Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency(434 views) Longobardi S, Cuocolo A, Merola B, Di Rella F, Colao A, Nicolai E, Cardei S, Salvatore M, Lombardi G
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Bonow, R. O., Bacharach, S. L., Green, M. V., Kent, K. M., Rosing, D. R., Lipson, L. C., Leon, M. B., Epstein, S. E., Impaired left ventricular diastolic filling in patients with coronary artery disease: Assessment with radionuclide angiography (1981) Circulation, 64, pp. 315-323
Bonow, R. O., Non invasive evaluation of left ventricular diastolic function by radionuclide angiography: Limitations and applications (1984) International Journal of Cadiology, 5, pp. 659-663
Cuneo, R. C., Salomon, F., Wilmshurst, P., Burne, C., Wiles, C. M., Hesp, R., Sonksen, P. H., Cardiovascular effects of growth hormone treatment in growth-hormone-deficient adults: Stimulation of renin-aldosteron system (1991) Clinical Science, 81, pp. 587-592
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Hanson, M. C., Kenneth, A. F., Alexander, R. W., DeLafontaine, P., Induction of cardiac insulin-like growth factor I gene expression in pressure overload hypertrophy (1993) American Journal of the Medical Sciences, 306, pp. 69-74
Jorgensen, J. O. L., Pedersen, S. A., Thuesen, L., Jorgensen, J., Ingemann-Hansen, T., Skakkehaek, N. E., Christiansen, J. S., Beneficial effects of growth hormone treatment in GH-deficient adults (1989) Lancet, 1, pp. 1221-1225
Mathews, L. S., Enberg, B., Norstedt, G., Regulation of rat growth hormone receptor gene expression (1980) Journal of Biological Chemistry, 17, pp. 9905-9910
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency
OBJECTIVE: The impairment of heart structure and function in adults with childhood onset GH deficiency has been recently described. However, previous echocardiographic studies have reported no differences in cardiac mass and function between adulthood onset GH deficient patients and healthy subjects. DESIGN: The aim of this study was to evaluate cardiac performance In adult patients with childhood and adulthood onset GH deficiency, using equilibrium radionuclide angiography, a method more accurate than echocardiography. PATIENTS: Eleven patients with childhood onset GH deficiency, 9 patients with adulthood onset GH deficiency and 12 age-, gender-, height- and weight- matched healthy subjects entered the study. MEASUREMENTS: All the study population underwent equilibrium radionuclide angiography st rest and during physical exercise. RESULTS: Both childhood and adulthood onset GH deficient patients had an impaired left ventricular systolic performance both at rest (ejection fraction was 55 ± 6%, 55 ± 10% and 66 ± 6% in childhood and adulthood onset GH deficient patients and control group, respectively; P
Left ventricular function in young adults with childhood and adulthood onset growth hormone deficiency
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