Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (445 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.16, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034999820&partnerID=40&md5=29ccdf385f633349ee0bac6931f83500
Keywords: Fibrinogen, High Density Lipoprotein Cholesterol, Recombinant Growth Hormone, Somatomedin C, Triacylglycerol, Adult, Article, Cardiovascular Risk, Clinical Article, Controlled Study, Female, Growth Hormone Deficiency, Heart Ejection Fraction, Heart Left Ventricle Mass, Heart Performance, Hormone Substitution, Human, Priority Journal, Scintiangiography, Adolescent, Cardiovascular Diseases, Cohort Studies, Hormone Replacement Therapy, Human Growth Hormone, Lipids, Prospective Studies, Risk Factors, Time Factors, Ventricular Function,
Affiliations:
*** IBB - CNR ***
Depts. Molec./Clinic. Endocrinol./O., Nuclear Med. Ctr. Natl. Cncl. Res., Federico II University of Naples, 80131 Naples, Italy
Dept. Biomorphological/Funct. Sci., Federico II University of Naples, 80131 Naples, Italy
Department of Internal Medicine I, Federico II University of Naples, 80131 Naples, Italy
Sci. Inst. for Res./Cure Neuromed, Pozzilli, Italy
Dept. Molec./Clinic. Endocrinol./O., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
Depts. Molec. /Clinic. Endocrinol. /O., Nuclear Med. Ctr. Natl. Cncl. Res., Federico II University of Naples, 80131 Naples, Italy
Dept. Molec. /Clinic. Endocrinol. /O., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
References:
Rosen, T., Bengtsson, B.A., Premature mortality due to cardiovascular disease in hypopitiutarism (1990) Lancet, 336, pp. 285-28
Bates, A.S., Vant'Hoff, W., Jones, P.J., Clayton, R.N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Bulöw, B., Hagmar, L., Mikoczy, Z., Nordström, C.H., Erfurth, E.M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol (Oxf), 46, pp. 75-81
Isgaard, J., Nilsson, A., Vickman, K., Isaksson, O.G.P., Growth hormone regulates the level of insulin-like growth factor-I mRNA in rats skeletal muscle (1989) J Endocrinol, 120, pp. 107-112
Ito, H., Hiroe, M., Hirata, Y., Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes (1993) Circulation, 87, pp. 1715-1721
Guse, A.H., Kiess, W., Funk, B., Kessler, U., Berg, I., Gercken, G., Identification and characterization of insulin-like growth factor receptors on adult rat myocytes: Linkage to inositol-1,4,5-trisphosphate formation (1992) Endocrinology, 130, pp. 145-151
Vetter, U., Kupferschmid, C., Lang, D., Pents, S., Insulin-like growth factors and insulin increase the contractility of neonatal rat cardiocytes in vitro (1988) Basic Res Cardiol, 83, pp. 647-654
Timsit, J., Riou, B., Bertherat, J., Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern and myosin-adenosine triphosphatase activity of rat left ventricle (1990) J Clin Invest, 86, pp. 507-515
López-Velasco, R., Escobar-Morreale, H.F., Vega, B., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Colao, A., Cuocolo, A., Marzullo, P., Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (1999) J Clin Endocrinol Metab, 84, pp. 1518-1523
Colao, A., Baldelli, R., Marzullo, P., Systemic hypertension and impaired glucose tolerance are independently correlated to the severity of the acromegalic cardiomyopathy (2000) J Clin Endocrinol Metab, 85, pp. 193-199
Shahi, M., Beshyah, S., Hackett, D., Sharp, P., Johnston, D., Foale, R., Myocardial dysfunction in treated adult hypopituitarism: A possible explanation for increased cardiovascular mortality (1992) Br Heart J, 67, pp. 92-96
Merola, B., Cittadini, A., Colao, A., Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency (1993) J Clin Endocrinol Metab, 77, pp. 1658-1661
Amato, G., Carella, C., Fazio, S., Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses (1993) J Clin Endocrinol Metab, 77, pp. 1671-1676
Nass, R., Huber, R.M., Klauss, V., Muller, O.A., Schopol, J., Strasburger, C.J., Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood (1995) J Clin Endocrinol Metab, 80, pp. 552-557
Valcavi, R., Gaddi, O., Zini, M., Iavicolli, M., Mellino, U., Portioli, I., Cardiac performance and mass in adult with hypopituitarism: Effects of one year of growth hormone treatment (1995) J Clin Endocrinol Metab, 80, pp. 659-666
Christiansen, J.S., Jorgensen, J.O.L., Thuesen, L., Cardiovascular aspects of growth hormone replacement therapy in adults (1996) Endocrinol Metab, 3, pp. 19-22
Saccà, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Cittadini, A., Cuocolo, A., Merola, B., Impaired cardiac performance in GH-deficient adults and its improvement after GH replacement (1994) Am J Physiol, 267, pp. E219-E225
Cuocolo, A., Nicolai, E., Colao, A., Improved left ventricular function after growth hormone replacement in patients with hypopituitarism: Assessment with radionuclide angiography (1996) Eur J Nucl Med, 23, pp. 390-394
Longobardi, S., Cuocolo, A., Merola, B., Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (1998) Clin Endocrinol (Oxf), 48, pp. 137-143
Carrol, P.V., Christ, E.R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-395
Beshyah, S.A., Johnston, D.G., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol (Oxf), 50, pp. 1-15
Vance, M.L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Harjai, K.J., Potential new cardiovascular risk factors: Left ventricular hypertrophy, homocysteine(a), triglycerides, oxidative stress and fibrinogen (1999) Ann Intern Med, 131, pp. 377-386
Attanasio, A., Lamberts, S.W.J., Matranga, A.M.C., Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment (1997) J Clin Endocrinol Metab, 82, pp. 82-88
Colao, A., Cerbone, G., Pivonello, R., The growth hormone (GH) response to arginine plus GH releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 1277-1282
Colao, A., Di Somma, C., Pivonello, R., Bone loss is correlated to the severity of growth hormone (GH) deficiency in adult patients with hypopituitarism (1999) J Clin Endocrinol Metab, 84, pp. 1919-1924
Aimaretti, G., Corneli, G., Razzore, P., Comparison between insulin- induced hypoglycemia and growth hormone (GH)-releasing hormone and arginine as provocative tests for the diagnosis of GH deficiency in adults (1998) J Clin Endocrinol Metab, 83, pp. 1615-1618
Colao, A., Lombardi, G., GH and PRL excess (1998) Lancet, 352, pp. 1455-1461
Castelli, W.P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
Feigenbaum, H., (1979) Echocardiography, 2nd Ed., , Philadelphia: Lea and Febiger
Miller, T.R., Grossman, S.G., Schechtman, K.B., Biello, D.R., Ludbrook, P.A., Ehansi, A.A., Left ventricular diastolic filling and its association with age (1986) Am J Cardiol, 58, pp. 531-535
Bonow, R.O., Vitale, D.F., Bacharach, S.L., Maron, B.J., Green, M.V., Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects (1988) J Am Coll Cardiol, 11, pp. 50-58
Caidahl, K., Eden, S., Bengtsson, B.A., Cardiovascular and renal effects of growth hormone (1994) Clin Endocrinol (Oxf), 40, pp. 393-400
Johansson, G., Bengtsson, B.A., Andersson, B., Isgaard, J., Caidahl, K., Long-term cardiovascular effects of growth hormone treatment in GH-deficient adults. Preliminary data in a small group of patients (1996) Clin Endocrinol (Oxf), 45, pp. 305-314
Thuesen, L., Jorgensen, J.O.L., Müller, J.R., Short and long-term cardiovascular effects of growth hormone therapy in growth hormone deficient adults (1994) Clin Endocrinol (Oxf), 41, pp. 615-620
Beshyah, S.A., Shahi, M., Foale, R., Johnston, D.G., Cardiovascular effects of prolonged growth hormone replacement in adults (1995) J Intern Med, 237, pp. 35-42
Ter Maaten, J., De Boer, H., Kamp, O., Stuurman, L., Van Der Veen, E., Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 2373-2380
Gibney, J., Wallace, J.D., Spinks, T., The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients (1999) J Clin Endocrinol Metab, 84, pp. 2596-2602
Cuneo, R.C., Salomon, F., Wiles, C.M., Hesp, R., Sonksen, P.H., Growth hormone treatment in growth hormone deficient adults. II Effects on exercise performance (1991) J Appl Physiol, 70, pp. 695-700
Fort, S., Weaver, J.U., Monson, J.P., Mills, P.G., The effect of low-dose recombinant human growth hormone on cardiovascular structure and function in growth hormone-deficient hypopituitary adults (1995) Endocrinol Metab, 2, pp. 119-126
Böger, R.H., Skamira, C., Bode-Böger, S.M., Brabant, C., Von Zur Muhlen, A., Frolich, J.C., Nitric oxide mediates the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency (1996) J Clin Invest, 98, pp. 2706-2713
Bates, A. S., Vant'Hoff, W., Jones, P. J., Clayton, R. N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Bul w, B., Hagmar, L., Mikoczy, Z., Nordstr m, C. H., Erfurth, E. M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol (Oxf), 46, pp. 75-81
Guse, A. H., Kiess, W., Funk, B., Kessler, U., Berg, I., Gercken, G., Identification and characterization of insulin-like growth factor receptors on adult rat myocytes: Linkage to inositol-1, 4, 5-trisphosphate formation (1992) Endocrinology, 130, pp. 145-151
L pez-Velasco, R., Escobar-Morreale, H. F., Vega, B., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Christiansen, J. S., Jorgensen, J. O. L., Thuesen, L., Cardiovascular aspects of growth hormone replacement therapy in adults (1996) Endocrinol Metab, 3, pp. 19-22
Sacc, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Carrol, P. V., Christ, E. R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-395
Beshyah, S. A., Johnston, D. G., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol (Oxf), 50, pp. 1-15
Vance, M. L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Harjai, K. J., Potential new cardiovascular risk factors: Left ventricular hypertrophy, homocysteine (a), triglycerides, oxidative stress and fibrinogen (1999) Ann Intern Med, 131, pp. 377-386
Castelli, W. P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
Miller, T. R., Grossman, S. G., Schechtman, K. B., Biello, D. R., Ludbrook, P. A., Ehansi, A. A., Left ventricular diastolic filling and its association with age (1986) Am J Cardiol, 58, pp. 531-535
Bonow, R. O., Vitale, D. F., Bacharach, S. L., Maron, B. J., Green, M. V., Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects (1988) J Am Coll Cardiol, 11, pp. 50-58
Beshyah, S. A., Shahi, M., Foale, R., Johnston, D. G., Cardiovascular effects of prolonged growth hormone replacement in adults (1995) J Intern Med, 237, pp. 35-42
Cuneo, R. C., Salomon, F., Wiles, C. M., Hesp, R., Sonksen, P. H., Growth hormone treatment in growth hormone deficient adults. II Effects on exercise performance (1991) J Appl Physiol, 70, pp. 695-700
B ger, R. H., Skamira, C., Bode-B ger, S. M., Brabant, C., Von Zur Muhlen, A., Frolich, J. C., Nitric oxide mediates the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency (1996) J Clin Invest, 98, pp. 2706-2713
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.16, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034999820&partnerID=40&md5=29ccdf385f633349ee0bac6931f83500
Keywords: Fibrinogen, High Density Lipoprotein Cholesterol, Recombinant Growth Hormone, Somatomedin C, Triacylglycerol, Adult, Article, Cardiovascular Risk, Clinical Article, Controlled Study, Female, Growth Hormone Deficiency, Heart Ejection Fraction, Heart Left Ventricle Mass, Heart Performance, Hormone Substitution, Human, Priority Journal, Scintiangiography, Adolescent, Cardiovascular Diseases, Cohort Studies, Hormone Replacement Therapy, Human Growth Hormone, Lipids, Prospective Studies, Risk Factors, Time Factors, Ventricular Function,
Affiliations:
*** IBB - CNR ***
Depts. Molec./Clinic. Endocrinol./O., Nuclear Med. Ctr. Natl. Cncl. Res., Federico II University of Naples, 80131 Naples, Italy
Dept. Biomorphological/Funct. Sci., Federico II University of Naples, 80131 Naples, Italy
Department of Internal Medicine I, Federico II University of Naples, 80131 Naples, Italy
Sci. Inst. for Res./Cure Neuromed, Pozzilli, Italy
Dept. Molec./Clinic. Endocrinol./O., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
Depts. Molec. /Clinic. Endocrinol. /O., Nuclear Med. Ctr. Natl. Cncl. Res., Federico II University of Naples, 80131 Naples, Italy
Dept. Molec. /Clinic. Endocrinol. /O., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
References:
Rosen, T., Bengtsson, B.A., Premature mortality due to cardiovascular disease in hypopitiutarism (1990) Lancet, 336, pp. 285-28
Bates, A.S., Vant'Hoff, W., Jones, P.J., Clayton, R.N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Bulöw, B., Hagmar, L., Mikoczy, Z., Nordström, C.H., Erfurth, E.M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol (Oxf), 46, pp. 75-81
Isgaard, J., Nilsson, A., Vickman, K., Isaksson, O.G.P., Growth hormone regulates the level of insulin-like growth factor-I mRNA in rats skeletal muscle (1989) J Endocrinol, 120, pp. 107-112
Ito, H., Hiroe, M., Hirata, Y., Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes (1993) Circulation, 87, pp. 1715-1721
Guse, A.H., Kiess, W., Funk, B., Kessler, U., Berg, I., Gercken, G., Identification and characterization of insulin-like growth factor receptors on adult rat myocytes: Linkage to inositol-1,4,5-trisphosphate formation (1992) Endocrinology, 130, pp. 145-151
Vetter, U., Kupferschmid, C., Lang, D., Pents, S., Insulin-like growth factors and insulin increase the contractility of neonatal rat cardiocytes in vitro (1988) Basic Res Cardiol, 83, pp. 647-654
Timsit, J., Riou, B., Bertherat, J., Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern and myosin-adenosine triphosphatase activity of rat left ventricle (1990) J Clin Invest, 86, pp. 507-515
López-Velasco, R., Escobar-Morreale, H.F., Vega, B., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Colao, A., Cuocolo, A., Marzullo, P., Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (1999) J Clin Endocrinol Metab, 84, pp. 1518-1523
Colao, A., Baldelli, R., Marzullo, P., Systemic hypertension and impaired glucose tolerance are independently correlated to the severity of the acromegalic cardiomyopathy (2000) J Clin Endocrinol Metab, 85, pp. 193-199
Shahi, M., Beshyah, S., Hackett, D., Sharp, P., Johnston, D., Foale, R., Myocardial dysfunction in treated adult hypopituitarism: A possible explanation for increased cardiovascular mortality (1992) Br Heart J, 67, pp. 92-96
Merola, B., Cittadini, A., Colao, A., Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency (1993) J Clin Endocrinol Metab, 77, pp. 1658-1661
Amato, G., Carella, C., Fazio, S., Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses (1993) J Clin Endocrinol Metab, 77, pp. 1671-1676
Nass, R., Huber, R.M., Klauss, V., Muller, O.A., Schopol, J., Strasburger, C.J., Effect of growth hormone (hGH) replacement therapy on physical work capacity and cardiac and pulmonary function in patients with hGH deficiency acquired in adulthood (1995) J Clin Endocrinol Metab, 80, pp. 552-557
Valcavi, R., Gaddi, O., Zini, M., Iavicolli, M., Mellino, U., Portioli, I., Cardiac performance and mass in adult with hypopituitarism: Effects of one year of growth hormone treatment (1995) J Clin Endocrinol Metab, 80, pp. 659-666
Christiansen, J.S., Jorgensen, J.O.L., Thuesen, L., Cardiovascular aspects of growth hormone replacement therapy in adults (1996) Endocrinol Metab, 3, pp. 19-22
Saccà, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Cittadini, A., Cuocolo, A., Merola, B., Impaired cardiac performance in GH-deficient adults and its improvement after GH replacement (1994) Am J Physiol, 267, pp. E219-E225
Cuocolo, A., Nicolai, E., Colao, A., Improved left ventricular function after growth hormone replacement in patients with hypopituitarism: Assessment with radionuclide angiography (1996) Eur J Nucl Med, 23, pp. 390-394
Longobardi, S., Cuocolo, A., Merola, B., Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (1998) Clin Endocrinol (Oxf), 48, pp. 137-143
Carrol, P.V., Christ, E.R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-395
Beshyah, S.A., Johnston, D.G., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol (Oxf), 50, pp. 1-15
Vance, M.L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Harjai, K.J., Potential new cardiovascular risk factors: Left ventricular hypertrophy, homocysteine(a), triglycerides, oxidative stress and fibrinogen (1999) Ann Intern Med, 131, pp. 377-386
Attanasio, A., Lamberts, S.W.J., Matranga, A.M.C., Adult growth hormone (GH)-deficient patients demonstrate heterogeneity between childhood onset and adult onset before and during human GH treatment (1997) J Clin Endocrinol Metab, 82, pp. 82-88
Colao, A., Cerbone, G., Pivonello, R., The growth hormone (GH) response to arginine plus GH releasing hormone test is correlated to the severity of lipid profile abnormalities in adult patients with GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 1277-1282
Colao, A., Di Somma, C., Pivonello, R., Bone loss is correlated to the severity of growth hormone (GH) deficiency in adult patients with hypopituitarism (1999) J Clin Endocrinol Metab, 84, pp. 1919-1924
Aimaretti, G., Corneli, G., Razzore, P., Comparison between insulin- induced hypoglycemia and growth hormone (GH)-releasing hormone and arginine as provocative tests for the diagnosis of GH deficiency in adults (1998) J Clin Endocrinol Metab, 83, pp. 1615-1618
Colao, A., Lombardi, G., GH and PRL excess (1998) Lancet, 352, pp. 1455-1461
Castelli, W.P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
Feigenbaum, H., (1979) Echocardiography, 2nd Ed., , Philadelphia: Lea and Febiger
Miller, T.R., Grossman, S.G., Schechtman, K.B., Biello, D.R., Ludbrook, P.A., Ehansi, A.A., Left ventricular diastolic filling and its association with age (1986) Am J Cardiol, 58, pp. 531-535
Bonow, R.O., Vitale, D.F., Bacharach, S.L., Maron, B.J., Green, M.V., Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects (1988) J Am Coll Cardiol, 11, pp. 50-58
Caidahl, K., Eden, S., Bengtsson, B.A., Cardiovascular and renal effects of growth hormone (1994) Clin Endocrinol (Oxf), 40, pp. 393-400
Johansson, G., Bengtsson, B.A., Andersson, B., Isgaard, J., Caidahl, K., Long-term cardiovascular effects of growth hormone treatment in GH-deficient adults. Preliminary data in a small group of patients (1996) Clin Endocrinol (Oxf), 45, pp. 305-314
Thuesen, L., Jorgensen, J.O.L., Müller, J.R., Short and long-term cardiovascular effects of growth hormone therapy in growth hormone deficient adults (1994) Clin Endocrinol (Oxf), 41, pp. 615-620
Beshyah, S.A., Shahi, M., Foale, R., Johnston, D.G., Cardiovascular effects of prolonged growth hormone replacement in adults (1995) J Intern Med, 237, pp. 35-42
Ter Maaten, J., De Boer, H., Kamp, O., Stuurman, L., Van Der Veen, E., Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency (1999) J Clin Endocrinol Metab, 84, pp. 2373-2380
Gibney, J., Wallace, J.D., Spinks, T., The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients (1999) J Clin Endocrinol Metab, 84, pp. 2596-2602
Cuneo, R.C., Salomon, F., Wiles, C.M., Hesp, R., Sonksen, P.H., Growth hormone treatment in growth hormone deficient adults. II Effects on exercise performance (1991) J Appl Physiol, 70, pp. 695-700
Fort, S., Weaver, J.U., Monson, J.P., Mills, P.G., The effect of low-dose recombinant human growth hormone on cardiovascular structure and function in growth hormone-deficient hypopituitary adults (1995) Endocrinol Metab, 2, pp. 119-126
Böger, R.H., Skamira, C., Bode-Böger, S.M., Brabant, C., Von Zur Muhlen, A., Frolich, J.C., Nitric oxide mediates the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency (1996) J Clin Invest, 98, pp. 2706-2713
Bates, A. S., Vant'Hoff, W., Jones, P. J., Clayton, R. N., The effect of hypopituitarism on life expectancy (1996) J Clin Endocrinol Metab, 81, pp. 1169-1172
Bul w, B., Hagmar, L., Mikoczy, Z., Nordstr m, C. H., Erfurth, E. M., Increased cerebrovascular mortality in patients with hypopituitarism (1997) Clin Endocrinol (Oxf), 46, pp. 75-81
Guse, A. H., Kiess, W., Funk, B., Kessler, U., Berg, I., Gercken, G., Identification and characterization of insulin-like growth factor receptors on adult rat myocytes: Linkage to inositol-1, 4, 5-trisphosphate formation (1992) Endocrinology, 130, pp. 145-151
L pez-Velasco, R., Escobar-Morreale, H. F., Vega, B., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Christiansen, J. S., Jorgensen, J. O. L., Thuesen, L., Cardiovascular aspects of growth hormone replacement therapy in adults (1996) Endocrinol Metab, 3, pp. 19-22
Sacc, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Carrol, P. V., Christ, E. R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-395
Beshyah, S. A., Johnston, D. G., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol (Oxf), 50, pp. 1-15
Vance, M. L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Harjai, K. J., Potential new cardiovascular risk factors: Left ventricular hypertrophy, homocysteine (a), triglycerides, oxidative stress and fibrinogen (1999) Ann Intern Med, 131, pp. 377-386
Castelli, W. P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
Miller, T. R., Grossman, S. G., Schechtman, K. B., Biello, D. R., Ludbrook, P. A., Ehansi, A. A., Left ventricular diastolic filling and its association with age (1986) Am J Cardiol, 58, pp. 531-535
Bonow, R. O., Vitale, D. F., Bacharach, S. L., Maron, B. J., Green, M. V., Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects (1988) J Am Coll Cardiol, 11, pp. 50-58
Beshyah, S. A., Shahi, M., Foale, R., Johnston, D. G., Cardiovascular effects of prolonged growth hormone replacement in adults (1995) J Intern Med, 237, pp. 35-42
Cuneo, R. C., Salomon, F., Wiles, C. M., Hesp, R., Sonksen, P. H., Growth hormone treatment in growth hormone deficient adults. II Effects on exercise performance (1991) J Appl Physiol, 70, pp. 695-700
B ger, R. H., Skamira, C., Bode-B ger, S. M., Brabant, C., Von Zur Muhlen, A., Frolich, J. C., Nitric oxide mediates the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency (1996) J Clin Invest, 98, pp. 2706-2713
Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency
Adult GH deficiency (GHD) is associated with increased cardiovascular morbidity and mortality due to unfavorable lipid profile, hyperfibrinogenemia, and impairment of cardiac performance. This prospective controlled cohort study evaluated the effects of 12-month GH replacement on lipid profile, fibrinogen levels, cardiac mass by echocardiography, and performance by equilibrium radionuclide angiography. To this end we studied 20 patients (11 men and 9 women, aged 19-40 yr), 10 with childhood-onset (co-) and 10 with adult-onset (ao-) disease, and 20 sex- and age-matched healthy subjects. At study entry, insulin-like growth factor I (IGF-I; P < 0.0001) and high density lipoprotein (HDL) cholesterol (P < 0.0001) levels, left ventricular mass index (LVMi; P < 0.0001), ejection fraction (LVEF) at rest (P = 0.001) and at peak exercise (P < 0.0001), peak ejection rate (P = 0.005), and exercise duration (P < 0.0001) and capacity (P = 0.002) were lower, whereas total cholesterol (P = 0.02), triglycerides (P = 0.003), and fibrinogen (P = 0.005) levels were higher in patients than in controls. After 12 months, increases in IGF-I (P < 0.0001) and HDL cholesterol levels (P = 0.04), LVMi (P < 0.0001), LVEF at peak exercise (P < 0.0001), and exercise duration (P = 0.009) and capacity (P = 0.003) and decreases in total cholesterol (P < 0.0001), low density lipoprotein cholesterol (P < 0.0001), triglycerides (P < 0.0001), and fibrinogen (P = 0.01) levels were found in all patients, without any difference between co- and ao-GHD. At the end of treatment, however, total cholesterol, triglycerides, and fibrinogen levels were still higher, and HDL cholesterol levels, IGF-I levels, and LVEF at rest and at peak exercise were lower in patients than in controls. In conclusion, GH replacement for 12 months significantly improved lipid profile, decreased fibrinogen levels, and increased LVMi and LVEF in young adults with co- or ao-GHD. However, lipid profile, fibrinogen levels, and systolic function remained abnormal compared with those in age- and sex-matched controls, suggesting that a longer period of GH replacement is necessary to normalize cardiovascular parameters and reverse the cardiovascular risk of these patients.
Adult GH deficiency (GHD) is associated with increased cardiovascular morbidity and mortality due to unfavorable lipid profile, hyperfibrinogenemia, and impairment of cardiac performance. This prospective controlled cohort study evaluated the effects of 12-month GH replacement on lipid profile, fibrinogen levels, cardiac mass by echocardiography, and performance by equilibrium radionuclide angiography. To this end we studied 20 patients (11 men and 9 women, aged 19-40 yr), 10 with childhood-onset (co-) and 10 with adult-onset (ao-) disease, and 20 sex- and age-matched healthy subjects. At study entry, insulin-like growth factor I (IGF-I; P < 0.0001) and high density lipoprotein (HDL) cholesterol (P < 0.0001) levels, left ventricular mass index (LVMi; P < 0.0001), ejection fraction (LVEF) at rest (P = 0.001) and at peak exercise (P < 0.0001), peak ejection rate (P = 0.005), and exercise duration (P < 0.0001) and capacity (P = 0.002) were lower, whereas total cholesterol (P = 0.02), triglycerides (P = 0.003), and fibrinogen (P = 0.005) levels were higher in patients than in controls. After 12 months, increases in IGF-I (P < 0.0001) and HDL cholesterol levels (P = 0.04), LVMi (P < 0.0001), LVEF at peak exercise (P < 0.0001), and exercise duration (P = 0.009) and capacity (P = 0.003) and decreases in total cholesterol (P < 0.0001), low density lipoprotein cholesterol (P < 0.0001), triglycerides (P < 0.0001), and fibrinogen (P = 0.01) levels were found in all patients, without any difference between co- and ao-GHD. At the end of treatment, however, total cholesterol, triglycerides, and fibrinogen levels were still higher, and HDL cholesterol levels, IGF-I levels, and LVEF at rest and at peak exercise were lower in patients than in controls. In conclusion, GH replacement for 12 months significantly improved lipid profile, decreased fibrinogen levels, and increased LVMi and LVEF in young adults with co- or ao-GHD. However, lipid profile, fibrinogen levels, and systolic function remained abnormal compared with those in age- and sex-matched controls, suggesting that a longer period of GH replacement is necessary to normalize cardiovascular parameters and reverse the cardiovascular risk of these patients.
Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency
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Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency
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Impact Factor: 4.609
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Vitale M, Luongo D, Naviglio D, Bozzetto L, Mirabella M, Rivieccio AM, Giacco A, Rivellese AA
* Trans fatty acids consumption in type 1 diabetic patients: evaluation by dietary records and measurement in serum phospholipids (388 views)
Acta Diabetol (ISSN: 0940-5429, 1432-5233electronic), 2013 Aug; 50(4): 651-654.
Impact Factor: 3.679
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1104 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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De Natale C, Minerva V, Patti L, Mazzarella R, Ciano O, Maione S, Luongo D, Naviglio D, Marotta G, Turco S, Ciati R, Melegari C, Rivellese AA, Riccardi G
* Effects Of Baked Products Enriched With N-3 Fatty Acids, Folates, β -Glucans, And Tocopherol In Patients With Mild Mixed Hyperlipidemia (452 views)
J Am Coll Nutr (ISSN: 1541-1087, 0731-5724), 2012 Oct; 31(5): 311-319.
Impact Factor: 1.738
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Berisio R, Ciccarelli L, Squeglia F, De Simone A, Vitagliano L
* Structural and Dynamic properties of incomplete immunoglobulin-like fold domains (477 views)
Protein Pept Lett (ISSN: 0929-8665, 1875-5305), 2012 Oct; 19(10): 1045-1053.
Impact Factor: 1.994
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Bucci M, Cigliano L, Vellecco V, D'Andrea LD, Ziaco B, Rossi A, Sautebin L, Carlucci A, Abrescia P, Pedone C, Ianaro A, Cirino G
* Apolipoprotein A-I (ApoA-I) mimetic peptide P2a by restoring cholesterol esterification unmasks ApoA-I anti-inflammatory endogenous activity in vivo (401 views)
J Pharmacol Exp Ther (ISSN: 1521-0103, 0022-3565), 2012 Mar; 340(3): 716-722.
Impact Factor: 3.891
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D.
Impact Factor: 2.882
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Acampa W, Di Taranto MD, Morgante A, Salvatore B, Evangelista L, Ricci F, Costanzo P, De Sisto E, Filardi PP, Petretta M, Fortunato G, Cuocolo A
* C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging (377 views)
Scand J Clin Lab Invest (ISSN: 0036-5513, 1502-7686), 2011 May; 71(3): 179-184.
Impact Factor: 1.156
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Bozzetto L, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA, Annuzzi G
* Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (418 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2011 Jan; 41(1): 39-44.
Impact Factor: 3.018
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (410 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (659 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (611 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (401 views)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
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Galloro G, Napolitano V, Magno L, Diamantis G, Nardone G, Bruno M, Mollica C, Persico G
* Diagnosis and therapeutic management of cystic dystrophy of the duodenal wall in heterotopic pancreas. A case report and revision of the literature (1189 views)
Jop (ISSN: 1590-8577, 1590-0857), 2008 Nov 03; 9(6): 725-732.
Impact Factor: 0
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Cigliano L, D'Andrea LD, Maresca B, Serino M, Carlucci A, Salvatore A, Spagnuolo MS, Scigliuolo G, Pedone C, Abrescia P
* Relevance of the amino acid conversions L144R (Zaragoza) and L159P (Zavalla) in the apolipoprotein A-I binding site for haptoglobin (393 views)
Biol Chem Biological Chemistry (ISSN: 1431-6730, 1437-4315), 2008 Nov; 389(11): 1421-1426.
Impact Factor: 3.035
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Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (367 views)
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.
Impact Factor: 0.481
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Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R
* The role of insulin receptors and IGF-I receptors in cancer and other diseases (1586 views)
Archives Of Physiology And Biochemistry (ISSN: 1381-3455), 2008 Feb; 114(1): 23-37.
Impact Factor: 2.028
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Palmieri V, Storto G, Arezzi E, Pellegrino T, Mancini M, Di Minno G, Ferrara AL, Cuocolo A, Celentano A
* Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects (311 views)
J Hum Hypertens (ISSN: 0950-9240), 2005 Dec; 19(12): 941-950.
Impact Factor: 2.405
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (422 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
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De Simone G, Menchise V, Alterio V, Mandrich L, Rossi M, Manco G, Pedone C
* The crystal structure of an EST2 mutant unveils structural insights on the H group of the carboxylesterase/lipase family (853 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2004 Oct 8; 343(1): 137-146.
Impact Factor: 5.542
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Giacco R, Clemente G, Luongo D, Lasorella G, Fiume I, Brouns F, Bornet F, Patti L, Cipriano P, Rivellese AA, Riccardi G
* Effects of short-chain fructo-oligosaccharides on glucose and lipid metabolism in mild hypercholesterolaemic individuals (486 views)
Clin Nutr (ISSN: 0261-5614, 0261-5614linking), 2004 Jun; 23(3): 331-340.
Impact Factor: 2.019
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Clemente G, Mancini M, Nazzaro F, Lasorella G, Rivieccio A, Palumbo AM, Rivellese AA, Ferrara L, Giacco R
* Effects of different dairy products on postprandial lipemia (933 views)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2003 Dec; 13(6): 377-383.
Impact Factor: 2.148
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Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (445 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (611 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
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Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (420 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (380 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
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De Simone G, Menchise V, Manco G, Mandrich L, Sorrentino N, Lang D, Rossi M, Pedone C
* The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus (425 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2001 Nov 30; 314(3): 507-518.
Impact Factor: 5.826
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (329 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
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De Simone G, Galdiero S, Manco G, Lang D, Rossi M, Pedone C
A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase (574 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2000 Nov 10; 303(5): 761-771.
Impact Factor: 5.388
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Colao A, Marzullo P, Ferone D, Spinelli L, Cuocolo A, Bonaduce D, Salvatore M, Boerlin V, Lancranjan I, Lombardi G
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (428 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Impact Factor: 5.447
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Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (479 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (303 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (344 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (287 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
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Lombardi A, De Simone G, Nastri F, Galdiero S, Della Morte R, Staiano N, Pedone C, Bolognesi M, Pavone V
The Crystal Structure Of Alpha-Thrombin-Hirunorm Iv Complex Reveals A Novel Specificity Site Recognition Mode (428 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic), 1999 Jan; 8(1): 91-95.
Impact Factor: 4.457
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Lombardi A, De Simone G, Galdiero S, Staiano N, Nastri F, Pavone V
From natural to synthetic multisite thrombin inhibitors (349 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1999; 51(1): 19-39.
Impact Factor: 2.331
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (318 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
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Giacco R, Mancini M, Clemente G, Coppola S, Lasorella G, D’Avanzo G, Rivieccio A M, Ruffa G, Brighenti F, Rivellese AA, Riccardi G
Metabolic effects of resistant starch in patients with Type 2 diabetes (521 views)
Diabetes Nutr Metab Clin Exp (ISSN: 0394-3402), 1998; 11(6): 330-335.
Impact Factor: 0.629
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (482 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
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Marotta T, Ferrara LA, Di Marino L, Mancini M, Annuzzi G, Russo O, D'Orta G, Lucarelli C, Rossi F
Factors affecting lipoprotein lipase in hypertensive patients (376 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 1995 Jun; 44(6): 712-718.
Impact Factor: 1.681
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Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (263 views)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
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Marchetti P, Benzi L, Trischitta V, Brunetti A, Cecchetti P, Ciccarone AM, Pezzino V, Vigneri R, Navalesi R
Complementary use of gel permeation and reversed-phase liquid chromatography for the analysis of A14-[125I]insulin and its degradation products in isolated human monocytes (1719 views)
J Chromatogr B Biomed Sci Appl (ISSN: 0378-4347), 1986 Apr 25; 377(C): 339-344.
Impact Factor: 1.588
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Greco AM, de Franciscis P, Bozza P, Salvatore M
Thyroid function and lipid metabolism in rats treated with lithium and cholesterol deficient Nath diet (685 views)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Dec 30; 55(24): 2589-2595.
Impact Factor: 0
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49 Records (47 excluding Abstracts).
Total impact factor: 188.016 (181.225 excluding Abstracts).
Total 5 year impact factor: 161.537 (161.537 excluding Abstracts).
Total impact factor: 188.016 (181.225 excluding Abstracts).
Total 5 year impact factor: 161.537 (161.537 excluding Abstracts).
445 views. Last view on Saturday 01 April 2023, 16:48:03
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