Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins (629 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
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Paper type: Journal Article,
Impact factor: 2.326, 5-year impact factor: 3.148
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874850186&partnerID=40&md5=8bb221fcb760d60daed2fc2a9ceedfd4
Keywords: Bacteria, Immunobiology, Porin, Signaling Pathways, Structure, Antibiotic Agent, Bacteriorhodopsin, Cd11 Antigen, Cd14 Antigen, Cd18 Antigen, Immunoglobulin Enhancer Binding Protein, Interleukin 6, Lipopolysaccharide, Mitogen Activated Protein Kinase Kinase 1, Myeloid Differentiation Factor 88, Outer Membrane Protein F, Toll Like Receptor 1, Tumor Necrosis Factor Alpha, Antibiotic Resistance, Bacterial Infection, Bacterial Membrane, Gram Negative Bacterium, Haemophilus Influenzae, Host Pathogen Interaction, Human, Nonhuman, Oligomerization, Pathogenesis, Protein Assembly, Protein Structure, Pseudomonas Aeruginosa, Review, Signal Transduction, Animals, Drug Resistance, Microbial, Gram-Negative Bacteria, Host-Pathogen Interactions, Structure-Activity Relationship,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, Division of Biostructures, University of Naples Federico II and Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134, Naples, Italy
Department of Experimental Medicine, Division of Microbiology -II University of Naples, Via De Crecchio 7, 80138, Naples, Italy
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West, A. P., Koblansky, A. A., Ghosh, S., Recognition and signaling by toll-like receptors (2006) Annu Rev Cell Dev. Biol, 22, pp. 409-437
Jin, M. S., Kim, S. E., Heo, J. Y., Lee, M. E., Kim, H. M., Paik, S. G., Lee, H., Lee, J. O., Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide (2007) Cell, 130, pp. 1071-1082
Ferguson, A. D., Welte, W., Hofmann, E., Lindner, B., Holst, O., Coulton, J. W., Diederichs, K., A conserved structural motif for lipopolysaccharide recognition by procaryotic and eucaryotic proteins (2000) Structure, 8, pp. 585-592
Yi, K., Murphy, T. F., Importance of an immunodominant surfaceexposed loop on outer membrane protein P2 of nontypeable Haemophilus influenzae (1997) Infect. Immun, 65, pp. 150-155
Haase, E. M., Yi, K., Morse, G. D., Murphy, T. F., Mapping of bactericidal epitopes on the P2 porin protein of nontypeable Haemophilus influenzae (1994) Infect. Immun, 62, pp. 3712-3722
Neary, J. M., Yi, K., Karalus, R. J., Murphy, T. F., Antibodies to loop 6 of the P2 porin protein of nontypeable Haemophilus influenzae are bactericidal against multiple strains (2001) Infect Immun, 69, pp. 773-778
Hughes, E. E., Gilleland, L. B., Gilleland Jr., H. E., Synthetic peptides representing epitopes of outer membrane protein F of Pseudomonas aeruginosa that elicit antibodies reactive with whole cells of heterologous immunotype strains of P. aeruginosa (1992) Infect Immun, 60, pp. 3497-3503
Maiden, M. C., Suker, J., McKenna, A. J., Bygraves, J. A., Feavers, I. M., Comparison of the class 1 outer membrane proteins of eight serological reference strains of Neisseria meningitidis (1991) Mol. Microbiol, 5, pp. 727-736
Thompson, E. A., Feavers, I. M., Maiden, M. C., Antigenic diversity of meningococcal enterobactin receptor FetA, a vaccine component (2003) Microbiology, 149, pp. 1849-1858
Li, S., Sedivy, J. M., Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 9247-9251
Rice, L. B., Emerging issues in the management of infections caused by multidrug-resistant gram-negative bacteria (2007) Cleve. Clin. J. Med, 74 (SUPPL. 4), pp. S12-S20
Hancock, R. E., Bell, A., Antibiotic uptake into gram-negative bacteria (1988) Eur. J. Clin. Microbiol. Infect. Dis, 7, pp. 713-720
George, A. M., Levy, S. B., Gene in the major cotransduction gap of the Escherichia coli K-12 linkage map required for the expression of chromosomal resistance to tetracycline and other antibiotics (1983) J. Bacteriol, 155, pp. 541-548
Gill, M. J., Simjee, S., Al-Hattawi, K., Robertson, B. D., Easmon, C. S., Ison, C. A., Gonococcal resistance to beta-lactams and tetracycline involves mutation in loop 3 of the porin encoded at the penB locus (1998) Antimicrob. Agents Chemother, 42, pp. 2799-2803
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2012 Dec; 13(8): 843-854.
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Paper type: Journal Article,
Impact factor: 2.326, 5-year impact factor: 3.148
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84874850186&partnerID=40&md5=8bb221fcb760d60daed2fc2a9ceedfd4
Keywords: Bacteria, Immunobiology, Porin, Signaling Pathways, Structure, Antibiotic Agent, Bacteriorhodopsin, Cd11 Antigen, Cd14 Antigen, Cd18 Antigen, Immunoglobulin Enhancer Binding Protein, Interleukin 6, Lipopolysaccharide, Mitogen Activated Protein Kinase Kinase 1, Myeloid Differentiation Factor 88, Outer Membrane Protein F, Toll Like Receptor 1, Tumor Necrosis Factor Alpha, Antibiotic Resistance, Bacterial Infection, Bacterial Membrane, Gram Negative Bacterium, Haemophilus Influenzae, Host Pathogen Interaction, Human, Nonhuman, Oligomerization, Pathogenesis, Protein Assembly, Protein Structure, Pseudomonas Aeruginosa, Review, Signal Transduction, Animals, Drug Resistance, Microbial, Gram-Negative Bacteria, Host-Pathogen Interactions, Structure-Activity Relationship,
Affiliations:
*** IBB - CNR ***
Department of Biological Sciences, Division of Biostructures, University of Naples Federico II and Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134, Naples, Italy
Department of Experimental Medicine, Division of Microbiology -II University of Naples, Via De Crecchio 7, 80138, Naples, Italy
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Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins
Gram negative bacteria have evolved many mechanisms of attaching to and invading host epithelial and immune cells. In particular, many outer membrane proteins (OMPs) are involved in this initial interaction between the pathogen and their host. The outer membrane (OM) of Gram-negative bacteria performs the crucial role of providing an extra layer of protection to the organism without compromising the exchange of material required for sustaining life. The OM, therefore, represents a sophisticated macromolecular assembly, whose complexity has yet to be fully elucidated. This review will summarize the structural information available for porins, a class of OMP, and highlight their role in bacterial pathogenesis and their potential as therapeutic targets. The functional role of porins in microbe-host interactions during various bacterial infections has emerged only during the last few decades, and their interaction with a variety of host tissues for adhesion to and invasion of the cell and for evasion of host-defense mechanisms have placed bacterial porins at the forefront of research in bacterial pathogenesis. This review will discuss the role that porins play in activating immunological responses, in inducing signaling pathways and their influence on antibiotic resistance mechanisms that involve modifications of the properties of the OM lipid barrier.
Gram negative bacteria have evolved many mechanisms of attaching to and invading host epithelial and immune cells. In particular, many outer membrane proteins (OMPs) are involved in this initial interaction between the pathogen and their host. The outer membrane (OM) of Gram-negative bacteria performs the crucial role of providing an extra layer of protection to the organism without compromising the exchange of material required for sustaining life. The OM, therefore, represents a sophisticated macromolecular assembly, whose complexity has yet to be fully elucidated. This review will summarize the structural information available for porins, a class of OMP, and highlight their role in bacterial pathogenesis and their potential as therapeutic targets. The functional role of porins in microbe-host interactions during various bacterial infections has emerged only during the last few decades, and their interaction with a variety of host tissues for adhesion to and invasion of the cell and for evasion of host-defense mechanisms have placed bacterial porins at the forefront of research in bacterial pathogenesis. This review will discuss the role that porins play in activating immunological responses, in inducing signaling pathways and their influence on antibiotic resistance mechanisms that involve modifications of the properties of the OM lipid barrier.
Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins
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Microbe-Host Interactions: Structure and Role of Gram-Negative Bacterial Porins
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Link W, Ilardi G, Zannetti A
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Impact Factor: 3.463
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Leone M, Barile E, Vazquez J, Mei A, Guiney D, Dahl R, Pellecchia M
* NMR-based design and evaluation of novel bidentate inhibitors of the protein tyrosine phosphatase YopH (519 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285), 2010 Jul; 76(1): 10-16.
Impact Factor: 2.527
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Capparelli R, Romanelli A, Iannaccone M, Nocerino N, Ripa R, Pensato S, Pedone C, Iannelli D
* Synergistic antibacterial and anti-inflammatory activity of temporin A and modified temporin B in vivo (452 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 28; 4(9): e7191-e7191.
Impact Factor: 4.351
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Dalla Serra M, Cirioni O, Vitale RM, Renzone G, Coraiola M, Giacometti A, Potrich C, Baroni E, Guella G, Sanseverino M, De Luca S, Scalise G, Amodeo P, Scaloni A
* Structural features of distinctin affecting peptide biological and biochemical properties (577 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 29; 47(30): 7888-7899.
Impact Factor: 3.379
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Ronga L, Langella E, Palladino P, Marasco D, Tizzano B, Saviano M, Pedone C, Improta R, Ruvo M
* Does Tetracycline Bind Helix 2 Of Prion? An Integrated Spectroscopical And Computational Study Of The Interaction Between The Antibiotic And Alpha Helix 2 Human Prion Protein Fragments (512 views)
Proteins (ISSN: 0887-3585, 1097-0134, 1097-0134electronic), 2007 Feb 15; 66(3): 707-715.
Impact Factor: 3.354
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Ronga L, Palladino P, Costantini S, Facchiano A, Ruvo M, Benedetti E, Ragone R, Rossi F
* Conformational diseases and structure-toxicity relationships: Lessons from prion-derived peptides (553 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 83-90.
Impact Factor: 3.259
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Agmon I, Amit M, Auerbach T, Bashan A, Baram D, Bartels H, Berisio R, Greenberg I, Harms J, Hansen HAS, Kessler M, Pyetan E, Schluenzen F, Sittner A, Yonath A, Zarivach R
* Ribosomal crystallography: A flexible nucleotide anchoring tRNA translocation, facilitates peptide-bond formation, chirality discrimination and antibiotics synergism (312 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2004 Jun 1; 567(1): 20-26.
Impact Factor: 3.843
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Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
* Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (589 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
Impact Factor: 2.863
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Bashan A, Zarivach R, Schluenzen F, Agmon I, Harms J, Auerbach T, Baram D, Berisio R, Bartels H, Hansen HAS, Fucini P, Wilson D, Peretz M, Kessler M, Yonath A
* Ribosomal crystallography: Peptide bond formation and its inhibition (544 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2003 Sep; 70(1): 19-41.
Impact Factor: 2.733
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Berisio R, Schluenzen F, Harms J, Bashan A, Auerbach T, Baram D, Yonath A
* Structural insight into the role of the ribosomal tunnel in cellular regulation (375 views)
Nat Struct Biol (ISSN: 1072-8368), 2003 May; 10(5): 366-370.
Impact Factor: 11.579
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Monti SM, Fogliano V, Logrieco A, Ferracane R, Ritieni A
Simultaneous determination of beauvericin, enniatins, and fusaproliferin by high performance liquid chromatography (493 views)
J Agric Food Chem (ISSN: 0021-8561), 2000 Sep; 48(8): 3317-3320.
Impact Factor: 1.56
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29 Records (27 excluding Abstracts).
Total impact factor: 110.223 (104.096 excluding Abstracts).
Total 5 year impact factor: 108.226 (101.88 excluding Abstracts).
Total impact factor: 110.223 (104.096 excluding Abstracts).
Total 5 year impact factor: 108.226 (101.88 excluding Abstracts).
629 views. Last view on Wednesday 22 March 2023, 13:21:09
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