Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (511 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.474, 5-year impact factor: 3.692
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651314991&partnerID=40&md5=b515c0051bdd4718936f6b61a82085ce
Keywords: Arginylglycylaspartic Acid, Cilengitide, Echistatin, Vitronectin Receptor, Angiogenesis Inhibitor, Cyclopeptide, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Antiangiogenic Activity, C57bl 6 Mouse, Cell Proliferation, Controlled Study, Drug Effect, Endothelium Cell, In Vitro Study, In Vivo Study, Nonhuman, Signal Transduction, Smooth Muscle Fiber, Vascular Smooth Muscle, Wistar Kyoto Rat, Wound Healing Impairment, C57bl Mouse, Cell Culture, Drug Antagonism, Drug Screening, Enzyme Specificity, Neoplasm, Pathology, Physiology, Vascularization, Drug Evaluation, Preclinical, Endothelial Cells, Integrin Alphavbeta3, Mice, Inbred C57bl, Myocytes, Neovascularization, Inbred Wky, Substrate Specificity, Pharmacology, Therapeutic Use, Blood Supply, Drug Therapy,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Italy
Department of Biological Sciences, Federico II University of Naples, Italy
Institute of Crystallography (Consiglio Nazionale delle Ricerche CNR), Bari, Italy
Institute of Biostructures and Bioimaging (Consiglio Nazionale delle Ricerche CNR), Naples, Italy
References:
Santulli, G., Ciccarelli, M., Palumbo, G., Campanile, A., Galasso, G., Ziaco, B., Altobelli, G.G., D'Andrea, L.D., In vivo properties of the proangiogenic peptide QK (2009) J Transl Med, 7, p. 41. , 10.1186/1479-5876-7-41, 2702279, 1950532
Bonauer, A., Carmona, G., Iwasaki, M., Mione, M., Koyanagi, M., Fischer, A., Burchfield, J., Ohtani, K., MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice (2009) Science, 324, pp. 1710-1713. , 10.1126/science.1174381, 19460962
Desgrosellier, J.S., Cheresh, D.A., Integrins in cancer: biological implications and therapeutic opportunities (2010) Nat Rev Cancer, 10, pp. 9-22. , 10.1038/nrc2748, 20029421
Hood, J.D., Frausto, R., Kiosses, W.B., Schwartz, M.A., Cheresh, D.A., Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis (2003) J Cell Biol, 162, pp. 933-943. , 10.1083/jcb.200304105, 2172815, 12952943
Takahashi, S., Moser, M., Montanez, E., Nakano, T., Seo, M., Backert, S., Inoue, I., Fassler, R., The fibronectin RGD motif is required for multiple angiogenic events during early embryonic development (2010) Arterioscler Thromb Vasc Biol, 30, pp. e1. , 10.1161/ATVBAHA.108.181164, 19713531
Castel, S., Pagan, R., Garcia, R., Casaroli-Marano, R.P., Reina, M., Mitjans, F., Piulats, J., Vilaro, S., Alpha v integrin antagonists induce the disassembly of focal contacts in melanoma cells (2000) Eur J Cell Biol, 79, pp. 502-512. , 10.1078/0171-9335-00067, 10961450
Soldi, R., Mitola, S., Strasly, M., Defilippi, P., Tarone, G., Bussolino, F., Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2 (1999) Embo J, 18, pp. 882-892. , 10.1093/emboj/18.4.882, 1171181, 10022831
Lu, H., Murtagh, J., Schwartz, E.L., The microtubule binding drug laulimalide inhibits vascular endothelial growth factor-induced human endothelial cell migration and is synergistic when combined with docetaxel (taxotere) (2006) Mol Pharmacol, 69, pp. 1207-1215. , 10.1124/mol.105.019075, 1462867, 16415178
Bayless, K.J., Salazar, R., Davis, G.E., RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the alpha(v)beta(3) and alpha(5)beta(1) integrins (2000) Am J Pathol, 156, pp. 1673-1683. , 1876924, 10793078
Brooks, P.C., Stromblad, S., Sanders, L.C., von Schalscha, T.L., Aimes, R.T., Stetler-Stevenson, W.G., Quigley, J.P., Cheresh, D.A., Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3 (1996) Cell, 85, pp. 683-693. , 10.1016/S0092-8674(00)81235-0, 8646777
Abumiya, T., Lucero, J., Heo, J.H., Tagaya, M., Koziol, J.A., Copeland, B.R., del Zoppo, G.J., Activated microvessels express vascular endothelial growth factor and integrin alpha(v)beta3 during focal cerebral ischemia (1999) J Cereb Blood Flow Metab, 19, pp. 1038-1050. , 10.1097/00004647-199909000-00012, 10478656
Mahabeleshwar, G.H., Feng, W., Reddy, K., Plow, E.F., Byzova, T.V., Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis (2007) Circ Res, 101, pp. 570-580. , 10.1161/CIRCRESAHA.107.155655, 2723825, 17641225
Xiong, J.P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S.L., Arnaout, M.A., Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand (2002) Science, 296, pp. 151-155. , 10.1126/science.1069040, 11884718
Aumailley, M., Gurrath, M., Muller, G., Calvete, J., Timpl, R., Kessler, H., Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1 (1991) FEBS Lett, 291, pp. 50-54. , 10.1016/0014-5793(91)81101-D, 1718779
Schottelius, M., Laufer, B., Kessler, H., Wester, H.J., Ligands for mapping alphavbeta3-integrin expression in vivo (2009) Acc Chem Res, 42, pp. 969-980. , 10.1021/ar800243b, 19489579
Eliceiri, B.P., Klemke, R., Stromblad, S., Cheresh, D.A., Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis (1998) J Cell Biol, 140, pp. 1255-1263. , 10.1083/jcb.140.5.1255, 2132684, 9490736
Bai, J., Zhang, J., Wu, J., Shen, L., Zeng, J., Ding, J., Wu, Y., Xu, S., JWA regulates melanoma metastasis by integrin alpha(V)beta(3) signaling (2010) Oncogene, 29, pp. 1227-1237. , 10.1038/onc.2009.408, 19946336
Eskens, F.A., Dumez, H., Hoekstra, R., Perschl, A., Brindley, C., Bottcher, S., Wynendaele, W., van Oosterom, A.T., Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours (2003) Eur J Cancer, 39, pp. 917-926. , 10.1016/S0959-8049(03)00057-1, 12706360
Dechantsreiter, M.A., Planker, E., Matha, B., Lohof, E., Holzemann, G., Jonczyk, A., Goodman, S.L., Kessler, H., N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists (1999) J Med Chem, 42, pp. 3033-3040. , 10.1021/jm970832g, 10447947
Del Gatto, A., Zaccaro, L., Grieco, P., Novellino, E., Zannetti, A., Del Vecchio, S., Iommelli, F., Saviano, M., Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior (2006) J Med Chem, 49, pp. 3416-3420. , 10.1021/jm060233m, 16722662
Ciccarelli, M., Cipolletta, E., Santulli, G., Campanile, A., Pumiglia, K., Cervero, P., Pastore, L., Iaccarino, G., Endothelial beta2 adrenergic signaling to AKT: role of Gi and SRC (2007) Cell Signal, 19, pp. 1949-1955. , 10.1016/j.cellsig.2007.05.007, 17629454
Iaccarino, G., Ciccarelli, M., Sorriento, D., Cipolletta, E., Cerullo, V., Iovino, G.L., Paudice, A., Campanile, A., AKT participates in endothelial dysfunction in hypertension (2004) Circulation, 109, pp. 2587-2593. , 10.1161/01.CIR.0000129768.35536.FA, 15136501
Illario, M., Cavallo, A.L., Monaco, S., Di Vito, E., Mueller, F., Marzano, L.A., Troncone, G., Vitale, M., Fibronectin-induced proliferation in thyroid cells is mediated by alphavbeta3 integrin through Ras/Raf-1/MEK/ERK and calcium/CaMKII signals (2005) J Clin Endocrinol Metab, 90, pp. 2865-2873. , 10.1210/jc.2004-1520, 15687337
Iaccarino, G., Smithwick, L.A., Lefkowitz, R.J., Koch, W.J., Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis (1999) Proc Natl Acad Sci USA, 96, pp. 3945-3950. , 10.1073/pnas.96.7.3945, 22400, 10097143
Ciccarelli, M., Santulli, G., Campanile, A., Galasso, G., Cervero, P., Altobelli, G.G., Cimini, V., Iaccarino, G., Endothelial alpha1-adrenoceptors regulate neo-angiogenesis (2008) Br J Pharmacol, 153, pp. 936-946. , 10.1038/sj.bjp.0707637, 2267280, 18084315
Sorriento, D., Ciccarelli, M., Santulli, G., Campanile, A., Altobelli, G.G., Cimini, V., Galasso, G., Pastore, L., The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha (2008) Proc Natl Acad Sci USA, 105, pp. 17818-17823. , 10.1073/pnas.0804446105, 2584738, 19008357
Sorriento, D., Santulli, G., Fusco, A., Anastasio, A., Trimarco, B., Iaccarino, G., Intracardiac Injection of AdGRK5-NT Reduces Left Ventricular Hypertrophy by Inhibiting NF-{kappa}B-Dependent Hypertrophic Gene Expression (2010) Hypertension, 56, pp. 696-704. , 10.1161/HYPERTENSIONAHA.110.155960, 20660817
Santulli, G., Illario, M., Palumbo, G., Sorriento, D., Cipolletta, E., Trimarco, V., Del Giudice, C., Iaccarino, G., CaMK4 partecipates in the settings of the hypertensive phenotype: a human genome wide analysis supported by animal model (2009) Eur Heart J, 30 (SUPPL.1), p. 161
Astrof, S., Hynes, R.O., Fibronectins in vascular morphogenesis (2009) Angiogenesis, 12, pp. 165-175. , 10.1007/s10456-009-9136-6, 2716138, 19219555
Zaccaro, L., Del Gatto, A., Pedone, C., Saviano, M., Peptides for tumour therapy and diagnosis: current status and future directions (2009) Curr Med Chem, 16, pp. 780-795. , 10.2174/092986709787549307, 19275595
Verbisck, N.V., Costa, E.T., Costa, F.F., Cavalher, F.P., Costa, M.D., Muras, A., Paixao, V.A., Ierardi, D.F., ADAM23 negatively modulates alpha(v)beta(3) integrin activation during metastasis (2009) Cancer Res, 69, pp. 5546-5552. , 10.1158/0008-5472.CAN-08-2976, 19549921
Laitinen, I., Saraste, A., Weidl, E., Poethko, T., Weber, A.W., Nekolla, S.G., Leppanen, P., Walch, A., Evaluation of alphavbeta3 integrin-targeted positron emission tomography tracer 18F-galacto-RGD for imaging of vascular inflammation in atherosclerotic mice (2009) Circ Cardiovasc Imaging, 2, pp. 331-338. , 10.1161/CIRCIMAGING.108.846865, 19808614
Furundzija, V., Fritzsche, J., Kaufmann, J., Meyborg, H., Fleck, E., Kappert, K., Stawowy, P., IGF-1 increases macrophage motility via PKC/p38-dependent alphavbeta3-integrin inside-out signaling (2010) Biochem Biophys Res Commun, 394, pp. 786-791. , 10.1016/j.bbrc.2010.03.072, 20230795
Vanderslice, P., Woodside, D.G., Integrin antagonists as therapeutics for inflammatory diseases (2006) Expert Opin Investig Drugs, 15, pp. 1235-1255. , 10.1517/13543784.15.10.1235, 16989599
Tani, N., Higashiyama, S., Kawaguchi, N., Madarame, J., Ota, I., Ito, Y., Ohoka, Y., Matsuura, N., Expression level of integrin alpha 5 on tumour cells affects the rate of metastasis to the kidney (2003) Br J Cancer, 88, pp. 327-333. , 10.1038/sj.bjc.6600710, 2377056, 12610521
Crawford, T.N., Alfaro, D.V., Kerrison, J.B., Jablon, E.P., Diabetic retinopathy and angiogenesis (2009) Curr Diabetes Rev, 5, pp. 8-13. , 10.2174/157339909787314149, 19199892
Santulli, R.J., Kinney, W.A., Ghosh, S., Decorte, B.L., Liu, L., Tuman, R.W., Zhou, Z., Clermont, A.C., Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats (2008) J Pharmacol Exp Ther, 324, pp. 894-901. , 10.1124/jpet.107.131656, 18083913
Desgrosellier, J. S., Cheresh, D. A., Integrins in cancer: biological implications and therapeutic opportunities (2010) Nat Rev Cancer, 10, pp. 9-22. , 10. 1038/nrc2748, 20029421
Hood, J. D., Frausto, R., Kiosses, W. B., Schwartz, M. A., Cheresh, D. A., Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis (2003) J Cell Biol, 162, pp. 933-943. , 10. 1083/jcb. 200304105, 2172815, 12952943
Bayless, K. J., Salazar, R., Davis, G. E., RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the alpha (v) beta (3) and alpha (5) beta (1) integrins (2000) Am J Pathol, 156, pp. 1673-1683. , 1876924, 10793078
Brooks, P. C., Stromblad, S., Sanders, L. C., von Schalscha, T. L., Aimes, R. T., Stetler-Stevenson, W. G., Quigley, J. P., Cheresh, D. A., Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3 (1996) Cell, 85, pp. 683-693. , 10. 1016/S0092-8674 (00) 81235-0, 8646777
Mahabeleshwar, G. H., Feng, W., Reddy, K., Plow, E. F., Byzova, T. V., Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis (2007) Circ Res, 101, pp. 570-580. , 10. 1161/CIRCRESAHA. 107. 155655, 2723825, 17641225
Xiong, J. P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S. L., Arnaout, M. A., Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand (2002) Science, 296, pp. 151-155. , 10. 1126/science. 1069040, 11884718
Eliceiri, B. P., Klemke, R., Stromblad, S., Cheresh, D. A., Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis (1998) J Cell Biol, 140, pp. 1255-1263. , 10. 1083/jcb. 140. 5. 1255, 2132684, 9490736
Eskens, F. A., Dumez, H., Hoekstra, R., Perschl, A., Brindley, C., Bottcher, S., Wynendaele, W., van Oosterom, A. T., Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours (2003) Eur J Cancer, 39, pp. 917-926. , 10. 1016/S0959-8049 (03) 00057-1, 12706360
Dechantsreiter, M. A., Planker, E., Matha, B., Lohof, E., Holzemann, G., Jonczyk, A., Goodman, S. L., Kessler, H., N-Methylated cyclic RGD peptides as highly active and selective alpha (V) beta (3) integrin antagonists (1999) J Med Chem, 42, pp. 3033-3040. , 10. 1021/jm970832g, 10447947
Verbisck, N. V., Costa, E. T., Costa, F. F., Cavalher, F. P., Costa, M. D., Muras, A., Paixao, V. A., Ierardi, D. F., ADAM23 negatively modulates alpha (v) beta (3) integrin activation during metastasis (2009) Cancer Res, 69, pp. 5546-5552. , 10. 1158/0008-5472. CAN-08-2976, 19549921
Crawford, T. N., Alfaro, D. V., Kerrison, J. B., Jablon, E. P., Diabetic retinopathy and angiogenesis (2009) Curr Diabetes Rev, 5, pp. 8-13. , 10. 2174/157339909787314149, 19199892
Santulli, R. J., Kinney, W. A., Ghosh, S., Decorte, B. L., Liu, L., Tuman, R. W., Zhou, Z., Clermont, A. C., Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats (2008) J Pharmacol Exp Ther, 324, pp. 894-901. , 10. 1124/jpet. 107. 131656, 18083913
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.474, 5-year impact factor: 3.692
Url: http://www.scopus.com/inward/record.url?eid=2-s2.0-78651314991&partnerID=40&md5=b515c0051bdd4718936f6b61a82085ce
Keywords: Arginylglycylaspartic Acid, Cilengitide, Echistatin, Vitronectin Receptor, Angiogenesis Inhibitor, Cyclopeptide, Animal Cell, Animal Experiment, Animal Model, Animal Tissue, Antiangiogenic Activity, C57bl 6 Mouse, Cell Proliferation, Controlled Study, Drug Effect, Endothelium Cell, In Vitro Study, In Vivo Study, Nonhuman, Signal Transduction, Smooth Muscle Fiber, Vascular Smooth Muscle, Wistar Kyoto Rat, Wound Healing Impairment, C57bl Mouse, Cell Culture, Drug Antagonism, Drug Screening, Enzyme Specificity, Neoplasm, Pathology, Physiology, Vascularization, Drug Evaluation, Preclinical, Endothelial Cells, Integrin Alphavbeta3, Mice, Inbred C57bl, Myocytes, Neovascularization, Inbred Wky, Substrate Specificity, Pharmacology, Therapeutic Use, Blood Supply, Drug Therapy,
Affiliations:
*** IBB - CNR ***
Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Italy
Department of Biological Sciences, Federico II University of Naples, Italy
Institute of Crystallography (Consiglio Nazionale delle Ricerche CNR), Bari, Italy
Institute of Biostructures and Bioimaging (Consiglio Nazionale delle Ricerche CNR), Naples, Italy
References:
Santulli, G., Ciccarelli, M., Palumbo, G., Campanile, A., Galasso, G., Ziaco, B., Altobelli, G.G., D'Andrea, L.D., In vivo properties of the proangiogenic peptide QK (2009) J Transl Med, 7, p. 41. , 10.1186/1479-5876-7-41, 2702279, 1950532
Bonauer, A., Carmona, G., Iwasaki, M., Mione, M., Koyanagi, M., Fischer, A., Burchfield, J., Ohtani, K., MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice (2009) Science, 324, pp. 1710-1713. , 10.1126/science.1174381, 19460962
Desgrosellier, J.S., Cheresh, D.A., Integrins in cancer: biological implications and therapeutic opportunities (2010) Nat Rev Cancer, 10, pp. 9-22. , 10.1038/nrc2748, 20029421
Hood, J.D., Frausto, R., Kiosses, W.B., Schwartz, M.A., Cheresh, D.A., Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis (2003) J Cell Biol, 162, pp. 933-943. , 10.1083/jcb.200304105, 2172815, 12952943
Takahashi, S., Moser, M., Montanez, E., Nakano, T., Seo, M., Backert, S., Inoue, I., Fassler, R., The fibronectin RGD motif is required for multiple angiogenic events during early embryonic development (2010) Arterioscler Thromb Vasc Biol, 30, pp. e1. , 10.1161/ATVBAHA.108.181164, 19713531
Castel, S., Pagan, R., Garcia, R., Casaroli-Marano, R.P., Reina, M., Mitjans, F., Piulats, J., Vilaro, S., Alpha v integrin antagonists induce the disassembly of focal contacts in melanoma cells (2000) Eur J Cell Biol, 79, pp. 502-512. , 10.1078/0171-9335-00067, 10961450
Soldi, R., Mitola, S., Strasly, M., Defilippi, P., Tarone, G., Bussolino, F., Role of alphavbeta3 integrin in the activation of vascular endothelial growth factor receptor-2 (1999) Embo J, 18, pp. 882-892. , 10.1093/emboj/18.4.882, 1171181, 10022831
Lu, H., Murtagh, J., Schwartz, E.L., The microtubule binding drug laulimalide inhibits vascular endothelial growth factor-induced human endothelial cell migration and is synergistic when combined with docetaxel (taxotere) (2006) Mol Pharmacol, 69, pp. 1207-1215. , 10.1124/mol.105.019075, 1462867, 16415178
Bayless, K.J., Salazar, R., Davis, G.E., RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the alpha(v)beta(3) and alpha(5)beta(1) integrins (2000) Am J Pathol, 156, pp. 1673-1683. , 1876924, 10793078
Brooks, P.C., Stromblad, S., Sanders, L.C., von Schalscha, T.L., Aimes, R.T., Stetler-Stevenson, W.G., Quigley, J.P., Cheresh, D.A., Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3 (1996) Cell, 85, pp. 683-693. , 10.1016/S0092-8674(00)81235-0, 8646777
Abumiya, T., Lucero, J., Heo, J.H., Tagaya, M., Koziol, J.A., Copeland, B.R., del Zoppo, G.J., Activated microvessels express vascular endothelial growth factor and integrin alpha(v)beta3 during focal cerebral ischemia (1999) J Cereb Blood Flow Metab, 19, pp. 1038-1050. , 10.1097/00004647-199909000-00012, 10478656
Mahabeleshwar, G.H., Feng, W., Reddy, K., Plow, E.F., Byzova, T.V., Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis (2007) Circ Res, 101, pp. 570-580. , 10.1161/CIRCRESAHA.107.155655, 2723825, 17641225
Xiong, J.P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S.L., Arnaout, M.A., Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand (2002) Science, 296, pp. 151-155. , 10.1126/science.1069040, 11884718
Aumailley, M., Gurrath, M., Muller, G., Calvete, J., Timpl, R., Kessler, H., Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1 (1991) FEBS Lett, 291, pp. 50-54. , 10.1016/0014-5793(91)81101-D, 1718779
Schottelius, M., Laufer, B., Kessler, H., Wester, H.J., Ligands for mapping alphavbeta3-integrin expression in vivo (2009) Acc Chem Res, 42, pp. 969-980. , 10.1021/ar800243b, 19489579
Eliceiri, B.P., Klemke, R., Stromblad, S., Cheresh, D.A., Integrin alphavbeta3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis (1998) J Cell Biol, 140, pp. 1255-1263. , 10.1083/jcb.140.5.1255, 2132684, 9490736
Bai, J., Zhang, J., Wu, J., Shen, L., Zeng, J., Ding, J., Wu, Y., Xu, S., JWA regulates melanoma metastasis by integrin alpha(V)beta(3) signaling (2010) Oncogene, 29, pp. 1227-1237. , 10.1038/onc.2009.408, 19946336
Eskens, F.A., Dumez, H., Hoekstra, R., Perschl, A., Brindley, C., Bottcher, S., Wynendaele, W., van Oosterom, A.T., Phase I and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins alphavbeta3 and alphavbeta5 in patients with advanced solid tumours (2003) Eur J Cancer, 39, pp. 917-926. , 10.1016/S0959-8049(03)00057-1, 12706360
Dechantsreiter, M.A., Planker, E., Matha, B., Lohof, E., Holzemann, G., Jonczyk, A., Goodman, S.L., Kessler, H., N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists (1999) J Med Chem, 42, pp. 3033-3040. , 10.1021/jm970832g, 10447947
Del Gatto, A., Zaccaro, L., Grieco, P., Novellino, E., Zannetti, A., Del Vecchio, S., Iommelli, F., Saviano, M., Novel and selective alpha(v)beta3 receptor peptide antagonist: design, synthesis, and biological behavior (2006) J Med Chem, 49, pp. 3416-3420. , 10.1021/jm060233m, 16722662
Ciccarelli, M., Cipolletta, E., Santulli, G., Campanile, A., Pumiglia, K., Cervero, P., Pastore, L., Iaccarino, G., Endothelial beta2 adrenergic signaling to AKT: role of Gi and SRC (2007) Cell Signal, 19, pp. 1949-1955. , 10.1016/j.cellsig.2007.05.007, 17629454
Iaccarino, G., Ciccarelli, M., Sorriento, D., Cipolletta, E., Cerullo, V., Iovino, G.L., Paudice, A., Campanile, A., AKT participates in endothelial dysfunction in hypertension (2004) Circulation, 109, pp. 2587-2593. , 10.1161/01.CIR.0000129768.35536.FA, 15136501
Illario, M., Cavallo, A.L., Monaco, S., Di Vito, E., Mueller, F., Marzano, L.A., Troncone, G., Vitale, M., Fibronectin-induced proliferation in thyroid cells is mediated by alphavbeta3 integrin through Ras/Raf-1/MEK/ERK and calcium/CaMKII signals (2005) J Clin Endocrinol Metab, 90, pp. 2865-2873. , 10.1210/jc.2004-1520, 15687337
Iaccarino, G., Smithwick, L.A., Lefkowitz, R.J., Koch, W.J., Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis (1999) Proc Natl Acad Sci USA, 96, pp. 3945-3950. , 10.1073/pnas.96.7.3945, 22400, 10097143
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Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit
Background: Integrins are heterodimeric receptors that play a critical role in cell-cell and cell-matrix adhesion processes. Among them, αVβ3integrin, that recognizes the aminoacidic RGD triad, is reported to be involved in angiogenesis, tissue repair and tumor growth. We have recently synthesized a new and selective ligand of αVβ3receptor, referred to as RGDechiHCit, that contains a cyclic RGD motif and two echistatin moieties.Methods: The aim of this study is to evaluate in vitro and in vivo the effects of RGDechiHCit. Therefore, we assessed its properties in cellular (endothelial cells [EC], and vascular smooth muscle cells [VSMC]) and animal models (Wistar Kyoto rats and c57Bl/6 mice) of angiogenesis.Results: In EC, but not VSMC, RGDechiHCit inhibits intracellular mitogenic signaling and cell proliferation. Furthermore, RGDechiHCit blocks the ability of EC to form tubes on Matrigel. In vivo, wound healing is delayed in presence of RGDechiHCit. Similarly, Matrigel plugs demonstrate an antiangiogenic effect of RGDechiHCit.Conclusions: Our data indicate the importance of RGDechiHCit in the selective inhibition of endothelial αVβ3integrin in vitro and in vivo. Such inhibition opens new fields of investigation on the mechanisms of angiogenesis, offering clinical implications for treatment of pathophysiological conditions such as cancer, proliferative retinopathy and inflammatory disease. © 2011 Santulli et al; licensee BioMed Central Ltd.
Background: Integrins are heterodimeric receptors that play a critical role in cell-cell and cell-matrix adhesion processes. Among them, αVβ3integrin, that recognizes the aminoacidic RGD triad, is reported to be involved in angiogenesis, tissue repair and tumor growth. We have recently synthesized a new and selective ligand of αVβ3receptor, referred to as RGDechiHCit, that contains a cyclic RGD motif and two echistatin moieties.Methods: The aim of this study is to evaluate in vitro and in vivo the effects of RGDechiHCit. Therefore, we assessed its properties in cellular (endothelial cells [EC], and vascular smooth muscle cells [VSMC]) and animal models (Wistar Kyoto rats and c57Bl/6 mice) of angiogenesis.Results: In EC, but not VSMC, RGDechiHCit inhibits intracellular mitogenic signaling and cell proliferation. Furthermore, RGDechiHCit blocks the ability of EC to form tubes on Matrigel. In vivo, wound healing is delayed in presence of RGDechiHCit. Similarly, Matrigel plugs demonstrate an antiangiogenic effect of RGDechiHCit.Conclusions: Our data indicate the importance of RGDechiHCit in the selective inhibition of endothelial αVβ3integrin in vitro and in vivo. Such inhibition opens new fields of investigation on the mechanisms of angiogenesis, offering clinical implications for treatment of pathophysiological conditions such as cancer, proliferative retinopathy and inflammatory disease. © 2011 Santulli et al; licensee BioMed Central Ltd.
Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit
| ▼ Development of integrin subtypes selective ligands: from a first rationally designed peptide to a wide range of molecules |
Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit
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* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (454 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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Carriero MV, Bifulco K, Minopoli M, Lista L, Maglio O, Mele L, Di Carluccio G, De Rosa M, Pavone V
* UPARANT: a urokinase receptor-derived peptide inhibitor of VEGF-driven angiogenesis with enhanced stability and in vitro and in vivo potency (468 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic), 2014 May; 13(5): 1092-1104.
Impact Factor: 5.683
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (846 views)
J Immunol (ISSN: 0022-1767), 2014 Jan 15; 192(2): 589-602.
Impact Factor: 4.922
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Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (447 views)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
Impact Factor: 1.045
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Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (564 views)
Bioconjug Chem (ISSN: 1520-4812, 1043-1802, 1520-4812electronic), 2012 Mar 21; 23(3): 340-349.
Impact Factor: 4.58
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Basile A, Del Gatto A, Diana D, Di Stasi R, Falco A, Festa M, Rosati A, Barbieri A, Franco R, Arra C, Pedone C, Fattorusso R, Turco MC, D'Andrea LD
* Characterization of a designed vascular endothelial growth factor receptor antagonist helical peptide with antiangiogenic activity in vivo (559 views)
J Med Chem (ISSN: 1520-4804, 0022-2623, 0022-2623print), 2011 Mar 10; 54(5): 1391-1400.
Impact Factor: 5.248
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Guarnieri D, De Capua A, Ventre M, Borzacchiello A, Pedone C, Marasco D, Ruvo M, Netti PA
* Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters (656 views)
Acta Biomaterialia (ISSN: 1878-7568, 1742-7061), 2010 Jul; 6(7): 2532-2539.
Impact Factor: 4.824
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Monfregola L, Saviano M, De Luca S
* Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling (378 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2010 Mar; 16(1): 1-5.
Impact Factor: 1.034
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Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
* Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (542 views)
J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
Impact Factor: 3.068
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (928 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (498 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
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D'Andrea LD, Del Gatto A, De Rosa L, Romanelli A, Pedone C
* Peptides targeting angiogenesis related growth factor receptors (14589 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1873-4286, 1381-6128), 2009 Jul; 15(21): 2414-2429.
Impact Factor: 4.414
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Zaccaro L, Del Gatto A, Pedone C, Saviano M
* Peptides for tumour therapy and diagnosis: current status and future directions (1133 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2009 Mar; 16(7): 780-795.
Impact Factor: 4.708
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De Luca S, Del Gatto A, Ruvo M, Panico M, Zannetti A, Del Vecchio S, Salvatore M, Pedone C, Saviano M, Zaccaro L
* A new and selective radiolabeled alpha(V)beta(3) peptide antagonist as tracer in tumor diagnosis (443 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 439-440.
Impact Factor: 2.02
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Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (464 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (730 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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D'Andrea LD, Del Gatto A, Pedone C, Benedetti E
* Peptide-based molecules in angiogenesis (843 views)
Chem Biol Drug Des (ISSN: 1747-0277, 1747-0285, 1747-0277linking), 2006 Feb; 67(2): 115-126.
Impact Factor: 2.507
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Carriero M, Del Vecchio S, Capozzoli M, Franco P, Fontana L, Zannetti A, Botti G, D'Aiuto G, Salvatore M, Stoppelli M
Urokinase receptor interacts with alpha(v)beta(5) vitronectin receptor, promoting urokinase-dependent cell migration in breast cancer (394 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1999 Oct 15; 59(20): N/D-N/D.
Impact Factor: 8.614
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27 Records (25 excluding Abstracts).
Total impact factor: 109.982 (98.134 excluding Abstracts).
Total 5 year impact factor: 107.419 (95.681 excluding Abstracts).
Total impact factor: 109.982 (98.134 excluding Abstracts).
Total 5 year impact factor: 107.419 (95.681 excluding Abstracts).
511 views. Last view on Saturday 01 April 2023, 16:04:04
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