Keywords: Delivery, Fusion, Hydrophobicity, Membranotropic Peptide, Viral Inhibition, Antivirus Agent, Doxorubicin, Liposome, Nanoparticle, Polystyrene, Protein Gh625, Unclassified Drug, Virus Fusion Protein, Virus Protein, Bilayer Membrane, Blood Brain Barrier, Cell Membrane Transport, Drug Delivery System, Drug Design, Herpes Simplex Virus 1, Human, In Vitro Study, In Vivo Study, Molecular Mechanics, Nonhuman, Review, Virus Entry, Virus Inhibition, Amino Acid Sequence, Cell Membrane Metabolism Virology, Herpes Simplex Metabolism Virology, Herpesvirus 1, Human Metabolism Physiology, Host-Pathogen Interactions, Models, Molecular Sequence Data, Peptides Chemistry Metabolism, Protein Conformation, Viral Envelope Proteins Chemistry Metabolism, Gh625 Peptide, Herpes Simplex Virus Type I, Virus Envelope Protein, Chemical Structure, Host Pathogen Interaction, Molecular Genetics,
Affiliations: *** IBB - CNR ***
Department of Pharmacy, University of Naples Federico II, Via Mezzocannone 16Naples, Italy
DFM Scarl, University of Naples Federico II, Via Mezzocannone 16Naples, Italy
Department of Experimental Medicine, II University of Naples, Via De Crecchio 7Naples, Italy
References: Not available.
gH625: A milestone in understanding the many roles of membranotropic peptides
Here, we review the current knowledge about viral derived membranotropic peptides, and we discuss how they may be used for many therapeutic applications. While they have been initially discovered in viral fusion proteins and have been involved in the mechanism of viral entry, it is now clear that their features and their mode of interaction with membrane bilayers can be exploited to design viral inhibitors as well as to favor delivery of cargos across the cell membrane and across the blood-brain barrier. The peptide gH625 has been extensively used for all these purposes and provides a significant contribution to the field. We describe the roles of this sequence in order to close the gap between the many functions that are now emerging for membranotropic peptides. (C) 2014 Elsevier B.V. All rights reserved.
gH625: A milestone in understanding the many roles of membranotropic peptides
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gH625: A milestone in understanding the many roles of membranotropic peptides