Interaction of human amylin with phosphatidylcholine and phosphatidylserine membranes(415 views) Sciacca MFM, Carbone V, Pappalardo M, Milardi D, La Rosa C, Grasso DM
Dipartimento di Scienze Chimiche, Universita' di Catania, Catania, Italy
Istituto CNR di Biostrutture e Bioimmagini, Sezione di Catania, Catania, Italy
Department of Chemistry, University of Catania, Viale Andrea Doria 6, Catania 95125, Italy
References: Not available.
Interaction of human amylin with phosphatidylcholine and phosphatidylserine membranes
We studied the interaction of human amylin with dipalmitoylphosphatidylcholine and dipalmitoylphosphatidylserine vesicles using differential scanning calorimetry, circular dichroism and molecular modelling. The results suggest that inappropriate insertion of amylin into the hydrophobic core of a lipid bilayer could hinder the secretion of amylin from pancreatic -cells.
Interaction of human amylin with phosphatidylcholine and phosphatidylserine membranes