Branched peptides for the modulation of protein-protein interactions: More arms are better than one? (532 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.859, 5-year impact factor: 4.806
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79957946154&partnerID=40&md5=217b1041fdbe4141be5b25db8e55c835
Keywords: Combinatorial Peptide Library, Cripto, Fc Receptor, Hepatitis B Virus, Immunoglobulin Purification, Interleukin-6, Map (mulptiple Antigen Peptide), Multimeric Peptides, Neurotensin, Pam (protein A Mimetic), Squamous Cell Carcinoma Antigen 1, Tnfα, Vegfr-1, Growth Factor, Growth Factor Receptor, Protein A Mimetic Peptide, Tripeptide, Unclassified Drug, Vasculotropin Receptor 1, Affinity Chromatography, Amino Acid Sequence, Angiogenesis, Article, Binding Affinity, Cell Differentiation, Cell Fate, Embryonic Stem Cell, Nonhuman, Protein Multimerization, Protein Protein Interaction, Protein Stability, Protein Structure, Systemic Lupus Erythematosus, Animals, Combinatorial Chemistry Techniques, Molecular Structure, Oligopeptides, Protein Binding,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone, 16, 80134, Napoli, Italy
Angiogenesis Lab, Institute of Genetics and Biophysic Adriano Buzzati-Traverso, CNR, Via Pietro Castellino, 111, 80131 Napoli, Italy
References:
Schnur, D.M., Beno, B.R., Tebben, A.J., Cavallaro, C., Methods for combinatorial and parallel library design (2010) Methods. Mol. Biol., 672, pp. 387-43
Timmerman, P., Barderas, R., Desmet, J., Altschuh, D., Shochat, S., Hollestelle, M.J., Hoppener, J.W., Meloen, R.H., A combinatorial approach for the design of complementarity-determining region-derived peptidomimetics with in vitro anti-tumoral activity (2009) J. Biol. Chem., 284 (49), pp. 34126-34134
Merrifield, R.B., Solid phase peptide synthesis i. the synthesis of a tetrapeptide (1963) J. Am. Chem. Soc., 85, pp. 2149-2154
Geysen, H.M., Barteling, S.J., Meloen, R.H., Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised agaist the native protein (1985) Proceedings of the National Academy of Sciences of the United States of America, 82 (1), pp. 178-182. , DOI 10.1073/pnas.82.1.178
Houghten, R.A., General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids (1985) Proceedings of the National Academy of Sciences of the United States of America, 82 (15), pp. 5131-5135. , DOI 10.1073/pnas.82.15.5131
Edwards, P.J., Current parallel chemistry principles and practice: Application to the discovery of biologically active molecules (2009) Curr. Opin. Drug. Discov. Devel., 12 (6), pp. 899-914
Shin, D.S., Kim, D.H., Chung, W.J., Lee, Y.S., Combinatorial solid phase peptide synthesis and bioassays (2005) J. Biochem. Mol. Biol., 38 (5), pp. 517-525
Bracci, L., Falciani, C., Lelli, B., Lozzi, L., Runci, Y., Pini, A., De Montis, M.G., Neri, P., Synthetic Peptides in the Form of Dendrimers Become Resistant to Protease Activity (2003) Journal of Biological Chemistry, 278 (47), pp. 46590-46595. , DOI 10.1074/jbc.M308615200
Verdoliva, A., Marasco, D., De Capua, A., Saporito, A., Bellofiore, P., Manfredi, V., Fattorusso, R., Ruvo, M., A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (2005) ChemBioChem, 6 (7), pp. 1242-1253. , DOI 10.1002/cbic.200400368
Ruvo, M., Scardino, P., Cassani, G., Fassina, G., Facile manual synthesis of peptide libraries (1994) Peptide & Protein Letters, 1, pp. 187-192
Tam, J.P., Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system (1988) Proc. Natl. Acad. Sci. U. S. A., 85 (15), pp. 5409-5413
Francis, M.J., Hastings, G.Z., Brown, F., McDermed, J., Lu, Y.A., Tam, J.P., Immunological evaluation of the multiple antigen peptide (MAP) system using the major immunogenic site of foot-and-mouth disease virus (1991) Immunology, 73 (3), pp. 249-254
Defoort, J.P., Nardelli, B., Huang, W., Tam, J.P., A rational design of synthetic peptide vaccine with a built-in adjuvant. A modular approach for unambiguity (1992) Int. J. Pept. Protein Res., 40 (3-4), pp. 214-221
Fassina, G., Oriented immobilization of peptide ligands on solid supports (1992) J. Chromatogr., 591 (1-2), pp. 99-106
Fassina, G., Corti, A., Cassani, G., Affinity enhancement of complementary peptide recognition (1992) Int. J. Pept. Protein Res., 39 (6), pp. 549-556
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Ruvo, M., Fassina, G., End-group modified retro-inverso isomers of tripeptide oxytocin analogues: Binding to neurophysin II and enhancement of its self-association properties (1995) Int. J. Pept. Protein. Res., 45 (4), pp. 356-365
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Marino, M., Ruvo, M., De Falco, S., Fassina, G., Prevention of systemic lupus erythematosus in MRL/lpr mice by administration of an immunoglobulin-binding peptide (2000) Nature Biotechnology, 18 (7), pp. 735-739. , DOI 10.1038/77296
Ponticelli, S., Marasco, D., Tarallo, V., Albuquerque, R.J., Mitola, S., Takeda, A., Stassen, J.M., De Falco, S., Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1 (2008) J. Biol. Chem., 283 (49), pp. 34250-34259
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Shepard, C.W., Simard, E.P., Finelli, L., Fiore, A.E., Bell, B.P., Hepatitis B virus infection: Epidemiology and vaccination (2006) Epidemiologic Reviews, 28 (1), pp. 112-125. , DOI 10.1093/epirev/mxj009
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Pontisso, P., Calabrese, F., Benvegnu, L., Lise, M., Belluco, C., Ruvoletto, M.G., De Falco, S., Fassina, G., Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma (2004) British Journal of Cancer, 90 (4), pp. 833-837. , DOI 10.1038/sj.bjc.6601543
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Schnur, D. M., Beno, B. R., Tebben, A. J., Cavallaro, C., Methods for combinatorial and parallel library design (2010) Methods. Mol. Biol., 672, pp. 387-43
Merrifield, R. B., Solid phase peptide synthesis i. the synthesis of a tetrapeptide (1963) J. Am. Chem. Soc., 85, pp. 2149-2154
Geysen, H. M., Barteling, S. J., Meloen, R. H., Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised agaist the native protein (1985) Proceedings of the National Academy of Sciences of the United States of America, 82 (1), pp. 178-182. , DOI 10. 1073/pnas. 82. 1. 178
Houghten, R. A., General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids (1985) Proceedings of the National Academy of Sciences of the United States of America, 82 (15), pp. 5131-5135. , DOI 10. 1073/pnas. 82. 15. 5131
Edwards, P. J., Current parallel chemistry principles and practice: Application to the discovery of biologically active molecules (2009) Curr. Opin. Drug. Discov. Devel., 12 (6), pp. 899-914
Shin, D. S., Kim, D. H., Chung, W. J., Lee, Y. S., Combinatorial solid phase peptide synthesis and bioassays (2005) J. Biochem. Mol. Biol., 38 (5), pp. 517-525
Tam, J. P., Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system (1988) Proc. Natl. Acad. Sci. U. S. A., 85 (15), pp. 5409-5413
Francis, M. J., Hastings, G. Z., Brown, F., McDermed, J., Lu, Y. A., Tam, J. P., Immunological evaluation of the multiple antigen peptide (MAP) system using the major immunogenic site of foot-and-mouth disease virus (1991) Immunology, 73 (3), pp. 249-254
Defoort, J. P., Nardelli, B., Huang, W., Tam, J. P., A rational design of synthetic peptide vaccine with a built-in adjuvant. A modular approach for unambiguity (1992) Int. J. Pept. Protein Res., 40 (3-4), pp. 214-221
Radulescu, R. T., Bellitti, M. R., Ruvo, M., Cassani, G., Fassina, G., Binding of the LXCXE insulin motif to a hexapeptide derived from retinoblastoma protein (1995) Biochem. Biophys. Res. Commun., 206 (1), pp. 97-102
Brennan, D. J., O'Connor, D. P., Rexhepaj, E., Ponten, F., Gallagher, W. M., Antibody-based proteomics: Fast-tracking molecular diagnostics in oncology (2010) Nat. Rev. Cancer, 10 (9), pp. 605-617
Theofilopoulos, A. N., Dixon, F. J., Etiopathogenesis of murine SLE (1981) Immunological Reviews, 55, pp. 179-216
Ambati, B. K., Nozaki, M., Singh, N., Takeda, A., Jani, P. D., Suthar, T., Albuquerque, R. J. C., Ambati, J., Corneal avascularity is due to soluble VEGF receptor-1 (2006) Nature, 443 (7114), pp. 993-997. , DOI 10. 1038/nature05249, PII NATURE05249
Li, J. Y., Christophersen, N. S., Hall, V., Soulet, D., Brundin, P., Critical issues of clinical human embryonic stem cell therapy for brain repair (2008) Trends Neurosci., 31 (3), pp. 146-153
Boheler, K. R., Crider, D. G., Tarasova, Y., Maltsev, V. A., Cardiomyocytes derived from embryonic stem cells (2005) Methods Mol. Med., 108, pp. 417-435
Parish, C. L., Parisi, S., Persico, M. G., Arenas, E., Minchiotti, G., Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease (2005) Stem Cells, 23 (4), pp. 471-476. , DOI 10. 1634/stemcells. 2004-0294
Shepard, C. W., Simard, E. P., Finelli, L., Fiore, A. E., Bell, B. P., Hepatitis B virus infection: Epidemiology and vaccination (2006) Epidemiologic Reviews, 28 (1), pp. 112-125. , DOI 10. 1093/epirev/mxj009
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2011 Jun; 18(16): 2429-2437.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.859, 5-year impact factor: 4.806
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-79957946154&partnerID=40&md5=217b1041fdbe4141be5b25db8e55c835
Keywords: Combinatorial Peptide Library, Cripto, Fc Receptor, Hepatitis B Virus, Immunoglobulin Purification, Interleukin-6, Map (mulptiple Antigen Peptide), Multimeric Peptides, Neurotensin, Pam (protein A Mimetic), Squamous Cell Carcinoma Antigen 1, Tnfα, Vegfr-1, Growth Factor, Growth Factor Receptor, Protein A Mimetic Peptide, Tripeptide, Unclassified Drug, Vasculotropin Receptor 1, Affinity Chromatography, Amino Acid Sequence, Angiogenesis, Article, Binding Affinity, Cell Differentiation, Cell Fate, Embryonic Stem Cell, Nonhuman, Protein Multimerization, Protein Protein Interaction, Protein Stability, Protein Structure, Systemic Lupus Erythematosus, Animals, Combinatorial Chemistry Techniques, Molecular Structure, Oligopeptides, Protein Binding,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, CNR, Via Mezzocannone, 16, 80134, Napoli, Italy
Angiogenesis Lab, Institute of Genetics and Biophysic Adriano Buzzati-Traverso, CNR, Via Pietro Castellino, 111, 80131 Napoli, Italy
References:
Schnur, D.M., Beno, B.R., Tebben, A.J., Cavallaro, C., Methods for combinatorial and parallel library design (2010) Methods. Mol. Biol., 672, pp. 387-43
Timmerman, P., Barderas, R., Desmet, J., Altschuh, D., Shochat, S., Hollestelle, M.J., Hoppener, J.W., Meloen, R.H., A combinatorial approach for the design of complementarity-determining region-derived peptidomimetics with in vitro anti-tumoral activity (2009) J. Biol. Chem., 284 (49), pp. 34126-34134
Merrifield, R.B., Solid phase peptide synthesis i. the synthesis of a tetrapeptide (1963) J. Am. Chem. Soc., 85, pp. 2149-2154
Geysen, H.M., Barteling, S.J., Meloen, R.H., Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised agaist the native protein (1985) Proceedings of the National Academy of Sciences of the United States of America, 82 (1), pp. 178-182. , DOI 10.1073/pnas.82.1.178
Houghten, R.A., General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids (1985) Proceedings of the National Academy of Sciences of the United States of America, 82 (15), pp. 5131-5135. , DOI 10.1073/pnas.82.15.5131
Edwards, P.J., Current parallel chemistry principles and practice: Application to the discovery of biologically active molecules (2009) Curr. Opin. Drug. Discov. Devel., 12 (6), pp. 899-914
Shin, D.S., Kim, D.H., Chung, W.J., Lee, Y.S., Combinatorial solid phase peptide synthesis and bioassays (2005) J. Biochem. Mol. Biol., 38 (5), pp. 517-525
Bracci, L., Falciani, C., Lelli, B., Lozzi, L., Runci, Y., Pini, A., De Montis, M.G., Neri, P., Synthetic Peptides in the Form of Dendrimers Become Resistant to Protease Activity (2003) Journal of Biological Chemistry, 278 (47), pp. 46590-46595. , DOI 10.1074/jbc.M308615200
Verdoliva, A., Marasco, D., De Capua, A., Saporito, A., Bellofiore, P., Manfredi, V., Fattorusso, R., Ruvo, M., A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (2005) ChemBioChem, 6 (7), pp. 1242-1253. , DOI 10.1002/cbic.200400368
Ruvo, M., Scardino, P., Cassani, G., Fassina, G., Facile manual synthesis of peptide libraries (1994) Peptide & Protein Letters, 1, pp. 187-192
Tam, J.P., Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system (1988) Proc. Natl. Acad. Sci. U. S. A., 85 (15), pp. 5409-5413
Francis, M.J., Hastings, G.Z., Brown, F., McDermed, J., Lu, Y.A., Tam, J.P., Immunological evaluation of the multiple antigen peptide (MAP) system using the major immunogenic site of foot-and-mouth disease virus (1991) Immunology, 73 (3), pp. 249-254
Defoort, J.P., Nardelli, B., Huang, W., Tam, J.P., A rational design of synthetic peptide vaccine with a built-in adjuvant. A modular approach for unambiguity (1992) Int. J. Pept. Protein Res., 40 (3-4), pp. 214-221
Fassina, G., Oriented immobilization of peptide ligands on solid supports (1992) J. Chromatogr., 591 (1-2), pp. 99-106
Fassina, G., Corti, A., Cassani, G., Affinity enhancement of complementary peptide recognition (1992) Int. J. Pept. Protein Res., 39 (6), pp. 549-556
Bracci, L., Lozzi, L., Pini, A., Lelli, B., Falciani, C., Niccolai, N., Bernini, A., Neri, P., A branched peptide mimotope of the nicotinic receptor binding site is a potent synthetic antidote against the snake neurotoxin α-bungarotoxin (2002) Biochemistry, 41 (32), pp. 10194-10199. , DOI 10.1021/bi0256025
Ruvo, M., Fassina, G., End-group modified retro-inverso isomers of tripeptide oxytocin analogues: Binding to neurophysin II and enhancement of its self-association properties (1995) Int. J. Pept. Protein. Res., 45 (4), pp. 356-365
Fassina, G., Cassani, G., Corti, A., Binding of human tumor necrosis factor alpha to multimeric complementary peptides (1992) Arch. Biochem. Biophys., 296 (1), pp. 137-143
Palombo, G., Dani, M., Fassina, G., Selection of peptide ligands for α-1 antitrypsin from a phage display library (1999) Protein and Peptide Letters, 6 (1), pp. 43-48
Radulescu, R.T., Bellitti, M.R., Ruvo, M., Cassani, G., Fassina, G., Binding of the LXCXE insulin motif to a hexapeptide derived from retinoblastoma protein (1995) Biochem. Biophys. Res. Commun., 206 (1), pp. 97-102
Marino, M., Ruvo, M., De Falco, S., Fassina, G., Prevention of systemic lupus erythematosus in MRL/lpr mice by administration of an immunoglobulin-binding peptide (2000) Nature Biotechnology, 18 (7), pp. 735-739. , DOI 10.1038/77296
Ponticelli, S., Marasco, D., Tarallo, V., Albuquerque, R.J., Mitola, S., Takeda, A., Stassen, J.M., De Falco, S., Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1 (2008) J. Biol. Chem., 283 (49), pp. 34250-34259
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Branched peptides for the modulation of protein-protein interactions: More arms are better than one?
Combinatorial peptide libraries from synthetic or biological sources have been largely used in the last two-decades with the aim of identifying bioactive peptides that specifically bind proteins and modulate their interactions with other protein partners. Differently from biological libraries, synthetic methods allow the development of different kinds of libraries based on two main characteristics: i) the use of building blocks and chemical bonds different from those naturally occurring and ii) the possibility of designing scaffolds with non-linear shapes, as cyclic and branched structures. These two features, alone or in combination, have increased the chemical and structural diversity of peptide libraries expanding the offer of collections for the screenings. Here we describe our and other experiences with branched peptides and the results obtained in the last fifteen years. These clearly indicate how the use of short multimerized peptides can represent a successful approach for different applications ranging from affinity chromatography to the modulation of protein-protein interactions in different biological contexts. © 2011 Bentham Science Publishers Ltd.
Combinatorial peptide libraries from synthetic or biological sources have been largely used in the last two-decades with the aim of identifying bioactive peptides that specifically bind proteins and modulate their interactions with other protein partners. Differently from biological libraries, synthetic methods allow the development of different kinds of libraries based on two main characteristics: i) the use of building blocks and chemical bonds different from those naturally occurring and ii) the possibility of designing scaffolds with non-linear shapes, as cyclic and branched structures. These two features, alone or in combination, have increased the chemical and structural diversity of peptide libraries expanding the offer of collections for the screenings. Here we describe our and other experiences with branched peptides and the results obtained in the last fifteen years. These clearly indicate how the use of short multimerized peptides can represent a successful approach for different applications ranging from affinity chromatography to the modulation of protein-protein interactions in different biological contexts. © 2011 Bentham Science Publishers Ltd.
Branched peptides for the modulation of protein-protein interactions: More arms are better than one?
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Branched peptides for the modulation of protein-protein interactions: More arms are better than one?
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Impact Factor: 6.78
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Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (341 views)
N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
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Galdiero S, Vitiello M, Falanga A, Cantisani M, Incoronato N, Galdiero M
* Intracellular Delivery: Exploiting Viral Membranotropic Peptides (934 views)
Current Drug Metabolism (ISSN: 1389-2002), 2012 Jan; 13(1): 93-104.
Impact Factor: 4.405
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Sandomenico A, Monti SM, Palumbo R, Ruvo M
* A New Fc Epsilon Ri Receptor-Mimetic Peptide (pepe) That Blocks Ige Binding To Its High Affinity Receptor And Prevents Mediator Release From Rbl 2h3 Cells (696 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Sep; 17(9): 604-609.
Impact Factor: 1.799
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Sandomenico A, Monti SM, Marasco D, Dathan N, Palumbo R, Saviano M, Ruvo M
* Ige-Binding Properties And Selectivity Of Peptide Mimics Of The Fcvarepsilonri Binding Site (1651 views)
Mol Immunol (ISSN: 0161-5890), 2009 Oct; 46(16): 3300-3309.
Impact Factor: 3.202
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Verdoliva A, Marasco D, De Capua A, Saporito A, Bellofiore P, Manfredi V, Fattorusso R, Pedone C, Ruvo M
* A new ligand for immunoglobulin G subdomains by screening of a synthetic peptide library (501 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2005 Jul; 6(7): 1242-1253.
Impact Factor: 3.94
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Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C
* Synthetic peptides mimicking the interleukin-6/gp130 interaction: a two-helix bundle system. Design and conformational studies (1033 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003 Feb; 9(2): 105-105.
Impact Factor: 1.377
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Zaccaro L, Bucci E, Vitale RM, Perretta G, Fattorusso R, Benedetti E, Saviano M, Pedone C
* Synthetic peptides mimicking the interleukin-6/gp130 interaction: A two-helix bundle system. Design and confirmational studies (472 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2003; 9(2): 90-105.
Impact Factor: 1.377
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (399 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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De Falco S, Ruvoletto MG, Verdoliva A, Ruvo M, Raucci A, Marino M, Senatore S, Cassani G, Alberti A, Pontisso P, Fassina G
* Cloning and Expression of a Novel Hepatitis B Virus-binding Protein from HepG2 Cells (626 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2001 Sep 28; 276(39): 36613-36623.
Impact Factor: 7.258
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De Falco S, Ruvo M, Verdoliva A, Scarallo A, Raimondo D, Raucci A, Fassina G
* N-terminal myristylation of HBV preS1 domain enhances receptor recognition (714 views)
J Pept Res (ISSN: 1397-002x, 1397-002xlinking), 2001 May; 57(5): 390-400.
Impact Factor: 1.522
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16 Records (15 excluding Abstracts).
Total impact factor: 113.421 (112.044 excluding Abstracts).
Total 5 year impact factor: 85.696 (83.981 excluding Abstracts).
Total impact factor: 113.421 (112.044 excluding Abstracts).
Total 5 year impact factor: 85.696 (83.981 excluding Abstracts).
532 views. Last view on Tuesday 30 May 2023, 10:19:21
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