Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency
Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency(445 views) Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
Depts. Molec./Clinic. Endocrinol./O., Nuclear Med. Ctr. Natl. Cncl. Res., Federico II University of Naples, 80131 Naples, Italy
Dept. Biomorphological/Funct. Sci., Federico II University of Naples, 80131 Naples, Italy
Department of Internal Medicine I, Federico II University of Naples, 80131 Naples, Italy
Sci. Inst. for Res./Cure Neuromed, Pozzilli, Italy
Dept. Molec./Clinic. Endocrinol./O., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
Depts. Molec. /Clinic. Endocrinol. /O., Nuclear Med. Ctr. Natl. Cncl. Res., Federico II University of Naples, 80131 Naples, Italy
Dept. Molec. /Clinic. Endocrinol. /O., Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy
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L pez-Velasco, R., Escobar-Morreale, H. F., Vega, B., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Christiansen, J. S., Jorgensen, J. O. L., Thuesen, L., Cardiovascular aspects of growth hormone replacement therapy in adults (1996) Endocrinol Metab, 3, pp. 19-22
Sacc, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Carrol, P. V., Christ, E. R., Growth hormone deficiency in adulthood and the effects of growth hormone replacement: A review (1998) J Clin Endocrinol Metab, 83, pp. 382-395
Beshyah, S. A., Johnston, D. G., Cardiovascular disease and risk factors in adults with hypopituitarism (1999) Clin Endocrinol (Oxf), 50, pp. 1-15
Vance, M. L., Mauras, N., Growth hormone therapy in adults and children (1999) N Engl J Med, 341, pp. 1206-1216
Harjai, K. J., Potential new cardiovascular risk factors: Left ventricular hypertrophy, homocysteine (a), triglycerides, oxidative stress and fibrinogen (1999) Ann Intern Med, 131, pp. 377-386
Castelli, W. P., Lipid, risk factors and ischaemic heart disease (1996) Atherosclerosis, 124 (SUPPL.), pp. S1-S9
Miller, T. R., Grossman, S. G., Schechtman, K. B., Biello, D. R., Ludbrook, P. A., Ehansi, A. A., Left ventricular diastolic filling and its association with age (1986) Am J Cardiol, 58, pp. 531-535
Bonow, R. O., Vitale, D. F., Bacharach, S. L., Maron, B. J., Green, M. V., Effects of aging on asynchronous left ventricular regional function and global ventricular filling in normal human subjects (1988) J Am Coll Cardiol, 11, pp. 50-58
Beshyah, S. A., Shahi, M., Foale, R., Johnston, D. G., Cardiovascular effects of prolonged growth hormone replacement in adults (1995) J Intern Med, 237, pp. 35-42
Cuneo, R. C., Salomon, F., Wiles, C. M., Hesp, R., Sonksen, P. H., Growth hormone treatment in growth hormone deficient adults. II Effects on exercise performance (1991) J Appl Physiol, 70, pp. 695-700
B ger, R. H., Skamira, C., Bode-B ger, S. M., Brabant, C., Von Zur Muhlen, A., Frolich, J. C., Nitric oxide mediates the hemodynamic effects of recombinant growth hormone in patients with acquired growth hormone deficiency (1996) J Clin Invest, 98, pp. 2706-2713
Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency
Adult GH deficiency (GHD) is associated with increased cardiovascular morbidity and mortality due to unfavorable lipid profile, hyperfibrinogenemia, and impairment of cardiac performance. This prospective controlled cohort study evaluated the effects of 12-month GH replacement on lipid profile, fibrinogen levels, cardiac mass by echocardiography, and performance by equilibrium radionuclide angiography. To this end we studied 20 patients (11 men and 9 women, aged 19-40 yr), 10 with childhood-onset (co-) and 10 with adult-onset (ao-) disease, and 20 sex- and age-matched healthy subjects. At study entry, insulin-like growth factor I (IGF-I; P < 0.0001) and high density lipoprotein (HDL) cholesterol (P < 0.0001) levels, left ventricular mass index (LVMi; P < 0.0001), ejection fraction (LVEF) at rest (P = 0.001) and at peak exercise (P < 0.0001), peak ejection rate (P = 0.005), and exercise duration (P < 0.0001) and capacity (P = 0.002) were lower, whereas total cholesterol (P = 0.02), triglycerides (P = 0.003), and fibrinogen (P = 0.005) levels were higher in patients than in controls. After 12 months, increases in IGF-I (P < 0.0001) and HDL cholesterol levels (P = 0.04), LVMi (P < 0.0001), LVEF at peak exercise (P < 0.0001), and exercise duration (P = 0.009) and capacity (P = 0.003) and decreases in total cholesterol (P < 0.0001), low density lipoprotein cholesterol (P < 0.0001), triglycerides (P < 0.0001), and fibrinogen (P = 0.01) levels were found in all patients, without any difference between co- and ao-GHD. At the end of treatment, however, total cholesterol, triglycerides, and fibrinogen levels were still higher, and HDL cholesterol levels, IGF-I levels, and LVEF at rest and at peak exercise were lower in patients than in controls. In conclusion, GH replacement for 12 months significantly improved lipid profile, decreased fibrinogen levels, and increased LVMi and LVEF in young adults with co- or ao-GHD. However, lipid profile, fibrinogen levels, and systolic function remained abnormal compared with those in age- and sex-matched controls, suggesting that a longer period of GH replacement is necessary to normalize cardiovascular parameters and reverse the cardiovascular risk of these patients.
Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency
No results.
Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(349 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote