The crystal structure of a Dcp-containing peptide(455 views) De Simone G, Lombardi A, Galdiero S, Nastri F, Di Costanzo L, Gohda S, Sano A, Yamada T, Pavone V
Keywords: C(α, α)-Disubstituted Amino Acids, Conformation, Crystal Structure, Amino Acid Sequence, Article, Protein Conformation, Protein Folding, Protein Structure, Structure Activity Relation, Synthesis, Crystallography, X-Ray, Dipeptides, Glycine, Models, Molecular,
Affiliations: Ctro. Interuniversitario di Ric., Ctro. di Stud., di B., University of Napoli Federico II, via Mezzocannone 4, I-80134 Napoli, Italy
Department of Chemistry, Faculty of Science, Konan University, 658 Kobe, Japan
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The crystal structure of a Dcp-containing peptide
We have investigated the conformational preferences of a newly synthesized C(α,α) symmetrically disubstituted glycine, namely α,α- dicyclopropylglycine (Dcp). We report here the crystal structure of a fully protected dipeptide containing Dcp, namely Z-Dcp 1-Dcp 2-OCH 3. Both Dcp residues are in a folded conformation. The overall peptide structural organization corresponds to an α-pleated sheet conformation, similar to that observed in linear peptides made up of alternating D- and L-residues and in Z-Aib-Aib-OCH 3 (Aib: α,α-dimethylglycine). These preliminary data suggest that the Dcp could represent an alternative as molecular tool to stabilize folded conformations. (C) 2000 John Wiley and Sons, Inc.
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