Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells (591 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2014 Mar 12; 4: 4293-4293.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.578, 5-year impact factor: 5.597
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84896264352&partnerID=40&md5=cc5ff63303895a4dc006e430e7d0c965
Keywords: Antiinfective Agent, Antimicrobial Cationic Peptide, Cecropin A, Lipopolysaccharide, Magainin 2 Peptide, Xenopus, Magainin Derivative, Xenopus Protein, Animal, Article, Chemistry, Circular Dichroism, Escherichia Coli, Metabolism, Protein Folding, Protein Secondary Structure, Xenopus Laevis, Anti-Bacterial Agents, Protein Structure, Time Factors,
Affiliations:
*** IBB - CNR ***
Diagnostica e Farmaceutica Molecolari Scarl, via Mezzocannone 16, 80134 Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Napoli, Italy
Dipartimento di Farmacia, Università di Napoli Federico II, via Mezzocannone 16, 80134 Napoli, Italy
References:
Yount, N.Y., Yeaman, M.R., Emerging themes and therapeutic prospects for anti-infective peptides (2012) Annu Rev Pharmacol Toxicol, 52, pp. 337-360. , doi:10.1146/ annurev-pharmtox-010611-13453
Schuerholz, T., Brandenburg, K., Marx, G., Antimicrobial peptides and their potential application in inflammation and sepsis (2012) Crit Care, 16, p. 207. , doi:10.1186/ cc11220
Zasloff, M., Antimicrobial peptides of multicellular organisms (2002) Nature, 415 (6870), pp. 389-395. , DOI 10.1038/415389a
Yang, L., Harroun, T.A., Weiss, T.M., Ding, L., Huang, H.W., Barrel-stave model or toroidal model? A case study on melittin pores (2001) Biophysical Journal, 81 (3), pp. 1475-1485
Pouny, Y., Rapaport, D., Mor, A., Nicolas, P., Shai, Y., Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes (1992) Biochemistry, 31 (49), pp. 12416-12423. , DOI 10.1021/bi00164a017
Matsuzaki, K., Murase, O., Fujii, N., Miyajima, K., An antimicrobial peptide, magainin 2, induced rapid flip-flop of phospholipids coupled with pore formation and peptide translocation (1996) Biochemistry, 35 (35), pp. 11361-11368. , DOI 10.1021/bi960016v
Ding, L., Yang, L., Weiss, T.M., Waring, A.J., Lehrer, R.I., Huang, H.W., Interaction of Antimicrobial Peptides with Lipopolysaccharides (2003) Biochemistry, 42 (42), pp. 12251-12259. , DOI 10.1021/bi035130+
Bhunia, A., Saravanan, R., Mohanram, H., Mangoni, M.L., Bhattacharjya, S., NMR structures and interactions of temporin-1Tl and temporin-1Tb with lipopolysaccharide micelles: Mechanistic insights into outer membrane permeabilization and synergistic activity (2011) J Biol Chem, 286, pp. 24394-24406. , doi:10.1074/jbc.M110.189662
Gesell, J., Zasloff, M., Opella, S.J., Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an α-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution (1997) Journal of Biomolecular NMR, 9 (2), pp. 127-135
Holak, T.A., The solution conformation of the antibacterial peptide cecropin A: A nuclear magnetic resonance and dynamical simulated annealing study (1988) Biochemistry, 27, pp. 7620-7629
Bozzi, A., Mangoni, M.L., Rinaldi, A.C., Mignogna, G., Aschi, M., Folding propensity and biological activity of peptides: The effect of a single stereochemical isomerization on the conformational properties of bombinins in aqueous solution (2008) Biopolymers, 89, pp. 769-778. , doi:10.1002/bip.21006
Avitabile, C., Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria (2013) Biochim Biophys Acta, 1830, pp. 3767-3775. , doi:10.1016/j.bbagen.2013.01.026
Ramamoorthy, A., Beyond NMR spectra of antimicrobial peptides: Dynamical images at atomic resolution and functional insights (2009) Solid State Nucl Magn Reson, 35, pp. 201-207. , doi:10.1016/j.ssnmr.2009.03.003
Henzler Wildman, K.A., Lee, D.-K., Ramamoorthy, A., Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37 (2003) Biochemistry, 42 (21), pp. 6545-6558. , DOI 10.1021/bi0273563
Porcelli, F., Buck, B., Lee, D.-K., Hallock, K.J., Ramamoorthy, A., Vegliai, G., Structure and orientation of pardaxin determined by NMR experiments in model membranes (2004) Journal of Biological Chemistry, 279 (44), pp. 45815-45823. , DOI 10.1074/jbc.M405454200
Hallock, K.J., Lee, D.-K., Ramamoorthy, A., MSI-78, an analogue of the magainin antimicrobial peptides, disrupts lipid bilayer structure via positive curvature strain (2003) Biophysical Journal, 84 (5), pp. 3052-3060
Silhavy, T.J., Kahne, D., Walker, S., The bacterial cell envelope (2010) Cold Spring Harb Perspect Biol, 2, pp. a000414. , doi:10.1101/cshperspect.a000414
Duong, F., Eichler, J., Price, A., Leonard, M.R., Wickner, W., Biogenesis of the gram-negative bacterial envelope (1997) Cell, 91 (5), pp. 567-573
Santos, N.C., Silva, A.C., Castanho, M.A.R.B., Martins-Silva, J., Saldanha, C., Evaluation of Lipopolysaccharide aggregation by light scattering spectroscopy (2003) ChemBioChem, 4 (1), pp. 96-100. , DOI 10.1002/cbic.200390020
Hancock, R.E.W., Chapple, D.S., Peptide antibiotics (1999) Antimicrobial Agents and Chemotherapy, 43 (6), pp. 1317-1323
Brogden, K.A., Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? (2005) Nature Reviews Microbiology, 3 (3), pp. 238-250. , DOI 10.1038/nrmicro1098
Gee, M.L., Imaging the action of antimicrobial peptides on living bacterial cells (2013) Sci Rep, 3, p. 1557. , doi:10.1038/srep01557
Silvestro, L., Axelsen, P.H., Membrane-induced folding of cecropin A (2000) Biophys J, 79, pp. 1465-1477. , doi:10.1016/S0006-3495(00)76398-3
Silvestro, L., Weiser, J.N., Axelsen, P.H., Antibacterial and antimembrane activities of cecropin A in Escherichia coli (2000) Antimicrobial Agents and Chemotherapy, 44 (3), pp. 602-607. , DOI 10.1128/AAC.44.3.602-607.2000
Bechinger, B., Zasloff, M., Opella, S.J., Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy (1993) Protein Science, 2 (12), pp. 2077-2084
Bland, J.M., De Lucca, A.J., Jacks, T.J., Vigo, C.B., All-D-cecropin B: Synthesis, conformation, lipopolysaccharide binding, and antibacterial activity (2001) Molecular and Cellular Biochemistry, 218 (1-2), pp. 105-111. , DOI 10.1023/A:1007293816634
Tietze, L.F., Krewer, B., Major, F., Schuberth, I., CD-spectroscopy as a powerful tool for investigating the mode of action of unmodified drugs in live cells (2009) J Am Chem Soc, 131, pp. 13031-13036. , doi:10.1021/ja902767f
Steiner, H., Hultmark, D., Engstrom, A., Sequence and specificity of two antibacterial proteins involved in insect immunity (1981) Nature, 292 (5820), pp. 246-248. , DOI 10.1038/292246a0
Zasloff, M., Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor (1987) Proceedings of the National Academy of Sciences of the United States of America, 84 (15), pp. 5449-5453
Imura, Y., Choda, N., Matsuzaki, K., Magainin 2 in action: Distinct modes of membrane permeabilization in living bacterial andmammalian cells (2008) Biophys J, 95, pp. 5757-5765. , doi:10.1529/biophysj.108.133488
Kim, C., Spano, J., Park, E.K., Wi, S., Evidence of pores and thinned lipid bilayers induced in oriented lipid membranes interacting with the antimicrobial peptides, magainin-2 and aurein-3.3 (2009) Biochim Biophys Acta, 1788, pp. 1482-1496. , doi:10.1016/ j.bbamem.2009.04.017
Matsuzaki, K., Sugishita, K.-I., Harada, M., Fujii, N., Miyajima, K., Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria (1997) Biochimica et Biophysica Acta - Biomembranes, 1327 (1), pp. 119-130. , DOI 10.1016/S0005-2736(97)00051-5, PII S0005273697000515
Christensen, B., Fink, J., Merrifield, R.B., Mauzerall, D., Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes (1988) Proc Natl Acad Sci U S A, 85, pp. 5072-5076
Hong, R.W., Shchepetov, M., Weiser, J.N., Axelsen, P.H., Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A (2003) Antimicrobial Agents and Chemotherapy, 47 (1), pp. 1-6. , DOI 10.1128/AAC.47.1.1-6.2003
Yount, N. Y., Yeaman, M. R., Emerging themes and therapeutic prospects for anti-infective peptides (2012) Annu Rev Pharmacol Toxicol, 52, pp. 337-360. , doi: 10. 1146/ annurev-pharmtox-010611-13453
Holak, T. A., The solution conformation of the antibacterial peptide cecropin A: A nuclear magnetic resonance and dynamical simulated annealing study (1988) Biochemistry, 27, pp. 7620-7629
Hallock, K. J., Lee, D. -K., Ramamoorthy, A., MSI-78, an analogue of the magainin antimicrobial peptides, disrupts lipid bilayer structure via positive curvature strain (2003) Biophysical Journal, 84 (5), pp. 3052-3060
Silhavy, T. J., Kahne, D., Walker, S., The bacterial cell envelope (2010) Cold Spring Harb Perspect Biol, 2, pp. a000414. , doi: 10. 1101/cshperspect. a000414
Santos, N. C., Silva, A. C., Castanho, M. A. R. B., Martins-Silva, J., Saldanha, C., Evaluation of Lipopolysaccharide aggregation by light scattering spectroscopy (2003) ChemBioChem, 4 (1), pp. 96-100. , DOI 10. 1002/cbic. 200390020
Hancock, R. E. W., Chapple, D. S., Peptide antibiotics (1999) Antimicrobial Agents and Chemotherapy, 43 (6), pp. 1317-1323
Brogden, K. A., Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? (2005) Nature Reviews Microbiology, 3 (3), pp. 238-250. , DOI 10. 1038/nrmicro1098
Gee, M. L., Imaging the action of antimicrobial peptides on living bacterial cells (2013) Sci Rep, 3, p. 1557. , doi: 10. 1038/srep01557
Bland, J. M., De Lucca, A. J., Jacks, T. J., Vigo, C. B., All-D-cecropin B: Synthesis, conformation, lipopolysaccharide binding, and antibacterial activity (2001) Molecular and Cellular Biochemistry, 218 (1-2), pp. 105-111. , DOI 10. 1023/A: 1007293816634
Tietze, L. F., Krewer, B., Major, F., Schuberth, I., CD-spectroscopy as a powerful tool for investigating the mode of action of unmodified drugs in live cells (2009) J Am Chem Soc, 131, pp. 13031-13036. , doi: 10. 1021/ja902767f
Hong, R. W., Shchepetov, M., Weiser, J. N., Axelsen, P. H., Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A (2003) Antimicrobial Agents and Chemotherapy, 47 (1), pp. 1-6. , DOI 10. 1128/AAC. 47. 1. 1-6. 2003
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2014 Mar 12; 4: 4293-4293.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T,
Impact factor: 5.578, 5-year impact factor: 5.597
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84896264352&partnerID=40&md5=cc5ff63303895a4dc006e430e7d0c965
Keywords: Antiinfective Agent, Antimicrobial Cationic Peptide, Cecropin A, Lipopolysaccharide, Magainin 2 Peptide, Xenopus, Magainin Derivative, Xenopus Protein, Animal, Article, Chemistry, Circular Dichroism, Escherichia Coli, Metabolism, Protein Folding, Protein Secondary Structure, Xenopus Laevis, Anti-Bacterial Agents, Protein Structure, Time Factors,
Affiliations:
*** IBB - CNR ***
Diagnostica e Farmaceutica Molecolari Scarl, via Mezzocannone 16, 80134 Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone 16, 80134 Napoli, Italy
Dipartimento di Farmacia, Università di Napoli Federico II, via Mezzocannone 16, 80134 Napoli, Italy
References:
Yount, N.Y., Yeaman, M.R., Emerging themes and therapeutic prospects for anti-infective peptides (2012) Annu Rev Pharmacol Toxicol, 52, pp. 337-360. , doi:10.1146/ annurev-pharmtox-010611-13453
Schuerholz, T., Brandenburg, K., Marx, G., Antimicrobial peptides and their potential application in inflammation and sepsis (2012) Crit Care, 16, p. 207. , doi:10.1186/ cc11220
Zasloff, M., Antimicrobial peptides of multicellular organisms (2002) Nature, 415 (6870), pp. 389-395. , DOI 10.1038/415389a
Yang, L., Harroun, T.A., Weiss, T.M., Ding, L., Huang, H.W., Barrel-stave model or toroidal model? A case study on melittin pores (2001) Biophysical Journal, 81 (3), pp. 1475-1485
Pouny, Y., Rapaport, D., Mor, A., Nicolas, P., Shai, Y., Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes (1992) Biochemistry, 31 (49), pp. 12416-12423. , DOI 10.1021/bi00164a017
Matsuzaki, K., Murase, O., Fujii, N., Miyajima, K., An antimicrobial peptide, magainin 2, induced rapid flip-flop of phospholipids coupled with pore formation and peptide translocation (1996) Biochemistry, 35 (35), pp. 11361-11368. , DOI 10.1021/bi960016v
Ding, L., Yang, L., Weiss, T.M., Waring, A.J., Lehrer, R.I., Huang, H.W., Interaction of Antimicrobial Peptides with Lipopolysaccharides (2003) Biochemistry, 42 (42), pp. 12251-12259. , DOI 10.1021/bi035130+
Bhunia, A., Saravanan, R., Mohanram, H., Mangoni, M.L., Bhattacharjya, S., NMR structures and interactions of temporin-1Tl and temporin-1Tb with lipopolysaccharide micelles: Mechanistic insights into outer membrane permeabilization and synergistic activity (2011) J Biol Chem, 286, pp. 24394-24406. , doi:10.1074/jbc.M110.189662
Gesell, J., Zasloff, M., Opella, S.J., Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an α-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution (1997) Journal of Biomolecular NMR, 9 (2), pp. 127-135
Holak, T.A., The solution conformation of the antibacterial peptide cecropin A: A nuclear magnetic resonance and dynamical simulated annealing study (1988) Biochemistry, 27, pp. 7620-7629
Bozzi, A., Mangoni, M.L., Rinaldi, A.C., Mignogna, G., Aschi, M., Folding propensity and biological activity of peptides: The effect of a single stereochemical isomerization on the conformational properties of bombinins in aqueous solution (2008) Biopolymers, 89, pp. 769-778. , doi:10.1002/bip.21006
Avitabile, C., Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria (2013) Biochim Biophys Acta, 1830, pp. 3767-3775. , doi:10.1016/j.bbagen.2013.01.026
Ramamoorthy, A., Beyond NMR spectra of antimicrobial peptides: Dynamical images at atomic resolution and functional insights (2009) Solid State Nucl Magn Reson, 35, pp. 201-207. , doi:10.1016/j.ssnmr.2009.03.003
Henzler Wildman, K.A., Lee, D.-K., Ramamoorthy, A., Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37 (2003) Biochemistry, 42 (21), pp. 6545-6558. , DOI 10.1021/bi0273563
Porcelli, F., Buck, B., Lee, D.-K., Hallock, K.J., Ramamoorthy, A., Vegliai, G., Structure and orientation of pardaxin determined by NMR experiments in model membranes (2004) Journal of Biological Chemistry, 279 (44), pp. 45815-45823. , DOI 10.1074/jbc.M405454200
Hallock, K.J., Lee, D.-K., Ramamoorthy, A., MSI-78, an analogue of the magainin antimicrobial peptides, disrupts lipid bilayer structure via positive curvature strain (2003) Biophysical Journal, 84 (5), pp. 3052-3060
Silhavy, T.J., Kahne, D., Walker, S., The bacterial cell envelope (2010) Cold Spring Harb Perspect Biol, 2, pp. a000414. , doi:10.1101/cshperspect.a000414
Duong, F., Eichler, J., Price, A., Leonard, M.R., Wickner, W., Biogenesis of the gram-negative bacterial envelope (1997) Cell, 91 (5), pp. 567-573
Santos, N.C., Silva, A.C., Castanho, M.A.R.B., Martins-Silva, J., Saldanha, C., Evaluation of Lipopolysaccharide aggregation by light scattering spectroscopy (2003) ChemBioChem, 4 (1), pp. 96-100. , DOI 10.1002/cbic.200390020
Hancock, R.E.W., Chapple, D.S., Peptide antibiotics (1999) Antimicrobial Agents and Chemotherapy, 43 (6), pp. 1317-1323
Brogden, K.A., Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? (2005) Nature Reviews Microbiology, 3 (3), pp. 238-250. , DOI 10.1038/nrmicro1098
Gee, M.L., Imaging the action of antimicrobial peptides on living bacterial cells (2013) Sci Rep, 3, p. 1557. , doi:10.1038/srep01557
Silvestro, L., Axelsen, P.H., Membrane-induced folding of cecropin A (2000) Biophys J, 79, pp. 1465-1477. , doi:10.1016/S0006-3495(00)76398-3
Silvestro, L., Weiser, J.N., Axelsen, P.H., Antibacterial and antimembrane activities of cecropin A in Escherichia coli (2000) Antimicrobial Agents and Chemotherapy, 44 (3), pp. 602-607. , DOI 10.1128/AAC.44.3.602-607.2000
Bechinger, B., Zasloff, M., Opella, S.J., Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy (1993) Protein Science, 2 (12), pp. 2077-2084
Bland, J.M., De Lucca, A.J., Jacks, T.J., Vigo, C.B., All-D-cecropin B: Synthesis, conformation, lipopolysaccharide binding, and antibacterial activity (2001) Molecular and Cellular Biochemistry, 218 (1-2), pp. 105-111. , DOI 10.1023/A:1007293816634
Tietze, L.F., Krewer, B., Major, F., Schuberth, I., CD-spectroscopy as a powerful tool for investigating the mode of action of unmodified drugs in live cells (2009) J Am Chem Soc, 131, pp. 13031-13036. , doi:10.1021/ja902767f
Steiner, H., Hultmark, D., Engstrom, A., Sequence and specificity of two antibacterial proteins involved in insect immunity (1981) Nature, 292 (5820), pp. 246-248. , DOI 10.1038/292246a0
Zasloff, M., Magainins, a class of antimicrobial peptides from Xenopus skin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor (1987) Proceedings of the National Academy of Sciences of the United States of America, 84 (15), pp. 5449-5453
Imura, Y., Choda, N., Matsuzaki, K., Magainin 2 in action: Distinct modes of membrane permeabilization in living bacterial andmammalian cells (2008) Biophys J, 95, pp. 5757-5765. , doi:10.1529/biophysj.108.133488
Kim, C., Spano, J., Park, E.K., Wi, S., Evidence of pores and thinned lipid bilayers induced in oriented lipid membranes interacting with the antimicrobial peptides, magainin-2 and aurein-3.3 (2009) Biochim Biophys Acta, 1788, pp. 1482-1496. , doi:10.1016/ j.bbamem.2009.04.017
Matsuzaki, K., Sugishita, K.-I., Harada, M., Fujii, N., Miyajima, K., Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria (1997) Biochimica et Biophysica Acta - Biomembranes, 1327 (1), pp. 119-130. , DOI 10.1016/S0005-2736(97)00051-5, PII S0005273697000515
Christensen, B., Fink, J., Merrifield, R.B., Mauzerall, D., Channel-forming properties of cecropins and related model compounds incorporated into planar lipid membranes (1988) Proc Natl Acad Sci U S A, 85, pp. 5072-5076
Hong, R.W., Shchepetov, M., Weiser, J.N., Axelsen, P.H., Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A (2003) Antimicrobial Agents and Chemotherapy, 47 (1), pp. 1-6. , DOI 10.1128/AAC.47.1.1-6.2003
Yount, N. Y., Yeaman, M. R., Emerging themes and therapeutic prospects for anti-infective peptides (2012) Annu Rev Pharmacol Toxicol, 52, pp. 337-360. , doi: 10. 1146/ annurev-pharmtox-010611-13453
Holak, T. A., The solution conformation of the antibacterial peptide cecropin A: A nuclear magnetic resonance and dynamical simulated annealing study (1988) Biochemistry, 27, pp. 7620-7629
Hallock, K. J., Lee, D. -K., Ramamoorthy, A., MSI-78, an analogue of the magainin antimicrobial peptides, disrupts lipid bilayer structure via positive curvature strain (2003) Biophysical Journal, 84 (5), pp. 3052-3060
Silhavy, T. J., Kahne, D., Walker, S., The bacterial cell envelope (2010) Cold Spring Harb Perspect Biol, 2, pp. a000414. , doi: 10. 1101/cshperspect. a000414
Santos, N. C., Silva, A. C., Castanho, M. A. R. B., Martins-Silva, J., Saldanha, C., Evaluation of Lipopolysaccharide aggregation by light scattering spectroscopy (2003) ChemBioChem, 4 (1), pp. 96-100. , DOI 10. 1002/cbic. 200390020
Hancock, R. E. W., Chapple, D. S., Peptide antibiotics (1999) Antimicrobial Agents and Chemotherapy, 43 (6), pp. 1317-1323
Brogden, K. A., Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria? (2005) Nature Reviews Microbiology, 3 (3), pp. 238-250. , DOI 10. 1038/nrmicro1098
Gee, M. L., Imaging the action of antimicrobial peptides on living bacterial cells (2013) Sci Rep, 3, p. 1557. , doi: 10. 1038/srep01557
Bland, J. M., De Lucca, A. J., Jacks, T. J., Vigo, C. B., All-D-cecropin B: Synthesis, conformation, lipopolysaccharide binding, and antibacterial activity (2001) Molecular and Cellular Biochemistry, 218 (1-2), pp. 105-111. , DOI 10. 1023/A: 1007293816634
Tietze, L. F., Krewer, B., Major, F., Schuberth, I., CD-spectroscopy as a powerful tool for investigating the mode of action of unmodified drugs in live cells (2009) J Am Chem Soc, 131, pp. 13031-13036. , doi: 10. 1021/ja902767f
Hong, R. W., Shchepetov, M., Weiser, J. N., Axelsen, P. H., Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A (2003) Antimicrobial Agents and Chemotherapy, 47 (1), pp. 1-6. , DOI 10. 1128/AAC. 47. 1. 1-6. 2003
Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells
Studying how antimicrobial peptides interact with bacterial cells is pivotal to understand their mechanism of action. In this paper we explored the use of Circular Dichroism to detect the secondary structure of two antimicrobial peptides, magainin 2 and cecropin A, with E. coli bacterial cells. The results of our studies allow us to gain two important information in the context of antimicrobial peptides- bacterial cells interactions: peptides fold mainly due to interaction with LPS, which is the main component of the Gram negative bacteria outer membrane and the time required for the folding on the bacterial cells depends on the peptide analyzed.
Studying how antimicrobial peptides interact with bacterial cells is pivotal to understand their mechanism of action. In this paper we explored the use of Circular Dichroism to detect the secondary structure of two antimicrobial peptides, magainin 2 and cecropin A, with E. coli bacterial cells. The results of our studies allow us to gain two important information in the context of antimicrobial peptides- bacterial cells interactions: peptides fold mainly due to interaction with LPS, which is the main component of the Gram negative bacteria outer membrane and the time required for the folding on the bacterial cells depends on the peptide analyzed.
Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells
| ▼ Peptides of therapeutic interest with antimicrobial and/ or antitumoral activity |
Circular Dichroism studies on the interactions of antimicrobial peptides with bacterial cells
Other filter: ([btitle,keywords] "Antiinfective Agent" ...
Mercurio FA, Scaloni A, Caira S, Leone M
* The antimicrobial peptides casocidins I and II: Solution structural studies in water and different membrane-mimetic environments (277 views)
Peptides (ISSN: 0196-9781linking, 1873-5169electronic), 2018 Sep 19; 114: 50-58.
Impact Factor: 2.851
View Export to BibTeX Export to EndNote
Falanga A, Mercurio FA, Siciliano A, Lombardi L, Galdiero S, Guida M, Libralato G, Leone M, Galdiero E
* Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna (91 views)
Aquat Toxicol (ISSN: 0166-445xlinking), 2018 May; 198: 158-164.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E, Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P
* Insights into the anticancer properties of the first antimicrobial peptide from Archaea (409 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0304-4165linking), 2017 Jun 15; 1861(9): 2155-2164.
Impact Factor: 4.28
View Export to BibTeX Export to EndNote
Dennehy R, RomanoM, Ruggiero A, Mohamed YF, Dignam SL, Mujica Troncoso C, Callaghan M, Valvano MA, Berisio R, Mcclean S
* The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involved in epithelial cell attachment and elicitation of inflammation (294 views)
Cell Microbiol (ISSN: 1462-5814), 2017 May; 19(5): e12691-e12691.
Impact Factor: 4.41
View Export to BibTeX Export to EndNote
Avitabile C, D'Andrea LD, Romanelli A
* Studying the Interaction of Magainin 2 and Cecropin A with E. coli Bacterial Cells Using Circular Dichroism (378 views)
Methods Mol Biol (ISSN: 1940-6029electronic, 1064-3745linking), 2017; 1548: 247-253.
Impact Factor: 3.221
View Export to BibTeX Export to EndNote
Pane K, Sgambati V, Zanfardino A, Smaldone G, Cafaro V, Angrisano T, Pedone E, Di Gaetano S, Capasso D, Haney EF, Izzo V, Varcamonti M, Notomista E, Hancock RE, Di Donato A, Pizzo E
* A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells (427 views)
Febs J (ISSN: 1742-464x), 2016; N/D: N/D-N/D.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Molinaro A, Holst O, Lorenzo FD, Callaghan M, Nurisso A, D'Errico G, Zamyatina A, Peri F, Berisio R, Jerala R, Jiménez-Barbero J, Silipo A, Martín-Santamarí S
* Chemistry of lipid a: At the heart of innate immunity (1606 views) (PDF 306 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 7; 21(2): 500-519.
Impact Factor: 5.771
View Export to BibTeX Export to EndNote
Speciale I, Paciello I, Fazio LL, Sturiale L, Palmigiano A, Lanzetta R, Parrilli M, Garozzo D, Lemaitre B, Bernardini ML, Molinaro A, De Castro C
* Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties (396 views)
Carbohyd Res (ISSN: 0008-6215, 0008-6215linking), 2015; 412: 20-27.
Impact Factor: 1.817
View Export to BibTeX Export to EndNote
Kim JK, Son DW, Kim C-H, Cho JH, Marchetti R, Silipo A, Sturiale L, Park HY, Huh YR, Nakayama H, Fukatsu T, Molinaro A, Lee BL
* Insect gut symbiont susceptibility to host antimicrobial peptides caused by alteration of the bacterial cell envelope (958 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2015; 290(34): 21042-21053.
Impact Factor: 4.258
View Export to BibTeX Export to EndNote
Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (367 views)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
View Export to BibTeX Export to EndNote
Malgieri G, Avitabile C, Palmieri M, D'Andrea LD, Isernia C, Romanelli A, Fattorusso R
* Structural basis of a temporin 1b analogue antimicrobial activity against gram negative bacteria determined by CD and NMR techniques in cellular environment (584 views)
Acs Chem Biol (ISSN: 1554-8929), 2015; 10(4): 965-969.
Impact Factor: 5.09
View Export to BibTeX Export to EndNote
Calce E, Mignogna E, Bugatti V, Galdiero M, Vittoria V, De Luca S
* Pectin functionalized with natural fatty acids as antimicrobial agent (391 views)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2014 Jul; 68: 28-32.
Impact Factor: 2.858
View Export to BibTeX Export to EndNote
Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (559 views)
Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
View Export to BibTeX Export to EndNote
Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (772 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
View Export to BibTeX Export to EndNote
D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
* Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis (456 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Feb; 97(1): 114-120.
Impact Factor: 2.963
View Export to BibTeX Export to EndNote
Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (650 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Nov 13; 8(11): e79455-e79455.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S
* Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish (728 views)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2013 Nov; 57(11): 5665-5673.
Impact Factor: 4.451
View Export to BibTeX Export to EndNote
Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
* Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis (402 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Sep; 69(Pt9): 1697-1706.
Impact Factor: 7.232
View Export to BibTeX Export to EndNote
Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A
* Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria (490 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 0925-4439), 2013 Jun; 1830(6): 3767-3775.
Impact Factor: 3.829
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (1149 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Mar; 19(3): 148-158.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (439 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
View Export to BibTeX Export to EndNote
Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (428 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
View Export to BibTeX Export to EndNote
Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (557 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
View Export to BibTeX Export to EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (554 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (676 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L, De Luca S, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A
* Antimicrobial properties of distinctin in an experimental model of MRSA-infected wounds (512 views)
Eur J Clin Microbiol Infect Dis (ISSN: 0934-9723), 2012 Nov; 31(11): 3047-3055.
Impact Factor: 3.024
View Export to BibTeX Export to EndNote
Berisio R
* Editorial: cell processes in bacterial diseases (409 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
Impact Factor: 1.994
View Export to BibTeX Export to EndNote
De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (443 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
View Export to BibTeX Export to EndNote
Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (481 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A
* Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers (489 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Jan; 1808(1): 34-40.
Impact Factor: 3.99
View Export to BibTeX Export to EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
View Export to BibTeX Export to EndNote
Scudiero O, Galdiero S, Cantisani M, Di Noto R, Vitiello M, Galdiero M, Naclerio G, Cassiman JJ, Pedone C, Castaldo G, Salvatore F
* Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (643 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Impact Factor: 4.672
View Export to BibTeX Export to EndNote
Capparelli R, Romanelli A, Iannaccone M, Nocerino N, Ripa R, Pensato S, Pedone C, Iannelli D
* Synergistic antibacterial and anti-inflammatory activity of temporin A and modified temporin B in vivo (452 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 28; 4(9): e7191-e7191.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Cirioni O, Ghiselli R, Orlando F, Silvestri C, De Luca S, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A
* Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis (315 views)
Critical Care Medicine (ISSN: 0090-3493), 2008 Sep; 36(9): 2629-2633.
Impact Factor: 6.594
View Export to BibTeX Export to EndNote
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
View Export to BibTeX Export to EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (711 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (465 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
View Export to BibTeX Export to EndNote
Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (387 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (549 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
View Export to BibTeX Export to EndNote
Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (776 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
View Export to BibTeX Export to EndNote
* The antimicrobial peptides casocidins I and II: Solution structural studies in water and different membrane-mimetic environments (277 views)
Peptides (ISSN: 0196-9781linking, 1873-5169electronic), 2018 Sep 19; 114: 50-58.
Impact Factor: 2.851
View Export to BibTeX Export to EndNote
Falanga A, Mercurio FA, Siciliano A, Lombardi L, Galdiero S, Guida M, Libralato G, Leone M, Galdiero E
* Metabolomic and oxidative effects of quantum dots-indolicidin on three generations of Daphnia magna (91 views)
Aquat Toxicol (ISSN: 0166-445xlinking), 2018 May; 198: 158-164.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E, Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P
* Insights into the anticancer properties of the first antimicrobial peptide from Archaea (409 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0304-4165linking), 2017 Jun 15; 1861(9): 2155-2164.
Impact Factor: 4.28
View Export to BibTeX Export to EndNote
Dennehy R, RomanoM, Ruggiero A, Mohamed YF, Dignam SL, Mujica Troncoso C, Callaghan M, Valvano MA, Berisio R, Mcclean S
* The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involved in epithelial cell attachment and elicitation of inflammation (294 views)
Cell Microbiol (ISSN: 1462-5814), 2017 May; 19(5): e12691-e12691.
Impact Factor: 4.41
View Export to BibTeX Export to EndNote
Avitabile C, D'Andrea LD, Romanelli A
* Studying the Interaction of Magainin 2 and Cecropin A with E. coli Bacterial Cells Using Circular Dichroism (378 views)
Methods Mol Biol (ISSN: 1940-6029electronic, 1064-3745linking), 2017; 1548: 247-253.
Impact Factor: 3.221
View Export to BibTeX Export to EndNote
Pane K, Sgambati V, Zanfardino A, Smaldone G, Cafaro V, Angrisano T, Pedone E, Di Gaetano S, Capasso D, Haney EF, Izzo V, Varcamonti M, Notomista E, Hancock RE, Di Donato A, Pizzo E
* A new cryptic cationic antimicrobial peptide from human apolipoprotein E with antibacterial activity and immunomodulatory effects on human cells (427 views)
Febs J (ISSN: 1742-464x), 2016; N/D: N/D-N/D.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Molinaro A, Holst O, Lorenzo FD, Callaghan M, Nurisso A, D'Errico G, Zamyatina A, Peri F, Berisio R, Jerala R, Jiménez-Barbero J, Silipo A, Martín-Santamarí S
* Chemistry of lipid a: At the heart of innate immunity (1606 views) (PDF 306 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015 Jan 7; 21(2): 500-519.
Impact Factor: 5.771
View Export to BibTeX Export to EndNote
Speciale I, Paciello I, Fazio LL, Sturiale L, Palmigiano A, Lanzetta R, Parrilli M, Garozzo D, Lemaitre B, Bernardini ML, Molinaro A, De Castro C
* Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties (396 views)
Carbohyd Res (ISSN: 0008-6215, 0008-6215linking), 2015; 412: 20-27.
Impact Factor: 1.817
View Export to BibTeX Export to EndNote
Kim JK, Son DW, Kim C-H, Cho JH, Marchetti R, Silipo A, Sturiale L, Park HY, Huh YR, Nakayama H, Fukatsu T, Molinaro A, Lee BL
* Insect gut symbiont susceptibility to host antimicrobial peptides caused by alteration of the bacterial cell envelope (958 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2015; 290(34): 21042-21053.
Impact Factor: 4.258
View Export to BibTeX Export to EndNote
Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (367 views)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
View Export to BibTeX Export to EndNote
Malgieri G, Avitabile C, Palmieri M, D'Andrea LD, Isernia C, Romanelli A, Fattorusso R
* Structural basis of a temporin 1b analogue antimicrobial activity against gram negative bacteria determined by CD and NMR techniques in cellular environment (584 views)
Acs Chem Biol (ISSN: 1554-8929), 2015; 10(4): 965-969.
Impact Factor: 5.09
View Export to BibTeX Export to EndNote
Calce E, Mignogna E, Bugatti V, Galdiero M, Vittoria V, De Luca S
* Pectin functionalized with natural fatty acids as antimicrobial agent (391 views)
Int J Biol Macromol (ISSN: 0141-8130, 0141-8130linking, 1879-0003electronic), 2014 Jul; 68: 28-32.
Impact Factor: 2.858
View Export to BibTeX Export to EndNote
Musumeci D, Roviello GN, Montesarchio D
* An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies (559 views)
Pharmacol Ther (ISSN: 0163-7258, 0163-7258linking), 2014 Mar; 141(3): 347-357.
Impact Factor: 9.723
View Export to BibTeX Export to EndNote
Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (772 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
View Export to BibTeX Export to EndNote
D'Ambrosio K, Lopez M, Dathan NA, Ouahrani-bettache S, Köhler S, Ascione G, Monti SM, Winum JY, De Simone G
* Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis (456 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Feb; 97(1): 114-120.
Impact Factor: 2.963
View Export to BibTeX Export to EndNote
Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (650 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Nov 13; 8(11): e79455-e79455.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Cantisani M, Leone M, Mignogna E, Kampanaraki K, Falanga A, Morelli G, Galdiero M, Galdiero S
* Structure-Activity Relations of Myxinidin, an Antibacterial Peptide Derived from the Epidermal Mucus of Hagfish (728 views)
Antimicrob Agents Ch (ISSN: 0066-4804, 1098-6596), 2013 Nov; 57(11): 5665-5673.
Impact Factor: 4.451
View Export to BibTeX Export to EndNote
Correale S, Ruggiero A, Capparelli R, Pedone E, Berisio R
* Structures of free and inhibited forms of the L, D-transpeptidase LdtMt1 from Mycobacterium tuberculosis (402 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2013 Sep; 69(Pt9): 1697-1706.
Impact Factor: 7.232
View Export to BibTeX Export to EndNote
Avitabile C, Netti F, Orefice G, Palmieri M, Nocerino N, Malgieri G, D'Andrea LD, Capparelli R, Fattorusso R, Romanelli A
* Design, structural and functional characterization of a Temporin-1b analog active against Gram-negative bacteria (490 views)
Bba-Gen Subjects (ISSN: 0304-4165, 0006-3002, 0925-4439), 2013 Jun; 1830(6): 3767-3775.
Impact Factor: 3.829
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (1149 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Mar; 19(3): 148-158.
Impact Factor: 1.862
View Export to BibTeX Export to EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (439 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
View Export to BibTeX Export to EndNote
Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (428 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
View Export to BibTeX Export to EndNote
Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (557 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
View Export to BibTeX Export to EndNote
Berisio R
* Learning from pathogens: Exploiting host-pathogen liaison for therapeutic development (554 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 697-698.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Galdiero S, Falanga A, Cantisani M, Tarallo R, della Pepa ME, D'Oriano V, Galdiero M
* Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (676 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
Impact Factor: 2.326
View Export to BibTeX Export to EndNote
Simonetti O, Cirioni O, Ghiselli R, Goteri G, Orlando F, Monfregola L, De Luca S, Zizzi A, Silvestri C, Veglia G, Giacometti A, Guerrieri M, Offidani A, Scaloni A
* Antimicrobial properties of distinctin in an experimental model of MRSA-infected wounds (512 views)
Eur J Clin Microbiol Infect Dis (ISSN: 0934-9723), 2012 Nov; 31(11): 3047-3055.
Impact Factor: 3.024
View Export to BibTeX Export to EndNote
Berisio R
* Editorial: cell processes in bacterial diseases (409 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1011-1012.
Impact Factor: 1.994
View Export to BibTeX Export to EndNote
De Simone G
* Editorial: Zinc Metallo-Enzymes As Target For Drug Design (443 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2012 Feb; 19(6): 820-1012.
Impact Factor: 4.07
View Export to BibTeX Export to EndNote
Musumeci D, Bucci EM, Roviello GN, Sapio R, Valente M, Moccia M, Bianchi ME, Pedone C
* DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes (481 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051, 1742-2051electronic), 2011 May; 7(5): 1742-1752.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A
* Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers (489 views)
Bba-Gen Subjects (ISSN: 0005-2736, 0006-3002, 0925-4439), 2011 Jan; 1808(1): 34-40.
Impact Factor: 3.99
View Export to BibTeX Export to EndNote
Spina-Purrello V, Giliberto S, Barresi V, Nicoletti VG, Giuffrida Stella AM, Rizzarelli E
* Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress (450 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2010 Dec; 35(12): 2144-2153.
Impact Factor: 2.608
View Export to BibTeX Export to EndNote
Scudiero O, Galdiero S, Cantisani M, Di Noto R, Vitiello M, Galdiero M, Naclerio G, Cassiman JJ, Pedone C, Castaldo G, Salvatore F
* Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity (643 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2010 Jun; 54(6): 2312-2322.
Impact Factor: 4.672
View Export to BibTeX Export to EndNote
Capparelli R, Romanelli A, Iannaccone M, Nocerino N, Ripa R, Pensato S, Pedone C, Iannelli D
* Synergistic antibacterial and anti-inflammatory activity of temporin A and modified temporin B in vivo (452 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 28; 4(9): e7191-e7191.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Cirioni O, Ghiselli R, Orlando F, Silvestri C, De Luca S, Salzano AM, Mocchegiani F, Saba V, Scalise G, Scaloni A, Giacometti A
* Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis (315 views)
Critical Care Medicine (ISSN: 0090-3493), 2008 Sep; 36(9): 2629-2633.
Impact Factor: 6.594
View Export to BibTeX Export to EndNote
Sorriento D, Ciccarelli M, Santulli G, Campanile A, Altobelli GG, Cimini V, Galasso G, Astone D, Piscione F, Pastore L, Trimarco B, Iaccarino G
* The G-protein-coupled receptor kinase 5 inhibits NFκB transcriptional activity by inducing nuclear accumulation of IκBα (438 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2008; 105(46): 17818-17823.
Impact Factor: 9.38
View Export to BibTeX Export to EndNote
Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (668 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (711 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
View Export to BibTeX Export to EndNote
Paesano N, Marzocco S, Vicidomini C, Saturnino C, Autore G, De Martino G, Sbardella G
* Synthesis and biological evaluation of 3-benzyl-1-methyl- and 1-methyl-3-phenyl-isothioureas as potential inhibitors of iNOS (465 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 Feb 1; 15(3): 539-543.
Impact Factor: 2.478
View Export to BibTeX Export to EndNote
Saviano M, Improta R, Benedetti E, Carrozzini B, Cascarano GL, Didierjean C, Toniolo C, Crisma M
* Benzophenone photophore flexibility and proximity: Molecular and crystal-state structure of a Bpa-containing trichogin dodecapeptide analogue (387 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2004 Apr 2; 5(4): 541-544.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Galdiero M, Vitiello M, Galdiero S
* Eukaryotic cell signaling and transcriptional activation induced by bacterial porins (549 views)
Fems Microbiology Letters (ISSN: 0378-1097), 2003 Sep 12; 226(1): 57-64.
Impact Factor: 1.932
View Export to BibTeX Export to EndNote
Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A
* Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and no donors: Insights into listeriocidal activity of oxidative and nitrosative stress (776 views)
Free Radic Biol Med (ISSN: 0891-5849, 0891-5849linking, 1873-4596electronic), 2001 Feb 1; 30(3): 268-276.
Impact Factor: 5.082
View Export to BibTeX Export to EndNote
41 Records (40 excluding Abstracts).
Total impact factor: 157.412 (153.061 excluding Abstracts).
Total 5 year impact factor: 166.255 (161.872 excluding Abstracts).
Total impact factor: 157.412 (153.061 excluding Abstracts).
Total 5 year impact factor: 166.255 (161.872 excluding Abstracts).
591 views. Last view on Thursday 25 May 2023, 9:41:13
ibb.cnr.it
