Cardiological aspects of growth hormone and insulin-like growth factor-(467 views) Lombardi G, Colao A, Cuocolo A, Longobardi S, Di Somma C, Orio F, Merola B, Nicolai E, Salvatore M
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Guse, A. H., Kiess, W., Funk, B., Kessler, U., Berg, I., Gercken, G., Identification and characterization of insulin-like growth factor receptors on adult rat myocytes: Linkage to inositol-1, 4, 5-trisphosphate formation (1992) Endocrinology, 130, pp. 145-151
Hanson, M. C., Kenneth, A. F., Alexander, R. V., Delafontaine, P., Induction of cardiac insulin-like growth factor-I gene expression in pressure overload hypertrophy (1993) Am J Med Sci, 306, pp. 69-74
Str mer, H., Cittadini, A., Douglas, P. S., Morgan, J. P., Exogenously administered growth hormone and insulin-like growth factor-1 alter intracellular Ca2+ handling and enhance cardiac performance. In vitro evaluation in the isolated isovolumic buffer-perfused rat heart (1996) Circ Res, 79, pp. 227-235
Rodrigues, E. A., Caruana, M. P., Lahiri, A., Nabarro, J. D., Jacobs, H. S., Raftery, E. B., Subclinical cardiac dysfunction in acromegaly evidence for a specific disease of heart muscle (1989) Br Heart J, 62, pp. 185-194
L pez-Velasco, R., Escobar-Morreale, H. F., Vega, B., Villa, E., Sancho, J. M., Moya-Mur, J. L., Garc a-Robles, R., Cardiac involvement in acromegaly: Specific myocardiopathy or consequence of systemic hypertension (1997) J Clin Endocrinol Metab, 82, pp. 1047-1053
Sacc, L., GH deficiency and vascular disease: In search of the linking mechanism (1997) Eur J Endocrinol, 136, pp. 148-149
Duerr, R. L., Huang, S., Miraliakbar, H. R., Clark, R. G., Chien, K. R., Ross Jr., J., Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure (1995) J Clin Invest, 95, pp. 619-627
Duerr, R. L., Dan McKirnan, M., Gim, R. D., Clark, R. G., Chen, K. R., Ross Jr., J., Cardiovascular effects of insulin-like growth factor 1 and growth hormone in chronic left ventricular failure in the rat (1996) Circulation, 93, pp. 2188-2196
Ingwall, J. S., Is cardiac failure a consequence of decreased energy reserve? (1993) Circulation, 87 (7 SUPPL.), pp. VII58-62
Ros n, T., Bengtsson, A., Premature cardiovascular mortality in hypopituitarism - A study of 333 consecutive patients (1990) Lancet, 336, pp. 285-288
Cardiological aspects of growth hormone and insulin-like growth factor-
In recent years it has been demonstrated that both GH deficiency and excess include in their advanced clinical manifestations an impaired cardiovascular function, which may reduce life expectancy. This observation has allowed the investigation of the role played by the GH/IGF-I axis on cardiac structure and function. In particular, several recent experimental and clinical studies support the evidence implicating GH and/or IGF-I in the regulation of heart development. Acromegalic cardiomyopathy is characterized by myocardial hypertrophy with interstitial fibrosis, lymphomononuclear infiltration and areas of monocyte necrosis which often result in increased right and left ventricular mass and concentric hypertrophy. Conversely, patients with childhood or adulthood-onset GH deficiency (GHD) have a reduced left ventricular mass and ejection fraction and the indexes of left ventricular systolic function remained markedly depressed during exercise. In addition, a significant increase in the thickness of the vascular intima- media wall and a higher number of atheromatous plaques have been reported. These abnormalities of the cardiovascular system are partially reversed after normalization of GH and IGF-I levels, by octreotide in acromegaly or after GH replacement therapy in GHD patients. The evidence that GH is able to increase cardiac mass suggested its use in the treatment of idiopathic dilated cardiomyopathy. In a recent study on such patients, the administration of rhGH was demonstrated to increase myocardial mass and to reduce the size of the left ventricular chamber, resulting in an improvement in hemodynamics, myocardial energy metabolism and clinical status. These promising results might open a new field for GH treatment.
Cardiological aspects of growth hormone and insulin-like growth factor-
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