Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies (403 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2010 Nov; 45(11): 715-724.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.67, 5-year impact factor: 4.33
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77958454897&partnerID=40&md5=35c88991dd8366c53b9a3b09abc14062
Keywords: Automatic Nanoparticle Detection, Echographic Contrast Enhancement, Radiofrequency Signal Analysis, Silica Nanoparticles, Ultrasound Imaging, Agarose, Nanosphere, Silicon Dioxide, Unclassified Drug, Amplitude Modulation, Clinical Assessment, Concentration (parameters), Controlled Study, Diagnostic Accuracy, Diagnostic Imaging, Diagnostic Value, Dispersion, Endothelium, Image Quality, Particle Size, Priority Journal, Radiosensitivity, Reticuloendothelial System, Sensitivity And Specificity, Signal Processing, Tissue Typing, Tumor, Contrast Media, Feasibility Studies, Humans, Image Processing, Computer-Assisted, Linear Models, Spectroscopy, Fourier Transform Infrared, Ultrasonography, X-Ray Diffraction,
Affiliations:
*** IBB - CNR ***
Biomedical Engineering Science and Technology Division, Institute of Clinical Physiology, National Research Council, Lecce, Italy
National Nanotechnology Laboratory, CNR-INFM, Distretto Tecnologico ISUFI, Lecce, Italy
References:
Villanueva, F.S., Molecular imaging of cardiovascular disease using ultrasound (2008) J Nucl Cardiol, 15, pp. 576-58
Jensen, J.A., Medical ultrasound imaging (2007) Prog Biophys Mol Biol, 93, pp. 153-165
Pasqualini, R., Arap, W., McDonald, D.M., Probing the structural and molecular diversity of tumor vasculature (2002) Trend Mol Med., 8, pp. 563-571
Hobbs, S.K., Monsky, W.L., Yuan, F., Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment (1998) Proc Natl Acad Sci, 95, pp. 4607-4612
Maeda, H., Wu, J., Sawa, T., Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review (2000) J Control Release, 65, pp. 271-284
Lijowski, M., Caruthers, S., Hu, G., High-resolution SPECT-CT/MR molecular imaging of angiogenesis in the Vx2 model (2009) Invest Radiol, 44, pp. 15-22
Zhu, D., Lu, X., Hardy, P.A., Nanotemplate-engineered nanoparticles containing gadolinium for magnetic resonance imaging of tumors (2008) Invest Radiol, 43, pp. 129-140
Lisy, M.R., Hartung, A., Lang, C., Fluorescent bacterial magnetic nanopar-ticles as bimodal contrast agents (2007) Invest Radiol, 42, pp. 235-241
Liu, J., Levine, A.L., Mattoon, J.S., Nanoparticles as image enhancing agents for ultrasonography (2006) Phys Med Biol, 51, pp. 2179-2189
Buchanan, K.D., Huang, S., Kim, H., Echogenic liposome compositions for increased retention of ultrasound reflectivity at physiologic temperature (2008) J Pharm Sci, 97, pp. 2242-2249
Dayton, P.A., Zhao, S., Bloch, S.H., Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy (2006) Mol Imaging, 5, pp. 160-174
Wheatley, M.A., Forsberg, F., Dube, N., Surfacant-stabilized contrast agent on the nanoscale for diagnostic ultrasound imaging (2006) Ultrasound Med Biol, 32, pp. 83-93
Liu, J., Li, J., Rosol, T.J., Biodegradable nanoparticles for targeted ultrasound imaging of breast cancer cells in vitro (2007) Phys Med Biol, 52, pp. 4739-4747
Jin, Y., Kannan, S., Wu, M., Toxicity of luminescent silica nanoparticles to living cells (2007) Chem Res Toxicol, 20, pp. 1126-1133
Barbè, C., Bartlett, J., Kong, L., Silica particles: A novel drug-delivery system (2004) Adv Mater, 16, pp. 1959-1966
Piao, Y., Burns, A., Kim, J., Designed fabrication of silica-based nano-structured particle systems for nanomedicine applications (2008) Adv Funct Mater, 18, pp. 3745-3758
Moulari, B., Pertuit, D., Pellequer, Y., The targeting of surface modified silica nanoparticles to inflamed tissue in experimental colitis (2008) Biomaterials, 29, pp. 4554-4560
Roy, I., Ohulchanskyy, T.Y., Bharali, D.J., Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery (2005) Proc Natl Acad Sci USA, 102, pp. 279-284
Stober, W., Fink, A., Bohn, E., Controlled growth of mono-disperse silica spheres in the micron size range (1968) J Colloid Interface Sci, 26, pp. 62-69
Gill, P.R., Murray, W., Wright, M.H., The Levenberg-Marquardt method (1981) Practical Optimization, pp. 136-137. , London Academic Press
Greaby, R., Zderic, V., Vaezy, S., Pulsatile flow phantom for ultrasound image-guided HIFU treatment of vascular injuries (2007) Ultrasound Med Biol, 33, pp. 1269-1276
Rhee, P.L., Liu, J., Puckett, J.L., Measuring esophageal distension by high-frequency intraluminal ultrasound probe (2002) Am J Physiol Gastrointest Liver Physiol, 283, pp. G886-G892
Masotti, L., Biagi, E., Scabia, M., FEMMINA: Real-time, radio-frequency echo-signal equipment for testing novel investigation methods (2006) IEEE Trans Ultrason Ferroelectr Freq Control, 53, pp. 1783-1795
Massoptier, L., Casciaro, S., A new fully automatic and robust algorithm for fast segmentation of liver tissue and tumors from CT scans (2008) Eur Radiol, 18, pp. 1658-1665
Morse, P.M., Ingard, K.V., (1968) Theoretical Acoustics, , New York NY McGraw-Hill
Liang, H.D., Blomley, M.J., The role of ultrasound in molecular imaging (2003) Br J Radiol, 76 (2), pp. S140-S150
Pochon, S., Tardy, I., Bussat, P., BR55: A lipopeptide-based VEGFR2-targeted ultrasound contrast agent for molecular imaging of angiogenesis (2010) Invest Radiol., 45, pp. 89-95
Napierska, D., Thomassen, L.C., Rabolli, V., Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells (2009) Small, 5, pp. 846-853
Smith, M.J., Ho, V.H., Darton, N.J., Effect of magnetite nanoparticle agglomerates on ultrasound induced inertial cavitation (2009) Ultrasound Med Biol, 35, pp. 1010-1014
Villanueva, F. S., Molecular imaging of cardiovascular disease using ultrasound (2008) J Nucl Cardiol, 15, pp. 576-58
Jensen, J. A., Medical ultrasound imaging (2007) Prog Biophys Mol Biol, 93, pp. 153-165
Hobbs, S. K., Monsky, W. L., Yuan, F., Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment (1998) Proc Natl Acad Sci, 95, pp. 4607-4612
Lisy, M. R., Hartung, A., Lang, C., Fluorescent bacterial magnetic nanopar-ticles as bimodal contrast agents (2007) Invest Radiol, 42, pp. 235-241
Buchanan, K. D., Huang, S., Kim, H., Echogenic liposome compositions for increased retention of ultrasound reflectivity at physiologic temperature (2008) J Pharm Sci, 97, pp. 2242-2249
Dayton, P. A., Zhao, S., Bloch, S. H., Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy (2006) Mol Imaging, 5, pp. 160-174
Wheatley, M. A., Forsberg, F., Dube, N., Surfacant-stabilized contrast agent on the nanoscale for diagnostic ultrasound imaging (2006) Ultrasound Med Biol, 32, pp. 83-93
Barb, C., Bartlett, J., Kong, L., Silica particles: A novel drug-delivery system (2004) Adv Mater, 16, pp. 1959-1966
Gill, P. R., Murray, W., Wright, M. H., The Levenberg-Marquardt method (1981) Practical Optimization, pp. 136-137. , London Academic Press
Rhee, P. L., Liu, J., Puckett, J. L., Measuring esophageal distension by high-frequency intraluminal ultrasound probe (2002) Am J Physiol Gastrointest Liver Physiol, 283, pp. G886-G892
Morse, P. M., Ingard, K. V., (1968) Theoretical Acoustics, , New York NY McGraw-Hill
Liang, H. D., Blomley, M. J., The role of ultrasound in molecular imaging (2003) Br J Radiol, 76 (2), pp. S140-S150
Smith, M. J., Ho, V. H., Darton, N. J., Effect of magnetite nanoparticle agglomerates on ultrasound induced inertial cavitation (2009) Ultrasound Med Biol, 35, pp. 1010-1014
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2010 Nov; 45(11): 715-724.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.67, 5-year impact factor: 4.33
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-77958454897&partnerID=40&md5=35c88991dd8366c53b9a3b09abc14062
Keywords: Automatic Nanoparticle Detection, Echographic Contrast Enhancement, Radiofrequency Signal Analysis, Silica Nanoparticles, Ultrasound Imaging, Agarose, Nanosphere, Silicon Dioxide, Unclassified Drug, Amplitude Modulation, Clinical Assessment, Concentration (parameters), Controlled Study, Diagnostic Accuracy, Diagnostic Imaging, Diagnostic Value, Dispersion, Endothelium, Image Quality, Particle Size, Priority Journal, Radiosensitivity, Reticuloendothelial System, Sensitivity And Specificity, Signal Processing, Tissue Typing, Tumor, Contrast Media, Feasibility Studies, Humans, Image Processing, Computer-Assisted, Linear Models, Spectroscopy, Fourier Transform Infrared, Ultrasonography, X-Ray Diffraction,
Affiliations:
*** IBB - CNR ***
Biomedical Engineering Science and Technology Division, Institute of Clinical Physiology, National Research Council, Lecce, Italy
National Nanotechnology Laboratory, CNR-INFM, Distretto Tecnologico ISUFI, Lecce, Italy
References:
Villanueva, F.S., Molecular imaging of cardiovascular disease using ultrasound (2008) J Nucl Cardiol, 15, pp. 576-58
Jensen, J.A., Medical ultrasound imaging (2007) Prog Biophys Mol Biol, 93, pp. 153-165
Pasqualini, R., Arap, W., McDonald, D.M., Probing the structural and molecular diversity of tumor vasculature (2002) Trend Mol Med., 8, pp. 563-571
Hobbs, S.K., Monsky, W.L., Yuan, F., Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment (1998) Proc Natl Acad Sci, 95, pp. 4607-4612
Maeda, H., Wu, J., Sawa, T., Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review (2000) J Control Release, 65, pp. 271-284
Lijowski, M., Caruthers, S., Hu, G., High-resolution SPECT-CT/MR molecular imaging of angiogenesis in the Vx2 model (2009) Invest Radiol, 44, pp. 15-22
Zhu, D., Lu, X., Hardy, P.A., Nanotemplate-engineered nanoparticles containing gadolinium for magnetic resonance imaging of tumors (2008) Invest Radiol, 43, pp. 129-140
Lisy, M.R., Hartung, A., Lang, C., Fluorescent bacterial magnetic nanopar-ticles as bimodal contrast agents (2007) Invest Radiol, 42, pp. 235-241
Liu, J., Levine, A.L., Mattoon, J.S., Nanoparticles as image enhancing agents for ultrasonography (2006) Phys Med Biol, 51, pp. 2179-2189
Buchanan, K.D., Huang, S., Kim, H., Echogenic liposome compositions for increased retention of ultrasound reflectivity at physiologic temperature (2008) J Pharm Sci, 97, pp. 2242-2249
Dayton, P.A., Zhao, S., Bloch, S.H., Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy (2006) Mol Imaging, 5, pp. 160-174
Wheatley, M.A., Forsberg, F., Dube, N., Surfacant-stabilized contrast agent on the nanoscale for diagnostic ultrasound imaging (2006) Ultrasound Med Biol, 32, pp. 83-93
Liu, J., Li, J., Rosol, T.J., Biodegradable nanoparticles for targeted ultrasound imaging of breast cancer cells in vitro (2007) Phys Med Biol, 52, pp. 4739-4747
Jin, Y., Kannan, S., Wu, M., Toxicity of luminescent silica nanoparticles to living cells (2007) Chem Res Toxicol, 20, pp. 1126-1133
Barbè, C., Bartlett, J., Kong, L., Silica particles: A novel drug-delivery system (2004) Adv Mater, 16, pp. 1959-1966
Piao, Y., Burns, A., Kim, J., Designed fabrication of silica-based nano-structured particle systems for nanomedicine applications (2008) Adv Funct Mater, 18, pp. 3745-3758
Moulari, B., Pertuit, D., Pellequer, Y., The targeting of surface modified silica nanoparticles to inflamed tissue in experimental colitis (2008) Biomaterials, 29, pp. 4554-4560
Roy, I., Ohulchanskyy, T.Y., Bharali, D.J., Optical tracking of organically modified silica nanoparticles as DNA carriers: A nonviral, nanomedicine approach for gene delivery (2005) Proc Natl Acad Sci USA, 102, pp. 279-284
Stober, W., Fink, A., Bohn, E., Controlled growth of mono-disperse silica spheres in the micron size range (1968) J Colloid Interface Sci, 26, pp. 62-69
Gill, P.R., Murray, W., Wright, M.H., The Levenberg-Marquardt method (1981) Practical Optimization, pp. 136-137. , London Academic Press
Greaby, R., Zderic, V., Vaezy, S., Pulsatile flow phantom for ultrasound image-guided HIFU treatment of vascular injuries (2007) Ultrasound Med Biol, 33, pp. 1269-1276
Rhee, P.L., Liu, J., Puckett, J.L., Measuring esophageal distension by high-frequency intraluminal ultrasound probe (2002) Am J Physiol Gastrointest Liver Physiol, 283, pp. G886-G892
Masotti, L., Biagi, E., Scabia, M., FEMMINA: Real-time, radio-frequency echo-signal equipment for testing novel investigation methods (2006) IEEE Trans Ultrason Ferroelectr Freq Control, 53, pp. 1783-1795
Massoptier, L., Casciaro, S., A new fully automatic and robust algorithm for fast segmentation of liver tissue and tumors from CT scans (2008) Eur Radiol, 18, pp. 1658-1665
Morse, P.M., Ingard, K.V., (1968) Theoretical Acoustics, , New York NY McGraw-Hill
Liang, H.D., Blomley, M.J., The role of ultrasound in molecular imaging (2003) Br J Radiol, 76 (2), pp. S140-S150
Pochon, S., Tardy, I., Bussat, P., BR55: A lipopeptide-based VEGFR2-targeted ultrasound contrast agent for molecular imaging of angiogenesis (2010) Invest Radiol., 45, pp. 89-95
Napierska, D., Thomassen, L.C., Rabolli, V., Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells (2009) Small, 5, pp. 846-853
Smith, M.J., Ho, V.H., Darton, N.J., Effect of magnetite nanoparticle agglomerates on ultrasound induced inertial cavitation (2009) Ultrasound Med Biol, 35, pp. 1010-1014
Villanueva, F. S., Molecular imaging of cardiovascular disease using ultrasound (2008) J Nucl Cardiol, 15, pp. 576-58
Jensen, J. A., Medical ultrasound imaging (2007) Prog Biophys Mol Biol, 93, pp. 153-165
Hobbs, S. K., Monsky, W. L., Yuan, F., Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment (1998) Proc Natl Acad Sci, 95, pp. 4607-4612
Lisy, M. R., Hartung, A., Lang, C., Fluorescent bacterial magnetic nanopar-ticles as bimodal contrast agents (2007) Invest Radiol, 42, pp. 235-241
Buchanan, K. D., Huang, S., Kim, H., Echogenic liposome compositions for increased retention of ultrasound reflectivity at physiologic temperature (2008) J Pharm Sci, 97, pp. 2242-2249
Dayton, P. A., Zhao, S., Bloch, S. H., Application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy (2006) Mol Imaging, 5, pp. 160-174
Wheatley, M. A., Forsberg, F., Dube, N., Surfacant-stabilized contrast agent on the nanoscale for diagnostic ultrasound imaging (2006) Ultrasound Med Biol, 32, pp. 83-93
Barb, C., Bartlett, J., Kong, L., Silica particles: A novel drug-delivery system (2004) Adv Mater, 16, pp. 1959-1966
Gill, P. R., Murray, W., Wright, M. H., The Levenberg-Marquardt method (1981) Practical Optimization, pp. 136-137. , London Academic Press
Rhee, P. L., Liu, J., Puckett, J. L., Measuring esophageal distension by high-frequency intraluminal ultrasound probe (2002) Am J Physiol Gastrointest Liver Physiol, 283, pp. G886-G892
Morse, P. M., Ingard, K. V., (1968) Theoretical Acoustics, , New York NY McGraw-Hill
Liang, H. D., Blomley, M. J., The role of ultrasound in molecular imaging (2003) Br J Radiol, 76 (2), pp. S140-S150
Smith, M. J., Ho, V. H., Darton, N. J., Effect of magnetite nanoparticle agglomerates on ultrasound induced inertial cavitation (2009) Ultrasound Med Biol, 35, pp. 1010-1014
Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies
Objectives: To experimentally investigate the acoustical behavior of silica nanoparticles within conventional diagnostic ultrasound fields and to determine a suitable configuration, in terms of particle size and concentration, for their employment as targetable contrast agents. We also assessed the effectiveness of a novel method for automatic detection of targeted silica nanoparticles for future tissue typing applications. Materials and Methods: Silica nanospheres of variable size (160, 330, and 660 nm in diameter) and concentration (10 10-10 13 part/mL) were dispersed in different custom-designed agarose-based gel samples and imaged at 7.5 MHz with a conventional echograph linked to a research platform for radiofrequency signal acquisition. Off-line analysis included evaluation of backscattered ultrasound amplitude, image brightness, and nanoparticle automatic detection through radiofrequency signal processing. Results: Amplitude of nanoparticle- backscattered signals linearly increased with particle number concentration, but image brightness did not show the same trend, because the logarithmic compression caused the reaching of a "plateau" where brightness remained almost constant for further increments in particle concentration. On the other hand, both backscatter amplitude and image brightness showed significant increments when particle diameter was increased. Taking into account particle size constraints for tumor targeting (pore size of tumor endothelium and trapping effects because of reticulo-endothelial system limit the dimension of effectively employable particles to less than 380 nm), a suitable compromise is represented by the employment of 330-nm silica nanospheres at a concentration of about 1 to 2 × 10 11 part/mL. These particles, in fact, showed the best combination of number concentration and diameter value to obtain an effective enhancement on conventional echographic images. Furthermore, also the sensitivity of the developed method for automatic nanoparticle detection had a maximum (72.8%) with 330-nm particles, whereas it was lower with both bigger and smaller particles (being equal to 64.1% and 17.5%, respectively). Conclusions: Silica nanoparticles at a diameter of about 330 nm are very promising contrast agents for ultrasound imaging and specific tumor targeting at conventional diagnostic frequencies, being in particular automatically detectable with high sensitivity already at low doses. Future studies will be carried out to assess the acoustic behavior of nanoparticles with different geometries/sizes and to improve sensitivity of the automatic detection algorithm. Copyright © 2010 by Lippincott Williams and Wilkins.
Objectives: To experimentally investigate the acoustical behavior of silica nanoparticles within conventional diagnostic ultrasound fields and to determine a suitable configuration, in terms of particle size and concentration, for their employment as targetable contrast agents. We also assessed the effectiveness of a novel method for automatic detection of targeted silica nanoparticles for future tissue typing applications. Materials and Methods: Silica nanospheres of variable size (160, 330, and 660 nm in diameter) and concentration (10 10-10 13 part/mL) were dispersed in different custom-designed agarose-based gel samples and imaged at 7.5 MHz with a conventional echograph linked to a research platform for radiofrequency signal acquisition. Off-line analysis included evaluation of backscattered ultrasound amplitude, image brightness, and nanoparticle automatic detection through radiofrequency signal processing. Results: Amplitude of nanoparticle- backscattered signals linearly increased with particle number concentration, but image brightness did not show the same trend, because the logarithmic compression caused the reaching of a "plateau" where brightness remained almost constant for further increments in particle concentration. On the other hand, both backscatter amplitude and image brightness showed significant increments when particle diameter was increased. Taking into account particle size constraints for tumor targeting (pore size of tumor endothelium and trapping effects because of reticulo-endothelial system limit the dimension of effectively employable particles to less than 380 nm), a suitable compromise is represented by the employment of 330-nm silica nanospheres at a concentration of about 1 to 2 × 10 11 part/mL. These particles, in fact, showed the best combination of number concentration and diameter value to obtain an effective enhancement on conventional echographic images. Furthermore, also the sensitivity of the developed method for automatic nanoparticle detection had a maximum (72.8%) with 330-nm particles, whereas it was lower with both bigger and smaller particles (being equal to 64.1% and 17.5%, respectively). Conclusions: Silica nanoparticles at a diameter of about 330 nm are very promising contrast agents for ultrasound imaging and specific tumor targeting at conventional diagnostic frequencies, being in particular automatically detectable with high sensitivity already at low doses. Future studies will be carried out to assess the acoustic behavior of nanoparticles with different geometries/sizes and to improve sensitivity of the automatic detection algorithm. Copyright © 2010 by Lippincott Williams and Wilkins.
Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies
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Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies
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View Export to BibTeX Export to EndNote
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Panminerva Med (ISSN: 1827-1898electronic, 0031-0808linking), 2018 Jun; 60(2): 44-51.
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
Greco A, D'Alterio C, Auletta L, Albanese S, Napolitano M, Portella L, Santagata S, Ierano C, Brunetti A, Scala S, Zannetti A
* Longitudinal evaluation with High Frequency Ultrasound imaging of response to CXCR4 new cyclic peptide antagonist with conventional chemotherapy in colorectal cancer mice model (397 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 1619-7070print), 2015; 42: S425-S425.
Impact Factor: 5.537
View Export to BibTeX Export to EndNote
Mancini M
The Current Status Of Ultrasound Imaging For The Screening Of Ccsvi (261 views)
International Society For Neurovascular Disease 4th Annual Meeting San Francisco Ca, 2014 Sep; N/D: N/D-N/D.
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View Export to BibTeX Export to EndNote
Rampazzo E, Bonacchi S, Genovese D, Juris R, Sgarzi M, Montalti M, Prodi L, Zaccheroni N, Tomaselli G, Gentile S, Satriano C, Rizzarelli E
* A versatile strategy for signal amplification based on core/shell silica nanoparticles (475 views)
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Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Ferrara LA, Mancini M, Celentano A, Galderisi M, Iannuzzi R, Marotta T, Gaeta I
Early changes of the arterial carotid wall in uncomplicated primary hypertensive patients: Study by ultrasound high-resolution B-mode imaging (284 views)
Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 1994 Sep; 14(8): 1290-1296.
Impact Factor: 5.317
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11 Records (9 excluding Abstracts).
Total impact factor: 36.327 (36.327 excluding Abstracts).
Total 5 year impact factor: 38.259 (38.259 excluding Abstracts).
Total impact factor: 36.327 (36.327 excluding Abstracts).
Total 5 year impact factor: 38.259 (38.259 excluding Abstracts).
403 views. Last view on Saturday 27 May 2023, 10:57:05
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