Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (847 views)
J Transl Med (ISSN: 1479-5876electronic, 1479-5876linking), 2011 Jan 13; 9: 7-7.
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Paper type: Journal Article,
Impact factor: 3.474, 5-year impact factor: 3.692
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651314991&partnerID=40&md5=b515c0051bdd4718936f6b61a82085ce
Keywords: Arginylglycylaspartic Acid, Cilengitide, Echistatin, Vitronectin Receptor, Angiogenesis Inhibitor, Cyclopeptide, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Antiangiogenic Activity, C57bl 6 Mouse, Cell Proliferation, Controlled Study, Drug Effect, Endothelium Cell, In Vitro Study, In Vivo Study, Nonhuman, Signal Transduction, Smooth Muscle Fiber, Vascular Smooth Muscle, Wistar Kyoto Rat, Wound Healing Impairment, C57bl Mouse, Cell Culture, Drug Antagonism, Drug Screening, Enzyme Specificity, Neoplasm, Pathology, Physiology, Vascularization, Drug Evaluation, Preclinical, Endothelial Cells, Integrin Alphavbeta3, Mice, Inbred C57bl, Myocytes, Neovascularization, Inbred Wky, Substrate Specificity, Pharmacology, Therapeutic Use, Blood Supply, Drug Therapy,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Italy
Department of Biological Sciences, Federico II University of Naples, Italy
Institute of Crystallography (Consiglio Nazionale delle Ricerche CNR), Bari, Italy
Institute of Biostructures and Bioimaging (Consiglio Nazionale delle Ricerche CNR), Naples, Italy
References:
Not available.
J Transl Med (ISSN: 1479-5876electronic, 1479-5876linking), 2011 Jan 13; 9: 7-7.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.474, 5-year impact factor: 3.692
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651314991&partnerID=40&md5=b515c0051bdd4718936f6b61a82085ce
Keywords: Arginylglycylaspartic Acid, Cilengitide, Echistatin, Vitronectin Receptor, Angiogenesis Inhibitor, Cyclopeptide, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Antiangiogenic Activity, C57bl 6 Mouse, Cell Proliferation, Controlled Study, Drug Effect, Endothelium Cell, In Vitro Study, In Vivo Study, Nonhuman, Signal Transduction, Smooth Muscle Fiber, Vascular Smooth Muscle, Wistar Kyoto Rat, Wound Healing Impairment, C57bl Mouse, Cell Culture, Drug Antagonism, Drug Screening, Enzyme Specificity, Neoplasm, Pathology, Physiology, Vascularization, Drug Evaluation, Preclinical, Endothelial Cells, Integrin Alphavbeta3, Mice, Inbred C57bl, Myocytes, Neovascularization, Inbred Wky, Substrate Specificity, Pharmacology, Therapeutic Use, Blood Supply, Drug Therapy,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Italy
Department of Biological Sciences, Federico II University of Naples, Italy
Institute of Crystallography (Consiglio Nazionale delle Ricerche CNR), Bari, Italy
Institute of Biostructures and Bioimaging (Consiglio Nazionale delle Ricerche CNR), Naples, Italy
References:
Not available.
Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit
Background: Integrins are heterodimeric receptors that play a critical role in cell-cell and cell-matrix adhesion processes. Among them, αVβ3integrin, that recognizes the aminoacidic RGD triad, is reported to be involved in angiogenesis, tissue repair and tumor growth. We have recently synthesized a new and selective ligand of αVβ3receptor, referred to as RGDechiHCit, that contains a cyclic RGD motif and two echistatin moieties.Methods: The aim of this study is to evaluate in vitro and in vivo the effects of RGDechiHCit. Therefore, we assessed its properties in cellular (endothelial cells [EC], and vascular smooth muscle cells [VSMC]) and animal models (Wistar Kyoto rats and c57Bl/6 mice) of angiogenesis.Results: In EC, but not VSMC, RGDechiHCit inhibits intracellular mitogenic signaling and cell proliferation. Furthermore, RGDechiHCit blocks the ability of EC to form tubes on Matrigel. In vivo, wound healing is delayed in presence of RGDechiHCit. Similarly, Matrigel plugs demonstrate an antiangiogenic effect of RGDechiHCit.Conclusions: Our data indicate the importance of RGDechiHCit in the selective inhibition of endothelial αVβ3integrin in vitro and in vivo. Such inhibition opens new fields of investigation on the mechanisms of angiogenesis, offering clinical implications for treatment of pathophysiological conditions such as cancer, proliferative retinopathy and inflammatory disease. © 2011 Santulli et al; licensee BioMed Central Ltd.
Background: Integrins are heterodimeric receptors that play a critical role in cell-cell and cell-matrix adhesion processes. Among them, αVβ3integrin, that recognizes the aminoacidic RGD triad, is reported to be involved in angiogenesis, tissue repair and tumor growth. We have recently synthesized a new and selective ligand of αVβ3receptor, referred to as RGDechiHCit, that contains a cyclic RGD motif and two echistatin moieties.Methods: The aim of this study is to evaluate in vitro and in vivo the effects of RGDechiHCit. Therefore, we assessed its properties in cellular (endothelial cells [EC], and vascular smooth muscle cells [VSMC]) and animal models (Wistar Kyoto rats and c57Bl/6 mice) of angiogenesis.Results: In EC, but not VSMC, RGDechiHCit inhibits intracellular mitogenic signaling and cell proliferation. Furthermore, RGDechiHCit blocks the ability of EC to form tubes on Matrigel. In vivo, wound healing is delayed in presence of RGDechiHCit. Similarly, Matrigel plugs demonstrate an antiangiogenic effect of RGDechiHCit.Conclusions: Our data indicate the importance of RGDechiHCit in the selective inhibition of endothelial αVβ3integrin in vitro and in vivo. Such inhibition opens new fields of investigation on the mechanisms of angiogenesis, offering clinical implications for treatment of pathophysiological conditions such as cancer, proliferative retinopathy and inflammatory disease. © 2011 Santulli et al; licensee BioMed Central Ltd.
Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit
| ▼ Development of integrin subtypes selective ligands: from a first rationally designed peptide to a wide range of molecules |
Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit
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Impact Factor: 6.747
View Export to BibTeX Export to EndNote
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Impact Factor: 4.953
View Export to BibTeX Export to EndNote
D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
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Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1792 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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De Luca S, Del Gatto A, Ruvo M, Panico M, Zannetti A, Del Vecchio S, Salvatore M, Pedone C, Saviano M, Zaccaro L
* A new and selective radiolabeled alpha(V)beta(3) peptide antagonist as tracer in tumor diagnosis (798 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 439-440.
Impact Factor: 2.02
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (732 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (1142 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (1223 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Carriero M, Del Vecchio S, Capozzoli M, Franco P, Fontana L, Zannetti A, Botti G, D'Aiuto G, Salvatore M, Stoppelli M
Urokinase receptor interacts with alpha(v)beta(5) vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer (583 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1999 Oct 15; 59(20): N/D-N/D.
Impact Factor: 8.614
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27 Records (25 excluding Abstracts).
Total impact factor: 109.982 (98.134 excluding Abstracts).
Total 5 year impact factor: 107.419 (95.681 excluding Abstracts).
Total impact factor: 109.982 (98.134 excluding Abstracts).
Total 5 year impact factor: 107.419 (95.681 excluding Abstracts).
847 views. Last view on Tuesday 18 March 2025, 15:03:48
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