Selective alpha v beta 3 receptor peptide antagonist for therapeutic and diagnostic applications(1221 views) Del Gatto A, Zaccaro L, Pedone C, Saviano M
Patents Official Gazette Of The United States Patent And Trademark Office (ISSN: 0098-1133), 2013 Oct 1; N/D: N/D-N/D.
Paper type: Journal Article, Abstract, Conference,
Impact factor: 0, 5-year impact factor: 0
Url: Not available.
Keywords: Not available.
Affiliations: *** IBB - CNR ***
References: Not available.
Selective alpha v beta 3 receptor peptide antagonist for therapeutic and diagnostic applications
The present invention is related to new peptide antagonists of alpha(v)beta(3 )receptor, designed on the basis of the crystal structure of integrin alpha(v)beta(3 )in complex with c(RGDf[NMe]V) and the NMR structure of echistatin. These peptides are potent and selective antagonists of the alpha(v)beta(3 )receptor and can be used as novel anticancer drugs and/or new class of diagnostic non-invasive tracers as suitable tools for alpha(v)beta(3)-targeted therapy and imaging.
Selective alpha v beta 3 receptor peptide antagonist for therapeutic and diagnostic applications
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