Biophysical Characterization and Membrane Interaction of the Two Fusion Loops of Glycoprotein B from Herpes Simplex Type I Virus (526 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Feb 23; 7(2): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Abstract, Conference,
Impact factor: 3.73, 5-year impact factor: 4.244
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857612232&partnerID=40&md5=d3404d873c65fcde5228d3bc0f3f3fa9
Keywords: Glycoprotein B, Peptide, Acrylamide, Simplexvirus, Lipid, Tryptophan, Tyrosine, Virus Envelope Protein, Article, Controlled Study, Herpes Simplex Virus 1, Hydrophobicity, Lipid Bilayer, Membrane Binding, Nonhuman, Protein Domain, Biophysics, Chemistry, Metabolism, Methodology, Protein Motif, Protein Secondary Structure, Spectrofluorometry, X Ray Crystallography, Herpesviridae, Human Herpesvirus 1, Amino Acid Motifs, X-Ray, Protein Structure, Spectrometry, Fluorescence, Viral Envelope Proteins,
Affiliations:
*** IBB - CNR ***
Division of Biostructures, Department of Biological Sciences, University of Naples Federico II, Napoli, Italy
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples Federico II, Napoli, Italy
Department of Chemistry, University of Naples Federico II, Consorzio per lo Studio dei Sistemi a Grande Interfase, CSGI, Monte Sant'Angelo, Napoli, Italy
Department of Experimental Medicine, II University of Naples, Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy
References:
Falanga, A., Cantisani, M., Pedone, C., Galdiero, S., Membrane fusion and fission: enveloped viruses (2009) Prot Pept Lett, 16, pp. 751-75
Galdiero, S., Developments in membrane fusion (2009) Prot Pept Lett, 16, p. 711
Chernomordik, L.V., Kozlov, M.M., Protein-lipid interplay in fusion and fission of biological membranes (2003) Annu Rev Biochem, 72, pp. 175-207
Harrison, S.C., Viral membrane fusion (2008) Nature Structural Molecular Biology, 15, pp. 690-698
Drin, G., Casella, J.F., Gautier, R., Boehmer, T., Schwartz, T.U., A general amphipathic alpha-helical motif for sensing membrane curvature (2007) Nat Struct Mol Biol, 14, pp. 138-146
Antonny, B., Mechanisms of membrane curvature sensing (2011) Annu Rev Biochem, 80, pp. 101-123
Connolly, S.A., Jackson, J.O., Jardetzky, T.S., Longnecker, R., Fusing structure and function: a structural view of the herpesvirus entry machinery (2011) Nat Rev Microbiol, 9, pp. 369-381
Turner, A., Bruun, B., Minson, T., Browne, H., Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system (1998) J Virol, 72, pp. 873-875
Farnsworth, A., Wisner, T.W., Webb, M., Roller, R., Cohen, G., Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane (2007) Proc Natl Acad Sci U S A, 104, pp. 10187-10192
Atanasiu, D., Whitbeck, J.C., Cairns, T.M., Reilly, B., Cohen, G.H., Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion (2007) Proc Natl Acad Sci U S A, 104, pp. 18718-18723
Avitabile, E., Forghieri, C., Campadelli-Fiume, G., Complexes between herpes simplex virus glycoproteins gD, gB, and gH detected in cells by complementation of split enhanced green fluorescent protein (2007) J Virol, 81, pp. 11532-11537
Galdiero, S., Vitiello, M., D'Isanto, M., Falanga, A., Collins, C., Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and B (2006) J Gen Virol, 87, pp. 1085-1097
Galdiero, S., Falanga, A., Vitiello, M., Browne, H., Pedone, C., Fusogenic domains in herpes simplex virus type 1 glycoprotein H (2005) J Biol Chem, 280, pp. 28632-28643
Chowdary, T.K., Cairns, T.M., Atanasiu, D., Cohen, G.H., Eisenberg, R.J., Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL (2010) Nat Struct Mol Biol, 17, pp. 882-888
Matsuura, H., Kirschner, A.N., Longnecker, R., Jardetzky, T.S., Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex (2010) Proc Natl Acad Sci U S A, 107, pp. 22641-22646
Heldwein, E.E., Lou, H., Bender, F.C., Cohen, G.H., Eisenberg, R.J., Crystal structure of glycoprotein B from herpes simplex virus 1 (2006) Science, 313, pp. 217-220
Backovic, M., Longnecker, R., Jardetzky, T.S., Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B (2009) Proc Natl Acad Sci U S A, 106, pp. 2880-2885
Roche, S., Bressanelli, S., Rey, F.A., Gaudin, Y., Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G (2006) Science, 313, pp. 187-191
Kadlec, J., Loureiro, S., Abrescia, N.G., Stuart, D.I., Jones, I.M., The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines (2008) Nat Struct Mol Biol, 15, pp. 1024-1030
Akkarawongsa, R., Pocaro, N.E., Case, G., Kolb, A.W., Brandt, C.R., Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection (2009) Antimicrob Agents Chem, 53, pp. 987-996
Hannah, B.P., Heldwein, E.E., Bender, F.C., Cohen, G.H., Eisenberg, R.J., Mutational evidence of internal fusion loops in herpes simplex virus glycoprotein B (2007) J Virol, 81, pp. 4858-4865
Roche, S., Albertini, A.A., Lepault, J., Bressanelli, S., Gaudin, Y., Structures of vesicular stomatitis virus glycoprotein: membrane fusion revisited (2008) Cell Mol Life Sci, 65, pp. 1716-1728
Sun, X., Belouzard, S., Whittaker, G.R., Molecular architecture of the bipartite fusion loops of vesicular stomatitis virus glycoprotein G, a class III viral fusion protein (2008) J Biol Chem, 283, pp. 6418-6427
Vitiello, G., Falanga, A., Galdiero, M., Marsh, D., Galdiero, S., Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes (2011) Biochim Biophys Acta, 1808, pp. 1526-2517
Bender, F.C., Whitbeck, J.C., Ponce de Leon, M., Lou, H., Eisenberg, R.J., Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry (2003) J Virol, 77, pp. 9542-9552
de Almeida, R.F.M., Fedorov, A., Prieto, M., Sphingomyelin/Phosphatidylcholine/cholesterol phase diagram: boundaries and composition of lipid rafts (2003) Biophys J, 85, pp. 2406-2416
Ellens, H., Bentz, J., Szoka Jr., F.C., pH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact (1984) Biochemistry, 23, pp. 1532-1538
Parente, R.A., Nir, S., Szoka Jr., F.C., Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA (1990) Biochemistry, 29, pp. 8713-8719
Levine III., H., Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution (1993) Prot Sci, 2, pp. 404-410
Yau, W.M., Wimley, W.C., Gawrisch, K., White, S.H., The preference of tryptophan for membrane interfaces (1998) Biochemistry, 37, pp. 14713-14718
Gordon, L.M., Curtain, C.C., Zhong, Y.C., Kirkpatrick, A., Mobley, P.W., The amino-terminal peptide of HIV-1 glycoprotein 41 interacts with human erythrocyte membranes: peptide conformation, orientation and aggregation (1992) Biochim Biophys Acta, 1139, pp. 257-274
Curtain, C., Separovic, F., Nielsen, K., Craik, D., Zhong, Y., The interactions of the N-terminal fusogenic peptide of HIV-1 gp41 with neutral phospholipids (1999) European Biophysical Journal, 28, pp. 427-436
D'Errico, G., D'Ursi, A.M., Marsh, D., Interaction of a peptide derived from glycoprotein gp36 of feline immunodeficiency virus and its lipoylated analogue with phospholipid membranes (2008) Biochemistry, 47, pp. 5317-5327
Spadaccini, R., D'Errico, G., D'Alessio, V., Notomista, E., Bianchi, A., Structural characterization of the transmembrane proximal region of the hepatitis C virus E1 glycoprotein (2010) Biochim Biophys Acta, 1798, pp. 344-353
Marsh, D., Liquid-ordered phases induced by cholesterol: a compendium of binary phase diagrams (2010) Biochim Biophys Acta, 1798, pp. 688-699
Swamy, M.J., Marsh, D., Spin-label electron spin resonance studies on the dynamics of the different phases of N-biotinylphosphatidylethanolamines (1994) Biochemistry, 33, pp. 11656-11663
Moser, M., Marsh, D., Meier, P., Wassmer, K.H., Kothe, G., Chain configuration and flexibility gradient in phospholipid membranes. Comparison between spin-label electron spin resonance and deuteron nuclear magnetic resonance, and identification of new conformations (1989) Biophys J, 55, pp. 111-123
Rama Krishna, Y.V.S., Marsh, D., Spin label ESR and 31P-NMR studies of the cubic and inverted hexagonal phases of dimyristoylphosphatidylcholine/myristic acid (1:2, mol/mol) mixtures (1990) Biochim Biophys Acta, 1024, pp. 89-94
Lange, A., Marsh, D., Wassmer, K.H., Meier, P., Kothe, G., Electron spin resonance study of phospholipid membranes employing a comprehensive line-shape model (1985) Biochemistry, 24, pp. 4383-4392
D'Errico, G., Vitiello, G., Ortona, O., Tedeschi, A., Ramunno, A., Interaction between Alzheimer's Abeta(25-35) peptide and phospholipid bilayers: the role of cholesterol (2008) Biochim Biophys Acta, 1778, pp. 2710-2716
Hannah, B.P., Cairns, T.M., Bender, F.C., Whitbeck, J.C., Lou, H., Herpes simplex virus glycoprotein B associates with target membranes via its fusion loops (2009) J Virol, 83, pp. 6825-6836
Ahn, A., Gibbons, D.L., Kielian, M., The fusion peptide of Semliki Forest virus associates with sterol-rich membrane domains (2002) J Virol, 76, pp. 3267-3275
Chatterjee, P.K., Eng, C.H., Kielian, M., Novel mutations that control the sphingolipid and cholesterol dependence of the Semliki Forest virus fusion protein (2002) J Virol, 76, pp. 12712-12722
Vashishtha, M., Phalen, T., Marquardt, M.T., Ryu, J.S., Ng, A.C., A single point mutation controls the cholesterol dependence of Semliki Forest virus entry and exit (1998) J Cell Biol, 14, pp. 91-99
Thorén, P.E., Persson, D., Lincoln, P., Nordén, B., Membrane destabilizing properties of cell-penetrating peptides (2005) Biophys Chem, 114, pp. 169-179
Stankowski, S., Schwarz, G., Electrostatics of a peptide at a membrane/water interface. The pH dependence of melittin association with lipid vesicles (1990) Biochim Biophys Acta, 1025, pp. 164-172
Thiaudière, E., Siffert, O., Talbot, J.C., Bolard, J., Alouf, J.E., Theamphiphilic alpha-helix concept. Consequences on the structure of staphylococcal delta-toxin in solution and bound to lipids (1991) Eur J Biochem, 195, pp. 203-213
Pouny, Y., Rapaport, D., Mor, A., Nicolas, P., Shai, Y., Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes (1992) Biochemistry, 31, pp. 12416-12423
Rapaport, D., Shai, Y., Interaction of fluorescently labeled pardaxin and its analogues with lipid bilayers (1991) J Biol Chem, 266, pp. 23769-23775
Tarallo, R., Accardo, A., Falanga, A., Guarnieri, D., Vitiello, G., Clickable Functionalization of Liposomes with the gH625 Peptide from Herpes simplex Virus Type I for Intracellular Drug Delivery (2011) Chem Eur J, 17, pp. 12659-12668
Marsh, D., Electron spin resonance in membrane research: Protein-lipid interactions (2008) Methods, 46, pp. 83-96
Hope, M.J., Bally, M.B., Webb, G., Cullis, P.R., Vesicles of variable sizes produced by a rapid extrusion procedure (1985) Biochim Biophys Acta, 812, pp. 55-65
Fiske, C.H., Subbarow, Y., The colorimetric determination of phosphorus (1925) J Biol Chem, 66, pp. 375-400
Struck, D.K., Hoekstra, D., Pagano, R.E., Use of resonance energy transfer to monitor membrane fusion (1981) Biochemistry, 20, pp. 4093-4099
Cummings, J.E., Vanderlock, T.K., Aggregation and hemi-fusion of anionic vesicles induced by the antimicrobial peptide cryptdin-4 (2007) Biochim Biophys Acta, 1768, pp. 1796-1804
Schwarz, G., Stankowsky, S., Rizzo, V., Thermodynamic analysis of incorporation and aggregation in a membrane: application to the pore-forming peptide alamethicin (1986) Biochim Biophys Acta, 861, pp. 141-151
Beschiaschvili, G., Seelig, J., Melittin binding to mixed phosphatidylglycerol/phosphatidylcholine membranes (1990) Biochemistry, 29, pp. 52-58
de Kroon, A.I.P.M., Soekarjo, M.W., de Gier, J., de Kruijff, B., The role of charge and hydrophobicity in peptide-lipid interaction: a comparative study based on tryptophan fluorescence measurements combined with the use of aqueous and hydrophobic quenchers (1990) Biochemistry, 29, pp. 8229-8240
Eftink, M.R., Ghiron, C.A., Fluorescence quenching of indole and model micelle systems (1976) J Phys Chem, 80, pp. 486-493
Chernomordik, L. V., Kozlov, M. M., Protein-lipid interplay in fusion and fission of biological membranes (2003) Annu Rev Biochem, 72, pp. 175-207
Harrison, S. C., Viral membrane fusion (2008) Nature Structural Molecular Biology, 15, pp. 690-698
Connolly, S. A., Jackson, J. O., Jardetzky, T. S., Longnecker, R., Fusing structure and function: a structural view of the herpesvirus entry machinery (2011) Nat Rev Microbiol, 9, pp. 369-381
Chowdary, T. K., Cairns, T. M., Atanasiu, D., Cohen, G. H., Eisenberg, R. J., Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL (2010) Nat Struct Mol Biol, 17, pp. 882-888
Heldwein, E. E., Lou, H., Bender, F. C., Cohen, G. H., Eisenberg, R. J., Crystal structure of glycoprotein B from herpes simplex virus 1 (2006) Science, 313, pp. 217-220
Hannah, B. P., Heldwein, E. E., Bender, F. C., Cohen, G. H., Eisenberg, R. J., Mutational evidence of internal fusion loops in herpes simplex virus glycoprotein B (2007) J Virol, 81, pp. 4858-4865
Bender, F. C., Whitbeck, J. C., Ponce de Leon, M., Lou, H., Eisenberg, R. J., Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry (2003) J Virol, 77, pp. 9542-9552
de Almeida, R. F. M., Fedorov, A., Prieto, M., Sphingomyelin/Phosphatidylcholine/cholesterol phase diagram: boundaries and composition of lipid rafts (2003) Biophys J, 85, pp. 2406-2416
Parente, R. A., Nir, S., Szoka Jr., F. C., Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA (1990) Biochemistry, 29, pp. 8713-8719
Yau, W. M., Wimley, W. C., Gawrisch, K., White, S. H., The preference of tryptophan for membrane interfaces (1998) Biochemistry, 37, pp. 14713-14718
Gordon, L. M., Curtain, C. C., Zhong, Y. C., Kirkpatrick, A., Mobley, P. W., The amino-terminal peptide of HIV-1 glycoprotein 41 interacts with human erythrocyte membranes: peptide conformation, orientation and aggregation (1992) Biochim Biophys Acta, 1139, pp. 257-274
Swamy, M. J., Marsh, D., Spin-label electron spin resonance studies on the dynamics of the different phases of N-biotinylphosphatidylethanolamines (1994) Biochemistry, 33, pp. 11656-11663
Rama Krishna, Y. V. S., Marsh, D., Spin label ESR and 31P-NMR studies of the cubic and inverted hexagonal phases of dimyristoylphosphatidylcholine/myristic acid (1: 2, mol/mol) mixtures (1990) Biochim Biophys Acta, 1024, pp. 89-94
Hannah, B. P., Cairns, T. M., Bender, F. C., Whitbeck, J. C., Lou, H., Herpes simplex virus glycoprotein B associates with target membranes via its fusion loops (2009) J Virol, 83, pp. 6825-6836
Chatterjee, P. K., Eng, C. H., Kielian, M., Novel mutations that control the sphingolipid and cholesterol dependence of the Semliki Forest virus fusion protein (2002) J Virol, 76, pp. 12712-12722
Thor n, P. E., Persson, D., Lincoln, P., Nord n, B., Membrane destabilizing properties of cell-penetrating peptides (2005) Biophys Chem, 114, pp. 169-179
Thiaudi re, E., Siffert, O., Talbot, J. C., Bolard, J., Alouf, J. E., Theamphiphilic alpha-helix concept. Consequences on the structure of staphylococcal delta-toxin in solution and bound to lipids (1991) Eur J Biochem, 195, pp. 203-213
Hope, M. J., Bally, M. B., Webb, G., Cullis, P. R., Vesicles of variable sizes produced by a rapid extrusion procedure (1985) Biochim Biophys Acta, 812, pp. 55-65
Fiske, C. H., Subbarow, Y., The colorimetric determination of phosphorus (1925) J Biol Chem, 66, pp. 375-400
Struck, D. K., Hoekstra, D., Pagano, R. E., Use of resonance energy transfer to monitor membrane fusion (1981) Biochemistry, 20, pp. 4093-4099
Cummings, J. E., Vanderlock, T. K., Aggregation and hemi-fusion of anionic vesicles induced by the antimicrobial peptide cryptdin-4 (2007) Biochim Biophys Acta, 1768, pp. 1796-1804
de Kroon, A. I. P. M., Soekarjo, M. W., de Gier, J., de Kruijff, B., The role of charge and hydrophobicity in peptide-lipid interaction: a comparative study based on tryptophan fluorescence measurements combined with the use of aqueous and hydrophobic quenchers (1990) Biochemistry, 29, pp. 8229-8240
Eftink, M. R., Ghiron, C. A., Fluorescence quenching of indole and model micelle systems (1976) J Phys Chem, 80, pp. 486-493
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2012 Feb 23; 7(2): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Abstract, Conference,
Impact factor: 3.73, 5-year impact factor: 4.244
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84857612232&partnerID=40&md5=d3404d873c65fcde5228d3bc0f3f3fa9
Keywords: Glycoprotein B, Peptide, Acrylamide, Simplexvirus, Lipid, Tryptophan, Tyrosine, Virus Envelope Protein, Article, Controlled Study, Herpes Simplex Virus 1, Hydrophobicity, Lipid Bilayer, Membrane Binding, Nonhuman, Protein Domain, Biophysics, Chemistry, Metabolism, Methodology, Protein Motif, Protein Secondary Structure, Spectrofluorometry, X Ray Crystallography, Herpesviridae, Human Herpesvirus 1, Amino Acid Motifs, X-Ray, Protein Structure, Spectrometry, Fluorescence, Viral Envelope Proteins,
Affiliations:
*** IBB - CNR ***
Division of Biostructures, Department of Biological Sciences, University of Naples Federico II, Napoli, Italy
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi, University of Naples Federico II, Napoli, Italy
Department of Chemistry, University of Naples Federico II, Consorzio per lo Studio dei Sistemi a Grande Interfase, CSGI, Monte Sant'Angelo, Napoli, Italy
Department of Experimental Medicine, II University of Naples, Napoli, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Napoli, Italy
References:
Falanga, A., Cantisani, M., Pedone, C., Galdiero, S., Membrane fusion and fission: enveloped viruses (2009) Prot Pept Lett, 16, pp. 751-75
Galdiero, S., Developments in membrane fusion (2009) Prot Pept Lett, 16, p. 711
Chernomordik, L.V., Kozlov, M.M., Protein-lipid interplay in fusion and fission of biological membranes (2003) Annu Rev Biochem, 72, pp. 175-207
Harrison, S.C., Viral membrane fusion (2008) Nature Structural Molecular Biology, 15, pp. 690-698
Drin, G., Casella, J.F., Gautier, R., Boehmer, T., Schwartz, T.U., A general amphipathic alpha-helical motif for sensing membrane curvature (2007) Nat Struct Mol Biol, 14, pp. 138-146
Antonny, B., Mechanisms of membrane curvature sensing (2011) Annu Rev Biochem, 80, pp. 101-123
Connolly, S.A., Jackson, J.O., Jardetzky, T.S., Longnecker, R., Fusing structure and function: a structural view of the herpesvirus entry machinery (2011) Nat Rev Microbiol, 9, pp. 369-381
Turner, A., Bruun, B., Minson, T., Browne, H., Glycoproteins gB, gD, and gHgL of herpes simplex virus type 1 are necessary and sufficient to mediate membrane fusion in a Cos cell transfection system (1998) J Virol, 72, pp. 873-875
Farnsworth, A., Wisner, T.W., Webb, M., Roller, R., Cohen, G., Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane (2007) Proc Natl Acad Sci U S A, 104, pp. 10187-10192
Atanasiu, D., Whitbeck, J.C., Cairns, T.M., Reilly, B., Cohen, G.H., Bimolecular complementation reveals that glycoproteins gB and gH/gL of herpes simplex virus interact with each other during cell fusion (2007) Proc Natl Acad Sci U S A, 104, pp. 18718-18723
Avitabile, E., Forghieri, C., Campadelli-Fiume, G., Complexes between herpes simplex virus glycoproteins gD, gB, and gH detected in cells by complementation of split enhanced green fluorescent protein (2007) J Virol, 81, pp. 11532-11537
Galdiero, S., Vitiello, M., D'Isanto, M., Falanga, A., Collins, C., Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and B (2006) J Gen Virol, 87, pp. 1085-1097
Galdiero, S., Falanga, A., Vitiello, M., Browne, H., Pedone, C., Fusogenic domains in herpes simplex virus type 1 glycoprotein H (2005) J Biol Chem, 280, pp. 28632-28643
Chowdary, T.K., Cairns, T.M., Atanasiu, D., Cohen, G.H., Eisenberg, R.J., Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL (2010) Nat Struct Mol Biol, 17, pp. 882-888
Matsuura, H., Kirschner, A.N., Longnecker, R., Jardetzky, T.S., Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex (2010) Proc Natl Acad Sci U S A, 107, pp. 22641-22646
Heldwein, E.E., Lou, H., Bender, F.C., Cohen, G.H., Eisenberg, R.J., Crystal structure of glycoprotein B from herpes simplex virus 1 (2006) Science, 313, pp. 217-220
Backovic, M., Longnecker, R., Jardetzky, T.S., Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B (2009) Proc Natl Acad Sci U S A, 106, pp. 2880-2885
Roche, S., Bressanelli, S., Rey, F.A., Gaudin, Y., Crystal structure of the low-pH form of the vesicular stomatitis virus glycoprotein G (2006) Science, 313, pp. 187-191
Kadlec, J., Loureiro, S., Abrescia, N.G., Stuart, D.I., Jones, I.M., The postfusion structure of baculovirus gp64 supports a unified view of viral fusion machines (2008) Nat Struct Mol Biol, 15, pp. 1024-1030
Akkarawongsa, R., Pocaro, N.E., Case, G., Kolb, A.W., Brandt, C.R., Multiple peptides homologous to herpes simplex virus type 1 glycoprotein B inhibit viral infection (2009) Antimicrob Agents Chem, 53, pp. 987-996
Hannah, B.P., Heldwein, E.E., Bender, F.C., Cohen, G.H., Eisenberg, R.J., Mutational evidence of internal fusion loops in herpes simplex virus glycoprotein B (2007) J Virol, 81, pp. 4858-4865
Roche, S., Albertini, A.A., Lepault, J., Bressanelli, S., Gaudin, Y., Structures of vesicular stomatitis virus glycoprotein: membrane fusion revisited (2008) Cell Mol Life Sci, 65, pp. 1716-1728
Sun, X., Belouzard, S., Whittaker, G.R., Molecular architecture of the bipartite fusion loops of vesicular stomatitis virus glycoprotein G, a class III viral fusion protein (2008) J Biol Chem, 283, pp. 6418-6427
Vitiello, G., Falanga, A., Galdiero, M., Marsh, D., Galdiero, S., Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes (2011) Biochim Biophys Acta, 1808, pp. 1526-2517
Bender, F.C., Whitbeck, J.C., Ponce de Leon, M., Lou, H., Eisenberg, R.J., Specific association of glycoprotein B with lipid rafts during herpes simplex virus entry (2003) J Virol, 77, pp. 9542-9552
de Almeida, R.F.M., Fedorov, A., Prieto, M., Sphingomyelin/Phosphatidylcholine/cholesterol phase diagram: boundaries and composition of lipid rafts (2003) Biophys J, 85, pp. 2406-2416
Ellens, H., Bentz, J., Szoka Jr., F.C., pH-induced destabilization of phosphatidylethanolamine-containing liposomes: role of bilayer contact (1984) Biochemistry, 23, pp. 1532-1538
Parente, R.A., Nir, S., Szoka Jr., F.C., Mechanism of leakage of phospholipid vesicle contents induced by the peptide GALA (1990) Biochemistry, 29, pp. 8713-8719
Levine III., H., Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution (1993) Prot Sci, 2, pp. 404-410
Yau, W.M., Wimley, W.C., Gawrisch, K., White, S.H., The preference of tryptophan for membrane interfaces (1998) Biochemistry, 37, pp. 14713-14718
Gordon, L.M., Curtain, C.C., Zhong, Y.C., Kirkpatrick, A., Mobley, P.W., The amino-terminal peptide of HIV-1 glycoprotein 41 interacts with human erythrocyte membranes: peptide conformation, orientation and aggregation (1992) Biochim Biophys Acta, 1139, pp. 257-274
Curtain, C., Separovic, F., Nielsen, K., Craik, D., Zhong, Y., The interactions of the N-terminal fusogenic peptide of HIV-1 gp41 with neutral phospholipids (1999) European Biophysical Journal, 28, pp. 427-436
D'Errico, G., D'Ursi, A.M., Marsh, D., Interaction of a peptide derived from glycoprotein gp36 of feline immunodeficiency virus and its lipoylated analogue with phospholipid membranes (2008) Biochemistry, 47, pp. 5317-5327
Spadaccini, R., D'Errico, G., D'Alessio, V., Notomista, E., Bianchi, A., Structural characterization of the transmembrane proximal region of the hepatitis C virus E1 glycoprotein (2010) Biochim Biophys Acta, 1798, pp. 344-353
Marsh, D., Liquid-ordered phases induced by cholesterol: a compendium of binary phase diagrams (2010) Biochim Biophys Acta, 1798, pp. 688-699
Swamy, M.J., Marsh, D., Spin-label electron spin resonance studies on the dynamics of the different phases of N-biotinylphosphatidylethanolamines (1994) Biochemistry, 33, pp. 11656-11663
Moser, M., Marsh, D., Meier, P., Wassmer, K.H., Kothe, G., Chain configuration and flexibility gradient in phospholipid membranes. Comparison between spin-label electron spin resonance and deuteron nuclear magnetic resonance, and identification of new conformations (1989) Biophys J, 55, pp. 111-123
Rama Krishna, Y.V.S., Marsh, D., Spin label ESR and 31P-NMR studies of the cubic and inverted hexagonal phases of dimyristoylphosphatidylcholine/myristic acid (1:2, mol/mol) mixtures (1990) Biochim Biophys Acta, 1024, pp. 89-94
Lange, A., Marsh, D., Wassmer, K.H., Meier, P., Kothe, G., Electron spin resonance study of phospholipid membranes employing a comprehensive line-shape model (1985) Biochemistry, 24, pp. 4383-4392
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Biophysical Characterization and Membrane Interaction of the Two Fusion Loops of Glycoprotein B from Herpes Simplex Type I Virus
The molecular mechanism of entry of herpesviruses requires a multicomponent fusion system. Cell invasion by Herpes simplex virus (HSV) requires four virally encoded glycoproteins: namely gD, gB and gH/gL. The role of gB has remained elusive until recently when the crystal structure of HSV-1 gB became available and the fusion potential of gB was clearly demonstrated. Although much information on gB structure/function relationship has been gathered in recent years, the elucidation of the nature of the fine interactions between gB fusion loops and the membrane bilayer may help to understand the precise molecular mechanism behind herpesvirus-host cell membrane fusion. Here, we report the first biophysical study on the two fusion peptides of gB, with a particular focus on the effects determined by both peptides on lipid bilayers of various compositions. The two fusion loops constitute a structural subdomain wherein key hydrophobic amino acids form a ridge that is supported on both sides by charged residues. When used together the two fusion loops have the ability to significantly destabilize the target membrane bilayer, notwithstanding their low bilayer penetration when used separately. These data support the model of gB fusion loops insertion into cholesterol enriched membranes.
The molecular mechanism of entry of herpesviruses requires a multicomponent fusion system. Cell invasion by Herpes simplex virus (HSV) requires four virally encoded glycoproteins: namely gD, gB and gH/gL. The role of gB has remained elusive until recently when the crystal structure of HSV-1 gB became available and the fusion potential of gB was clearly demonstrated. Although much information on gB structure/function relationship has been gathered in recent years, the elucidation of the nature of the fine interactions between gB fusion loops and the membrane bilayer may help to understand the precise molecular mechanism behind herpesvirus-host cell membrane fusion. Here, we report the first biophysical study on the two fusion peptides of gB, with a particular focus on the effects determined by both peptides on lipid bilayers of various compositions. The two fusion loops constitute a structural subdomain wherein key hydrophobic amino acids form a ridge that is supported on both sides by charged residues. When used together the two fusion loops have the ability to significantly destabilize the target membrane bilayer, notwithstanding their low bilayer penetration when used separately. These data support the model of gB fusion loops insertion into cholesterol enriched membranes.
Biophysical Characterization and Membrane Interaction of the Two Fusion Loops of Glycoprotein B from Herpes Simplex Type I Virus
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Biophysical Characterization and Membrane Interaction of the Two Fusion Loops of Glycoprotein B from Herpes Simplex Type I Virus
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Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2010 Sep 8; 18(9): 1184-1190.
Impact Factor: 6.337
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Pérez de Vega MJ, García-López MT, Zaccaro L, Royo M, Albericio F, Fernández-Carvajal A, Ferrer-Montiel A, González-Muñiz R
* Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers (518 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2010 Jul 15; 15(7): 4924-4933.
Impact Factor: 1.988
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (471 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
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Castellano I, Merlino A, Rossi M, La Cara F
* Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity (659 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2010 May; 92(5): 464-474.
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Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
* Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (557 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0005-2736, 0925-4439), 2010 Mar; 1798(3): 579-591.
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (688 views)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Palmieri G, Langella E, Gogliettino M, Saviano M, Pocsfalvi G, Rossi M
* A novel class of protease targets of phosphatidylethanolamine-binding proteins (PEBP): A study of the acylpeptide hydrolase and the PEBP inhibitor from the archaeon Sulfolobus solfataricus (378 views)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(12): 2498-2507.
Impact Factor: 3.825
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Pennacchio A, Esposito L, Zagari A, Rossi M, Raia CA
* Role of Tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase (298 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2009 Sep; 13(5): 751-761.
Impact Factor: 2
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Falanga A, Cantisani M, Pedone C, Galdiero S
* Membrane fusion and fission: enveloped viruses (431 views)
Protein Pept Lett (ISSN: 1875-5305, 0929-8665), 2009 Jul; 16(7): 751-759.
Impact Factor: 1.755
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Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
* Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis (597 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009 Jan 9; 385(1): 153-162.
Impact Factor: 3.871
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Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
* Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (632 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 31; 283(44): 29993-30009.
Impact Factor: 5.52
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (923 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
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Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
* Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity (458 views)
Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2008 Sep; 29(9): 1461-1471.
Impact Factor: 2.565
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Grimaldi P, Ruocco MR, Lanzotti MA, Ruggiero A, Ruggiero I, Arcari P, Vitagliano L, Masullo M
* Characterisation of the components of the thioredoxin system in the archaeon Sulfolobus solfataricus (370 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2008 Jul; 12(4): 553-562.
Impact Factor: 1.782
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Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (417 views)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Impact Factor: 2.276
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Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
* The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2008 Mar 25; 9(5): 758-767.
Impact Factor: 3.322
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Staiano M, Saviano M, Herman P, Grycznyski Z, Fini C, Varriale A, Parracino A, Kold AB, Rossi M, D'Auria S
* Time-resolved fluorescence spectroscopy and molecular dynamics simulations point out the effects of pressure on the stability and dynamics of the porcine odorant-binding protein (653 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 89(4): 284-291.
Impact Factor: 2.823
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (495 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (617 views)
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Impact Factor: 3.446
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D'Auria S, Varriale A, Gonnelli M, Saviano M, Staiano M, Rossi M, Strambini GB
* Tryptophan phosphorescence studies of the D-galactose/ D-glucose-binding protein from Escherichia coli provide a molecular portrait with structural and dynamics features of the protein (693 views)
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Impact Factor: 5.675
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Calvanese L, Saporito A, Marasco D, D'Auria G, Minchiotti G, Pedone C, Paolillo L, Falcigno L, Ruvo M
* Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (489 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
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Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
* Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (619 views)
Journal Of General Virology (ISSN: 0022-1317), 2006 May; 87: 1085-1097.
Impact Factor: 3.11
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Galdiero S, Falanga A, Vitiello M, Browne H, Pedone C, Galdiero M
* Fusogenic domains in herpes simplex virus type 1 glycoprotein (592 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Sep 5; 280(31): 28632-28643.
Impact Factor: 5.854
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Naddeo M, Vitagliano L, Russo A, Gotte G, D'Alessio G, Sorrentino S
* Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor (408 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 May 9; 579(12): 2663-2668.
Impact Factor: 3.415
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Bonomo RP, Cucinotta V, Giuffrida A, Impellizzeri G, Magrì A, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* A re-investigation of copper coordination in the octa-repeats region of the prion protein (376 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Jan 7; (1): 150-158.
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Rivieccio V, Mannini R, Concilio L, D'Auria S, Pedone C, Grimaldi G
* Expression, purification and partial characterization of the Krüppel-associated box (KRAB) from the human ZNF2 protein (362 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2005; 12(6): 527-532.
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Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (350 views)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
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Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
* Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (617 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
Impact Factor: 2.863
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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D'Ambrosio K, Kauffmann B, Rouhier N, Benedetti E, Jacquot JP, Aubry A, Corbier C
* Crystallization and preliminary X-ray studies of the glutaredoxin from poplar in complex with glutathione (416 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2003 Jun; 59: 1043-1045.
Impact Factor: 2.208
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De Luca S, Ulhaq S, Dixon M J, EssexJ, Bradley M
* Solid-phase synthesis of a focused library of trypanothione reductase inhibitors (376 views)
Tetrahedron Lett (ISSN: 0040-4039), 2003 Apr 7; 44(15): 3195-3197.
Impact Factor: 2.326
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Vecchio G
* Ligand exchange chiral separations by cyclodextrin derivatives in capillary electrophoresis (427 views)
Analyst (ISSN: 0003-2654), 2003; 128(2): 134-136.
Impact Factor: 2.251
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Esposito G, Vitagliano L, Santamaria R, Viola A, Zagari A, Salvatore F
* Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance (311 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2002 Nov 6; 531(2): 152-156.
Impact Factor: 3.912
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Orru S, Ruoppolo M, Francese S, Vitagliano L, Marino G, Esposito C
* Identification of tissue transglutaminase-reactive lysine residues in glyceraldehyde-3-phosphate dehydrogenase (9804 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2002 Jan; 11(1): 137-146.
Impact Factor: 3.546
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De Falco S, Ruvo M, Verdoliva A, Scarallo A, Raimondo D, Raucci A, Fassina G
* N-terminal myristylation of HBV preS1 domain enhances receptor recognition (714 views)
J Pept Res (ISSN: 1397-002x, 1397-002xlinking), 2001 May; 57(5): 390-400.
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Cambria M, Cambria A, Ragusa S, Rizzarelli E
Production, purification, and properties of an extracellular laccase from Rigidoporus lignosus (339 views)
Protein Expr Purif (ISSN: 1046-5928), 2000 Mar; 18(2): 141-147.
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Fonti R, Latella G, Caprilli R, Frieri G, Marcheggiano A, Sambuy Y
Carbonic anhydrase I reduction in colonic mucosa of patients with active ulcerative colitis (469 views)
Digestive Diseases And Sciences (ISSN: 0163-2116), 1998; 43(9): 2086-2092.
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Bonomo RP, Cucinotta V, D'Alessandro F, Impellizzeri G, Maccarrone G, Rizzarelli E, Vecchio G, Carima L, Corradini R, Sartor G, Marchelli R
Chiral recognition by the copper(ii) complex of 6-deoxy-6-n-(2 - methylaminopyridine)-β-cyclodextrin (381 views)
Chirality (ISSN: 0899-0042), 1997; 9(4): 341-349.
Impact Factor: 1.915
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Adinolfi S, Piccoli R, Sica F, Mazzarella L
BS-RNase tetramers: An example of domain-swapped oligomers (421 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1996 Dec 2; 398(2-3): 326-332.
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Bonomo RP, Di Blasio B, Maccarrone G, Pavone V, Pedone C, Rizzarelli E, Saviano M, Vecchio G
Crystal and Molecular Structure of the [6-Deoxy-6-[(2-(4-imidazolyl)ethyl)amino]cyclomaltoheptaose]copper(II) Ternary Complex with L-Tryptophanate. Role of Weak Forces in the Chiral Recognition Process Assisted by a Metallocyclodextrin (314 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 1996 Jul 17; 35(15): 4497-4504.
Impact Factor: 2.736
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (446 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
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Della Ragione F, Oliva A, Palumbo R, Russo GL, Gragnaniello V, Zappia V
Deficiency of 5'-deoxy-5'-methylthioadenosine phosphorylase activity in malignancy. Absence of the protein in human enzyme-deficient cell lines (288 views)
Biochem J (ISSN: 0264-6021print, 0264-6021linking, 1470-8728electronic), 1992 Jan 15; 281(Pt2): 533-538.
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Montanaro V, Casamassimi A, D'Urso M, Yoon JY, Freije W, Schlessinger D, Muenke M, Nussbaum RL, Saccone S, Maugeri S
In Situ Hybridization To Cytogenetic Bands Of Yeast Artificial Chromosomes Covering 50% Of Human Xq24-Xq28 Dna (324 views)
Am J Hum Genet, 1991 Feb; 48(2): 183-194.
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Alberghina M, Brogna A, Mangiameli A, Marletta F, Rizzarelli E, Sammartano S
Copper(II) complexes of aminoacids: Gastric acid antisecretory activity in rats (2114 views)
Farmaco Ed Sci, 1982 Dec; 37(12): 805-814.
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Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (1341 views)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
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* Self‑assembly of thyminyl l‑tryptophanamide (TrpT) building blocks for the potential development of drug delivery nanosystems (13 views)
Journal Of Nanostructure In Chemistry, 2023 Feb; N/D: N/D-N/D.
Impact Factor: 8
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Greco F, Marzano M, Falanga AP, Terracciano M, Piccialli G, Roviello GN, D , #xerrico S, Borbone N, Oliviero G
* Cytosine-rich oligonucleotides incorporating a non-nucleotide loop: A further step towards the obtainment of physiologically stable i-motif DNA (8 views)
Int J Biol Macromol (ISSN: 0141-8130linking), 2022 Oct 31; 219: 626-636.
Impact Factor: 8.025
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Alterio V, Langella E, Buonanno M, Esposito D, Nocentini A, Berrino E, Bua S, Polentarutti M, Supuran CT, Monti SM, De Simone G
* Zeta-carbonic anhydrases show CS(2) hydrolase activity: A new metabolic carbon acquisition pathway in diatoms? (28 views)
Comput Struct Biotechnol J (ISSN: 2001-0370linking), 2021 Jun 5; 19: 3427-3436.
Impact Factor: 7.271
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Angeli A, Buonanno M, Donald WA, Monti SM, Supuran CT
* The zinc - but not cadmium - containing zeta-carbonic from the diatom Thalassiosira weissflogii is potently activated by amines and amino acids (284 views)
Bioorg Chem (ISSN: 1090-2120electronic, 0045-2068linking), 2018 Oct; 80: 261-265.
Impact Factor: 3.929
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Ruggiero A, Garcia-ortega L, Ragucci S, Russo R, Landi N, Berisio R, Di Maro A
* Structural and enzymatic properties of Ageritin, a novel metal-dependent ribotoxin-like protein with antitumor activity (333 views)
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Cuocolo A, Pappata S, Zampella E, Assante R
* Advances in SPECT Methodology (314 views)
Int Rev Neurobiol (ISSN: 0074-77429780128154182, 2162-5514electronic), 2018 Sep; 141: 77-96.
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Sbardella D, Tundo GR, Coletta A, Marcoux J, Koufogeorgou EI, Ciaccio C, Santoro AM, Milardi D, Grasso G, Cozza P, Bousquet-dubouch MP, Marini S, Coletta M
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Cell Mol Life Sci (ISSN: 1420-9071electronic, 1420-682xlinking), 2018 Sep; 75(18): 3441-3456.
Impact Factor: 7.047
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Diaferia C, Balasco N, Sibillano T, Giannini C, Vitagliano L, Morelli G, Accardo A
* Structural Characterization of Self-Assembled Tetra-Tryptophan Based Nanostructures: Variations on a Common Theme (78 views)
Chemphyschem (ISSN: 1439-4235linking, 1439-7641), 2018 Jul 5; 19 (13 ): 1635-1642.
Impact Factor: 3.502
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Giaquinto M, Micco A, Aliberti A, Bobeico E, La Ferrara V, Ruvo M, Ricciardi A, Cusano A
* Optimization Strategies for Responsivity Control of Microgel Assisted Lab-On-Fiber Optrodes (375 views) (PDF 218 views)
Sensors (ISSN: 1424-8220linking, 1424-3210, 1424-8220electronic), 2018 Apr 6; 18(4): N/D-N/D.
Impact Factor: 2.677
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Diana D, Di Salvo C, Celentano V, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* Conformational stabilization of a beta-hairpin through a triazole-tryptophan interaction (365 views)
Org Biomol Chem (ISSN: 1477-0539electronic, 1477-0520linking), 2018 Jan 31; 16(5): 787-795.
Impact Factor: 3.451
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Troise AD, Buonanno M, Fiore A, Monti SM, Fogliano V
* Evolution of protein bound Maillard reaction end-products and free Amadori compounds in low lactose milk in presence of fructosamine oxidase (334 views)
Food Chem (ISSN: 0308-8146, 0308-8146print), 2016 Dec 1; 212: 722-729.
Impact Factor: 4.529
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Ruvo M, Doti N, Lorenzo V, Vitagliano L, Mascanzoni F
* The Interacting Domains of PREP1 and p160 are Endowed with a Remarkable Structural Stability (280 views)
Mol Biotechnol (ISSN: 1073-6085, 1559-0305electronic, 1073-6085linking), 2016 May; 58(5): 328-339.
Impact Factor: 1.634
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Diana D, De Rosa L, Palmieri M, Russomanno A, Russo L, La Rosa C, Milardi D, Colombo G, D'Andrea LD, Fattorusso R
* Long range Trp-Trp interaction initiates the folding pathway of a pro-angiogenic beta-hairpin peptide (382 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2015 Nov 25; 5: 16651-16651.
Impact Factor: 5.228
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Galdiero S, Falanga A, Morelli G, Galdiero M
* gH625: A milestone in understanding the many roles of membranotropic peptides (530 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2015 Jan; 1848(PA): 16-25.
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Troise AD, Fiore A, Roviello GN, Monti SM, Fogliano V
* Simultaneous quantification of amino acids and Amadori products in foods through ion-pairing liquid chromatography-high-resolution mass spectrometry (1360 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015 Jan; 47(1): 111-124.
Impact Factor: 3.196
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Speciale I, Paciello I, Fazio LL, Sturiale L, Palmigiano A, Lanzetta R, Parrilli M, Garozzo D, Lemaitre B, Bernardini ML, Molinaro A, De Castro C
* Determination of the structure of the O-antigen and the lipid A from the entomopathogenic bacterium Pseudomonas entomophila lipopolysaccharide along with its immunological properties (396 views)
Carbohyd Res (ISSN: 0008-6215, 0008-6215linking), 2015; 412: 20-27.
Impact Factor: 1.817
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Vitiello G, Falanga A, Petruk AA, Merlino A, Fragneto G, Paduano L, Galdiero S, D'Errico G
* Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism (381 views)
Soft Matter (ISSN: 1744-683x), 2015; 11(15): 3003-3016.
Impact Factor: 3.798
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Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (367 views)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (527 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
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Cantisani M, Finamore E, Mignogna E, Falanga A, Nicoletti GF, Pedone C, Morelli G, Leone M, Galdiero M, Galdiero S
* Structural insights into and activity analysis of the antimicrobial peptide myxinidin (726 views)
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Impact Factor: 4.476
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Ruggiero A, Dattelbaum JD, Staiano M, Berisio R, D'Auria S, Vitagliano L
* A loose domain swapping organization confers a remarkable stability to the dimeric structure of the arginine binding protein from Thermotoga maritima (444 views)
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Impact Factor: 3.234
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Accardo A, Vitiello M, Tesauro D, Galdiero M, Finamore E, Martora F, Mansi R, Ringhieri P, Morelli G
* Self-assembled or mixed peptide amphiphile micelles from herpes simplex virus glycoproteins as potential immunomodulatory treatment (491 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1176-9114linking), 2014 May 7; 9(1): 2137-2148.
Impact Factor: 4.383
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Chi M-C, Lo Y-H, Chen Y-Y, Lin L-L, Merlino A
* γ-Glutamyl transpeptidase architecture: Effect of extra sequence deletion on autoprocessing, structure and stability of the protein from Bacillus licheniformis (318 views)
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Impact Factor: 4.882
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Portella L, Vitale R, De Luca S, D'Alterio C, Ieranò C, Napolitano M, Riccio A, Polimeno MN, Monfregola L, Barbieri A, Luciano A, Ciarmiello A, Arra C, Castello G, Amodeo P, Scala S
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Impact Factor: 3.534
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (423 views)
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Impact Factor: 4.906
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Carotenuto A, Auriemma L, Merlino F, Limatola A, Campiglia P, Gomez-monterrey I, Di Villa Bianca R, Brancaccio D, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P
* New insight into the binding mode of peptides at urotensin-II receptor by Trp-constrained analogues of P5U and urantide (519 views)
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Impact Factor: 1.862
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Galdiero S, Falanga A, Tarallo R, Russo L, Galdiero E, Cantisani M, Morelli G, Galdiero M
* Peptide inhibitors against herpes simplex virus infections (1149 views)
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Impact Factor: 1.862
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Pica A, Russo Krauss I, Castellano I, La Cara F, Graziano G, Sica F, Merlino A
* Effect Of Nacl On The Conformational Stability Of The Thermophilic Gamma-Glutamyltranspeptidase From Geobacillus Thermodenitrificans: Implication For Globular Protein Halotolerance (356 views)
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Kaprelyants AS, Mukamolova GV, Ruggiero A, Makarov VA, Demina GR, Shleeva MO, Potapov VD, Shramko PA
* Resuscitation-promoting Factors (Rpf): In Search of Inhibitors (503 views)
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Impact Factor: 1.994
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (934 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Galdiero S, Vitiello M, Finamore E, Mansi R, Galdiero M, Morelli G, Tesauro D
* Activation of monocytic cells by immunostimulatory lipids conjugated to peptide antigens (433 views)
Molecular Biosystems (ISSN: 1742-206x), 2012; 8(12): 3166-3177.
Impact Factor: 3.35
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (459 views)
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Impact Factor: 5.925
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Vitiello G, Falanga A, Galdiero M, Marsh D, Galdiero S, D'Errico G
* Lipid composition modulates the interaction of peptides deriving from herpes simplex virus type I glycoproteins B and H with biomembranes (687 views)
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Impact Factor: 3.99
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Zaccaro L, Garcia-lopez Mt Gonzalez-muniz RG
* TRPV1 modulators: Structure-activity relationships using a rational combinatorial approach (461 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2011 Jun 15; 21(12): 3541-3545.
Impact Factor: 2.554
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (612 views)
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Impact Factor: 4.092
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (559 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (508 views)
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Impact Factor: 1.799
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Ruggiero A, Marasco D, Squeglia F, Soldini S, Pedone E, Pedone C, Berisio R
* Structure and functional regulation of RipA, a mycobacterial enzyme essential for daughter cell separation (425 views)
Structure (ISSN: 0969-2126, 1878-4186, 0969-2126linking), 2010 Sep 8; 18(9): 1184-1190.
Impact Factor: 6.337
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Pérez de Vega MJ, García-López MT, Zaccaro L, Royo M, Albericio F, Fernández-Carvajal A, Ferrer-Montiel A, González-Muñiz R
* Solid-phase synthesis of new Trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers (518 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2010 Jul 15; 15(7): 4924-4933.
Impact Factor: 1.988
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Galdiero S, Falanga A, Vitiello M, Raiola L, Russo L, Pedone C, Isernia C, Galdiero M
* The presence of a single N-terminal histidine residue enhances the fusogenic properties of a Membranotropic peptide derived from herpes simplex virus type 1 glycoprotein (471 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2010 May 28; 285(22): 17123-17136.
Impact Factor: 5.328
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Castellano I, Merlino A, Rossi M, La Cara F
* Biochemical and structural properties of gamma-glutamyl transpeptidase from Geobacillus thermodenitrificans: An enzyme specialized in hydrolase activity (659 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 1638-6183electronic), 2010 May; 92(5): 464-474.
Impact Factor: 3.787
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Galdiero S, Falanga A, Vitiello G, Vitiello M, Pedone C, D'Errico G, Galdiero M
* Role of membranotropic sequences from herpes simplex virus type I glycoproteins B and H in the fusion process (557 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0005-2736, 0925-4439), 2010 Mar; 1798(3): 579-591.
Impact Factor: 4.647
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Canettieri G, Di Marcotullio L, Greco A, Coni S, Antonucci L, Infante P, Pietrosanti L, De Smaele E, Ferretti E, Miele E, Pelloni M, De Simone G, Pedone E, Gallinari P, Giorgi A, Steinkuhler C, Vitagliano L, Pedone C, Schinin ME, Screpanti I, Gulino A
* Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation (688 views)
Nature Cell Biol Nature Cell Biology (ISSN: 1476-4679, 1465-7392), 2010 Feb; 12(2): 132-142.
Impact Factor: 19.407
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Palmieri G, Langella E, Gogliettino M, Saviano M, Pocsfalvi G, Rossi M
* A novel class of protease targets of phosphatidylethanolamine-binding proteins (PEBP): A study of the acylpeptide hydrolase and the PEBP inhibitor from the archaeon Sulfolobus solfataricus (378 views)
Mol Biosyst (ISSN: 1742-206x), 2010; 6(12): 2498-2507.
Impact Factor: 3.825
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Pennacchio A, Esposito L, Zagari A, Rossi M, Raia CA
* Role of Tryptophan 95 in substrate specificity and structural stability of Sulfolobus solfataricus alcohol dehydrogenase (298 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2009 Sep; 13(5): 751-761.
Impact Factor: 2
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Falanga A, Cantisani M, Pedone C, Galdiero S
* Membrane fusion and fission: enveloped viruses (431 views)
Protein Pept Lett (ISSN: 1875-5305, 0929-8665), 2009 Jul; 16(7): 751-759.
Impact Factor: 1.755
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Ruggiero A, Tizzano B, Pedone E, Pedone C, Wilmanns M, Berisio R
* Crystal Structure of the Resuscitation-Promoting Factor (Delta DUF)RpfB from M. tuberculosis (597 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009 Jan 9; 385(1): 153-162.
Impact Factor: 3.871
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Galdiero S, Falanga A, Vitiello M, Raiola L, Fattorusso R, Browne H, Pedone C, Isernia C, Galdiero M
* Analysis of a membrane interacting region of herpes simplex virus type 1 glycoprotein (632 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 31; 283(44): 29993-30009.
Impact Factor: 5.52
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Dudar GK, D'Andrea LD, Di Stasi R, Pedone C, Wallace JL
* A vascular endothelial growth factor mimetic accelerates gastric ulcer healing in an iNOS-dependent manner (923 views)
Am J Physiol Gastrointest Liver Physiol American Journal Of Physiology Gastrointestinal And Liver Physiology (ISSN: 0193-1857), 2008 Sep; 295(2): G374-G381.
Impact Factor: 3.587
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Galdiero S, Vitiello M, Falanga A, D'Isanto M, Cantisani M, Kampanaraki A, Benedetti E, Browne H, Galdiero M
* Peptides containing membrane-interacting motifs inhibit herpes simplex virus type 1 infectivity (458 views)
Peptides (ISSN: 0196-9781, 1873-5169electronic, 0196-9781linking), 2008 Sep; 29(9): 1461-1471.
Impact Factor: 2.565
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Grimaldi P, Ruocco MR, Lanzotti MA, Ruggiero A, Ruggiero I, Arcari P, Vitagliano L, Masullo M
* Characterisation of the components of the thioredoxin system in the archaeon Sulfolobus solfataricus (370 views)
Extremophiles (ISSN: 1431-0651, 1433-4909, 1433-4909electronic), 2008 Jul; 12(4): 553-562.
Impact Factor: 1.782
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Cigliano L, Maresca B, Salvatore A, Nino M, Monfrecola G, Ayala F, Carlucci A, Pugliese RC, Pedone C, Abrescia P
* Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity (417 views)
Journal Of The European Academy Of Dermatology And Venereology (ISSN: 1468-3083, 0926-9959), 2008 Apr; 22(4): 417-425.
Impact Factor: 2.276
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Galdiero S, Vitiello M, D'Isanto M, Falanga A, Cantisani M, Browne H, Pedone C, Galdiero M
* The identification and characterization of fusogenic domains in herpes virus glycoprotein B molecules (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2008 Mar 25; 9(5): 758-767.
Impact Factor: 3.322
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Staiano M, Saviano M, Herman P, Grycznyski Z, Fini C, Varriale A, Parracino A, Kold AB, Rossi M, D'Auria S
* Time-resolved fluorescence spectroscopy and molecular dynamics simulations point out the effects of pressure on the stability and dynamics of the porcine odorant-binding protein (653 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2008; 89(4): 284-291.
Impact Factor: 2.823
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Salvatore A, Cigliano L, Bucci EM, Corpillo D, Velasco S, Carlucci A, Pedone C, Abrescia P
* Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase (495 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2007 Oct 2; 46(39): 11158-11168.
Impact Factor: 3.368
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Galdiero S, Falanga A, Vitiello M, D'Isanto M, Collins C, Orrei V, Browne H, Pedone C, Galdiero M
* Evidence for a role of the membrane-proximal region of herpes simplex virus type 1 glycoprotein H in membrane fusion and virus inhibition (617 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2007 May 25; 8(8): 885-895.
Impact Factor: 3.446
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D'Auria S, Varriale A, Gonnelli M, Saviano M, Staiano M, Rossi M, Strambini GB
* Tryptophan phosphorescence studies of the D-galactose/ D-glucose-binding protein from Escherichia coli provide a molecular portrait with structural and dynamics features of the protein (693 views)
J Proteome Res (ISSN: 1535-3893), 2007; 6(4): 1306-1312.
Impact Factor: 5.675
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Calvanese L, Saporito A, Marasco D, D'Auria G, Minchiotti G, Pedone C, Paolillo L, Falcigno L, Ruvo M
* Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala (489 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Nov 30; 49(24): 7054-7062.
Impact Factor: 5.115
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Galdiero S, Vitiello M, D'Isanto M, Falanga A, Collins C, Raieta K, Pedone C, Browne H, Galdiero M
* Analysis of synthetic peptides from heptad-repeat domains of herpes simplex virus type 1 glycoproteins H and (619 views)
Journal Of General Virology (ISSN: 0022-1317), 2006 May; 87: 1085-1097.
Impact Factor: 3.11
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Galdiero S, Falanga A, Vitiello M, Browne H, Pedone C, Galdiero M
* Fusogenic domains in herpes simplex virus type 1 glycoprotein (592 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 Sep 5; 280(31): 28632-28643.
Impact Factor: 5.854
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Naddeo M, Vitagliano L, Russo A, Gotte G, D'Alessio G, Sorrentino S
* Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor (408 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2005 May 9; 579(12): 2663-2668.
Impact Factor: 3.415
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Bonomo RP, Cucinotta V, Giuffrida A, Impellizzeri G, Magrì A, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* A re-investigation of copper coordination in the octa-repeats region of the prion protein (376 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Jan 7; (1): 150-158.
Impact Factor: 3.003
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Rivieccio V, Mannini R, Concilio L, D'Auria S, Pedone C, Grimaldi G
* Expression, purification and partial characterization of the Krüppel-associated box (KRAB) from the human ZNF2 protein (362 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2005; 12(6): 527-532.
Impact Factor: 0.84
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Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (350 views)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
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Galdiero S, Vitiello M, D'Isanto M, Di Niola E, Peluso L, Raieta K, Pedone C, Galdiero M, Benedetti E
* Induction of signaling pathways by herpes simplex virus type 1 through glycoprotein H peptides (617 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 494-502.
Impact Factor: 2.863
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Mansi R, Tesauro D, De Capua A, Fattorusso R, Carac C, Aloj L, Benedetti E, Morelli G
* Peptide-chelating agent conjugate for selective targeting of somatostatin receptor type 1: Synthesis and characterization (472 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 527-534.
Impact Factor: 2.863
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De Luca S, Ragone R, Bracco C, Digilio G, Aloj L, Tesauro D, Saviano M, Pedone C, Morelli G
* A cyclic CCK8 analogue selective for the cholecystokinin type A receptor: design, synthesis, NMR structure and binding measurements (472 views)
Chembiochem (ISSN: 1439-7633, 1439-4227, 1439-7633electronic), 2003 Nov 7; 4(11): 1176-1187.
Impact Factor: 3.992
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D'Ambrosio K, Kauffmann B, Rouhier N, Benedetti E, Jacquot JP, Aubry A, Corbier C
* Crystallization and preliminary X-ray studies of the glutaredoxin from poplar in complex with glutathione (416 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 2003 Jun; 59: 1043-1045.
Impact Factor: 2.208
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De Luca S, Ulhaq S, Dixon M J, EssexJ, Bradley M
* Solid-phase synthesis of a focused library of trypanothione reductase inhibitors (376 views)
Tetrahedron Lett (ISSN: 0040-4039), 2003 Apr 7; 44(15): 3195-3197.
Impact Factor: 2.326
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Vecchio G
* Ligand exchange chiral separations by cyclodextrin derivatives in capillary electrophoresis (427 views)
Analyst (ISSN: 0003-2654), 2003; 128(2): 134-136.
Impact Factor: 2.251
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Esposito G, Vitagliano L, Santamaria R, Viola A, Zagari A, Salvatore F
* Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance (311 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2002 Nov 6; 531(2): 152-156.
Impact Factor: 3.912
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Orru S, Ruoppolo M, Francese S, Vitagliano L, Marino G, Esposito C
* Identification of tissue transglutaminase-reactive lysine residues in glyceraldehyde-3-phosphate dehydrogenase (9804 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 2002 Jan; 11(1): 137-146.
Impact Factor: 3.546
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De Falco S, Ruvo M, Verdoliva A, Scarallo A, Raimondo D, Raucci A, Fassina G
* N-terminal myristylation of HBV preS1 domain enhances receptor recognition (714 views)
J Pept Res (ISSN: 1397-002x, 1397-002xlinking), 2001 May; 57(5): 390-400.
Impact Factor: 1.522
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Cambria M, Cambria A, Ragusa S, Rizzarelli E
Production, purification, and properties of an extracellular laccase from Rigidoporus lignosus (339 views)
Protein Expr Purif (ISSN: 1046-5928), 2000 Mar; 18(2): 141-147.
Impact Factor: 1.569
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Fonti R, Latella G, Caprilli R, Frieri G, Marcheggiano A, Sambuy Y
Carbonic anhydrase I reduction in colonic mucosa of patients with active ulcerative colitis (469 views)
Digestive Diseases And Sciences (ISSN: 0163-2116), 1998; 43(9): 2086-2092.
Impact Factor: 1.972
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Bonomo RP, Cucinotta V, D'Alessandro F, Impellizzeri G, Maccarrone G, Rizzarelli E, Vecchio G, Carima L, Corradini R, Sartor G, Marchelli R
Chiral recognition by the copper(ii) complex of 6-deoxy-6-n-(2 - methylaminopyridine)-β-cyclodextrin (381 views)
Chirality (ISSN: 0899-0042), 1997; 9(4): 341-349.
Impact Factor: 1.915
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Adinolfi S, Piccoli R, Sica F, Mazzarella L
BS-RNase tetramers: An example of domain-swapped oligomers (421 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1996 Dec 2; 398(2-3): 326-332.
Impact Factor: 3.504
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Bonomo RP, Di Blasio B, Maccarrone G, Pavone V, Pedone C, Rizzarelli E, Saviano M, Vecchio G
Crystal and Molecular Structure of the [6-Deoxy-6-[(2-(4-imidazolyl)ethyl)amino]cyclomaltoheptaose]copper(II) Ternary Complex with L-Tryptophanate. Role of Weak Forces in the Chiral Recognition Process Assisted by a Metallocyclodextrin (314 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 1996 Jul 17; 35(15): 4497-4504.
Impact Factor: 2.736
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FRITTITTA L, VIGNERI R, PAPA V, GOLDFINE I, GRASSO G, TRISCHITTA V
Structural and functional studies of insulin receptors in human breast cancer (446 views)
Breast Cancer Res Tr Kluwer Academic Publishers (ISSN: 0167-6806), 1993; 25(1): 73-82.
Impact Factor: 2.43
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Della Ragione F, Oliva A, Palumbo R, Russo GL, Gragnaniello V, Zappia V
Deficiency of 5'-deoxy-5'-methylthioadenosine phosphorylase activity in malignancy. Absence of the protein in human enzyme-deficient cell lines (288 views)
Biochem J (ISSN: 0264-6021print, 0264-6021linking, 1470-8728electronic), 1992 Jan 15; 281(Pt2): 533-538.
Impact Factor: 3.579
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Montanaro V, Casamassimi A, D'Urso M, Yoon JY, Freije W, Schlessinger D, Muenke M, Nussbaum RL, Saccone S, Maugeri S
In Situ Hybridization To Cytogenetic Bands Of Yeast Artificial Chromosomes Covering 50% Of Human Xq24-Xq28 Dna (324 views)
Am J Hum Genet, 1991 Feb; 48(2): 183-194.
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Alberghina M, Brogna A, Mangiameli A, Marletta F, Rizzarelli E, Sammartano S
Copper(II) complexes of aminoacids: Gastric acid antisecretory activity in rats (2114 views)
Farmaco Ed Sci, 1982 Dec; 37(12): 805-814.
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Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (1341 views)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
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85 Records (83 excluding Abstracts).
Total impact factor: 308.976 (301.35 excluding Abstracts).
Total 5 year impact factor: 304.007 (295.455 excluding Abstracts).
Total impact factor: 308.976 (301.35 excluding Abstracts).
Total 5 year impact factor: 304.007 (295.455 excluding Abstracts).
526 views. Last view on Sunday 04 June 2023, 20:25:52
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