound optimization has been realized by inserting different oligo-ethylene glycol spacers at the 5′-end and loop positions of the natural hairpin DNA, in order to improve its enzymatic stability and structuring capability, as well as its overall pharmacokinetic properties. Thermal stability data as well as activity assays proved that the ODN which contained two hexa-ethylene glycol spacers, one at the 5′-end and the other in the loop, was the best candidate to inhibit HMGB1. Plasma stability assays and hydrodynamic volume measurements afforded further encouraging results in view of future in vivo evaluation of the optimized ligand. This journal is © The Royal Society of Chemistry 2013.
Hairpin ODN-based ligands as potential inhibitors of HMGB1 cytokine activity
Hairpin ODN-based ligands as potential inhibitors of HMGB1 cytokine activity
Other filter: ([btitle,keywords] "Cytokine Activity" O ...
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Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
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Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
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* New Perspectives on the Potential Role of Aquaporins (AQPs) in the Physiology of Inflammation (260 views)
Front Physiol (ISSN: 1664-042xprint, 1664-042xlinking), 2018 Feb 16; 9(FEB): 101-101.
Impact Factor: 4.134
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, D'Alessandro C, Pedone C
* Binding ability of a thymine-functionalized oligolysine towards nucleic acids (347 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2014 Feb 1; 22(3): 997-1002.
Impact Factor: 2.793
View Export to BibTeX Export to EndNote
Musumeci D, Oliviero G, Roviello GN, Bucci EM, Piccialli G
* G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays (754 views)
Bioconjug Chem (ISSN: 1043-1802, 1520-4812, 1520-4812electronic), 2012 Mar 21; 23(3): 382-391.
Impact Factor: 4.58
View Export to BibTeX Export to EndNote
Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (462 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Bombardieri E, Ambrosini V, Aktolun C, Baum RP, Bishof-delaloye A, Del Vecchio S, Maffioli L, Mortelmans L, Oyen W, Pepe G, Chiti A
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Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jul; 37(7): 1441-1448.
Impact Factor: 5.036
View Export to BibTeX Export to EndNote
5 Records (5 excluding Abstracts).
Total impact factor: 20.077 (20.077 excluding Abstracts).
Total 5 year impact factor: 16.136 (16.136 excluding Abstracts).
Total impact factor: 20.077 (20.077 excluding Abstracts).
Total 5 year impact factor: 16.136 (16.136 excluding Abstracts).
435 views. Last view on Thursday 23 March 2023, 12:07:48
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