Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders(401 views) Vitagliano L, Zaccaro L, Morelli G, Martegani E
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2013 Jun 11; N/D: N/D-N/D.
Paper type: Journal Article, Abstract, Conference,
Impact factor: 0, 5-year impact factor: 0
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Keywords: Not available.
Affiliations: *** IBB - CNR ***
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Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders
Peptides having a structure characterized by the presence of two loops constrained in cyclic structure by the presence of covalent bonds between amino acid side chains, the amino acid sequences of the first and the second loop being substantially homologues to that of loop 1 (residues 29-38) and of loop 4 (residues 92-97) of NGF, respectively, displaying nerve growth factor (NGF) agonist or partial agonist activity.
Heterodimeric peptide compounds displaying NGF activity and their use to treat neurodegenerative disorders