Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly (428 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
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Paper type: Journal Article,
Impact factor: 5.447, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0033710082&partnerID=40&md5=d604d16b1db1939fbdaf9ae8f03e9aef
Keywords: Growth Hormone, Octreotide, Somatomedin C, Acromegaly, Adult, Aged, Article, Cardiovascular Disease, Cardiovascular Effect, Clinical Article, Controlled Study, Echocardiography, Female, Heart Scintiscanning, Human, Immunoradiometric Assay, Priority Journal, Delayed-Action Preparations, Electrocardiography, Exercise, Gated Blood-Pool Imaging, Hemodynamic Processes, Human Growth Hormone, Insulin-Like Growth Factor I, Middle Aged, Ventricular Function,
Affiliations:
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
Department of Internal Medicine I, Federico II University of Naples, 80131 Naples, Italy
Department of Biomorphological and Functional Sciences, National Council for Research, Federico II University of Naples, 80131 Naples, Italy
Scientific Institute for Research and Care Neuromed, Pozzilli, Italy
Novartis Pharma A.G., 4002 Basel, Switzerland
Novartis Pharma A. G., 4002 Basel, Switzerland
References:
Nabarro, J.D.N., Acromegaly (1987) Clin Endocrinol (Oxf), 26, pp. 481-51
Wright, A.D., Hill, D.M., Lowy, C., Russell-Fraser, T., Mortality in acromegaly (1970) Q J Med, 153, pp. 1-16
Bengtsson, B., Eden, S., Ernest, I., Oden, A., Sjogren, B., Epidemiology and long-term survival in acromegaly (1988) Acta Med Scand, 223, pp. 327-335
Rajasoorya, C., Holdaway, I.M., Wrightson, P., Scott, D.J., Ibbertson, H.K., Determinants of clinical outcome and survival in acromegaly (1994) Clin Endocrinol (Oxf), 41, pp. 95-102
Orme, S.M., McNally, R.J.Q., Cartwright, R.A., Belchetz, P.E., Mortality and cancer incidence in acromegaly: A retrospective cohort study (1998) J Clin Endocrinol Metab, 83, pp. 2730-2734
Morvan, D., Komajda, M., Grimaldi, A., Turpin, G., Grosgogeat, Y., Cardiac hypertrophy and function in asymptomatic acromegaly (1991) Eur Heart J, 12, pp. 666-672
Fazio, S., Cittadini, A., Sabatini, D., Evidence for biventricular involvement in acromegaly: A Doppler echocardiographic study (1993) Eur Heart J, 14, pp. 26-33
Bertoni, P.D., Morandi, G., Impaired left ventricular diastolic function in acromegaly: An echocardiographic study (1987) Acta Cardiol, 42, pp. 1-10
Rodrigues, E.A., Caruana, M.P., Lahiri, A., Nabarro, J.D.N., Jacobs, H.S., Raftery, E.B., Subclinical cardiac dysfunction in acromegaly: Evidence for a specific disease of heart muscle (1989) Br Heart J, 62, pp. 185-194
Sicolo, N., Bui, F., Sicolo, M., Acromegalic cardiopathy: A left ventricular scintigraphic study (1993) J Endocrinol Invest, 16, pp. 123-127
Lopez-Velasco, R., Escobar-Morreale, H.F., Vega, B., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Colao, A., Cuocolo, A., Marzullo, P., Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (1999) J Clin Endocrinol Metab, 84, pp. 1518-1526
Colao, A., Merola, B., Ferone, D., Lombardi, G., Acromegaly (1997) J Clin Endocrinol Metab, 82, pp. 2777-2781
Minniti, G., Jaffrain-Rea, M.L., Moroni, C., Echocardiographic evidence for a direct effect of GH/IGF-I hypersecretion on cardiac mass and function in young acromegalics (1998) Clin Endocrinol (Oxf), 49, pp. 101-106
Colao, A., Baldelli, R., Marzullo, P., Systemic hypertension and impaired glucose tolerance are independently correlated to the severity of the acromegalic cardiomyopathy (2000) J Clin Endocrinol Metab, 85, pp. 193-199
Sacca, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Thuesen, L., Christensen, S.E., Weeke, J., Orskow, H., Henningsen, P., The cardiovascular effects of octreotide treatment in acromegaly: An echocardiographic study (1989) Clin Endocrinol (Oxf), 30, pp. 619-625
Pereira, J.L., Rodriguez-Puras, M.J., Leal-Cerro, A., Acromegalic cardiopathy improves after treatment with increasing doses of octreotide (1991) J Endocrinol Invest, 14, pp. 17-23
Merola, B., Cittadini, A., Colao, A., Chronic treatment with the somatostatin analog octreotide improves cardiac abnormalities in acromegaly (1993) J Clin Endocrinol Metab, 77, pp. 790-793
Tokgozoglu, S.L., Erbas, T., Aytemir, K., Effects of octreotide on left ventricular mass in acromegaly (1994) Am J Cardiol, 74, pp. 1072-1074
Baldelli, R., Ferretti, E., Jaffrain-Rea, M.L., Cardiac effects of lanreotide, a slow release somatostatin analog, in acromegalic patients (1999) J Clin Endocrinol Metab, 84, pp. 527-532
Hradec, J., Kral, J., Janota, T., Regression of acromegalic left ventricular hypertrophy after lanreotide (a slow release somatostatin analog) (1999) Am J Cardiol, 83, pp. 1506-1509
Chanson, P., Timsit, J., Masquet, C., Cardiovascular effects of the somatostatin analog octreotide in acromegaly (1990) Ann Intern Med, 113, pp. 921-925
Lombardi, G., Colao, A., Ferone, D., Cardiovascular aspects in acromegaly: Effects of treatment (1996) Metabolism, 45 (SUPPL. 1), pp. 57-60
Colao, A., Lombardi, G., Growth-hormone and prolactin excess (1998) Lancet, 352, pp. 1455-1461
Lancranjan, I., Bruns, C., Grass, P., Sandostatin-LAR: Pharmacokinetics, pharmacodynamics, efficacy and tolerability in acromegalic patients (1995) Metabolism, 44 (SUPPL. 1), pp. 18-26
Gillis, J.C., Noble, S., Goa, K.L., Octreotide long-acting release (LAR). A review of its pharmacological properties and therapeutic use in the management of acromegaly (1997) Drugs, 53, pp. 681-699
Stewart, P.M., Kane, K.F., Stewart, S.E., Lancranjan, I., Sheppard, M.C., Depot long-acting somatostatin analog (sandostatin-LAR) is an effective treatment for acromegaly (1995) J Clin Endocrinol Metab, 80, pp. 3267-3272
Flogstad, A., Halse, J., Bakke, S., Sandostatin LAR in acromegalic patients: Long-term treatment (1997) J Clin Endocrinol Metab, 82, pp. 23-28
Sahn, D.J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Lim, M.J., Barkan, A.L., Buda, A.J., Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion (1992) Ann Intern Med, 117, pp. 719-726
Feigenbaum, H., (1979) Echocardiography, 2nd ed., , Philadelphia: Lea and Febiger
Bonow, R.O., Bacharach, S.L., Green, M.V., Impaired left ventricular diastolic filling in patients with coronary artery disease: Assessment with radionuclide angiography (1981) Circulation, 64, pp. 315-323
Bates, A.S., Van't Hoff, W., Jones, J.M., Clayton, R.N., An audit of outcome of treatment in acromegaly (1993) Q J Med, 86, pp. 293-299
Giustina, A., Barkan, A., Casanueva, F.F., Criteria for cure of acromegaly: A consensus statement (2000) J Clin Endocrinol Metab, 85, pp. 526-529
Gunal, A.I., Isik, A., Celiker, H., Short term reduction of left ventricular mass in primary hypertrophic cardiomyopathy by octreotide injections (1996) Heart, 76, pp. 418-421
Demirtas, E., Sag, C., Kursaklioglu, H., Effects of octreotide in patients with hypertrophic obstructive cardiomyopathy (1998) Jpn Heart J, 39, pp. 173-181
Padayatty, S.J., Perrins, E.J., Belchetz, P.E., Octreotide treatment increases exercise capacity in patients with acromegaly (1996) Eur J Endocrinol, 134, pp. 554-559
Giustina, A., Boni, E., Romanelli, G., Cardiopulmonary performance during exercise in acromegaly and the effects of acute suppression of growth hormone hypersecretion with octreotide (1995) Am J Cardiol, 75, pp. 1042-1047
Crick, S.J., Sheppard, M.N., Ho, S.Y., Anderson, R.H., Localisation and quantitation of autonomic innervation in the porcine heart I: Conduction system (1999) J Anat, 195, pp. 341-357
Wasko, R., Ruchala, M., Sawicka, J., Kotwocka, M., Liebert, W., Sowinski, J., Short-term pre-surgical treatment with somatostatin analogues, octreotide and lanreotide, in acromegaly (2000) J Endocrinol Invest, 23, pp. 12-18
Nabarro, J. D. N., Acromegaly (1987) Clin Endocrinol (Oxf), 26, pp. 481-51
Wright, A. D., Hill, D. M., Lowy, C., Russell-Fraser, T., Mortality in acromegaly (1970) Q J Med, 153, pp. 1-16
Orme, S. M., McNally, R. J. Q., Cartwright, R. A., Belchetz, P. E., Mortality and cancer incidence in acromegaly: A retrospective cohort study (1998) J Clin Endocrinol Metab, 83, pp. 2730-2734
Bertoni, P. D., Morandi, G., Impaired left ventricular diastolic function in acromegaly: An echocardiographic study (1987) Acta Cardiol, 42, pp. 1-10
Rodrigues, E. A., Caruana, M. P., Lahiri, A., Nabarro, J. D. N., Jacobs, H. S., Raftery, E. B., Subclinical cardiac dysfunction in acromegaly: Evidence for a specific disease of heart muscle (1989) Br Heart J, 62, pp. 185-194
Pereira, J. L., Rodriguez-Puras, M. J., Leal-Cerro, A., Acromegalic cardiopathy improves after treatment with increasing doses of octreotide (1991) J Endocrinol Invest, 14, pp. 17-23
Tokgozoglu, S. L., Erbas, T., Aytemir, K., Effects of octreotide on left ventricular mass in acromegaly (1994) Am J Cardiol, 74, pp. 1072-1074
Gillis, J. C., Noble, S., Goa, K. L., Octreotide long-acting release (LAR). A review of its pharmacological properties and therapeutic use in the management of acromegaly (1997) Drugs, 53, pp. 681-699
Stewart, P. M., Kane, K. F., Stewart, S. E., Lancranjan, I., Sheppard, M. C., Depot long-acting somatostatin analog (sandostatin-LAR) is an effective treatment for acromegaly (1995) J Clin Endocrinol Metab, 80, pp. 3267-3272
Sahn, D. J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Lim, M. J., Barkan, A. L., Buda, A. J., Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion (1992) Ann Intern Med, 117, pp. 719-726
Bonow, R. O., Bacharach, S. L., Green, M. V., Impaired left ventricular diastolic filling in patients with coronary artery disease: Assessment with radionuclide angiography (1981) Circulation, 64, pp. 315-323
Bates, A. S., Van't Hoff, W., Jones, J. M., Clayton, R. N., An audit of outcome of treatment in acromegaly (1993) Q J Med, 86, pp. 293-299
Gunal, A. I., Isik, A., Celiker, H., Short term reduction of left ventricular mass in primary hypertrophic cardiomyopathy by octreotide injections (1996) Heart, 76, pp. 418-421
Padayatty, S. J., Perrins, E. J., Belchetz, P. E., Octreotide treatment increases exercise capacity in patients with acromegaly (1996) Eur J Endocrinol, 134, pp. 554-559
Crick, S. J., Sheppard, M. N., Ho, S. Y., Anderson, R. H., Localisation and quantitation of autonomic innervation in the porcine heart I: Conduction system (1999) J Anat, 195, pp. 341-357
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Sep; 85(9): 3132-3140.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.447, 5-year impact factor: 1.273
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-0033710082&partnerID=40&md5=d604d16b1db1939fbdaf9ae8f03e9aef
Keywords: Growth Hormone, Octreotide, Somatomedin C, Acromegaly, Adult, Aged, Article, Cardiovascular Disease, Cardiovascular Effect, Clinical Article, Controlled Study, Echocardiography, Female, Heart Scintiscanning, Human, Immunoradiometric Assay, Priority Journal, Delayed-Action Preparations, Electrocardiography, Exercise, Gated Blood-Pool Imaging, Hemodynamic Processes, Human Growth Hormone, Insulin-Like Growth Factor I, Middle Aged, Ventricular Function,
Affiliations:
Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, 80131 Naples, Italy
Department of Internal Medicine I, Federico II University of Naples, 80131 Naples, Italy
Department of Biomorphological and Functional Sciences, National Council for Research, Federico II University of Naples, 80131 Naples, Italy
Scientific Institute for Research and Care Neuromed, Pozzilli, Italy
Novartis Pharma A.G., 4002 Basel, Switzerland
Novartis Pharma A. G., 4002 Basel, Switzerland
References:
Nabarro, J.D.N., Acromegaly (1987) Clin Endocrinol (Oxf), 26, pp. 481-51
Wright, A.D., Hill, D.M., Lowy, C., Russell-Fraser, T., Mortality in acromegaly (1970) Q J Med, 153, pp. 1-16
Bengtsson, B., Eden, S., Ernest, I., Oden, A., Sjogren, B., Epidemiology and long-term survival in acromegaly (1988) Acta Med Scand, 223, pp. 327-335
Rajasoorya, C., Holdaway, I.M., Wrightson, P., Scott, D.J., Ibbertson, H.K., Determinants of clinical outcome and survival in acromegaly (1994) Clin Endocrinol (Oxf), 41, pp. 95-102
Orme, S.M., McNally, R.J.Q., Cartwright, R.A., Belchetz, P.E., Mortality and cancer incidence in acromegaly: A retrospective cohort study (1998) J Clin Endocrinol Metab, 83, pp. 2730-2734
Morvan, D., Komajda, M., Grimaldi, A., Turpin, G., Grosgogeat, Y., Cardiac hypertrophy and function in asymptomatic acromegaly (1991) Eur Heart J, 12, pp. 666-672
Fazio, S., Cittadini, A., Sabatini, D., Evidence for biventricular involvement in acromegaly: A Doppler echocardiographic study (1993) Eur Heart J, 14, pp. 26-33
Bertoni, P.D., Morandi, G., Impaired left ventricular diastolic function in acromegaly: An echocardiographic study (1987) Acta Cardiol, 42, pp. 1-10
Rodrigues, E.A., Caruana, M.P., Lahiri, A., Nabarro, J.D.N., Jacobs, H.S., Raftery, E.B., Subclinical cardiac dysfunction in acromegaly: Evidence for a specific disease of heart muscle (1989) Br Heart J, 62, pp. 185-194
Sicolo, N., Bui, F., Sicolo, M., Acromegalic cardiopathy: A left ventricular scintigraphic study (1993) J Endocrinol Invest, 16, pp. 123-127
Lopez-Velasco, R., Escobar-Morreale, H.F., Vega, B., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Colao, A., Cuocolo, A., Marzullo, P., Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (1999) J Clin Endocrinol Metab, 84, pp. 1518-1526
Colao, A., Merola, B., Ferone, D., Lombardi, G., Acromegaly (1997) J Clin Endocrinol Metab, 82, pp. 2777-2781
Minniti, G., Jaffrain-Rea, M.L., Moroni, C., Echocardiographic evidence for a direct effect of GH/IGF-I hypersecretion on cardiac mass and function in young acromegalics (1998) Clin Endocrinol (Oxf), 49, pp. 101-106
Colao, A., Baldelli, R., Marzullo, P., Systemic hypertension and impaired glucose tolerance are independently correlated to the severity of the acromegalic cardiomyopathy (2000) J Clin Endocrinol Metab, 85, pp. 193-199
Sacca, L., Cittadini, A., Fazio, S., Growth hormone and the heart (1994) Endocr Rev, 15, pp. 555-573
Thuesen, L., Christensen, S.E., Weeke, J., Orskow, H., Henningsen, P., The cardiovascular effects of octreotide treatment in acromegaly: An echocardiographic study (1989) Clin Endocrinol (Oxf), 30, pp. 619-625
Pereira, J.L., Rodriguez-Puras, M.J., Leal-Cerro, A., Acromegalic cardiopathy improves after treatment with increasing doses of octreotide (1991) J Endocrinol Invest, 14, pp. 17-23
Merola, B., Cittadini, A., Colao, A., Chronic treatment with the somatostatin analog octreotide improves cardiac abnormalities in acromegaly (1993) J Clin Endocrinol Metab, 77, pp. 790-793
Tokgozoglu, S.L., Erbas, T., Aytemir, K., Effects of octreotide on left ventricular mass in acromegaly (1994) Am J Cardiol, 74, pp. 1072-1074
Baldelli, R., Ferretti, E., Jaffrain-Rea, M.L., Cardiac effects of lanreotide, a slow release somatostatin analog, in acromegalic patients (1999) J Clin Endocrinol Metab, 84, pp. 527-532
Hradec, J., Kral, J., Janota, T., Regression of acromegalic left ventricular hypertrophy after lanreotide (a slow release somatostatin analog) (1999) Am J Cardiol, 83, pp. 1506-1509
Chanson, P., Timsit, J., Masquet, C., Cardiovascular effects of the somatostatin analog octreotide in acromegaly (1990) Ann Intern Med, 113, pp. 921-925
Lombardi, G., Colao, A., Ferone, D., Cardiovascular aspects in acromegaly: Effects of treatment (1996) Metabolism, 45 (SUPPL. 1), pp. 57-60
Colao, A., Lombardi, G., Growth-hormone and prolactin excess (1998) Lancet, 352, pp. 1455-1461
Lancranjan, I., Bruns, C., Grass, P., Sandostatin-LAR: Pharmacokinetics, pharmacodynamics, efficacy and tolerability in acromegalic patients (1995) Metabolism, 44 (SUPPL. 1), pp. 18-26
Gillis, J.C., Noble, S., Goa, K.L., Octreotide long-acting release (LAR). A review of its pharmacological properties and therapeutic use in the management of acromegaly (1997) Drugs, 53, pp. 681-699
Stewart, P.M., Kane, K.F., Stewart, S.E., Lancranjan, I., Sheppard, M.C., Depot long-acting somatostatin analog (sandostatin-LAR) is an effective treatment for acromegaly (1995) J Clin Endocrinol Metab, 80, pp. 3267-3272
Flogstad, A., Halse, J., Bakke, S., Sandostatin LAR in acromegalic patients: Long-term treatment (1997) J Clin Endocrinol Metab, 82, pp. 23-28
Sahn, D.J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Lim, M.J., Barkan, A.L., Buda, A.J., Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion (1992) Ann Intern Med, 117, pp. 719-726
Feigenbaum, H., (1979) Echocardiography, 2nd ed., , Philadelphia: Lea and Febiger
Bonow, R.O., Bacharach, S.L., Green, M.V., Impaired left ventricular diastolic filling in patients with coronary artery disease: Assessment with radionuclide angiography (1981) Circulation, 64, pp. 315-323
Bates, A.S., Van't Hoff, W., Jones, J.M., Clayton, R.N., An audit of outcome of treatment in acromegaly (1993) Q J Med, 86, pp. 293-299
Giustina, A., Barkan, A., Casanueva, F.F., Criteria for cure of acromegaly: A consensus statement (2000) J Clin Endocrinol Metab, 85, pp. 526-529
Gunal, A.I., Isik, A., Celiker, H., Short term reduction of left ventricular mass in primary hypertrophic cardiomyopathy by octreotide injections (1996) Heart, 76, pp. 418-421
Demirtas, E., Sag, C., Kursaklioglu, H., Effects of octreotide in patients with hypertrophic obstructive cardiomyopathy (1998) Jpn Heart J, 39, pp. 173-181
Padayatty, S.J., Perrins, E.J., Belchetz, P.E., Octreotide treatment increases exercise capacity in patients with acromegaly (1996) Eur J Endocrinol, 134, pp. 554-559
Giustina, A., Boni, E., Romanelli, G., Cardiopulmonary performance during exercise in acromegaly and the effects of acute suppression of growth hormone hypersecretion with octreotide (1995) Am J Cardiol, 75, pp. 1042-1047
Crick, S.J., Sheppard, M.N., Ho, S.Y., Anderson, R.H., Localisation and quantitation of autonomic innervation in the porcine heart I: Conduction system (1999) J Anat, 195, pp. 341-357
Wasko, R., Ruchala, M., Sawicka, J., Kotwocka, M., Liebert, W., Sowinski, J., Short-term pre-surgical treatment with somatostatin analogues, octreotide and lanreotide, in acromegaly (2000) J Endocrinol Invest, 23, pp. 12-18
Nabarro, J. D. N., Acromegaly (1987) Clin Endocrinol (Oxf), 26, pp. 481-51
Wright, A. D., Hill, D. M., Lowy, C., Russell-Fraser, T., Mortality in acromegaly (1970) Q J Med, 153, pp. 1-16
Orme, S. M., McNally, R. J. Q., Cartwright, R. A., Belchetz, P. E., Mortality and cancer incidence in acromegaly: A retrospective cohort study (1998) J Clin Endocrinol Metab, 83, pp. 2730-2734
Bertoni, P. D., Morandi, G., Impaired left ventricular diastolic function in acromegaly: An echocardiographic study (1987) Acta Cardiol, 42, pp. 1-10
Rodrigues, E. A., Caruana, M. P., Lahiri, A., Nabarro, J. D. N., Jacobs, H. S., Raftery, E. B., Subclinical cardiac dysfunction in acromegaly: Evidence for a specific disease of heart muscle (1989) Br Heart J, 62, pp. 185-194
Pereira, J. L., Rodriguez-Puras, M. J., Leal-Cerro, A., Acromegalic cardiopathy improves after treatment with increasing doses of octreotide (1991) J Endocrinol Invest, 14, pp. 17-23
Tokgozoglu, S. L., Erbas, T., Aytemir, K., Effects of octreotide on left ventricular mass in acromegaly (1994) Am J Cardiol, 74, pp. 1072-1074
Gillis, J. C., Noble, S., Goa, K. L., Octreotide long-acting release (LAR). A review of its pharmacological properties and therapeutic use in the management of acromegaly (1997) Drugs, 53, pp. 681-699
Stewart, P. M., Kane, K. F., Stewart, S. E., Lancranjan, I., Sheppard, M. C., Depot long-acting somatostatin analog (sandostatin-LAR) is an effective treatment for acromegaly (1995) J Clin Endocrinol Metab, 80, pp. 3267-3272
Sahn, D. J., De Maria, A., Kissio, J., Weyman, A., The committee on M-mode standardization of the American Society of Echocardiography. Recommendations regarding quantification in M-mode echocardiography: Results of a survey of echocardiography measurements (1978) Circulation, 58, pp. 1072-1083
Lim, M. J., Barkan, A. L., Buda, A. J., Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion (1992) Ann Intern Med, 117, pp. 719-726
Bonow, R. O., Bacharach, S. L., Green, M. V., Impaired left ventricular diastolic filling in patients with coronary artery disease: Assessment with radionuclide angiography (1981) Circulation, 64, pp. 315-323
Bates, A. S., Van't Hoff, W., Jones, J. M., Clayton, R. N., An audit of outcome of treatment in acromegaly (1993) Q J Med, 86, pp. 293-299
Gunal, A. I., Isik, A., Celiker, H., Short term reduction of left ventricular mass in primary hypertrophic cardiomyopathy by octreotide injections (1996) Heart, 76, pp. 418-421
Padayatty, S. J., Perrins, E. J., Belchetz, P. E., Octreotide treatment increases exercise capacity in patients with acromegaly (1996) Eur J Endocrinol, 134, pp. 554-559
Crick, S. J., Sheppard, M. N., Ho, S. Y., Anderson, R. H., Localisation and quantitation of autonomic innervation in the porcine heart I: Conduction system (1999) J Anat, 195, pp. 341-357
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly
Cardiovascular disease is the most severe complication of acromegaly accounting for the increased mortality of these patients. Recently, the slow-release form of octreotide (OCT; Sandostatin LAR, OCT-LAR), for im injection every 28 days, was reported to induce suppression of GH levels below 7.5 mU/L (2.5 μg/L) in 39-75% of patients, and normalization of insulin-like growth factor (IGF)-I levels for age in 64-88% of patients, with an excellent patients' compliance. The aim of the present study was to investigate the early effect of OCT-LAR treatment on the left ventricular (LV) structure and performance in 15 somatostatin analog-naive patients with acromegaly (GH, 94.8 ± 24.9 mU/L; IGF-I, 757.9 ± 66.6 μg/L), focusing on the early effect of GH and IGF-I suppression on the heart. Cardiac structure was investigated by echocardiography, whereas LV performance was investigated by gated-blood-pool scintigraphy, before and after 3 and 6 months of treatment with OCT-LAR. OCT-LAR was initially administered im, at a dose of 20 mg every 28 days, for 3 months. In six patients, the dose was then increased to 30 mg every 28 days to achieve disease control, which was considered when fasting and/or glucose-suppressed GH values were below 7.5 and 3.0 mU/L, respectively, together with IGF-I values within the normal range for age. The treatment with OCT-LAR for 6 months induced a significant decrease of GH (to 12.9 ± 3.0 mU/L) and IGF-I levels (to 340.3 ± 40.2 μg/L) in all 15 patients. After 6 months of treatment, the percent IGF-I suppression was 52.8 ± 4.4%, and serum GH/IGF-I levels were normalized in 9 patients. A significant decrease of LV mass index (LVMi), interventricular septum thickness, and LV posterior wall thickness was observed in all 15 patients after 3 and 6 months of OCT-LAR treatment: LVMi was decreased by 19.1 ± 2.0% without any difference in patients with (19.9 ± 2.7%) or without disease control (17.8 ± 3.3%). Among the 11 patients with LV hypertrophy, 6 normalized their LVMi after treatment. At study entry, an inadequate LV ejection fraction (LVEF) at rest (
Cardiovascular disease is the most severe complication of acromegaly accounting for the increased mortality of these patients. Recently, the slow-release form of octreotide (OCT; Sandostatin LAR, OCT-LAR), for im injection every 28 days, was reported to induce suppression of GH levels below 7.5 mU/L (2.5 μg/L) in 39-75% of patients, and normalization of insulin-like growth factor (IGF)-I levels for age in 64-88% of patients, with an excellent patients' compliance. The aim of the present study was to investigate the early effect of OCT-LAR treatment on the left ventricular (LV) structure and performance in 15 somatostatin analog-naive patients with acromegaly (GH, 94.8 ± 24.9 mU/L; IGF-I, 757.9 ± 66.6 μg/L), focusing on the early effect of GH and IGF-I suppression on the heart. Cardiac structure was investigated by echocardiography, whereas LV performance was investigated by gated-blood-pool scintigraphy, before and after 3 and 6 months of treatment with OCT-LAR. OCT-LAR was initially administered im, at a dose of 20 mg every 28 days, for 3 months. In six patients, the dose was then increased to 30 mg every 28 days to achieve disease control, which was considered when fasting and/or glucose-suppressed GH values were below 7.5 and 3.0 mU/L, respectively, together with IGF-I values within the normal range for age. The treatment with OCT-LAR for 6 months induced a significant decrease of GH (to 12.9 ± 3.0 mU/L) and IGF-I levels (to 340.3 ± 40.2 μg/L) in all 15 patients. After 6 months of treatment, the percent IGF-I suppression was 52.8 ± 4.4%, and serum GH/IGF-I levels were normalized in 9 patients. A significant decrease of LV mass index (LVMi), interventricular septum thickness, and LV posterior wall thickness was observed in all 15 patients after 3 and 6 months of OCT-LAR treatment: LVMi was decreased by 19.1 ± 2.0% without any difference in patients with (19.9 ± 2.7%) or without disease control (17.8 ± 3.3%). Among the 11 patients with LV hypertrophy, 6 normalized their LVMi after treatment. At study entry, an inadequate LV ejection fraction (LVEF) at rest (
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly
| ▼ High-resolution positron emission tomography of the ischaemic mouse heart |
| ▼ Biomolecules able to modulate the VEGF-dependent angiogenesis |
| ▼ Clinical Oncology |
Cardiovascular effects of depot long-acting somatostatin analog sandostatin LAR in acromegaly
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* Recombinant thyrotropin-induced orbital uptake of [In-111-diethylenetriamine-pentacetic acid-D-phe(1)]octreotide in a patient with inactive Graves' ophthalmopathy (308 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2005 Apr; 90(4): 2440-2444.
Impact Factor: 6.02
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (348 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (284 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
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Spinelli L, Petretta M, Verderame G, Carbone G, Venetucci AA, Petretta A, Acampa W, Bonaduce D, Colao A, Cuocolo A
* Left ventricular diastolic function and cardiac performance during exercise in patients with acromegaly (433 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Sep; 88(9): 4105-4109.
Impact Factor: 5.873
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Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (430 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (611 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
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Camera L, Del Vecchio S, Quarantelli M, Ibello F, Pellegrino T, Salvatore M
* Radiolabeled somatostatin analogs in the diagnosis and staging of neuroendocrine tumors (329 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2003; 26(8Suppl): 60-62.
Impact Factor: 1.621
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (467 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (420 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (380 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (444 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (329 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
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Petretta M, Storto G, Ferro A, Cuocolo A
* Radionuclide monitoring of left ventricular function (281 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2001; 8(5): 606-615.
Impact Factor: 1.868
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Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (479 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (303 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (344 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (287 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
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Lastoria S, Vergara E, Palmieri G, Acampa W, Varrella P, Caracò C, Bianco RA, Muto P, Salvatore M
In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy (428 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Apr; 39(4): 634-639.
Impact Factor: 3.064
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Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (434 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 1998 Feb; 48(2): 137-143.
Impact Factor: 3.101
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (318 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (482 views)
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Impact Factor: 0.481
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Maurea S, Lastoria S, Caracò C, Klain M, Varrella P, Acampa W, Muto P, Salvatore M
The role of radiolabeled somatostatin analogs in adrenal imaging (358 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 677-680.
Impact Factor: 1.042
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Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors (336 views)
Q J Nucl Med (ISSN: 1125-0135, 1124-3937), 1995 Dec; 39(4Suppl1): 145-149.
Impact Factor: 2.125
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Cuocolo A, Nicolai E, Fazio S, Pace L, Maurea S, Cittadini A, Sacca L, Salvatore M
Impaired left ventricular diastolic filling in patients with acromegaly: Assessment with radionuclide angiography (261 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Feb; 36(2): 196-201.
Impact Factor: 3.491
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Palmeieri G, Lastoria S, Vergara E, Varrella P, Acampa W, Salvatore M, Bianco AR
Diagnosis and treatment of thymoma by octreotide (234 views)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 1995; 36(0): N/D-N/D.
Impact Factor: 0
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LASTORIA S, COLAO A, VERGARA E, FERONE D, VARRELLA P, MEROLA B, ACAMPA W, LOMBARDI G, SALVATORE M
IN-111 OCTREOTIDE UPTAKE LEVELS IN PITUITARY-ADENOMAS TO PREDICT THE RESPONSIVENESS TO CHRONIC OCTREOTIDE TREATMENT (240 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW DISEASES EXPRESSING SOMATOSTATIN RECEPTORS BY IN-111 OCTREOTIDE (267 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW NEOPLASTIC LESIONS EXPRESSING SOMATOSTATIN RECEPTORS USING IN-111 OCTREOTIDE (293 views)
Posters Tomes 1 4proceedings Of The Xvi International Cancer Congress Free Papers And, 1994; N/D: N/D-N/D.
Impact Factor: 0
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Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (263 views)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
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* Gut microbiota and cardiovascular diseases axis: a review (13 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2021 May 10; N/D: N/D-N/D.
Impact Factor: 1.202
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Pellicano R, Ianiro G, Fagoonee S, Settanni CR, Gasbarrini A
* Review: Extragastric diseases and Helicobacter pylori (59 views)
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De Rosa L, Di Stasi R, D'Andrea LD
* Pro-angiogenic peptides in biomedicine (476 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
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Lanzillo R, Di Somma C, Quarantelli M, Carotenuto A, Pivonello C, Moccia M, Cianflone A, Marsili A, Puorro G, Sacca F, Russo CV, De Luca Picione C, Ausiello F, Colao A, Brescia Morra V
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Impact Factor: 4.621
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Martinelli V, Cella L, Pugliese N, Cappuccio I, Scognamiglio IR, Marano L, Simeone L, Campagna G, Picardi M, Pane F
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Pisani A, Sabbatini M, Imbriaco M, Riccio E, Rubis N, Prinster A, Perna A, Liuzzi R, Spinelli L, Santangelo M, Remuzzi G, Ruggenenti P
* Long-term Effects of Octreotide on Liver Volume in Patients With Polycystic Kidney and Liver Disease (280 views)
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Impact Factor: 7.398
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De Luca S, Fonti R, Camera L, Salvatore B, Faggiano A, Ciarmiello A, Segreto S, Colao A, Salvatore M, Del Vecchio S
* Multimodal imaging with (18)F-FDG-PET/CT and (111)In-Octreotide SPECT in patients with metastatic medullary thyroid carcinoma (332 views)
Ann Nucl Med (ISSN: 0914-7187, 1864-6433, 0914-7187linking), 2016 Jan 11; 30(3): 1-8.
Impact Factor: 1.396
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
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Coppo C, Bonfanti D, Bo S, Giordanino C, Gallo M, Cococcia S, Ciccone G, Smedile A, Ciancio A, Bugianesi E, Fagoonee S, Pellicano R, Rizzetto M, Saracco GM
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Impact Factor: 2.719
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Ramundo V, Del Prete M, Marotta V, Marciello F, Camera L, Napolitano V, de LucaL, Circelli L, Colantuoni V, Di Sarno A, Carratu AC, Di Roseto CDL, Colao A, Faggiano A
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Picano E, Vañó E, Rehani MM, Cuocolo A, Mont L, Bodi V, Bar O, Maccia C, Pierard L, Sicari R, Plein S, Mahrholdt H, Lancellotti P, Knuuti J, Heidbuchel H, Di Mario C, Badano LP
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Impact Factor: 15.203
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Petretta M, Acampa W, Evangelista L, Daniele S, Zampella E, Assante R, Nappi C, Cantoni V, Fiumara G, Cuocolo A
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Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2014; 24(6): 588-593.
Impact Factor: 3.323
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
* The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime? (556 views)
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Impact Factor: 3.675
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
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Impact Factor: 19.358
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Fonti R, Mainolfi C, Anzivino A, Camera L, Faggiano A, Colao A, Salvatore M, Del Vecchio S
* 18F-FDG-PET/CT and 111In-Octreotide SPECT in Patients with Metastatic Medullary Thyroid Carcinoma (270 views)
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Impact Factor: 5.217
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Acampa W, Petretta MP, Daniele S, Perrone-Filardi P, Petretta M, Cuocolo A
* Myocardial perfusion imaging after coronary revascularization: A clinical appraisal (355 views)
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Impact Factor: 5.217
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Accardo A, Mangiapia G, Paduano L, Morelli G, Tesauro D
* Octreotide labeled aggregates containing platinum complexes as nanovectors for drug delivery (408 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2013 Apr; 19(4): 190-197.
Impact Factor: 1.862
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De Luca S, Fonti R, Palmieri G, Federico P, Del Prete G, Pacelli R, Pace L, De Placido S, Salvatore M, Del Vecchio S
* Combined Imaging With 18f-Fdg-Pet/Ct And 111in-Labeled Octreotide Spect For Evaluation Of Thymic Epithelial Tumors (350 views)
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Impact Factor: 2.857
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (1104 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Petretta M, Cuocolo A
Prediction models for risk classification in cardiovascular disease (589 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2012 Dec; 39(12): 1959-1969.
Impact Factor: 5.114
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Palmieri G, Fonti R, Federico P, Del Prete G, Pacelli R, Pace L, Salvatore M, Del Vecchio S
* Combined 18F-FDG-PET/CT and 111In-Octreotide SPECT for Evaluation of Thymic Epithelial Tumors (271 views)
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Impact Factor: 5.114
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De Natale C, Minerva V, Patti L, Mazzarella R, Ciano O, Maione S, Luongo D, Naviglio D, Marotta G, Turco S, Ciati R, Melegari C, Rivellese AA, Riccardi G
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Impact Factor: 1.738
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Petretta M, Cuocolo A
In search of a marker of vulnerable carotid plaque: is the key in the heart? (307 views)
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Impact Factor: 3.706
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Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
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Impact Factor: 3.578
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Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G
* CaMK4 gene deletion induces hypertension (349 views)
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Impact Factor: 2.882
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Malgieri G, Zaccaro L, Leone M, Bucci E, Esposito S, Baglivo I, Del Gatto A, Russo L, Scandurra R, Pedone PV, Fattorusso R, Isernia C
* Zinc to Cadmium Replacement in the A. thaliana SUPERMAN Cys(2)His(2) Zinc Finger Induces Structural Rearrangements of Typical DNA Base Determinant Positions (445 views)
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Impact Factor: 2.87
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Cuocolo A
Current research in nuclear medicine and molecular imaging in Italy: Highlights of the 10th National Congress of the Italian Association of Nuclear Medicine and Molecular Imaging (463 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2011 Jun; 55(3): 280-300.
Impact Factor: 1.724
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Rossi FF, Pedone C, Antonelli Incalzi R
Chronic obstructive pulmonary disease and cardiovascular disease: role of the systemic inflammation (445 views)
Recenti Prog Med (ISSN: 0034-1193, 0034-1193print), 2011 Mar; 102(3): 109-113.
Impact Factor: 0.318
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Accardo A, Morisco A, Gianolio E, Tesauro D, Mangiapia G, Radulescu A, Brandt A, Morelli G
* Nanoparticles containing octreotide peptides and gadolinium complexes for MRI applications (504 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2011 Feb; 17(2): 154-162.
Impact Factor: 1.799
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Nardelli A, Castaldi E, Ortosecco G, Speranza A, Storto G, Pace L, Salvatore M
* Enhancement of reaction conditions for the radiolabelling of DOTA-peptides with high activities of yttrium-90 (468 views)
Applied Radiation And Isotopes (ISSN: 1872-9800, 0969-8043, 0969-8043linking), 2011 Jan; 69(1): 52-55.
Impact Factor: 1.172
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Lanzillo R, Di Somma C, Quarantelli M, Ventrella G, Vacca G, Liuzzi R, Amato L, Orefice G, Colao A, Brescia Morra V
* Growth Hormone Axis In Early Multiple Sclerosis Patients Before And After 2 Years Treatment With Interferon Beta-1b - An Interim Analysis (275 views)
Proceedings Of The Xlii Meeting Of The Italian Society Of Neurology, 2011; nd: 360-360.
Impact Factor: 0
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Giacco R, Clemente G, Cipriano D, Luongo D, Viscovo D, Patti L, Di Marino L, Giacco A, Naviglio D, Bianchi MA, Ciati R, Brighenti F, Rivellese AA, Riccardi G
* Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people (665 views)
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Impact Factor: 3.438
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
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Impact Factor: 5.328
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (659 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Cuocolo A, Concilio C, Acampa W, Ferro A, Evangelista L, Daniele S, Petretta M
* Cardiovascular risk stratification of diabetic patients (580 views)
Minerva Endocrinol (ISSN: 0391-1977, 1827-1634electronic, 0391-1977linking), 2009 Sep; 34(3): 205-221.
Impact Factor: 1.464
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Cittadini A, Saldamarco L, Marra AM, Arcopinto M, Carlomagno G, Imbriaco M, Del Forno D, Vigorito C, Merola B, Oliviero U, Fazio S, Sacca L
* Growth Hormone Deficiency in Patients with Chronic Heart Failure and Beneficial Effects of Its Correction (610 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2009 Sep; 94(9): 3329-3336.
Impact Factor: 6.202
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Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Double-Blind, Placebo-Controlled, Randomized Trial of Growth Hormone as Add-On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis: Preliminary MRS, Hormonal, and Population Analysis (395 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 72(11): N/D-N/D.
Impact Factor: 8.172
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Sacca F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Carotenuto B, Marsili A, Palma V, Bresciamorra V, Brunetti A, De Michele G, Filla A, Salvatore M
* A Randomized Trial of Growth Hormone as Add. On Therapy to Riluzole in Patients with Amyotrophic Lateral Sclerosis (320 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2009 Mar 17; 76(9): N/D-N/D.
Impact Factor: 8.172
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Morisco A, Accardo A, Gianolio E, Tesauro D, Benedetti E, Morelli G
* Micelles derivatized with octreotide as potential target-selective contrast agents in MRI (417 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 242-250.
Impact Factor: 1.807
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1011 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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Cittadini A, Monti MG, Castiello MC, D'Arco E, Galasso G, Sorriento D, Saldamarco L, De Paulis A, Napoli R, Iaccarino G, Saccà L
* Insulin-like growth factor-1 protects from vascular stenosis and accelerates re-endothelialization in a rat model of carotid artery injury (401 views)
J Thromb Haemost Journal Of Thrombosis And Haemostasis (ISSN: 1538-7933), 2009; 7(11): 1920-1928.
Impact Factor: 6.069
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De Simone A, Esposito L, Pedone C, Vitagliano L
* Insights into stability and toxicity of amyloid-like oligomers by replica exchange molecular dynamics analyses (488 views)
Biophysical Journal (ISSN: 1542-0086, 0006-3495), 2008 Sep 15; 95(4): 1965-1973.
Impact Factor: 4.683
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (562 views)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Pulcrano M, Camera L, Pagano L, Del Vecchio S, Ferone D, Bodei L, Murgia A, Pace L, Storto G, Paganelli G, Colao A, Salvatore M, Lombardi G, Biondi B
* Usefulness of [(111)In-DTPA(0)] octreotide scintigraphy in a family with von Hippel-Lindau disease (359 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2008 Apr; 31(4): 352-359.
Impact Factor: 1.888
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De Simone G, Di Fiore A, Supuran CT
* Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs? (472 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008 Mar; 14(7): 655-660.
Impact Factor: 4.399
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Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (367 views)
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.
Impact Factor: 0.481
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Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R
* The role of insulin receptors and IGF-I receptors in cancer and other diseases (1586 views)
Archives Of Physiology And Biochemistry (ISSN: 1381-3455), 2008 Feb; 114(1): 23-37.
Impact Factor: 2.028
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Picardi M, De Renzo A, Pane F, Nicolai E, Pacelli R, Salvatore M, Rotoli B
* Randomized comparison of consolidation radiation versus observation in bulky Hodgkin's lymphoma with post-chemotherapy negative positron emission tomography scans (395 views)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2007 Sep; 48(9): 1721-1727.
Impact Factor: 1.512
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Bischof Delaloye A, Carrio I, Cuocolo A, Knapp W, Gourtsoyiannis N, Mccall I, Reiser M, Silberman B
* White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (318 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Sep; 34(8): 1147-1151.
Impact Factor: 4.101
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Imbriaco M, Spinelli L, Cuocolo A, Maurea S, Sica G, Quarantelli M, Pisani A, Liuzzi R, Cianciaruso B, Sabbatini M, Salvatore M
* MRI characterization of myocardial tissue in patients with Fabry's disease (591 views)
Ajr Am J Roentgenol (ISSN: 1546-3141, 0361-803x, 1546-3141electronic), 2007 Mar; 188(3): 850-853.
Impact Factor: 2.47
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (830 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Acampa W, Spiezia S, Rota F, Savanelli MC, Lombardi G
* Does a gender-related effect of growth hormone (GH) replacement exist on cardiovascular risk factors, cardiac morphology, and performance and atherosclerosis? Results of a two-year open, prospective study in young adult men and women with severe GH deficiency (422 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2005 Sep; 90(9): 5146-5155.
Impact Factor: 6.02
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Tauchmanovà L, Pensabene M, Capuano I, Spagnoletti I, Zeppa P, Del Vecchio S, Mainenti PP, De Rosa G, Colao A, Contegiacomo A
* Poorly differentiated small cell neuroendocrine carcinoma localized in three different endocrine glands: Response to chemotherapy and octreotide LAR (329 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2005 Apr; 28(4): 371-378.
Impact Factor: 1.496
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Savastano S, Pivonello R, Acampa W, Salvatore M, Lombardi G, Colao A, Fenzi G
* Recombinant thyrotropin-induced orbital uptake of [In-111-diethylenetriamine-pentacetic acid-D-phe(1)]octreotide in a patient with inactive Graves' ophthalmopathy (308 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2005 Apr; 90(4): 2440-2444.
Impact Factor: 6.02
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Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (348 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
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Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (284 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
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Spinelli L, Petretta M, Verderame G, Carbone G, Venetucci AA, Petretta A, Acampa W, Bonaduce D, Colao A, Cuocolo A
* Left ventricular diastolic function and cardiac performance during exercise in patients with acromegaly (433 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2003 Sep; 88(9): 4105-4109.
Impact Factor: 5.873
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Colao A, Marzullo P, Cuocolo A, Spinelli L, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Reversal of acromegalic cardiomyopathy in young but not in middle-aged patients after 12 months of treatment with the depot long-acting somatostatin analogue octreotide (430 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2003 Feb; 58(2): 169-176.
Impact Factor: 2.767
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Pauciullo P, Giannino A, De Michele M, Gentile M, Liguori R, Argiriou A, Carlotto A, Faccenda F, Mancini M, Bond MG, De Simone V, Rubba P
* Increased carotid artery intima-media thickness is associated with a novel mutation of low-density lipoprotein receptor independently of major cardiovascular risk factors (611 views)
Metab Clin Exp (ISSN: 0026-0495, 1532-8600), 2003; 52(11): 1433-1438.
Impact Factor: 2.013
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Camera L, Del Vecchio S, Quarantelli M, Ibello F, Pellegrino T, Salvatore M
* Radiolabeled somatostatin analogs in the diagnosis and staging of neuroendocrine tumors (329 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 2003; 26(8Suppl): 60-62.
Impact Factor: 1.621
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Acampa W, Petretta M, Cuocolo A
* Nuclear medicine procedures in cardiovascular diseases: An evidence based approach (467 views)
Q J Nucl Med (ISSN: 1124-3937, 1125-0135), 2002 Dec; 46(4): 323-330.
Impact Factor: 1.903
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Colao A, Spinelli L, Cuocolo A, Spiezia S, Pivonello R, Di Somma C, Bonaduce D, Salvatore M, Lombardi G
* Cardiovascular consequences of early-onset growth hormone excess (420 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Jul; 87(7): 3097-3104.
Impact Factor: 5.199
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Colao A, Di Somma C, Pivonello R, Cuocolo A, Spinelli L, Bonaduce D, Salvatore M, Lombardi G
* The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: A 12-month prospective study (380 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2002 Mar; 87(3): 1088-1093.
Impact Factor: 5.199
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Colao A, Di Somma C, Cuocolo A, Spinelli L, Tedesco N, Pivonello R, Bonaduce D, Salvatore M, Lombardi G
* Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients, with GH deficiency (444 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 May; 86(5): 1874-1881.
Impact Factor: 5.16
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Morte A, Pivonello R, Salvatore M, Lombardi G
* Is the acromegalic cardiomyopathy reversible? Effect of 5-year normalization of growth hormone and insulin-like growth factor I levels on cardiac performance (329 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2001 Apr; 86(4): 1551-1557.
Impact Factor: 5.16
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Petretta M, Storto G, Ferro A, Cuocolo A
* Radionuclide monitoring of left ventricular function (281 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2001; 8(5): 606-615.
Impact Factor: 1.868
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Marzullo P, Cuocolo A, Ferone D, Pivonello R, Salvatore M, Lombardi G, Colao A
Cardiac effect of thyrotoxicosis in acromegaly (479 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2000 Apr; 85(4): 1426-1432.
Impact Factor: 5.447
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Pivonello R, Nicolai E, Salvatore M, Lombardi G
Does the age of onset of growth hormone deficiency affect cardiac performance? A radionuclide angiography study (303 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 2000 Apr; 52(4): 447-455.
Impact Factor: 2.922
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Colao A, Cuocolo A, Di Somma C, Cerbone G, Della Morte A, Nicolai E, Lucci R, Salvatore M, Lombardi G
Impaired cardiac performance in elderly patients with growth hormone deficiency (344 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Nov; 84(11): 3950-3955.
Impact Factor: 5.805
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Della Morte A, Petretta M, Salvatore M, Lombardi G
Impact of patient's age and disease duration on cardiac performance in acromegaly: A radionuclide angiography study (287 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 May; 84(5): 1518-1523.
Impact Factor: 5.805
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Colao A, Lastoria S, Ferone D, Varrella P, Marzullo P, Pivonello R, Cerbone G, Acampa W, Salvatore M, Lombardi G
The pituitary uptake of In-111-DTPA-D-Phe(1)-octreotide in the normal pituitary and in pituitary adenomas (387 views)
J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic), 1999 Mar; 22(3): 176-183.
Impact Factor: 0.957
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Colao A, Cuocolo A, Marzullo P, Nicolai E, Ferone D, Florimonte L, Salvatore M, Lombardi G
Effects of 1-year treatment with octreotide on cardiac performance in patients with acromegaly (365 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1999 Jan; 84(1): 17-23.
Impact Factor: 5.805
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Lastoria S, Vergara E, Palmieri G, Acampa W, Varrella P, Caracò C, Bianco RA, Muto P, Salvatore M
In vivo detection of malignant thymic masses by indium-111-DTPA-D- Phe1-octreotide scintigraphy (428 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1998 Apr; 39(4): 634-639.
Impact Factor: 3.064
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Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency (434 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 1365-2265electronic), 1998 Feb; 48(2): 137-143.
Impact Factor: 3.101
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Ferone D, Lastoria S, Colao A, Varrella P, Cerbone G, Acampa W, Merola B, Salvatore M, Lombardi G
Correlation of scintigraphic results using 123I-methoxybenzamide with hormone levels and tumor size response to quinagolide in patients with pituitary adenomas (318 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 1998 Jan; 83(1): 248-252.
Impact Factor: 5.641
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Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
Cardiological aspects of growth hormone and insulin-like growth factor- (482 views)
J Pediatr Endocrinol Metab (ISSN: 0334-018x), 1997 Nov; 10(6): 553-560.
Impact Factor: 0.481
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Maurea S, Lastoria S, Caracò C, Klain M, Varrella P, Acampa W, Muto P, Salvatore M
The role of radiolabeled somatostatin analogs in adrenal imaging (358 views)
Nucl Med Biol (ISSN: 0969-8051, 0883-2897), 1996 Sep; 23(6): 677-680.
Impact Factor: 1.042
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Lastoria S, Maurea S, Vergara E, Acampa W, Varrella P, Klain M, Muto P, Bernardy JD, Salvatore M
Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors (336 views)
Q J Nucl Med (ISSN: 1125-0135, 1124-3937), 1995 Dec; 39(4Suppl1): 145-149.
Impact Factor: 2.125
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Cuocolo A, Nicolai E, Fazio S, Pace L, Maurea S, Cittadini A, Sacca L, Salvatore M
Impaired left ventricular diastolic filling in patients with acromegaly: Assessment with radionuclide angiography (261 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Feb; 36(2): 196-201.
Impact Factor: 3.491
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Palmeieri G, Lastoria S, Vergara E, Varrella P, Acampa W, Salvatore M, Bianco AR
Diagnosis and treatment of thymoma by octreotide (234 views)
Meetingproceedings Of The American Association For Cancer Research Annual (ISSN: 0197-016x), 1995; 36(0): N/D-N/D.
Impact Factor: 0
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LASTORIA S, COLAO A, VERGARA E, FERONE D, VARRELLA P, MEROLA B, ACAMPA W, LOMBARDI G, SALVATORE M
IN-111 OCTREOTIDE UPTAKE LEVELS IN PITUITARY-ADENOMAS TO PREDICT THE RESPONSIVENESS TO CHRONIC OCTREOTIDE TREATMENT (240 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW DISEASES EXPRESSING SOMATOSTATIN RECEPTORS BY IN-111 OCTREOTIDE (267 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1994 May; 35(5): N/D-N/D.
Impact Factor: 3.491
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LASTORIA S, VERGARA E, VARRELLA P, ACAMPA W, PALMIERI G, SALVATORE M
IN-VIVO DETECTION OF NEW NEOPLASTIC LESIONS EXPRESSING SOMATOSTATIN RECEPTORS USING IN-111 OCTREOTIDE (293 views)
Posters Tomes 1 4proceedings Of The Xvi International Cancer Congress Free Papers And, 1994; N/D: N/D-N/D.
Impact Factor: 0
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Pezzino V, Papa V, Trischitta V, Brunetti A, Goodman PA, Treutelaar MK, Williams JA, Maddux BA, Vigneri R, Goldfine ID
Human insulin receptor radioimmunoassay: Applicability to insulin-resistant states (263 views)
Am J Physiol Endocrinol Metab (ISSN: 0002-9513), 1989 Sep; 257(3): N/D-N/D.
Impact Factor: 3.116
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84 Records (72 excluding Abstracts).
Total impact factor: 318.872 (275.705 excluding Abstracts).
Total 5 year impact factor: 283.873 (246.393 excluding Abstracts).
Total impact factor: 318.872 (275.705 excluding Abstracts).
Total 5 year impact factor: 283.873 (246.393 excluding Abstracts).
428 views. Last view on Friday 24 March 2023, 10:13:24
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