Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (553 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.384, 5-year impact factor: 3.236
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-3042834662&partnerID=40&md5=55a782564a4b405b6b1ada54cb81118e
Keywords: β-Amyloid, Alzheimer, S Disease, Apoptosis, Dickkopf-1, Tau Phosphorylation, Wnt Pathway, Amyloid Beta Protein, Antisense Oligonucleotide, Dickkopf 1 Protein, Glycogen Synthase Kinase 3beta, Glycoprotein, Protein P53, Regulator Protein, Tau Protein, Tumor Suppressor Protein, Unclassified Drug, Wnt Protein, Alzheimer Disease, Animal Cell, Article, Brain Cell, Controlled Study, Dystrophy, Embryo, Enzyme Activation, Gene Expression, Human, Human Tissue, Knockout Gene, Nerve Cell Culture, Nerve Cell Degeneration, Neurite, Neurofibrillary Tangle, Neurotoxicity, Nonhuman, Priority Journal, Protein Hyperphosphorylation, Protein Induction, Protein Localization, Protein Phosphorylation, Signal Transduction, Aged, 80 And Over, Amyloid Beta-Protein, Bcl-2-Associated X Protein, Dizocilpine Maleate, Gene Expression Regulation, Glutamic Acid, Immunoenzyme Techniques, Intercellular Signaling Peptides And Proteins, Nerve Degeneration, Nerve Tissue Proteins, Oligodeoxyribonucleotides, Peptide Fragments, Protein Processing, Post-Translational, Proto-Oncogene Proteins, Proto-Oncogene Proteins C-Bcl-2, Quinoxalines, Messenger, Tumor Suppressor Protein P53,
Affiliations:
*** IBB - CNR ***
Siena Biotech., 53100 Siena, Italy
Dept. of Pharmaceutical Sciences, University of Catania, 95125 Catania, Italy
Department of Neuropathology, Academic Medical Center, University of Amsterdam Meibergdreef, Amsterdam 1105 AZ, Netherlands
Dept. Hum. Physiol. and Pharmacol., University of Rome La Sapienza, 00185 Rome, Italy
Istituto Neurologico Mediterraneo, Neuromed., 86077 Pozzilli, Isernia, Italy
Ist. di Bioimmagini e Biostrutture, CNR-95125, Catania, Italy
References:
Arends, M., Duyckaerts, C., Rozemuller, J.M., Eikelenboom, P., Hauw, J.-J., Microglia, amyloid and dementia in Alzheimer disease. A correlative study (2000) Neurobiol Aging, 21, pp. 39-4
Bettini, E., Magnani, E., Terstappen, G.C., Lithium induces gene expression through lymphoid enhancer-binding factor/T-cell factor responsive element in rat PC12 cells (2002) Neurosci Lett, 317, pp. 50-52
Braak, H., Braak, E., Staging of Alzheimer's disease-related neurofibrillary changes (1995) Neurobiol Aging, 16, pp. 271-278
Caricasole, A., Ferraro, T., Rimland, J.M., Terstappen, G.C., Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine (2002) Gene, 288, pp. 147-157
Caricasole, A., Copani, A., Caruso, A., Caraci, F., Iacovelli, L., Sortino, M.A., Terstappen, G.C., Nicoletti, F., The Wnt pathway, cell-cycle activation and beta-amyloid: Novel therapeutic strategies in Alzheimer's disease? (2003) Trends Pharmacol Sci, 24, pp. 233-238
Chen, R.-W., Saunders, P.A., Wei, H., Li, Z., Seth, P., Chuang, D.M., Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53 (1999) J Neurosci, 19, pp. 9654-9662
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., Erratic expression of DNA polymerases by beta-amyloid causes neuronal death (2002) FASEB J, 16, pp. 2006-2008
Cotman, C.W., Anderson, A.J., A potential role for apoptosis in neurodegeneration and Alzheimer's disease (1995) Mol Neurobiol, 10, pp. 19-45
Cotter, D., Kerwin, R., Al-Sarraji, S., Brion, J.P., Chadwich, A., Lovestone, S., Anderton, B., Everall, I., Abnormalities of Wnt signalling in schizophrenia-evidence for neurodevelopmental abnormality (1998) NeuroReport, 9, pp. 1379-1383. , 1998
Dale, T.C., Signal transduction by the Wnt family of ligands (1998) Biochem J, 329, pp. 209-223
De Ferrari, G.V., Inestrosa, N.C., Wnt signaling function in Alzheimer's disease (2000) Brain Res Brain Res Rev, 33, pp. 1-12
De Ferrari, G.V., Chacon, M.A., Barria, M.I., Garrido, I.L., Godoy, J.A., Olivares, G., Reyes, A.E., Inestrosa, N.C., Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils (2003) Mol Psychiatry, 8, pp. 195-208
Fukumoto, S., Hsieh, C.M., Maemura, K., Layne, M.D., Yet, S.F., Lee, K.H., Matsui, T., Lee, M.E., Akt participation in the Wnt signaling pathway through Dishevelled (2001) J Biol Chem, 276, pp. 17479-17483
Garrido, J.L., Godoy, J.A., Alvarez, A., Bronfman, M., Inestrosa, N.C., Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway (2002) FASEB J, 16, pp. 1982-1984
Godemann, R., Biernat, J., Mandelkow, E., Mandelkow, E.M., Phosphorylation of tau protein by recombinant GSK-3beta: Pronounced phosphorylation at select Ser/Thr-Pro motifs but no phosphorylation at Ser262 in the repeat domain (1999) FEBS Lett, 454, pp. 157-164
Grimes, C.A., Jope, R.S., The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling (2001) Prog Neurobiol, 65, pp. 391-426
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-356
Hinck, L., Nelson, W.J., Papkoff, J., Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin (1994) J Cell Biol, 124, pp. 729-741
Inestrosa, N., De Ferrari, G.V., Garrido, J.L., Alvarez, A., Olivares, G.H., Barria, M.I., Bronfman, M., Chacon, M.A., Wnt signaling involvement in beta-amyloid-dependent neurodegeneration (2002) Neurochem Int, 41, pp. 341-344
Lakin, N.D., Jackson, S.P., Regulation of p53 in response to DNA damage (1999) Oncogene, 18, pp. 7644-7655
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc Natl Acad Sci USA, 90, pp. 7951-7955
Otth, C., Concha, I.I., Arendt, T., Stieler, J., Schliebs, R., Gonzalez-Billault, C., Maccioni, R.B., AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576 (2002) J Alzheimer's Dis, 4, pp. 417-430
Rocchi, A., Pellegrini, S., Siciliano, G., Murri, L., Causative and susceptibility genes for Alzheimer's disease: A review (2003) Brain Res Bull, 61, pp. 1-24
Roelen, B.A., Lin, Y.H., Knezevic, V., Freund, E., Mummery, C.L., Expression of TGF-betas and their receptors during implantation and organogenesis of the mouse embryo (1994) Dev Biol, 166, pp. 716-728
Saunders, A.M., Trowers, M.K., Shimkets, R.A., Blakemore, S., Crowther, D.J., Mansfield, T.A., Wallace, D.M., Roses, A.D., The role of apolipoprotein E in Alzheimer's disease: Pharmacogenomic target selection (2000) Biochim Biophys Acta, 1502, pp. 85-94
Shen, Y., White, E., p53-dependent apoptosis pathways (2001) Adv Cancer Res, 82, pp. 55-84
Shou, J., Ali-Osman, F., Multani, A.S., Pathak, S., Fedi, P., Srivenugopal, K.S., Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA (2002) Oncogene, 21, pp. 878-889
Smale, G., Nichols, N.R., Brady, D.R., Finch, C.E., Horton Jr., W.E., Evidence for apoptotic cell death in Alzheimer's disease (1995) Exp Neurol, 133, pp. 225-230
Takashima, A., Honda, T., Yasutake, K., Michel, G., Murayama, O., Murayama, M., Ishiguro, K., Yamaguchi, H., Activation of tau protein kinase I/gly cogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons (1998) Neurosci Res, 4, pp. 317-323
Wang, J., Shou, J., Chen, X., Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53 (2000) Oncogene, 19, pp. 1843-1848
Wassink, T.H., Piven, J., Vieland, V.J., Huang, J., Swiderski, R.E., Pietila, J., Braun, T., Sheffield, V.C., Evidence supporting WNT2 as an autism susceptibility gene (2001) Am J Med Genet, 105, pp. 406-413
Willert, K., Nusse, R., Beta-catenin: A key mediator of Wnt signaling (1998) Curr Opin Genet Dev, 8, pp. 95-102
Yu, X., Malenka, R.C., Beta-catenin is critical for dendritic morphogenesis (2003) Nat Neurosci, 6, pp. 1179-1187
Zhang, Y., McLaughlin, R., Goodyer, C., LeBlanc, A., Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons (2002) J Cell Biol, 156, pp. 519-529
Zorn, A.M., Wnt signalling: Antagonistic Dickkopfs (2001) Curr Biol, 11, pp. R592-R595
Chen, R. -W., Saunders, P. A., Wei, H., Li, Z., Seth, P., Chuang, D. M., Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53 (1999) J Neurosci, 19, pp. 9654-9662
Cotman, C. W., Anderson, A. J., A potential role for apoptosis in neurodegeneration and Alzheimer's disease (1995) Mol Neurobiol, 10, pp. 19-45
Dale, T. C., Signal transduction by the Wnt family of ligands (1998) Biochem J, 329, pp. 209-223
De Ferrari, G. V., Inestrosa, N. C., Wnt signaling function in Alzheimer's disease (2000) Brain Res Brain Res Rev, 33, pp. 1-12
Garrido, J. L., Godoy, J. A., Alvarez, A., Bronfman, M., Inestrosa, N. C., Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway (2002) FASEB J, 16, pp. 1982-1984
Grimes, C. A., Jope, R. S., The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling (2001) Prog Neurobiol, 65, pp. 391-426
Lakin, N. D., Jackson, S. P., Regulation of p53 in response to DNA damage (1999) Oncogene, 18, pp. 7644-7655
Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., Cotman, C. W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc Natl Acad Sci USA, 90, pp. 7951-7955
Roelen, B. A., Lin, Y. H., Knezevic, V., Freund, E., Mummery, C. L., Expression of TGF-betas and their receptors during implantation and organogenesis of the mouse embryo (1994) Dev Biol, 166, pp. 716-728
Saunders, A. M., Trowers, M. K., Shimkets, R. A., Blakemore, S., Crowther, D. J., Mansfield, T. A., Wallace, D. M., Roses, A. D., The role of apolipoprotein E in Alzheimer's disease: Pharmacogenomic target selection (2000) Biochim Biophys Acta, 1502, pp. 85-94
Wassink, T. H., Piven, J., Vieland, V. J., Huang, J., Swiderski, R. E., Pietila, J., Braun, T., Sheffield, V. C., Evidence supporting WNT2 as an autism susceptibility gene (2001) Am J Med Genet, 105, pp. 406-413
Zorn, A. M., Wnt signalling: Antagonistic Dickkopfs (2001) Curr Biol, 11, pp. R592-R595
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.384, 5-year impact factor: 3.236
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-3042834662&partnerID=40&md5=55a782564a4b405b6b1ada54cb81118e
Keywords: β-Amyloid, Alzheimer, S Disease, Apoptosis, Dickkopf-1, Tau Phosphorylation, Wnt Pathway, Amyloid Beta Protein, Antisense Oligonucleotide, Dickkopf 1 Protein, Glycogen Synthase Kinase 3beta, Glycoprotein, Protein P53, Regulator Protein, Tau Protein, Tumor Suppressor Protein, Unclassified Drug, Wnt Protein, Alzheimer Disease, Animal Cell, Article, Brain Cell, Controlled Study, Dystrophy, Embryo, Enzyme Activation, Gene Expression, Human, Human Tissue, Knockout Gene, Nerve Cell Culture, Nerve Cell Degeneration, Neurite, Neurofibrillary Tangle, Neurotoxicity, Nonhuman, Priority Journal, Protein Hyperphosphorylation, Protein Induction, Protein Localization, Protein Phosphorylation, Signal Transduction, Aged, 80 And Over, Amyloid Beta-Protein, Bcl-2-Associated X Protein, Dizocilpine Maleate, Gene Expression Regulation, Glutamic Acid, Immunoenzyme Techniques, Intercellular Signaling Peptides And Proteins, Nerve Degeneration, Nerve Tissue Proteins, Oligodeoxyribonucleotides, Peptide Fragments, Protein Processing, Post-Translational, Proto-Oncogene Proteins, Proto-Oncogene Proteins C-Bcl-2, Quinoxalines, Messenger, Tumor Suppressor Protein P53,
Affiliations:
*** IBB - CNR ***
Siena Biotech., 53100 Siena, Italy
Dept. of Pharmaceutical Sciences, University of Catania, 95125 Catania, Italy
Department of Neuropathology, Academic Medical Center, University of Amsterdam Meibergdreef, Amsterdam 1105 AZ, Netherlands
Dept. Hum. Physiol. and Pharmacol., University of Rome La Sapienza, 00185 Rome, Italy
Istituto Neurologico Mediterraneo, Neuromed., 86077 Pozzilli, Isernia, Italy
Ist. di Bioimmagini e Biostrutture, CNR-95125, Catania, Italy
References:
Arends, M., Duyckaerts, C., Rozemuller, J.M., Eikelenboom, P., Hauw, J.-J., Microglia, amyloid and dementia in Alzheimer disease. A correlative study (2000) Neurobiol Aging, 21, pp. 39-4
Bettini, E., Magnani, E., Terstappen, G.C., Lithium induces gene expression through lymphoid enhancer-binding factor/T-cell factor responsive element in rat PC12 cells (2002) Neurosci Lett, 317, pp. 50-52
Braak, H., Braak, E., Staging of Alzheimer's disease-related neurofibrillary changes (1995) Neurobiol Aging, 16, pp. 271-278
Caricasole, A., Ferraro, T., Rimland, J.M., Terstappen, G.C., Molecular cloning and initial characterization of the MG61/PORC gene, the human homologue of the Drosophila segment polarity gene Porcupine (2002) Gene, 288, pp. 147-157
Caricasole, A., Copani, A., Caruso, A., Caraci, F., Iacovelli, L., Sortino, M.A., Terstappen, G.C., Nicoletti, F., The Wnt pathway, cell-cycle activation and beta-amyloid: Novel therapeutic strategies in Alzheimer's disease? (2003) Trends Pharmacol Sci, 24, pp. 233-238
Chen, R.-W., Saunders, P.A., Wei, H., Li, Z., Seth, P., Chuang, D.M., Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53 (1999) J Neurosci, 19, pp. 9654-9662
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Giuffrida Stella, A.M., Canonico, P.L., Sortino, M.A., Mitotic signaling by beta-amyloid causes neuronal death (1999) FASEB J, 13, pp. 2225-2234
Copani, A., Sortino, M.A., Caricasole, A., Chiechio, S., Chisari, M., Battaglia, G., Giuffrida-Stella, A.M., Nicoletti, F., Erratic expression of DNA polymerases by beta-amyloid causes neuronal death (2002) FASEB J, 16, pp. 2006-2008
Cotman, C.W., Anderson, A.J., A potential role for apoptosis in neurodegeneration and Alzheimer's disease (1995) Mol Neurobiol, 10, pp. 19-45
Cotter, D., Kerwin, R., Al-Sarraji, S., Brion, J.P., Chadwich, A., Lovestone, S., Anderton, B., Everall, I., Abnormalities of Wnt signalling in schizophrenia-evidence for neurodevelopmental abnormality (1998) NeuroReport, 9, pp. 1379-1383. , 1998
Dale, T.C., Signal transduction by the Wnt family of ligands (1998) Biochem J, 329, pp. 209-223
De Ferrari, G.V., Inestrosa, N.C., Wnt signaling function in Alzheimer's disease (2000) Brain Res Brain Res Rev, 33, pp. 1-12
De Ferrari, G.V., Chacon, M.A., Barria, M.I., Garrido, I.L., Godoy, J.A., Olivares, G., Reyes, A.E., Inestrosa, N.C., Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils (2003) Mol Psychiatry, 8, pp. 195-208
Fukumoto, S., Hsieh, C.M., Maemura, K., Layne, M.D., Yet, S.F., Lee, K.H., Matsui, T., Lee, M.E., Akt participation in the Wnt signaling pathway through Dishevelled (2001) J Biol Chem, 276, pp. 17479-17483
Garrido, J.L., Godoy, J.A., Alvarez, A., Bronfman, M., Inestrosa, N.C., Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway (2002) FASEB J, 16, pp. 1982-1984
Godemann, R., Biernat, J., Mandelkow, E., Mandelkow, E.M., Phosphorylation of tau protein by recombinant GSK-3beta: Pronounced phosphorylation at select Ser/Thr-Pro motifs but no phosphorylation at Ser262 in the repeat domain (1999) FEBS Lett, 454, pp. 157-164
Grimes, C.A., Jope, R.S., The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling (2001) Prog Neurobiol, 65, pp. 391-426
Hardy, J., Selkoe, D.J., The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics (2002) Science, 297, pp. 353-356
Hinck, L., Nelson, W.J., Papkoff, J., Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin (1994) J Cell Biol, 124, pp. 729-741
Inestrosa, N., De Ferrari, G.V., Garrido, J.L., Alvarez, A., Olivares, G.H., Barria, M.I., Bronfman, M., Chacon, M.A., Wnt signaling involvement in beta-amyloid-dependent neurodegeneration (2002) Neurochem Int, 41, pp. 341-344
Lakin, N.D., Jackson, S.P., Regulation of p53 in response to DNA damage (1999) Oncogene, 18, pp. 7644-7655
Loo, D.T., Copani, A., Pike, C.J., Whittemore, E.R., Walencewicz, A.J., Cotman, C.W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc Natl Acad Sci USA, 90, pp. 7951-7955
Otth, C., Concha, I.I., Arendt, T., Stieler, J., Schliebs, R., Gonzalez-Billault, C., Maccioni, R.B., AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576 (2002) J Alzheimer's Dis, 4, pp. 417-430
Rocchi, A., Pellegrini, S., Siciliano, G., Murri, L., Causative and susceptibility genes for Alzheimer's disease: A review (2003) Brain Res Bull, 61, pp. 1-24
Roelen, B.A., Lin, Y.H., Knezevic, V., Freund, E., Mummery, C.L., Expression of TGF-betas and their receptors during implantation and organogenesis of the mouse embryo (1994) Dev Biol, 166, pp. 716-728
Saunders, A.M., Trowers, M.K., Shimkets, R.A., Blakemore, S., Crowther, D.J., Mansfield, T.A., Wallace, D.M., Roses, A.D., The role of apolipoprotein E in Alzheimer's disease: Pharmacogenomic target selection (2000) Biochim Biophys Acta, 1502, pp. 85-94
Shen, Y., White, E., p53-dependent apoptosis pathways (2001) Adv Cancer Res, 82, pp. 55-84
Shou, J., Ali-Osman, F., Multani, A.S., Pathak, S., Fedi, P., Srivenugopal, K.S., Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA (2002) Oncogene, 21, pp. 878-889
Smale, G., Nichols, N.R., Brady, D.R., Finch, C.E., Horton Jr., W.E., Evidence for apoptotic cell death in Alzheimer's disease (1995) Exp Neurol, 133, pp. 225-230
Takashima, A., Honda, T., Yasutake, K., Michel, G., Murayama, O., Murayama, M., Ishiguro, K., Yamaguchi, H., Activation of tau protein kinase I/gly cogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons (1998) Neurosci Res, 4, pp. 317-323
Wang, J., Shou, J., Chen, X., Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53 (2000) Oncogene, 19, pp. 1843-1848
Wassink, T.H., Piven, J., Vieland, V.J., Huang, J., Swiderski, R.E., Pietila, J., Braun, T., Sheffield, V.C., Evidence supporting WNT2 as an autism susceptibility gene (2001) Am J Med Genet, 105, pp. 406-413
Willert, K., Nusse, R., Beta-catenin: A key mediator of Wnt signaling (1998) Curr Opin Genet Dev, 8, pp. 95-102
Yu, X., Malenka, R.C., Beta-catenin is critical for dendritic morphogenesis (2003) Nat Neurosci, 6, pp. 1179-1187
Zhang, Y., McLaughlin, R., Goodyer, C., LeBlanc, A., Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons (2002) J Cell Biol, 156, pp. 519-529
Zorn, A.M., Wnt signalling: Antagonistic Dickkopfs (2001) Curr Biol, 11, pp. R592-R595
Chen, R. -W., Saunders, P. A., Wei, H., Li, Z., Seth, P., Chuang, D. M., Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53 (1999) J Neurosci, 19, pp. 9654-9662
Cotman, C. W., Anderson, A. J., A potential role for apoptosis in neurodegeneration and Alzheimer's disease (1995) Mol Neurobiol, 10, pp. 19-45
Dale, T. C., Signal transduction by the Wnt family of ligands (1998) Biochem J, 329, pp. 209-223
De Ferrari, G. V., Inestrosa, N. C., Wnt signaling function in Alzheimer's disease (2000) Brain Res Brain Res Rev, 33, pp. 1-12
Garrido, J. L., Godoy, J. A., Alvarez, A., Bronfman, M., Inestrosa, N. C., Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway (2002) FASEB J, 16, pp. 1982-1984
Grimes, C. A., Jope, R. S., The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling (2001) Prog Neurobiol, 65, pp. 391-426
Lakin, N. D., Jackson, S. P., Regulation of p53 in response to DNA damage (1999) Oncogene, 18, pp. 7644-7655
Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., Cotman, C. W., Apoptosis is induced by beta-amyloid in cultured central nervous system neurons (1993) Proc Natl Acad Sci USA, 90, pp. 7951-7955
Roelen, B. A., Lin, Y. H., Knezevic, V., Freund, E., Mummery, C. L., Expression of TGF-betas and their receptors during implantation and organogenesis of the mouse embryo (1994) Dev Biol, 166, pp. 716-728
Saunders, A. M., Trowers, M. K., Shimkets, R. A., Blakemore, S., Crowther, D. J., Mansfield, T. A., Wallace, D. M., Roses, A. D., The role of apolipoprotein E in Alzheimer's disease: Pharmacogenomic target selection (2000) Biochim Biophys Acta, 1502, pp. 85-94
Wassink, T. H., Piven, J., Vieland, V. J., Huang, J., Swiderski, R. E., Pietila, J., Braun, T., Sheffield, V. C., Evidence supporting WNT2 as an autism susceptibility gene (2001) Am J Med Genet, 105, pp. 406-413
Zorn, A. M., Wnt signalling: Antagonistic Dickkopfs (2001) Curr Biol, 11, pp. R592-R595
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain
We used primary cultures of cortical neurons to examine the relationship between β-amyloid toxicity and hyperphosphorylation of the tau protein, the biochemical substrate for neurofibrillary tangles of Alzheimer's brain. Exposure of the cultures to β-amyloid peptide (βAP) induced the expression of the secreted glycoprotein Dickkopf-1 (DKK1). DKK1 negatively modulates the canonical Wnt signaling pathway, thus activating the tau-phosphorylating enzyme glycogen synthase kinase-3β. DKK1 was induced at late times after βAP exposure, and its expression was dependent on the tumor suppressing protein p53. The antisense induced knock-down of DKK1 attenuated neuronal apoptosis but nearly abolished the increase in tau phosphorylation in βAP-treated neurons. DKK1 was also expressed by degenerating neurons in the brain from Alzheimer's patients, where it colocalized with neurofibrillary tangles and distrophic neurites. We conclude that induction of DKK1 contributes to the pathological cascade triggered by β-amyloid and is critically involved in the process of tau phosphorylation.
We used primary cultures of cortical neurons to examine the relationship between β-amyloid toxicity and hyperphosphorylation of the tau protein, the biochemical substrate for neurofibrillary tangles of Alzheimer's brain. Exposure of the cultures to β-amyloid peptide (βAP) induced the expression of the secreted glycoprotein Dickkopf-1 (DKK1). DKK1 negatively modulates the canonical Wnt signaling pathway, thus activating the tau-phosphorylating enzyme glycogen synthase kinase-3β. DKK1 was induced at late times after βAP exposure, and its expression was dependent on the tumor suppressing protein p53. The antisense induced knock-down of DKK1 attenuated neuronal apoptosis but nearly abolished the increase in tau phosphorylation in βAP-treated neurons. DKK1 was also expressed by degenerating neurons in the brain from Alzheimer's patients, where it colocalized with neurofibrillary tangles and distrophic neurites. We conclude that induction of DKK1 contributes to the pathological cascade triggered by β-amyloid and is critically involved in the process of tau phosphorylation.
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain
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Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (489 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (544 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (794 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
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Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (642 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
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Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PLS, Carrotta R
* Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains (367 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2016; 208: 9-16.
Impact Factor: 2.402
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Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (528 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (527 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (806 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (527 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
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Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (708 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
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Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (500 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (543 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (838 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (629 views)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
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Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (739 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (457 views)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (770 views)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1583 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (1035 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (531 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (612 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (576 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (611 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (805 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (698 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (499 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (399 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
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Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (569 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (517 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (629 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (579 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (371 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
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* Plant isoquinoline alkaloids as potential neurodrugs: A comparative study of the effects of benzo[c]phenanthridine and berberine based compounds on β-amyloid aggregation (145 views)
Chem Biol Interact (ISSN: 0009-2797linking), 2021 Jan 25; 334: 109300-109301.
Impact Factor: 5.192
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Sciacca MFM, Monaco I, La Rosa C, Milardi D
* The active role of Ca(2+) ions in Abeta-mediated membrane damage (325 views)
Chem Commun (ISSN: 1364-548xelectronic, 1359-7345linking), 2018 Apr 5; 54(29): 3629-3631.
Impact Factor: 6.169
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (489 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (544 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (794 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
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Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
* The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ss1-42 oligomers in mice (642 views)
Pharmacol Res (ISSN: 1043-6618, 1096-1186electronic), 2016 Apr; 106: 10-20.
Impact Factor: 4.48
View Export to BibTeX Export to EndNote
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PLS, Carrotta R
* Amyloid β-peptide insertion in liposomes containing GM1-cholesterol domains (367 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2016; 208: 9-16.
Impact Factor: 2.402
View Export to BibTeX Export to EndNote
Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (528 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (527 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
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Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (806 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
View Export to BibTeX Export to EndNote
Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
View Export to BibTeX Export to EndNote
Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (527 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
View Export to BibTeX Export to EndNote
Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (708 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Autiero I, Saviano M, Langella E
* In silico investigation and targeting of amyloid beta oligomers of different size (500 views)
Mol Biosyst (ISSN: 1742-206x, 1742-2051electronic), 2013 Aug; 9(8): 2118-2124.
Impact Factor: 3.18
View Export to BibTeX Export to EndNote
Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (543 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (838 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Pandini G, Pace V, Copani A, Squatrito S, Milardi D, Vigneri R
* Insulin has multiple antiamyloidogenic effects on human neuronal cells (629 views)
Endocrinology (ISSN: 0013-7227, 1945-7170), 2013 Jan; 154(1): 375-387.
Impact Factor: 4.644
View Export to BibTeX Export to EndNote
Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (739 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
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Attanasio F, De Bona P, Cataldo S, Sciacca MFM, Milardi D, Pignataro B, Pappalardo G
* Copper(II) and zinc(II) dependent effects on A beta 42 aggregation: a CD, Th-T and SFM study (457 views)
New J Chem (ISSN: 1144-0546), 2013; 37(4): 1206-1215.
Impact Factor: 3.159
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Autiero I, Langella E, Saviano M
* Insights Into The Mechanism Of Interaction Between Trehalose-Conjugated Beta-Sheet Breaker Peptides And Aβ(1-42) Fibrils By Molecular Dynamics Simulations (770 views)
Molecular Biosystems (ISSN: 1742-206x, 1742-2206), 2013; 9(11): 2835-2841.
Impact Factor: 3.18
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1583 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (1035 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (597 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (1289 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (531 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (612 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (765 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (576 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (448 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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Jozsa E, Hosz K, Kallay C, De Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sovago I
* Nickel (ii) And Mixed Metal Complexes Of Amyloid-B N-Terminus. Results Of Potentiometric And Spectroscopic Studies On The Binary Nickel (ii) And Mixed Metal Nickel (ii)-Copper (ii) And Nickel (ii)-Copper (ii)-Zinc (ii) Complexes Of Peptide Fragments (489 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010; 39(30): 7046-7053.
Impact Factor: 3.647
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (681 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (611 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (805 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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De Bona P, Giuffrida ML, Caraci F, Copani A, Pignataro B, Attanasio F, Cataldo S, Pappalardo G, Rizzarelli E
* Design And Synthesis Of New Trehalose-Conjugated Pentapeptides As Inhibitors Of Abeta (1-42) Fibrillogenesis And Toxicity (698 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 220-228.
Impact Factor: 1.807
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D'Auria G, Vacatello M, Falcigno L, Paduano L, Mangiapia G, Calvanese L, Gambaretto R, Dettin M, Paolillo L
* Self-assembling properties of ionic-complementary peptides (499 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 210-219.
Impact Factor: 1.807
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (455 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti
* The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders (399 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2008 Dec; 33(12): 2401-2406.
Impact Factor: 2.26
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Damante CA, Ösz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* The Metal Loading Ability Of Beta-Amyloid N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Copper (ii) Complexes With Beta-Amyloid (1-16), Its Short Or Mutated Peptide Fragments, And Its Polyethylene Glycol (peg)-Ylated Analogue (569 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2008 Oct 20; 47(20): 9669-9683.
Impact Factor: 4.147
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Caraci F, Battaglia G, Busceti C, Biagioni F, Mastroiacovo F, Bosco P, Drago F, Nicoletti F, Sortino MA, Copani A
* TGF-β1 protects against Aβ-neurotoxicity via the phosphatidylinositol-3-kinase pathway (440 views)
Neurobiology Of Disease (ISSN: 0969-9961), 2008 May; 30(2): 234-242.
Impact Factor: 4.852
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Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (454 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (517 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (629 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (579 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (585 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (808 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (722 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
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Aime S, Dastrù W, Gobetto R, Viale A
An NMR study of H(μ-H)Os3(CO)11 (371 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2000; 39(11): 2422-2425.
Impact Factor: 2.712
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48 Records (47 excluding Abstracts).
Total impact factor: 184.682 (180.59 excluding Abstracts).
Total 5 year impact factor: 187.472 (182.935 excluding Abstracts).
Total impact factor: 184.682 (180.59 excluding Abstracts).
Total 5 year impact factor: 187.472 (182.935 excluding Abstracts).
553 views. Last view on Tuesday 06 June 2023, 6:04:57
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