New Conjugate Of Cyclodextrin Useful As Anti-Inflammatory And Anti-Tumoral Agents And For Preparation Of Medicaments With Colon Site-Specific Delivery (252 views)
Am J Obstet Gynecol (ISSN: 0002-9378), 2015; 212(3): 413-413.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 4.681, 5-year impact factor: 4.552
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84924765167&partnerID=40&md5=9fb50708bfa19fb257158eafc5cb56f5
Keywords: 25 Hydroxyvitamin D, Calcifediol, Estradiol, Gonadotropin, Vitamin D Binding Protein, 25-Hydroxyvitamin D, Blastocyst, Embryo Development, Ethnicity, Fertilization In Vitro, Hormonal Therapy, Hormone Substitution, Human, Infertility, Letter, Menstrual Cycle, Oocyte Donation, Ploidy, Pregnancy Outcome, Priority Journal, Self Report, Vitamin Blood Level, Analogs And Derivatives, Embryo Transfer, Female, Nidation, Pregnancy Rate, Embryo Implantation,
Affiliations:
*** IBB - CNR ***
Division of Reproductive Endocrinology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, United States
Reproductive Medicine Associates of New Jersey, 140 Allen Rd., Basking Ridge, NJ, United States
Department of Obstetrics, Gynecology, and Reproductive Sciences, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, United States
References:
Fabris, A., Pacheco, A., Cruz, M., Puente, J.M., Fatemi, H., Garcia-Velasco, J.A., Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients (2014) Fertil Steril, 102, pp. 1608-161
Ozkan, S., Jindal, S., Greenseid, K., Replete vitamin D stores predict reproductive success following in vitro fertilization (2010) Fertil Steril, 94, p. 1314
Du, H., Daftary, G.S., Lalwani, S.I., Taylor, H.S., Direct regulation of HOXA10 by 1, 25-(OH)2 D3 in human myelomonocytic cells and human endometrial stromal cells (2005) Mol Endocrinol, 19, pp. 2222-2233
Shastri, S., Werner, M., Devkota, B., Taylor, D., Treff, N., Scott, R., Comparison of clinical outcomes between genetically similar groups of in vitro fertilization patients (2012) Fertil Steril, 98, p. S26
Am J Obstet Gynecol (ISSN: 0002-9378), 2015; 212(3): 413-413.
Export to BibTeX Export to EndNote
Paper type: Letter, Journal Article,
Impact factor: 4.681, 5-year impact factor: 4.552
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-84924765167&partnerID=40&md5=9fb50708bfa19fb257158eafc5cb56f5
Keywords: 25 Hydroxyvitamin D, Calcifediol, Estradiol, Gonadotropin, Vitamin D Binding Protein, 25-Hydroxyvitamin D, Blastocyst, Embryo Development, Ethnicity, Fertilization In Vitro, Hormonal Therapy, Hormone Substitution, Human, Infertility, Letter, Menstrual Cycle, Oocyte Donation, Ploidy, Pregnancy Outcome, Priority Journal, Self Report, Vitamin Blood Level, Analogs And Derivatives, Embryo Transfer, Female, Nidation, Pregnancy Rate, Embryo Implantation,
Affiliations:
*** IBB - CNR ***
Division of Reproductive Endocrinology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, United States
Reproductive Medicine Associates of New Jersey, 140 Allen Rd., Basking Ridge, NJ, United States
Department of Obstetrics, Gynecology, and Reproductive Sciences, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, United States
References:
Fabris, A., Pacheco, A., Cruz, M., Puente, J.M., Fatemi, H., Garcia-Velasco, J.A., Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients (2014) Fertil Steril, 102, pp. 1608-161
Ozkan, S., Jindal, S., Greenseid, K., Replete vitamin D stores predict reproductive success following in vitro fertilization (2010) Fertil Steril, 94, p. 1314
Du, H., Daftary, G.S., Lalwani, S.I., Taylor, H.S., Direct regulation of HOXA10 by 1, 25-(OH)2 D3 in human myelomonocytic cells and human endometrial stromal cells (2005) Mol Endocrinol, 19, pp. 2222-2233
Shastri, S., Werner, M., Devkota, B., Taylor, D., Treff, N., Scott, R., Comparison of clinical outcomes between genetically similar groups of in vitro fertilization patients (2012) Fertil Steril, 98, p. S26
New Conjugate Of Cyclodextrin Useful As Anti-Inflammatory And Anti-Tumoral Agents And For Preparation Of Medicaments With Colon Site-Specific Delivery
NOVELTY - A conjugate of cyclodextrin (I) is new. USE - For the preparation of medicaments with colon site-specific delivery (claimed). ADVANTAGE - The (S) -etodolac conjugate of beta -cyclodextrin is potent cyclooxygenase (COX) inhibitor. The beta -cyclodextrin etodolac conjugates allow to suitably target the drug. The optically pure etodolac conjugates is advantageous in terms of activity/side effects ratio. The solubility of the mixture of the diastereomers of the conjugate of cyclodextrin, markedly more water-soluble than etodolac itself, where the two isolated diastereomers show different solubilities in water, higher in the case of the R-etodolac conjugate (6. 8 g/l). The conjugate of beta -cyclodextrin shows excellent anti-inflammatory and anti-tumoral activity. DETAILED DESCRIPTION - A conjugate of cyclodextrin of formula (I), is new. Y1=acyl residue of is (R) or (S) 1, 8-diethyl-1, 3, 4, 9-tetrahydropyran (3, 4-b) indole-1-acetic acid (etodolac). An INDEPENDENT CLAIM is included for a pharmaceutical compositions containing conjugate of cyclodextrin of formula (Ib) in admixture with carriers
NOVELTY - A conjugate of cyclodextrin (I) is new. USE - For the preparation of medicaments with colon site-specific delivery (claimed). ADVANTAGE - The (S) -etodolac conjugate of beta -cyclodextrin is potent cyclooxygenase (COX) inhibitor. The beta -cyclodextrin etodolac conjugates allow to suitably target the drug. The optically pure etodolac conjugates is advantageous in terms of activity/side effects ratio. The solubility of the mixture of the diastereomers of the conjugate of cyclodextrin, markedly more water-soluble than etodolac itself, where the two isolated diastereomers show different solubilities in water, higher in the case of the R-etodolac conjugate (6. 8 g/l). The conjugate of beta -cyclodextrin shows excellent anti-inflammatory and anti-tumoral activity. DETAILED DESCRIPTION - A conjugate of cyclodextrin of formula (I), is new. Y1=acyl residue of is (R) or (S) 1, 8-diethyl-1, 3, 4, 9-tetrahydropyran (3, 4-b) indole-1-acetic acid (etodolac). An INDEPENDENT CLAIM is included for a pharmaceutical compositions containing conjugate of cyclodextrin of formula (Ib) in admixture with carriers
New Conjugate Of Cyclodextrin Useful As Anti-Inflammatory And Anti-Tumoral Agents And For Preparation Of Medicaments With Colon Site-Specific Delivery
No results. |
New Conjugate Of Cyclodextrin Useful As Anti-Inflammatory And Anti-Tumoral Agents And For Preparation Of Medicaments With Colon Site-Specific Delivery
Other filter: ([btitle,keywords] "25 Hydroxyvitamin D" ...
Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M
* Bone mineral density in children, adolescents, and young adults with epilepsy (372 views)
Epilepsia (ISSN: 1528-1167, 0013-9580), 2009 Sep; 50(9): 2140-2146.
Impact Factor: 4.052
View Export to BibTeX Export to EndNote
* Bone mineral density in children, adolescents, and young adults with epilepsy (372 views)
Epilepsia (ISSN: 1528-1167, 0013-9580), 2009 Sep; 50(9): 2140-2146.
Impact Factor: 4.052
View Export to BibTeX Export to EndNote
1 Records (1 excluding Abstracts).
Total impact factor: 4.052 (4.052 excluding Abstracts).
Total 5 year impact factor: 4.299 (4.299 excluding Abstracts).
Total impact factor: 4.052 (4.052 excluding Abstracts).
Total 5 year impact factor: 4.299 (4.299 excluding Abstracts).
252 views. Last view on Saturday 14 January 2023, 17:41:15
ibb.cnr.it
